We are grateful for funding from the @cziscience.bsky.social data insights program for supporting this study, which we hope will be useful for the field!
#ovarian #singlecell #genomics #aging
Find the preprint at www.biorxiv.org/content/10.1...

Minhoo also leveraged #ASGARD to identify potential drugs that could revert transcriptional aging signatures across cell types and across species, yielding candidate conserved anti-ovarian aging compounds which will deserve further investigation. 5/5

Granulosa and Theca cells, major somatic cell types of ovarian follicles, showed clear changes with aging, with some species-specific gene regulation, but also conserved changes. Importantly, expression of FSHR and OSGIN2 was consistently decreased across datasets and models. 4/5

Datasets were processed with a unified standardized pipeline for easy #integration and #comparison. This included analysis of cell proportion changes, differential gene expression, and potential drug repurposing targets. 3/5

Minhoo identified a number of high-quality #ovarian aging datasets across mammalian species, spanning humans🚶‍♀️, monkeys🐒, mice 🐁, and goat🐐, with samples across the reproductive lifespan. We reasoned this would allow us to identify conserved signatures of #ovarian aging. 2/5

I think mandating preprinting (like many private funders like CZI do) would be the perfect compromise instead of mandating gold OA and then restricting the amount of APC that can be spent. We always preprint before 1st submission in my lab, and I consider it the “director’s cut” anyway.

Undergrad flash talks are starting - the future of #Geroscience research is here!

😅

USC LDS Vice Dean Sean Curran opening the day!!!

#GLAM2025

The outrage is great, but the reality is gold OA is >>$2K, and capping the spending will have 2 effects: (1) only rich labs will be able to afford publishing in the most prestigious journals, (2) ECR who need these papers in their CVs will be screwed. At this point- not a victory for us scientists.

When boasting of 8-day to 1st decision (and charging >10K APC), it is unbelievable to be unable to provide not even a timeline to 1st decision to authors after ≥6 weeks. #Scientific #publishing is just broken. I hope my trainees can get a respectful and timely review of their work elsewhere. 2/2