Wythe Lab at UVA School of Medicine
@wythelab.bsky.social
Vascular biologist. Brain AVMs and Kras, glioblastoma and angiogenesis, lymphatics, and developmental biology.
https://www.wythelab.com
https://www.wythelab.com
Pinned
Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse
Nature Cardiovascular Research - Cantu Gutierrez et al. identify the common and unique transcriptional regulatory networks in the endothelium of six different organs throughout development, and...
go.nature.com
Excited to share this paper that is a long time coming from the lab on epigenetic/transcriptional regulation of organotypic endothelial specialization out today @naturecvr.bsky.social go.nature.com/4krSJqh
Reposted by Wythe Lab at UVA School of Medicine
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
November 4, 2025 at 10:40 PM
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
Reposted by Wythe Lab at UVA School of Medicine
Meningeal vascular remodeling in 2~4 mo ovariectomized🐭
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
November 15, 2025 at 11:20 PM
Meningeal vascular remodeling in 2~4 mo ovariectomized🐭
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
Reposted by Wythe Lab at UVA School of Medicine
New paper from the lab on a new Gateway compatible toolkit for transgenesis in eukaryotes, led by former technician Will Gillespie.
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
MultiSite Assembly of Gateway Induced Clones (MAGIC): a flexible cloning toolbox for use in vertebrate model systems
Summary: A comprehensive suite of Gateway-compatible plasmids for in vitro and in vivo transgenesis in vertebrate model systems has been developed, together with a relational, modifiable, open-source ...
journals.biologists.com
November 14, 2025 at 5:33 PM
New paper from the lab on a new Gateway compatible toolkit for transgenesis in eukaryotes, led by former technician Will Gillespie.
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Such an iconic album. Insane.
In a world long forgotten, Jay-Z released his final album 22 years ago today.
And ill never forget the first time I heard "What More Can I Say."
Music just dont feel the same anymore. I rode the bus to Best Buy to get this album. What a time
"Ayo wassup pimp, this threats!!"
And ill never forget the first time I heard "What More Can I Say."
Music just dont feel the same anymore. I rode the bus to Best Buy to get this album. What a time
"Ayo wassup pimp, this threats!!"
November 15, 2025 at 1:45 AM
Such an iconic album. Insane.
Reposted by Wythe Lab at UVA School of Medicine
"The Cavalier Daily corresponded with former Rector Robert Hardie, whose term ended June 30, regarding the two accounts. He confirmed that he agreed with Ryan’s account.
'I concur fully with President Ryan’s recollection of events,' Hardie said."
Welp
www.cavalierdaily.com/article/2025...
'I concur fully with President Ryan’s recollection of events,' Hardie said."
Welp
www.cavalierdaily.com/article/2025...
Ryan and Sheridan provide full accounts of Ryan’s resignation. They differ significantly
“I concur fully with President Ryan’s recollection of events,” former Board Rector Robert Hardie said.
www.cavalierdaily.com
November 14, 2025 at 7:46 PM
"The Cavalier Daily corresponded with former Rector Robert Hardie, whose term ended June 30, regarding the two accounts. He confirmed that he agreed with Ryan’s account.
'I concur fully with President Ryan’s recollection of events,' Hardie said."
Welp
www.cavalierdaily.com/article/2025...
'I concur fully with President Ryan’s recollection of events,' Hardie said."
Welp
www.cavalierdaily.com/article/2025...
Reposted by Wythe Lab at UVA School of Medicine
MAGIC Toolbox: MultiSite Assembly of Gateway Induced Clones ✨🧬 Thanks for sharing @wythelab.bsky.social!
Find the plasmids here: www.addgene.org/browse/artic...
Find the plasmids here: www.addgene.org/browse/artic...
November 14, 2025 at 7:28 PM
MAGIC Toolbox: MultiSite Assembly of Gateway Induced Clones ✨🧬 Thanks for sharing @wythelab.bsky.social!
Find the plasmids here: www.addgene.org/browse/artic...
Find the plasmids here: www.addgene.org/browse/artic...
New paper from the lab on a new Gateway compatible toolkit for transgenesis in eukaryotes, led by former technician Will Gillespie.
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
MultiSite Assembly of Gateway Induced Clones (MAGIC): a flexible cloning toolbox for use in vertebrate model systems
Summary: A comprehensive suite of Gateway-compatible plasmids for in vitro and in vivo transgenesis in vertebrate model systems has been developed, together with a relational, modifiable, open-source ...
journals.biologists.com
November 14, 2025 at 5:33 PM
New paper from the lab on a new Gateway compatible toolkit for transgenesis in eukaryotes, led by former technician Will Gillespie.
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Reposted by Wythe Lab at UVA School of Medicine
108 years ago, the US military carried out the largest mass execution in American history. In December 1917, the military hanged 13 soldiers. Another 6 were hanged less than a year later.
Yes...they were all Black soldiers.
It's best known as the Houston Riot of 1917
🧵
Yes...they were all Black soldiers.
It's best known as the Houston Riot of 1917
🧵
November 13, 2025 at 10:37 PM
108 years ago, the US military carried out the largest mass execution in American history. In December 1917, the military hanged 13 soldiers. Another 6 were hanged less than a year later.
Yes...they were all Black soldiers.
It's best known as the Houston Riot of 1917
🧵
Yes...they were all Black soldiers.
It's best known as the Houston Riot of 1917
🧵
Reposted by Wythe Lab at UVA School of Medicine
See my pinned thread. Happy to have this version out!
Online now: A combined genomic arrhythmia propensity score delineates cumulative risk
A combined genomic arrhythmia propensity score delineates cumulative risk
Monroe et al. analyze genome sequencing from individuals with early-onset ventricular arrhythmias. Combining the effect of common genetic variants with rare coding and noncoding regulatory variants in cardiomyopathy and arrhythmia genes predicts outcomes. Each component additively predicts arrhythmia with the cumulative GAPS performing best.
dlvr.it
November 12, 2025 at 10:20 PM
See my pinned thread. Happy to have this version out!
Reposted by Wythe Lab at UVA School of Medicine
Proud to share L'Oréal USA’s 2025 For Women in Science awardees — five brilliant women driving discovery & innovation in STEM. Honored to be quoted in the release. 🌍🧪
Read: prn.to/3Xsnila
@aaas.org @aaascsew.bsky.social #WomenInSTEM #ForWomenInScience #L'OrealUSA
Read: prn.to/3Xsnila
@aaas.org @aaascsew.bsky.social #WomenInSTEM #ForWomenInScience #L'OrealUSA
L'Oréal USA Announces 2025 For Women in Science Awardees, Underscoring Commitment to Advancing Careers in STEM
/PRNewswire/ -- Today, L'Oréal USA revealed the 2025 For Women in Science (FWIS) awardees, providing five women postdoctoral scientists grants to advance their...
prn.to
November 12, 2025 at 11:09 PM
Proud to share L'Oréal USA’s 2025 For Women in Science awardees — five brilliant women driving discovery & innovation in STEM. Honored to be quoted in the release. 🌍🧪
Read: prn.to/3Xsnila
@aaas.org @aaascsew.bsky.social #WomenInSTEM #ForWomenInScience #L'OrealUSA
Read: prn.to/3Xsnila
@aaas.org @aaascsew.bsky.social #WomenInSTEM #ForWomenInScience #L'OrealUSA
Reposted by Wythe Lab at UVA School of Medicine
Many well-known perimenopause symptoms arise in the brain, but we still know little about the specific mechanisms at play. More research—both in animals and humans—is essential, writes @kundakoviclab.bsky.social.
#neuroskyence
www.thetransmitter.org/sex-hormones...
#neuroskyence
www.thetransmitter.org/sex-hormones...
Perimenopause: An understudied transition for the brain
We know little about the mechanisms underlying well-known perimenopause symptoms in the brain. More research—in animals and humans—is essential.
www.thetransmitter.org
November 12, 2025 at 6:00 PM
Many well-known perimenopause symptoms arise in the brain, but we still know little about the specific mechanisms at play. More research—both in animals and humans—is essential, writes @kundakoviclab.bsky.social.
#neuroskyence
www.thetransmitter.org/sex-hormones...
#neuroskyence
www.thetransmitter.org/sex-hormones...
Reposted by Wythe Lab at UVA School of Medicine
Our red calcium indicator, FRCaMPi, and its soma-localized version, SomaFRCaMPi, are now available from @addgene.bsky.social in various vectors, along with all the sensors used for benchmarking. www.addgene.org/browse/artic...
November 12, 2025 at 12:08 AM
Our red calcium indicator, FRCaMPi, and its soma-localized version, SomaFRCaMPi, are now available from @addgene.bsky.social in various vectors, along with all the sensors used for benchmarking. www.addgene.org/browse/artic...
Reposted by Wythe Lab at UVA School of Medicine
Single-cell atlas of intracranial arteries reveals sex-specific gene regulation linked to intracranial aneurysm risk https://www.medrxiv.org/content/10.1101/2025.11.06.25339724v1
November 11, 2025 at 1:26 AM
Single-cell atlas of intracranial arteries reveals sex-specific gene regulation linked to intracranial aneurysm risk https://www.medrxiv.org/content/10.1101/2025.11.06.25339724v1
November 11, 2025 at 1:31 AM
Reposted by Wythe Lab at UVA School of Medicine
After yesterday’s surrender, we’re launching the largest Democratic primary program that we’ve ever run.
We will not back any Senate primary candidate unless they call for Schumer to step down as Minority Leader.
If you’re as pissed as we are, join this campaign to rebuild the Democratic Party. 👇
We will not back any Senate primary candidate unless they call for Schumer to step down as Minority Leader.
If you’re as pissed as we are, join this campaign to rebuild the Democratic Party. 👇
Democratic leaders have failed us again. It's time to get new leaders.
After yet another capitulation by Chuck Schumer and Senate Democrats, it's clear we need new leadership capable of mounting a serious opposition to Trump's authoritarian regime. We're launching our la...
www.indivisible2026.org
November 11, 2025 at 12:00 AM
After yesterday’s surrender, we’re launching the largest Democratic primary program that we’ve ever run.
We will not back any Senate primary candidate unless they call for Schumer to step down as Minority Leader.
If you’re as pissed as we are, join this campaign to rebuild the Democratic Party. 👇
We will not back any Senate primary candidate unless they call for Schumer to step down as Minority Leader.
If you’re as pissed as we are, join this campaign to rebuild the Democratic Party. 👇
Reposted by Wythe Lab at UVA School of Medicine
The coordinated nature of this—none are facing voters in 2026—means that either Schumer approved it or failed in his job as Senate Majority Leader to stop it.
Dems voting "no" get zero credit until they demand a change in leadership. Schumer out as Leader, Durbin out as Whip.
Dems voting "no" get zero credit until they demand a change in leadership. Schumer out as Leader, Durbin out as Whip.
so currently defectors are:
Kaine (2030)
Shaheen (Retiring)
Hasan (2028)
Fetterman (2028)
Durbin (Retiring)
CCM (2028)
Rosen (2030)
King (2030)
Kaine (2030)
Shaheen (Retiring)
Hasan (2028)
Fetterman (2028)
Durbin (Retiring)
CCM (2028)
Rosen (2030)
King (2030)
November 10, 2025 at 2:43 AM
The coordinated nature of this—none are facing voters in 2026—means that either Schumer approved it or failed in his job as Senate Majority Leader to stop it.
Dems voting "no" get zero credit until they demand a change in leadership. Schumer out as Leader, Durbin out as Whip.
Dems voting "no" get zero credit until they demand a change in leadership. Schumer out as Leader, Durbin out as Whip.
Reposted by Wythe Lab at UVA School of Medicine
Trump and Republicans refuse to fight for American families, but I refuse to give up on them.
I simply cannot vote to do nothing to help protect them from Trump’s vindictive efforts in exchange for a vague promise from the least trustworthy Republican party in our nation’s history.
I simply cannot vote to do nothing to help protect them from Trump’s vindictive efforts in exchange for a vague promise from the least trustworthy Republican party in our nation’s history.
November 10, 2025 at 1:33 AM
Trump and Republicans refuse to fight for American families, but I refuse to give up on them.
I simply cannot vote to do nothing to help protect them from Trump’s vindictive efforts in exchange for a vague promise from the least trustworthy Republican party in our nation’s history.
I simply cannot vote to do nothing to help protect them from Trump’s vindictive efforts in exchange for a vague promise from the least trustworthy Republican party in our nation’s history.
Reposted by Wythe Lab at UVA School of Medicine
KATMAP infers splicing factor activity and regulatory targets from knockdown data - @daspliceisright.bsky.social go.nature.com/47ycrMJ
KATMAP infers splicing factor activity and regulatory targets from knockdown data - Nature Biotechnology
A biophysical model uses knockdown or overexpression data to infer splicing factor activity.
go.nature.com
November 4, 2025 at 3:13 PM
KATMAP infers splicing factor activity and regulatory targets from knockdown data - @daspliceisright.bsky.social go.nature.com/47ycrMJ
Reposted by Wythe Lab at UVA School of Medicine
Call now, leave a message, and call again tomorrow.
November 10, 2025 at 12:25 AM
Call now, leave a message, and call again tomorrow.
Reposted by Wythe Lab at UVA School of Medicine
👇🎯 Unfortunately, this is true & probably the only way. Voters need to realize that hating government, & illegally defunding & dismantling it, & pretending that we can run a modern society/economy on Ronald Reagan's shabby talking point & worn copies of Atlas Shrugged & Mein Kampf is untenable.
Democrats have to stop bailing out Republicans from facing the consequences of their own policies. And yeah, that means they have to stop sparing voters from experiencing what GOP government truly means.
Every time Dems step in, it only emboldens the GOP & they make it even worse the next time.
Every time Dems step in, it only emboldens the GOP & they make it even worse the next time.
So Democrats get:
1. A CR that will prevent the GOP from facing the wrath of Americans for a shutdown over the holidays
2. A coupon for one (1) meaningless ACA vote that will fail
3. An end to the illegal RIF/SNAP moves that are already before the courts
Those all seem like wins for the GOP.
1. A CR that will prevent the GOP from facing the wrath of Americans for a shutdown over the holidays
2. A coupon for one (1) meaningless ACA vote that will fail
3. An end to the illegal RIF/SNAP moves that are already before the courts
Those all seem like wins for the GOP.
November 10, 2025 at 12:35 AM
👇🎯 Unfortunately, this is true & probably the only way. Voters need to realize that hating government, & illegally defunding & dismantling it, & pretending that we can run a modern society/economy on Ronald Reagan's shabby talking point & worn copies of Atlas Shrugged & Mein Kampf is untenable.
Reposted by Wythe Lab at UVA School of Medicine
If I lived in Virginia, the second that Spanberger is sworn in as governor, I'd be demanding @kaine.senate.gov's resignation so she could replace him with someone who's actually aware of what is going on.
November 10, 2025 at 12:48 AM
If I lived in Virginia, the second that Spanberger is sworn in as governor, I'd be demanding @kaine.senate.gov's resignation so she could replace him with someone who's actually aware of what is going on.
Reposted by Wythe Lab at UVA School of Medicine
Virginians:
If you have voted for Kaine in the past, and aren't happy about this, please contact his office immediately.
You may have to wait until tomorrow to call, but here's an email form
www.kaine.senate.gov/contact/shar...
If you have voted for Kaine in the past, and aren't happy about this, please contact his office immediately.
You may have to wait until tomorrow to call, but here's an email form
www.kaine.senate.gov/contact/shar...
November 10, 2025 at 12:57 AM
Virginians:
If you have voted for Kaine in the past, and aren't happy about this, please contact his office immediately.
You may have to wait until tomorrow to call, but here's an email form
www.kaine.senate.gov/contact/shar...
If you have voted for Kaine in the past, and aren't happy about this, please contact his office immediately.
You may have to wait until tomorrow to call, but here's an email form
www.kaine.senate.gov/contact/shar...
Reposted by Wythe Lab at UVA School of Medicine
And now, if you read the devastating piece about what Venezuelan deportees endured at the El Salvador torture prison, read what incarcerated U.S. citizens endure in Alabama prisons.
State prisons in the U.S. that are massive systems of human rights violations.
www.theguardian.com/film/2025/oc...
State prisons in the U.S. that are massive systems of human rights violations.
www.theguardian.com/film/2025/oc...
‘How is this possible?’: a new film looks inside the appalling abuses of the Alabama prison system
In the year’s most shocking documentary, The Alabama Solution, prisoners share astonishing footage in a plea for help
www.theguardian.com
November 9, 2025 at 4:38 PM
And now, if you read the devastating piece about what Venezuelan deportees endured at the El Salvador torture prison, read what incarcerated U.S. citizens endure in Alabama prisons.
State prisons in the U.S. that are massive systems of human rights violations.
www.theguardian.com/film/2025/oc...
State prisons in the U.S. that are massive systems of human rights violations.
www.theguardian.com/film/2025/oc...
Reposted by Wythe Lab at UVA School of Medicine
We'll resume weekly open studio night soon, when anyone (member or no) can gather in our space to work on your own book arts+printing projects (like bookbinding, linoleum carving, zinemaking & more) while hanging out w/others doing the same. Join our newsletter to hear about these & more events:
Virginia Book Arts
vabookarts.org
November 10, 2025 at 12:51 AM
We'll resume weekly open studio night soon, when anyone (member or no) can gather in our space to work on your own book arts+printing projects (like bookbinding, linoleum carving, zinemaking & more) while hanging out w/others doing the same. Join our newsletter to hear about these & more events:
Reposted by Wythe Lab at UVA School of Medicine
you can see why fascism is so popular when the other option is The Loser Party That Loves Losing
November 10, 2025 at 12:49 AM
you can see why fascism is so popular when the other option is The Loser Party That Loves Losing