Matthia Karreman
@matthiakarreman.bsky.social
Passionate about studying #brainmetastases 🧠, #cancerneuroscience ⛓️💥, #microscopy🔬 and working with my #team 👏.
Team leader at the DKFZ and University Hospital Heidelberg, Germany
Team leader at the DKFZ and University Hospital Heidelberg, Germany
Pinned
How do #metastases survive (and thrive!) in the #brain microenvironment?
In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases:
Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠
In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases:
Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠
Reposted by Matthia Karreman
Thank you for the amazing #CancerNeuroscience conference @helloeacr.bsky.social!
We had a great time in Bilbao @winklerlab.bsky.social🧠.
We had a great time in Bilbao @winklerlab.bsky.social🧠.
October 19, 2025 at 6:49 PM
Thank you for the amazing #CancerNeuroscience conference @helloeacr.bsky.social!
We had a great time in Bilbao @winklerlab.bsky.social🧠.
We had a great time in Bilbao @winklerlab.bsky.social🧠.
Very much looking forward to presenting our work on the #cancerneuroscience of #brainmetastasis in session OS10 later today #EANO2025 !
#preclinical #NeuroOncology
#preclinical #NeuroOncology
The second day of EANO 2025 in Prague begins – featuring a full schedule of high-level science, clinical innovation, and exchange across all disciplines in #NeuroOncology.
See what’s on today 👉 eano.eu/eano2025/pro...
#Immuntherapy #Gliom #Neurosurgery #Youngsters #Radiotherapy #FamilyFocusedCare
See what’s on today 👉 eano.eu/eano2025/pro...
#Immuntherapy #Gliom #Neurosurgery #Youngsters #Radiotherapy #FamilyFocusedCare
October 18, 2025 at 7:53 AM
Very much looking forward to presenting our work on the #cancerneuroscience of #brainmetastasis in session OS10 later today #EANO2025 !
#preclinical #NeuroOncology
#preclinical #NeuroOncology
Reposted by Matthia Karreman
We want to say a huge thank you to all who attended and helped organise Cancer Neuroscience this week in Bilbao 🎉
The next EACR conference is virtual and just around the corner - register for Patient Involvement in Cancer Research by Monday! eacr.org/conference/p...
The next EACR conference is virtual and just around the corner - register for Patient Involvement in Cancer Research by Monday! eacr.org/conference/p...
October 18, 2025 at 7:21 AM
We want to say a huge thank you to all who attended and helped organise Cancer Neuroscience this week in Bilbao 🎉
The next EACR conference is virtual and just around the corner - register for Patient Involvement in Cancer Research by Monday! eacr.org/conference/p...
The next EACR conference is virtual and just around the corner - register for Patient Involvement in Cancer Research by Monday! eacr.org/conference/p...
Reposted by Matthia Karreman
We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...
Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature
Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...
www.nature.com
September 16, 2025 at 1:33 PM
We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...
Reposted by Matthia Karreman
My main PhD project is out in #CancerDiscovery @theaacr.bsky.social
We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.
Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.
Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
How to disconnect therapy-resistant tumor networks in glioblastoma?
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
October 10, 2025 at 7:21 AM
My main PhD project is out in #CancerDiscovery @theaacr.bsky.social
We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.
Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.
Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
A new step towards targeting #tumornetworks in #glioblastoma !
Very happy to have made a small contribution to this exciting work led by @danielazorin.bsky.social and @dirkchoffmann.bsky.social 💐
#cancerneuroscience #GBM #braintumors 🧠
For a #Bluetorial see 👇
Very happy to have made a small contribution to this exciting work led by @danielazorin.bsky.social and @dirkchoffmann.bsky.social 💐
#cancerneuroscience #GBM #braintumors 🧠
For a #Bluetorial see 👇
October 9, 2025 at 8:59 PM
A new step towards targeting #tumornetworks in #glioblastoma !
Very happy to have made a small contribution to this exciting work led by @danielazorin.bsky.social and @dirkchoffmann.bsky.social 💐
#cancerneuroscience #GBM #braintumors 🧠
For a #Bluetorial see 👇
Very happy to have made a small contribution to this exciting work led by @danielazorin.bsky.social and @dirkchoffmann.bsky.social 💐
#cancerneuroscience #GBM #braintumors 🧠
For a #Bluetorial see 👇
Reposted by Matthia Karreman
How to disconnect therapy-resistant tumor networks in glioblastoma?
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
October 9, 2025 at 8:52 PM
How to disconnect therapy-resistant tumor networks in glioblastoma?
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
Reposted by Matthia Karreman
Cancer cells hijack neurons to promote their growth. Here (and how) neurons form pseudo-synapses to promote pancreatic cancer's growth cell.com/cancer-cell/...
September 25, 2025 at 8:04 PM
Cancer cells hijack neurons to promote their growth. Here (and how) neurons form pseudo-synapses to promote pancreatic cancer's growth cell.com/cancer-cell/...
Reposted by Matthia Karreman
and last but not least two cancer neuroscience papers on small cell lung cancer. 1. www.nature.com/articles/s41...
Functional synapses between neurons and small cell lung cancer - Nature
Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.
www.nature.com
September 11, 2025 at 7:38 AM
and last but not least two cancer neuroscience papers on small cell lung cancer. 1. www.nature.com/articles/s41...
Reposted by Matthia Karreman
Wow congratulations, Mahak 🎊 , this is so well deserved !!!
Congratulations to Mahak Singhal @uniheidelberg.bsky.social on being awarded an @erc.europa.eu Starting Grant for his project "Vascular-Rhythm" focussing on "DeClocking the vascular rhythmic control of tissue homeostasis and disease initiation". Pioneering a new branch of vascular research!
September 4, 2025 at 10:23 AM
Wow congratulations, Mahak 🎊 , this is so well deserved !!!
Reposted by Matthia Karreman
Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨
Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth
Anastasaki and colleagues establish a previously unknown glutamate growth dependency
in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial
molecular circuits present d...
www.cell.com
September 3, 2025 at 2:22 PM
Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨
How do #metastases survive (and thrive!) in the #brain microenvironment?
In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases:
Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠
In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases:
Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠
September 4, 2025 at 5:41 AM
How do #metastases survive (and thrive!) in the #brain microenvironment?
In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases:
Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠
In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases:
Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠
Reposted by Matthia Karreman
Shameless self promotion of our new paper. So very excited to share our new work uncovering coupling of glutamate receptors ⚡️and RTKs to enable growth of low-grade gliomas 🧠 @gutmannlab.bsky.social @washuneurology.bsky.social
September 2, 2025 at 8:45 PM
Shameless self promotion of our new paper. So very excited to share our new work uncovering coupling of glutamate receptors ⚡️and RTKs to enable growth of low-grade gliomas 🧠 @gutmannlab.bsky.social @washuneurology.bsky.social
Reposted by Matthia Karreman
How can we reawaken the body’s own anti-viral defenses to fight brain cancer?
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
🧵
www.sciencedirect.com/science/arti...
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
🧵
www.sciencedirect.com/science/arti...
September 3, 2025 at 12:56 PM
How can we reawaken the body’s own anti-viral defenses to fight brain cancer?
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
🧵
www.sciencedirect.com/science/arti...
Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏
#BrainTIME 🧠🦠🧪
🧵
www.sciencedirect.com/science/arti...
Reposted by Matthia Karreman
A Review by Frank Winkler & @matthiakarreman.bsky.social on how neural-cancer interactions shape metastasis and tumor evolution
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Cancer neuroscience of brain metastasis: When in Rome, do as the Romans do
In this comprehensive review, Karreman & Winkler explore how neural influences on
the brain’s metastatic process govern brain tropism, colonization, and growth. Conversely,
metastatic cancer has disti...
www.cell.com
September 3, 2025 at 3:52 PM
A Review by Frank Winkler & @matthiakarreman.bsky.social on how neural-cancer interactions shape metastasis and tumor evolution
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Very much looking forward to this meeting!
Thank you for the invite to present our work here 🔬🐁🧠
Thank you for the invite to present our work here 🔬🐁🧠
Check out the detailed program for the 5th Day of Intravital Microscopy (18–19 Sept, Tübingen)!
Our keynote: @matthiakarreman.bsky.social: "Imaging cancer networks in brain metastases in vivo."
Full details 👉 bit.ly/3IOlJtJ
#IVMIC25
Our keynote: @matthiakarreman.bsky.social: "Imaging cancer networks in brain metastases in vivo."
Full details 👉 bit.ly/3IOlJtJ
#IVMIC25
5th Day of Intravital Microscopy - German BioImaging
Intravital microscopy (IVM) enables the observation and precise quantification of cellular processes within native tissue microenvironments, with resolutions unmatched by other techniques. This powerf...
bit.ly
September 3, 2025 at 8:50 PM
Very much looking forward to this meeting!
Thank you for the invite to present our work here 🔬🐁🧠
Thank you for the invite to present our work here 🔬🐁🧠
Reposted by Matthia Karreman
Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com) paper, Miranda Hunter (@mrndhntr.bsky.social) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2
August 28, 2025 at 3:15 PM
Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com) paper, Miranda Hunter (@mrndhntr.bsky.social) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2
Reposted by Matthia Karreman
HER3-targeted patritumab deruxtecan showed efficacy in leptomeningeal metastases from solid tumors in the Phase II TUXEDO-3 trial
📉 65% 3-month survival
🧬 Activity in intracranial lesions
🔷 From Matthias Preusser, MD, et al
🔗 ascopost.com/news/july-20...
📉 65% 3-month survival
🧬 Activity in intracranial lesions
🔷 From Matthias Preusser, MD, et al
🔗 ascopost.com/news/july-20...
July 28, 2025 at 7:07 PM
HER3-targeted patritumab deruxtecan showed efficacy in leptomeningeal metastases from solid tumors in the Phase II TUXEDO-3 trial
📉 65% 3-month survival
🧬 Activity in intracranial lesions
🔷 From Matthias Preusser, MD, et al
🔗 ascopost.com/news/july-20...
📉 65% 3-month survival
🧬 Activity in intracranial lesions
🔷 From Matthias Preusser, MD, et al
🔗 ascopost.com/news/july-20...
Reposted by Matthia Karreman
Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis
https://go.nature.com/46c474I
https://go.nature.com/46c474I
Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature
A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.
go.nature.com
June 25, 2025 at 4:31 PM
Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis
https://go.nature.com/46c474I
https://go.nature.com/46c474I
Reposted by Matthia Karreman
‼️Good news! Deadline for late breaking abstract submission extended until July 1, 2025! Don't miss this opportunity to present your very latest reasearch breakthrough to the #NeuroOncology community at #EANO2025. Submit your abstract👉https://eano.eu/eano2025/abstracts/ #btsm #braintumor
June 25, 2025 at 8:42 AM
‼️Good news! Deadline for late breaking abstract submission extended until July 1, 2025! Don't miss this opportunity to present your very latest reasearch breakthrough to the #NeuroOncology community at #EANO2025. Submit your abstract👉https://eano.eu/eano2025/abstracts/ #btsm #braintumor
Reposted by Matthia Karreman
We’re so excited for the
Cancer Neuroscience EACR conference!
📍Bilbao, Spain
📅 14-16 Oct 2025
‼️Upcoming abstract and travelgrant deadline *June 30th* ‼️
Looking forward to seeing many of you there! 🧠🔬
#cancerneuroscience @helloeacr.bsky.social #neuroscience #cancer
Submit your abstract here 👇
Cancer Neuroscience EACR conference!
📍Bilbao, Spain
📅 14-16 Oct 2025
‼️Upcoming abstract and travelgrant deadline *June 30th* ‼️
Looking forward to seeing many of you there! 🧠🔬
#cancerneuroscience @helloeacr.bsky.social #neuroscience #cancer
Submit your abstract here 👇
Abstracts and posters | Cancer Neuroscience | The European Association for Cancer Research
eacr.org
June 8, 2025 at 3:48 PM
We’re so excited for the
Cancer Neuroscience EACR conference!
📍Bilbao, Spain
📅 14-16 Oct 2025
‼️Upcoming abstract and travelgrant deadline *June 30th* ‼️
Looking forward to seeing many of you there! 🧠🔬
#cancerneuroscience @helloeacr.bsky.social #neuroscience #cancer
Submit your abstract here 👇
Cancer Neuroscience EACR conference!
📍Bilbao, Spain
📅 14-16 Oct 2025
‼️Upcoming abstract and travelgrant deadline *June 30th* ‼️
Looking forward to seeing many of you there! 🧠🔬
#cancerneuroscience @helloeacr.bsky.social #neuroscience #cancer
Submit your abstract here 👇
Reposted by Matthia Karreman
Reposted by Matthia Karreman
rdcu.be/emi9N
Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention
Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention
Fishing for melanoma metastasis-initiating cells in lymph nodes
Nature Cancer - The complex nature of metastasis-initiating cells (MICs) has long hindered our understanding of how cancer spreads and how to prevent it. A study now identifies a potential MIC...
rdcu.be
May 17, 2025 at 8:25 AM
rdcu.be/emi9N
Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention
Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention
This was a great meeting, inspiring, informative and with a lot of opportunity to network and catch up!
Thanks to all contributors, participants and especially to the organizers 🤩
Thanks to all contributors, participants and especially to the organizers 🤩
The organizing committee of the UNITE conference would like to thank all speakers for their excellent presentations and all participants for the valuable discussions. @wickwolfgang.bsky.social @michael-platten.bsky.social
May 15, 2025 at 8:44 PM
This was a great meeting, inspiring, informative and with a lot of opportunity to network and catch up!
Thanks to all contributors, participants and especially to the organizers 🤩
Thanks to all contributors, participants and especially to the organizers 🤩