Wang et al. introduce UniFORM, a universal normalization pipeline for multiplex tissue imaging. UniFORM applies automatic rigid landmark registration to align intensity distributions at both the featu...

Ekşi and her team investigate how interactions between nerves and cancer happen at the molecular level, with the goal of preventing it.

Organoid models are invaluable for studying organ processes in vitro, offering an unprecedented ability to replicate organ function. Despite recent advancements that have increased their cellular comp...

The brain controls the body, in large part, through nerves. So, what happens when nerves form new connections with tumors? How does the nervous system drive cancer progression? How do these interactio...

Nerve signaling within the tumor microenvironment (TME) plays a critical role in the initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior and activation upo...

Neurosignaling is increasingly recognized as a critical factor in cancer progression, where neuronal innervation of primary tumors contributes to the disease's advancement. This study focuses on segmenting individual axons within the prostate tumor microenvironment, which have been challenging to detect and analyze due to their irregular morphologies. We present a novel deep learning-based approach for the automated segmentation of axons, AxonFinder, leveraging a U-Net model with a ResNet-101 encoder, based on a multiplexed imaging approach.

Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

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