Jeremy Borniger
@jborniger.bsky.social
Asst. Prof in cancer neuroscience at CSHL; amateur astrophotographer; views are mine alone
https://www.cshl.edu/research/faculty-staff/jeremy-c-borniger/ 🇵🇸
https://www.cshl.edu/research/faculty-staff/jeremy-c-borniger/ 🇵🇸
Reposted by Jeremy Borniger
Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11
Read the thread below for a summary of our findings 🧵1/11
September 17, 2025 at 2:55 PM
Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11
Read the thread below for a summary of our findings 🧵1/11
Reposted by Jeremy Borniger
David Baltimore, giant of molecular biology, has died.
Co-discoverer of reverse transcriptase at 32, Nobel Prize at 37, played a key role at the 1975 Asilomar comference.
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87
www.nytimes.com
September 7, 2025 at 8:52 PM
David Baltimore, giant of molecular biology, has died.
www.biorxiv.org/content/10.1... new preprint from the lab where stellar postdoc @alixbattison.bsky.social demonstrates that two common proximity labeling approaches enrich different proteomes when localized to the same cellular compartments. Important implications for discovery proteomics.
APEX2 and TurboID define unique subcellular proteomes
Proximity labeling has emerged as a prominent, reliable tool for obtaining local proteomes from a wide range of cell-types. Two major classes of labeling reagents, peroxidase based (APEX family), or b...
www.biorxiv.org
September 6, 2025 at 5:17 PM
www.biorxiv.org/content/10.1... new preprint from the lab where stellar postdoc @alixbattison.bsky.social demonstrates that two common proximity labeling approaches enrich different proteomes when localized to the same cellular compartments. Important implications for discovery proteomics.
Reposted by Jeremy Borniger
Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨
Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth
Anastasaki and colleagues establish a previously unknown glutamate growth dependency
in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial
molecular circuits present d...
www.cell.com
September 3, 2025 at 2:22 PM
Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨
Andromeda (M31) in LRGBHa (~24.5h) #astrophotography
August 26, 2025 at 1:15 PM
Andromeda (M31) in LRGBHa (~24.5h) #astrophotography
Reposted by Jeremy Borniger
Thousands of brave people from all over DC have taken to the streets to protest the illegal military occupation by the Jeffrey Epstein associate, 36 time convicted felon and rapist, Donald Trump. #3E #removeTrump #freeDC (📹 @Ronxyz00)
August 11, 2025 at 9:04 PM
Thousands of brave people from all over DC have taken to the streets to protest the illegal military occupation by the Jeffrey Epstein associate, 36 time convicted felon and rapist, Donald Trump. #3E #removeTrump #freeDC (📹 @Ronxyz00)
Reposted by Jeremy Borniger
This is literally some of the craziest shit I have ever read.
And that's saying a lot.
www.whitehouse.gov/presidential...
And that's saying a lot.
www.whitehouse.gov/presidential...
Improving Oversight of Federal Grantmaking
By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal
www.whitehouse.gov
August 7, 2025 at 9:55 PM
This is literally some of the craziest shit I have ever read.
And that's saying a lot.
www.whitehouse.gov/presidential...
And that's saying a lot.
www.whitehouse.gov/presidential...
Nice synapse from synaptosome prep. From @mayywu.bsky.social :))) can see presynaptic vesicles and clear PSD.
August 7, 2025 at 2:25 PM
Nice synapse from synaptosome prep. From @mayywu.bsky.social :))) can see presynaptic vesicles and clear PSD.
Reposted by Jeremy Borniger
A little known - but hugely consequential - part of the government’s changes to science funding:
open.substack.com/pub/sciencea...
open.substack.com/pub/sciencea...
A Quiet Policy Shift That Could Devastate American Science
Why NIH’s sudden move to multi-year grant funding should alarm every principal investigator and university
open.substack.com
July 29, 2025 at 6:06 PM
A little known - but hugely consequential - part of the government’s changes to science funding:
open.substack.com/pub/sciencea...
open.substack.com/pub/sciencea...
Reposted by Jeremy Borniger
Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!
T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database
Banerjee et al. present a comprehensive T cell receptor cross-reactivity database
and a hierarchical Bayesian framework to predict T cell receptor targets. Together,
they reveal structural and biochem...
www.cell.com
July 25, 2025 at 3:00 PM
Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!
Reposted by Jeremy Borniger
Reposted by Jeremy Borniger
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
www.nature.com
July 17, 2025 at 11:28 AM
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jeremy Borniger
Prasad is UCSFs failure
An oncologist who botches basic facts and thinks temporary vaccine side effects are worse than death is imposing his will on millions of Americans.
July 15, 2025 at 11:02 PM
Prasad is UCSFs failure
Reposted by Jeremy Borniger
A discussion of the use of animals in research.
www.youtube.com/watch?v=iSvk...
1/n
(Warning: Rant coming)
www.youtube.com/watch?v=iSvk...
1/n
(Warning: Rant coming)
Director’s Desk: The Future of Animal Models in Research | NIH’s Dr. Nicole Kleinstreuer
YouTube video by National Institutes of Health (NIH)
www.youtube.com
July 15, 2025 at 1:47 PM
A discussion of the use of animals in research.
www.youtube.com/watch?v=iSvk...
1/n
(Warning: Rant coming)
www.youtube.com/watch?v=iSvk...
1/n
(Warning: Rant coming)
Reposted by Jeremy Borniger
i wrote an essay for @thetransmitter.bsky.social about what it feels like to serve on an NIH grant review panel (study section) right now
www.thetransmitter.org/craft-and-ca...
www.thetransmitter.org/craft-and-ca...
Fear and loathing on study section: Reviewing grant proposals while the system is burning
As grants are canceled, delayed and subject to general uncertainty, participating in study sections can feel futile. But it’s more important than ever.
www.thetransmitter.org
July 14, 2025 at 6:49 PM
i wrote an essay for @thetransmitter.bsky.social about what it feels like to serve on an NIH grant review panel (study section) right now
www.thetransmitter.org/craft-and-ca...
www.thetransmitter.org/craft-and-ca...
Reposted by Jeremy Borniger
immigration is good actually.
July 11, 2025 at 12:35 PM
immigration is good actually.
Visiting Santiago Ramon y Cajal’s house in Barcelona featuring @erikherzog.bsky.social , Charo Robles & Luis de Lecea :))) neuroscience pilgrimage
July 11, 2025 at 2:27 PM
Visiting Santiago Ramon y Cajal’s house in Barcelona featuring @erikherzog.bsky.social , Charo Robles & Luis de Lecea :))) neuroscience pilgrimage
Reposted by Jeremy Borniger
Former NOAA official Monica Medina says the scale of death and destruction from catastrophic flooding in Texas was "entirely preventable," faulting budget cuts for hampering preparedness.
"Many of those lost lives could have been saved if links in our disaster response chain hadn't been broken."
"Many of those lost lives could have been saved if links in our disaster response chain hadn't been broken."
July 11, 2025 at 1:21 PM
Former NOAA official Monica Medina says the scale of death and destruction from catastrophic flooding in Texas was "entirely preventable," faulting budget cuts for hampering preparedness.
"Many of those lost lives could have been saved if links in our disaster response chain hadn't been broken."
"Many of those lost lives could have been saved if links in our disaster response chain hadn't been broken."
Reposted by Jeremy Borniger
ICE now has a budget bigger than the United States Marine Corps.
ICE now has a budget bigger than what we spend on biomedical research in America.
This is sociopathic to the extreme.
ICE now has a budget bigger than what we spend on biomedical research in America.
This is sociopathic to the extreme.
I don’t think anyone is prepared for what they just did w/ ICE.
This is not a simple budget increase. It is an explosion - making ICE bigger than the FBI, US Bureau of Prisons, DEA,& others combined.
It is setting up to make what’s happening now look like child’s play. And people are disappearing.
This is not a simple budget increase. It is an explosion - making ICE bigger than the FBI, US Bureau of Prisons, DEA,& others combined.
It is setting up to make what’s happening now look like child’s play. And people are disappearing.
July 3, 2025 at 7:06 PM
ICE now has a budget bigger than the United States Marine Corps.
ICE now has a budget bigger than what we spend on biomedical research in America.
This is sociopathic to the extreme.
ICE now has a budget bigger than what we spend on biomedical research in America.
This is sociopathic to the extreme.
Reposted by Jeremy Borniger
Nazi Germany did literally ban Nature:
"Articles are often published in the London weekly scientific journal Nature containing outrageous and vile attacks on German science and the national socialist state.
The journal must therefore be excluded from general use in the scientific libraries."
"Articles are often published in the London weekly scientific journal Nature containing outrageous and vile attacks on German science and the national socialist state.
The journal must therefore be excluded from general use in the scientific libraries."
July 1, 2025 at 4:06 PM
Nazi Germany did literally ban Nature:
"Articles are often published in the London weekly scientific journal Nature containing outrageous and vile attacks on German science and the national socialist state.
The journal must therefore be excluded from general use in the scientific libraries."
"Articles are often published in the London weekly scientific journal Nature containing outrageous and vile attacks on German science and the national socialist state.
The journal must therefore be excluded from general use in the scientific libraries."
Reposted by Jeremy Borniger
RFK Jr. Says AI Will Approve New Drugs at FDA 'Very, Very Quickly'
gizmodo.com
July 1, 2025 at 8:31 PM
Center of Rho ophiuchi cloud complex, 7.5h LRGB. #astrophotography
June 27, 2025 at 5:04 PM
Center of Rho ophiuchi cloud complex, 7.5h LRGB. #astrophotography
Reposted by Jeremy Borniger
We have already received many interesting abstracts for the Cancer Neuroscience EACR Conference in Bilbao, Spain....
...and we are looking forward to reading *yours*! 🧠🔬
📢 Abstract Deadline June 30th 📢
#cancerneuroscience #neuroscience #cancer @helloeacr.bsky.social
...and we are looking forward to reading *yours*! 🧠🔬
📢 Abstract Deadline June 30th 📢
#cancerneuroscience #neuroscience #cancer @helloeacr.bsky.social
June 24, 2025 at 8:10 AM
We have already received many interesting abstracts for the Cancer Neuroscience EACR Conference in Bilbao, Spain....
...and we are looking forward to reading *yours*! 🧠🔬
📢 Abstract Deadline June 30th 📢
#cancerneuroscience #neuroscience #cancer @helloeacr.bsky.social
...and we are looking forward to reading *yours*! 🧠🔬
📢 Abstract Deadline June 30th 📢
#cancerneuroscience #neuroscience #cancer @helloeacr.bsky.social