Daniel D. Azorín
@danielazorin.bsky.social
PostDoc at Systems Physiology Moor Lab (ETH Zurich, D-BSSE) & Lunaphore
PhD in Neurooncology & Cancer Neuroscience
Spatial Biology, Intravital Microscopy, and Image Analysis
linkedin.com/in/daniel-azorín-phd-8826a9128
PhD in Neurooncology & Cancer Neuroscience
Spatial Biology, Intravital Microscopy, and Image Analysis
linkedin.com/in/daniel-azorín-phd-8826a9128
Reposted by Daniel D. Azorín
Now online in Cancer Discovery @aacrjournals.bsky.social: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression - by Daniel Azorín, Dirk Hoffmann, @winklerlab.bsky.social, and colleagues doi.org/10.1158/2159...
October 14, 2025 at 12:00 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression - by Daniel Azorín, Dirk Hoffmann, @winklerlab.bsky.social, and colleagues doi.org/10.1158/2159...
My main PhD project is out in #CancerDiscovery @theaacr.bsky.social
We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.
Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.
Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
How to disconnect therapy-resistant tumor networks in glioblastoma?
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
October 10, 2025 at 7:21 AM
My main PhD project is out in #CancerDiscovery @theaacr.bsky.social
We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.
Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy.
Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!
Reposted by Daniel D. Azorín
#Glioblastoma cells don’t just grow — they extend tumor microtubes that let them invade the brain 🧠 and link into multicellular networks that resist therapy ☢️.
We developed a strategy to inhibit these TMs — and make these cells vulnerable to therapy ☠️.
This study is now online @Cancer Discovery
We developed a strategy to inhibit these TMs — and make these cells vulnerable to therapy ☠️.
This study is now online @Cancer Discovery
October 9, 2025 at 10:07 PM
#Glioblastoma cells don’t just grow — they extend tumor microtubes that let them invade the brain 🧠 and link into multicellular networks that resist therapy ☢️.
We developed a strategy to inhibit these TMs — and make these cells vulnerable to therapy ☠️.
This study is now online @Cancer Discovery
We developed a strategy to inhibit these TMs — and make these cells vulnerable to therapy ☠️.
This study is now online @Cancer Discovery
Reposted by Daniel D. Azorín
📢New Article now published at Nature Cancer!
'Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth'
✏️By Tian-Ming Gao, Jian-Ming Li and colleagues
🔗 www.nature.com/articles/s43...
'Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth'
✏️By Tian-Ming Gao, Jian-Ming Li and colleagues
🔗 www.nature.com/articles/s43...
Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth - Nature Cancer
Li and colleagues report that a septo-enteric polysynaptic circuit that is activated by chronic stress links the brain to the tumor microenvironment to promote colorectal cancer growth.
www.nature.com
August 27, 2025 at 10:44 AM
📢New Article now published at Nature Cancer!
'Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth'
✏️By Tian-Ming Gao, Jian-Ming Li and colleagues
🔗 www.nature.com/articles/s43...
'Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth'
✏️By Tian-Ming Gao, Jian-Ming Li and colleagues
🔗 www.nature.com/articles/s43...
Reposted by Daniel D. Azorín
We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:
September 3, 2025 at 3:52 PM
We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:
Reposted by Daniel D. Azorín
Molecular recording of cellular protein kinase activity with chemical labeling:
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
Molecular recording of cellular protein kinase activity with chemical labeling - Nature Chemical Biology
Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.
www.nature.com
July 10, 2025 at 5:46 PM
Molecular recording of cellular protein kinase activity with chemical labeling:
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
Reposted by Daniel D. Azorín
Need a distraction to shift your TMEntality today?
If you’re curious about how sympathetic nerve signaling rewires immune and non-immune stromal cells in the TME, dive into this review article by Ariana Sattler and the team to reimagine the TME! link.springer.com/article/10.1...
If you’re curious about how sympathetic nerve signaling rewires immune and non-immune stromal cells in the TME, dive into this review article by Ariana Sattler and the team to reimagine the TME! link.springer.com/article/10.1...
Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity” - Cancer and Metastasis Reviews
Nerve signaling within the tumor microenvironment (TME) plays a critical role in the initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior and activation upo...
link.springer.com
January 20, 2025 at 5:55 PM
Need a distraction to shift your TMEntality today?
If you’re curious about how sympathetic nerve signaling rewires immune and non-immune stromal cells in the TME, dive into this review article by Ariana Sattler and the team to reimagine the TME! link.springer.com/article/10.1...
If you’re curious about how sympathetic nerve signaling rewires immune and non-immune stromal cells in the TME, dive into this review article by Ariana Sattler and the team to reimagine the TME! link.springer.com/article/10.1...
Reposted by Daniel D. Azorín
The EACR Cancer Neuroscience conference 14-16 October 2025 is open for registrations. Please bear in mind that the abstract deadline is June 30th 2025. We will be selecting a number of short talks from the abstracts! eacr.org/conference/c...
Introduction | Cancer Neuroscience | The European Association for Cancer Research
eacr.org
April 3, 2025 at 9:28 AM
The EACR Cancer Neuroscience conference 14-16 October 2025 is open for registrations. Please bear in mind that the abstract deadline is June 30th 2025. We will be selecting a number of short talks from the abstracts! eacr.org/conference/c...
Reposted by Daniel D. Azorín
and the News & Views: www.nature.com/articles/d41...
Pinpointing neurons that hinder cancer treatment
Method to identify neurons associated with pancreatic cancer.
www.nature.com
February 20, 2025 at 8:32 AM
and the News & Views: www.nature.com/articles/d41...
I am happy to share our PDAC study, led by @verat-h.bsky.social.
I developed a machine-learning pipeline to analyze large 3D light sheet microscopy volumes. We uncover how pancreatic cancer rewires neurons, advancing the field of Cancer Neuroscience.
Full text here: www.nature.com/articles/s41...
I developed a machine-learning pipeline to analyze large 3D light sheet microscopy volumes. We uncover how pancreatic cancer rewires neurons, advancing the field of Cancer Neuroscience.
Full text here: www.nature.com/articles/s41...
February 18, 2025 at 5:08 PM
I am happy to share our PDAC study, led by @verat-h.bsky.social.
I developed a machine-learning pipeline to analyze large 3D light sheet microscopy volumes. We uncover how pancreatic cancer rewires neurons, advancing the field of Cancer Neuroscience.
Full text here: www.nature.com/articles/s41...
I developed a machine-learning pipeline to analyze large 3D light sheet microscopy volumes. We uncover how pancreatic cancer rewires neurons, advancing the field of Cancer Neuroscience.
Full text here: www.nature.com/articles/s41...
Reposted by Daniel D. Azorín
Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature.
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...
February 18, 2025 at 9:37 AM
Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature.
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...
Reposted by Daniel D. Azorín
Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies | Cancer Discovery | American Association for Cancer Research
#paper
aacrjournals.org/cancerdiscov...
#paper
aacrjournals.org/cancerdiscov...
Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies
Abstract. Deepening our understanding of neuro-cancer interactions can innovate brain tumor treatment. This mini review unfolds the most relevant and recent insights into the neural mechanisms contrib...
aacrjournals.org
January 13, 2025 at 5:26 PM
Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies | Cancer Discovery | American Association for Cancer Research
#paper
aacrjournals.org/cancerdiscov...
#paper
aacrjournals.org/cancerdiscov...
Reposted by Daniel D. Azorín
So many nice starter packs.. I couldn't find one related to spatial biology yet, so I started one 🧬🔬! Here's who I’ve included so far—let me know if you'd like to be added or suggest other must-follow accounts! #SpatialBiology
go.bsky.app/SU34ELC
go.bsky.app/SU34ELC
November 16, 2024 at 10:13 PM
So many nice starter packs.. I couldn't find one related to spatial biology yet, so I started one 🧬🔬! Here's who I’ve included so far—let me know if you'd like to be added or suggest other must-follow accounts! #SpatialBiology
go.bsky.app/SU34ELC
go.bsky.app/SU34ELC