Congratulations 🥳

Thank you, @danielazorin.bsky.social and @dirkchoffmann.bsky.social,
on behalf of all of us at the Winkler Lab, for driving this project! It’s exciting new work and the next step towards new therapeutic strategies against this horrific disease.

Thank you, @danielazorin.bsky.social and @dirkchoffmann.bsky.social,
on behalf of all of us at the Winkler Lab, for driving this project! It’s exciting new work and the next step towards new therapeutic strategies against this horrific disease.

Thanks to collaborators, funders, and everyone involved. 🤝

Special thanks to patients and their families for donating samples.

Advancing #cancerneuroscience together.

#UNITE-GBM #disconnectGBM
@neurooncologyhd.bsky.social @aacrjournals.bsky.social @dkfz.bsky.social @cn-hd.bsky.social

In summary, we introduce a scalable anti-TM #drugscreening platform and reveal PKC activation as a TM master-regulator.
TM targeting disconnects tumor networks and sensitizes #GBM to #therapy.

#Translational #CancerNeuroscience

Spatial multi-omics analysis (with COMET) of brains revealed that cells in the TPPB/RT combination treatment group exhibited fewer and shorter TMs, reduced proliferation, increased cell death, and decreased TTYH1 expression (a driver of TM invasion)

#GBM #COMET #Lunaphore @bio-techne.bsky.social