Winkler Laboratory
@winklerlab.bsky.social
We are the Winkler Laboratory at the UKHD and DKFZ Heidelberg
Our focus: #cancerneuroscience of #braintumors ( #glioblastoma #brainmetastases), and beyond.
We use #intravitalimaging , #calciumimaging, #preclinicalmodels and more, to tackle these diseases
Our focus: #cancerneuroscience of #braintumors ( #glioblastoma #brainmetastases), and beyond.
We use #intravitalimaging , #calciumimaging, #preclinicalmodels and more, to tackle these diseases
Intravital 2-photon microscopy shows how TPPB breaks tumor networks and boosts radiotherapy in mice.
Control+RT → network persists.
TPPB+RT → fewer tumor microtubes, network collapse, regional regression!
#Radiotherapy #IntravitalMicroscopy #preclinicalmodels #invivo
Control+RT → network persists.
TPPB+RT → fewer tumor microtubes, network collapse, regional regression!
#Radiotherapy #IntravitalMicroscopy #preclinicalmodels #invivo
October 9, 2025 at 8:52 PM
Intravital 2-photon microscopy shows how TPPB breaks tumor networks and boosts radiotherapy in mice.
Control+RT → network persists.
TPPB+RT → fewer tumor microtubes, network collapse, regional regression!
#Radiotherapy #IntravitalMicroscopy #preclinicalmodels #invivo
Control+RT → network persists.
TPPB+RT → fewer tumor microtubes, network collapse, regional regression!
#Radiotherapy #IntravitalMicroscopy #preclinicalmodels #invivo
How to disconnect therapy-resistant tumor networks in glioblastoma?
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
October 9, 2025 at 8:52 PM
How to disconnect therapy-resistant tumor networks in glioblastoma?
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
Intravital 2-photon microscopy with RT: TPPB breaks tumor networks and boosts radiotherapy in mice. Control+RT → network persists. TPPB+RT → fewer tumor microtubes, network collapse, regional regression. #Radiotherapy #IntravitalMicroscopy
October 9, 2025 at 8:31 PM
Intravital 2-photon microscopy with RT: TPPB breaks tumor networks and boosts radiotherapy in mice. Control+RT → network persists. TPPB+RT → fewer tumor microtubes, network collapse, regional regression. #Radiotherapy #IntravitalMicroscopy