Winkler Laboratory
@winklerlab.bsky.social
We are the Winkler Laboratory at the UKHD and DKFZ Heidelberg
Our focus: #cancerneuroscience of #braintumors ( #glioblastoma #brainmetastases), and beyond.
We use #intravitalimaging , #calciumimaging, #preclinicalmodels and more, to tackle these diseases
Our focus: #cancerneuroscience of #braintumors ( #glioblastoma #brainmetastases), and beyond.
We use #intravitalimaging , #calciumimaging, #preclinicalmodels and more, to tackle these diseases
Pinned
How to disconnect therapy-resistant tumor networks in glioblastoma?
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
📢 Registration (free!) for the NCI webinar series 'Fueling Cancer Progression by the Nervous System' is open!
🧠🔬 Amongst many excellent speakers, Frank Winkler and @venkatesh-lab.bsky.social discuss #cancerneuroscience of #brainmetastasis
📅 6 exciting topics are covered by leaders in the field 💡!
🧠🔬 Amongst many excellent speakers, Frank Winkler and @venkatesh-lab.bsky.social discuss #cancerneuroscience of #brainmetastasis
📅 6 exciting topics are covered by leaders in the field 💡!
Fueling Cancer Progression by the Nervous System (Overview) | Events Registration
OverviewThe Fueling Cancer Progression by the Nervous System series will feature six webinars, each exploring the junction between neuroscience and cancer biology to advance our understanding of cance...
events.cancer.gov
November 21, 2025 at 7:53 AM
📢 Registration (free!) for the NCI webinar series 'Fueling Cancer Progression by the Nervous System' is open!
🧠🔬 Amongst many excellent speakers, Frank Winkler and @venkatesh-lab.bsky.social discuss #cancerneuroscience of #brainmetastasis
📅 6 exciting topics are covered by leaders in the field 💡!
🧠🔬 Amongst many excellent speakers, Frank Winkler and @venkatesh-lab.bsky.social discuss #cancerneuroscience of #brainmetastasis
📅 6 exciting topics are covered by leaders in the field 💡!
Reposted by Winkler Laboratory
1/ New ‘fundamental’ study shows that neuronal migration depends on blood flow in the adult mammalian brain.
elifesciences.org/articles/995...
elifesciences.org/articles/995...
November 13, 2025 at 2:44 PM
1/ New ‘fundamental’ study shows that neuronal migration depends on blood flow in the adult mammalian brain.
elifesciences.org/articles/995...
elifesciences.org/articles/995...
Reposted by Winkler Laboratory
New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
November 5, 2025 at 6:53 PM
New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
An amazing set of resources for all scientists working on the brain!
🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
Reposted by Winkler Laboratory
Autumn in #Heidelberg. We are excited to welcome the brightest scientists in Neurooncology at the 8th Harvard Heidelberg Alliance in #Neurooncology!
@dkfz.bsky.social @uniheidelberg.bsky.social
@dkfz.bsky.social @uniheidelberg.bsky.social
October 23, 2025 at 1:43 PM
Autumn in #Heidelberg. We are excited to welcome the brightest scientists in Neurooncology at the 8th Harvard Heidelberg Alliance in #Neurooncology!
@dkfz.bsky.social @uniheidelberg.bsky.social
@dkfz.bsky.social @uniheidelberg.bsky.social
Fantastic presentation @melinamueller.bsky.social ! We are very proud to have you in the lab and looking forward to future discoveries 🤩
#UNITE-GBM #cancerneuroscience
@neurooncologyhd.bsky.social
#UNITE-GBM #cancerneuroscience
@neurooncologyhd.bsky.social
Thank you for the amazing #CancerNeuroscience conference @helloeacr.bsky.social!
We had a great time in Bilbao @winklerlab.bsky.social🧠.
We had a great time in Bilbao @winklerlab.bsky.social🧠.
October 19, 2025 at 6:55 PM
Fantastic presentation @melinamueller.bsky.social ! We are very proud to have you in the lab and looking forward to future discoveries 🤩
#UNITE-GBM #cancerneuroscience
@neurooncologyhd.bsky.social
#UNITE-GBM #cancerneuroscience
@neurooncologyhd.bsky.social
Reposted by Winkler Laboratory
Thank you for the amazing #CancerNeuroscience conference @helloeacr.bsky.social!
We had a great time in Bilbao @winklerlab.bsky.social🧠.
We had a great time in Bilbao @winklerlab.bsky.social🧠.
October 19, 2025 at 6:49 PM
Thank you for the amazing #CancerNeuroscience conference @helloeacr.bsky.social!
We had a great time in Bilbao @winklerlab.bsky.social🧠.
We had a great time in Bilbao @winklerlab.bsky.social🧠.
Reposted by Winkler Laboratory
It’s a wrap! What a fantastic and inspiring #EANO2025. It was great to share projects and ideas. Looking forward to Rome.
@winklerlab.bsky.social
@hlsalliance.bsky.social
@cn-hd.bsky.social
@eanoassociation.bsky.social
@winklerlab.bsky.social
@hlsalliance.bsky.social
@cn-hd.bsky.social
@eanoassociation.bsky.social
October 19, 2025 at 2:53 PM
It’s a wrap! What a fantastic and inspiring #EANO2025. It was great to share projects and ideas. Looking forward to Rome.
@winklerlab.bsky.social
@hlsalliance.bsky.social
@cn-hd.bsky.social
@eanoassociation.bsky.social
@winklerlab.bsky.social
@hlsalliance.bsky.social
@cn-hd.bsky.social
@eanoassociation.bsky.social
Reposted by Winkler Laboratory
Very much looking forward to presenting our work on the #cancerneuroscience of #brainmetastasis in session OS10 later today #EANO2025 !
#preclinical #NeuroOncology
#preclinical #NeuroOncology
The second day of EANO 2025 in Prague begins – featuring a full schedule of high-level science, clinical innovation, and exchange across all disciplines in #NeuroOncology.
See what’s on today 👉 eano.eu/eano2025/pro...
#Immuntherapy #Gliom #Neurosurgery #Youngsters #Radiotherapy #FamilyFocusedCare
See what’s on today 👉 eano.eu/eano2025/pro...
#Immuntherapy #Gliom #Neurosurgery #Youngsters #Radiotherapy #FamilyFocusedCare
October 18, 2025 at 7:53 AM
Very much looking forward to presenting our work on the #cancerneuroscience of #brainmetastasis in session OS10 later today #EANO2025 !
#preclinical #NeuroOncology
#preclinical #NeuroOncology
Reposted by Winkler Laboratory
We want to say a huge thank you to all who attended and helped organise Cancer Neuroscience this week in Bilbao 🎉
The next EACR conference is virtual and just around the corner - register for Patient Involvement in Cancer Research by Monday! eacr.org/conference/p...
The next EACR conference is virtual and just around the corner - register for Patient Involvement in Cancer Research by Monday! eacr.org/conference/p...
October 18, 2025 at 7:21 AM
We want to say a huge thank you to all who attended and helped organise Cancer Neuroscience this week in Bilbao 🎉
The next EACR conference is virtual and just around the corner - register for Patient Involvement in Cancer Research by Monday! eacr.org/conference/p...
The next EACR conference is virtual and just around the corner - register for Patient Involvement in Cancer Research by Monday! eacr.org/conference/p...
Reposted by Winkler Laboratory
Now online in Cancer Discovery @aacrjournals.bsky.social: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression - by Daniel Azorín, Dirk Hoffmann, @winklerlab.bsky.social, and colleagues doi.org/10.1158/2159...
October 14, 2025 at 12:00 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression - by Daniel Azorín, Dirk Hoffmann, @winklerlab.bsky.social, and colleagues doi.org/10.1158/2159...
Reposted by Winkler Laboratory
Attending the @helloeacr.bsky.social Cancer Neuroscience meeting in Bilbao, Spain today? Check out my PhD student @austejabaleviciute.bsky.social poster in this evenings session "Targerting Microglia in Diffuse Midline Glioma - heating up the Tumour Microenvironment'
October 14, 2025 at 10:16 AM
Attending the @helloeacr.bsky.social Cancer Neuroscience meeting in Bilbao, Spain today? Check out my PhD student @austejabaleviciute.bsky.social poster in this evenings session "Targerting Microglia in Diffuse Midline Glioma - heating up the Tumour Microenvironment'
📣 Today is the day!! 📣
The @helloeacr.bsky.social #CancerNeuroscience conference will kick off in beautiful Bilbao, Spain.
🇪🇸 🧠🤩
It’s an excellent program 😍
We are looking forward to many interesting new insights and discussions! 💡
See you in a few hours! 👋
#cancer #neuroscience #EACRconference
The @helloeacr.bsky.social #CancerNeuroscience conference will kick off in beautiful Bilbao, Spain.
🇪🇸 🧠🤩
It’s an excellent program 😍
We are looking forward to many interesting new insights and discussions! 💡
See you in a few hours! 👋
#cancer #neuroscience #EACRconference
Introduction | Cancer Neuroscience | The European Association for Cancer Research
eacr.org
October 14, 2025 at 5:40 AM
📣 Today is the day!! 📣
The @helloeacr.bsky.social #CancerNeuroscience conference will kick off in beautiful Bilbao, Spain.
🇪🇸 🧠🤩
It’s an excellent program 😍
We are looking forward to many interesting new insights and discussions! 💡
See you in a few hours! 👋
#cancer #neuroscience #EACRconference
The @helloeacr.bsky.social #CancerNeuroscience conference will kick off in beautiful Bilbao, Spain.
🇪🇸 🧠🤩
It’s an excellent program 😍
We are looking forward to many interesting new insights and discussions! 💡
See you in a few hours! 👋
#cancer #neuroscience #EACRconference
Congratulations 🎊! Very well deserved 😊🤩🥳
Congratulations to @ucsfhealth.bsky.social neurosurgeon @herveyjumper.bsky.social on receiving the Guha Award from the AANS/CNS Section on Tumors & @neuroonc.bsky.social! 🎉 This award recognizes his lab’s research advances in cancer neuroscience and his dedication to mentoring. #2025CNS #CNSConnects
October 14, 2025 at 4:55 AM
Congratulations 🎊! Very well deserved 😊🤩🥳
Reposted by Winkler Laboratory
Presenting recipients of our 2025 Stimulator Grant:
👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism.
🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social
@dkfz.bsky.social
👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism.
🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social
@dkfz.bsky.social
October 13, 2025 at 2:19 PM
Presenting recipients of our 2025 Stimulator Grant:
👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism.
🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social
@dkfz.bsky.social
👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism.
🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social
@dkfz.bsky.social
Reposted by Winkler Laboratory
#CancerNeuroscience Online Seminar, October 21, 5-6 PM, CET.
Elizabeth Repasky, Roswell Park Comprehensive Cancer Center, Buffalo, NY - Chronic adrenergic stress and thermoregulation: critical neuro-immune interactions that promote cancer in laboratory mice.
us06web.zoom.us/meeting/regi...
Elizabeth Repasky, Roswell Park Comprehensive Cancer Center, Buffalo, NY - Chronic adrenergic stress and thermoregulation: critical neuro-immune interactions that promote cancer in laboratory mice.
us06web.zoom.us/meeting/regi...
October 13, 2025 at 2:01 PM
#CancerNeuroscience Online Seminar, October 21, 5-6 PM, CET.
Elizabeth Repasky, Roswell Park Comprehensive Cancer Center, Buffalo, NY - Chronic adrenergic stress and thermoregulation: critical neuro-immune interactions that promote cancer in laboratory mice.
us06web.zoom.us/meeting/regi...
Elizabeth Repasky, Roswell Park Comprehensive Cancer Center, Buffalo, NY - Chronic adrenergic stress and thermoregulation: critical neuro-immune interactions that promote cancer in laboratory mice.
us06web.zoom.us/meeting/regi...
Reposted by Winkler Laboratory
Come and join The Brain Prize Lecture from Larry Abbott, US, at #ECNP2025. The 2024 prize co-recipient will present work on how connectomics advance our understanding of two neural systems, as well as its implications for neurology.
Details: www.ecnp.eu/congress2025...
#TheBrainPrize #neuroscience
Details: www.ecnp.eu/congress2025...
#TheBrainPrize #neuroscience
October 13, 2025 at 1:03 PM
Come and join The Brain Prize Lecture from Larry Abbott, US, at #ECNP2025. The 2024 prize co-recipient will present work on how connectomics advance our understanding of two neural systems, as well as its implications for neurology.
Details: www.ecnp.eu/congress2025...
#TheBrainPrize #neuroscience
Details: www.ecnp.eu/congress2025...
#TheBrainPrize #neuroscience
Reposted by Winkler Laboratory
My main PhD project is out in #CancerDiscovery @theaacr.bsky.social
We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.
Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.
Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
How to disconnect therapy-resistant tumor networks in glioblastoma?
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
October 10, 2025 at 7:21 AM
My main PhD project is out in #CancerDiscovery @theaacr.bsky.social
We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.
Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.
Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
Reposted by Winkler Laboratory
Very excited to see this out and happy to have contributed!
How to disconnect therapy-resistant tumor networks in glioblastoma?
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
October 10, 2025 at 7:35 AM
Very excited to see this out and happy to have contributed!
Reposted by Winkler Laboratory
#Glioblastoma cells don’t just grow — they extend tumor microtubes that let them invade the brain 🧠 and link into multicellular networks that resist therapy ☢️.
We developed a strategy to inhibit these TMs — and make these cells vulnerable to therapy ☠️.
This study is now online @Cancer Discovery
We developed a strategy to inhibit these TMs — and make these cells vulnerable to therapy ☠️.
This study is now online @Cancer Discovery
October 9, 2025 at 10:07 PM
#Glioblastoma cells don’t just grow — they extend tumor microtubes that let them invade the brain 🧠 and link into multicellular networks that resist therapy ☢️.
We developed a strategy to inhibit these TMs — and make these cells vulnerable to therapy ☠️.
This study is now online @Cancer Discovery
We developed a strategy to inhibit these TMs — and make these cells vulnerable to therapy ☠️.
This study is now online @Cancer Discovery
How to disconnect therapy-resistant tumor networks in glioblastoma?
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
October 9, 2025 at 8:52 PM
How to disconnect therapy-resistant tumor networks in glioblastoma?
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
Reposted by Winkler Laboratory
#CancerNeuroscience Seminar with
Elizabeth Repasky from Roswell Park Comprehensive Cancer Center in Buffalo, NY.
🧠Chronic adrenergic stress and thermoregulation: critical neuro-immune interactions that promote cancer in laboratory mice🐭
🐁Virtual seminar on 10/21 from 5-6 PM, CET, register on zoom.
Elizabeth Repasky from Roswell Park Comprehensive Cancer Center in Buffalo, NY.
🧠Chronic adrenergic stress and thermoregulation: critical neuro-immune interactions that promote cancer in laboratory mice🐭
🐁Virtual seminar on 10/21 from 5-6 PM, CET, register on zoom.
October 9, 2025 at 8:26 AM
#CancerNeuroscience Seminar with
Elizabeth Repasky from Roswell Park Comprehensive Cancer Center in Buffalo, NY.
🧠Chronic adrenergic stress and thermoregulation: critical neuro-immune interactions that promote cancer in laboratory mice🐭
🐁Virtual seminar on 10/21 from 5-6 PM, CET, register on zoom.
Elizabeth Repasky from Roswell Park Comprehensive Cancer Center in Buffalo, NY.
🧠Chronic adrenergic stress and thermoregulation: critical neuro-immune interactions that promote cancer in laboratory mice🐭
🐁Virtual seminar on 10/21 from 5-6 PM, CET, register on zoom.
Reposted by Winkler Laboratory
A milestone moment! Founding directors Eva Winkler & Thorsten Moos officially opened the Camilla & Georg Jellinek Center @uniheidelberg. With music, discussions and a keynote by Thomas W. Simpson, a new platform for exploring #ethics at the intersection of #science and #society begins.
#ethikzentrum
#ethikzentrum
October 8, 2025 at 10:46 AM
A milestone moment! Founding directors Eva Winkler & Thorsten Moos officially opened the Camilla & Georg Jellinek Center @uniheidelberg. With music, discussions and a keynote by Thomas W. Simpson, a new platform for exploring #ethics at the intersection of #science and #society begins.
#ethikzentrum
#ethikzentrum
Reposted by Winkler Laboratory
As part of the call for applications below, the Heidelberg/Mannheim site is offering four clinician scientist/postdoc positions in the field of neuro-oncology in the departements of @wickwolfgang.bsky.social and @michael-platten.bsky.social. For applications use the link below.
🚨 Call for Applications: The Hertie Network of Excellence in Clinical Neuroscience (Berlin, Bonn, Hamburg, Heidelberg/Mannheim, Munich, Tübingen) offers up to 4 postdoc/clinician scientist positions per site. Apply by Oct 31! Details 👉 www.hertie-neuroscience-hamburg.de #HertieNetwork #Jobs
Hertie Neuroscience Hamburg
www.hertie-neuroscience-hamburg.de
October 6, 2025 at 10:10 AM
As part of the call for applications below, the Heidelberg/Mannheim site is offering four clinician scientist/postdoc positions in the field of neuro-oncology in the departements of @wickwolfgang.bsky.social and @michael-platten.bsky.social. For applications use the link below.
Reposted by Winkler Laboratory
🚨 At #EANO2025, we already expect more than 1,200 participants! Don’t miss out on this fantastic experience to meet experts in the field of #NeuroOncology from all over the world. Registration is still open eano.eu/eano2025/ We can’t wait to see you in #Prague!
September 26, 2025 at 9:37 AM
🚨 At #EANO2025, we already expect more than 1,200 participants! Don’t miss out on this fantastic experience to meet experts in the field of #NeuroOncology from all over the world. Registration is still open eano.eu/eano2025/ We can’t wait to see you in #Prague!
Reposted by Winkler Laboratory
We are proud to see our Brain Prize documentary film among the finalists at this year’s Cannes Corporate Media & TV Awards.
Watch the documentary: brainprize.org/winners/comp...
Watch the documentary: brainprize.org/winners/comp...
September 26, 2025 at 11:19 AM
We are proud to see our Brain Prize documentary film among the finalists at this year’s Cannes Corporate Media & TV Awards.
Watch the documentary: brainprize.org/winners/comp...
Watch the documentary: brainprize.org/winners/comp...