Vincent Tse
@vincenttse.bsky.social
PhD Candidate, Yale @ Che Lab • WTI Grad Fellow, NSF GRFP • Systems x computational neuroscience, Alzheimer's disease, and astrocytes • Prev. UCLA and UCSF • More about me: https://www.vincenttse.com/
Reposted by Vincent Tse
🚨 New paper alert from our lab @yaleschoolofmed.bsky.social !
We generated DNA methylation maps from 6 postmortem brain regions (amygdala + hippocampus subregions) in PTSD, MDD, and control donors — the largest dataset of its kind! 🧠✨
📖 Read more: www.biologicalpsychiatryjournal.com/article/S000...
We generated DNA methylation maps from 6 postmortem brain regions (amygdala + hippocampus subregions) in PTSD, MDD, and control donors — the largest dataset of its kind! 🧠✨
📖 Read more: www.biologicalpsychiatryjournal.com/article/S000...
Mapping DNA methylation signatures to identify epigenetic variation across subcortical regions of the human PTSD brain
Post-traumatic stress disorder is a mental disorder that may occur in the aftermath
of severe psychological trauma. Epigenetic changes in the brain may play a critical
role in understanding the neurob...
www.biologicalpsychiatryjournal.com
November 4, 2025 at 10:51 PM
🚨 New paper alert from our lab @yaleschoolofmed.bsky.social !
We generated DNA methylation maps from 6 postmortem brain regions (amygdala + hippocampus subregions) in PTSD, MDD, and control donors — the largest dataset of its kind! 🧠✨
📖 Read more: www.biologicalpsychiatryjournal.com/article/S000...
We generated DNA methylation maps from 6 postmortem brain regions (amygdala + hippocampus subregions) in PTSD, MDD, and control donors — the largest dataset of its kind! 🧠✨
📖 Read more: www.biologicalpsychiatryjournal.com/article/S000...
Reposted by Vincent Tse
At #NDiSTEM2025 & interested in cognition? Come by
@wutsaiyale.bsky.social booth #1144 tomorrow to learn abt research opportunities, a new graduate certificate, postdoc fellowships & faculty hiring! And if you tell us our full mission statement by memory, you’ll get some cool swag… 👀😉 #SACNAS
@wutsaiyale.bsky.social booth #1144 tomorrow to learn abt research opportunities, a new graduate certificate, postdoc fellowships & faculty hiring! And if you tell us our full mission statement by memory, you’ll get some cool swag… 👀😉 #SACNAS
October 29, 2025 at 9:51 PM
At #NDiSTEM2025 & interested in cognition? Come by
@wutsaiyale.bsky.social booth #1144 tomorrow to learn abt research opportunities, a new graduate certificate, postdoc fellowships & faculty hiring! And if you tell us our full mission statement by memory, you’ll get some cool swag… 👀😉 #SACNAS
@wutsaiyale.bsky.social booth #1144 tomorrow to learn abt research opportunities, a new graduate certificate, postdoc fellowships & faculty hiring! And if you tell us our full mission statement by memory, you’ll get some cool swag… 👀😉 #SACNAS
Reposted by Vincent Tse
WTI Postdoctoral Fellowship applications are open! Unique opportunity for those pivoting fields or working across disciplines. I’d be happy to support candidates with a background in immunology and/or in vivo 2-photon imaging, including collaborations with other WTI labs wti.yale.edu/initiatives/...
Postdoctoral Fellowships | Wu Tsai Institute
wti.yale.edu
October 3, 2025 at 6:32 PM
WTI Postdoctoral Fellowship applications are open! Unique opportunity for those pivoting fields or working across disciplines. I’d be happy to support candidates with a background in immunology and/or in vivo 2-photon imaging, including collaborations with other WTI labs wti.yale.edu/initiatives/...
Reposted by Vincent Tse
What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap
October 3, 2025 at 8:21 AM
What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap
Really excited to see this work from my postgrad days come out of its "slumber" 💤 If you are interested in how astrocytes interact with neuromodulatory systems to regulate cortical states, this is for you!
Congrats to Charlotte Taylor and team for dissecting how astrocyte networks integrate histamine to modulate adenosine over sleep and wake in unexpected ways:
dx.plos.org/10.1371/jour...
@vincenttse.bsky.social @maxine.science @trishavv.bsky.social
dx.plos.org/10.1371/jour...
@vincenttse.bsky.social @maxine.science @trishavv.bsky.social
Cortical astrocyte histamine-1-receptors regulate intracellular calcium and extracellular adenosine dynamics across sleep and wake
While histamine-1-receptor (H1R) signaling in neurons regulates arousal, these receptors are also abundant on cortical astrocytes. This study shows that astrocytic H1R signaling modulates calcium acti...
dx.plos.org
October 2, 2025 at 8:32 PM
Really excited to see this work from my postgrad days come out of its "slumber" 💤 If you are interested in how astrocytes interact with neuromodulatory systems to regulate cortical states, this is for you!
Reposted by Vincent Tse
Congrats to Charlotte Taylor and team for dissecting how astrocyte networks integrate histamine to modulate adenosine over sleep and wake in unexpected ways:
dx.plos.org/10.1371/jour...
@vincenttse.bsky.social @maxine.science @trishavv.bsky.social
dx.plos.org/10.1371/jour...
@vincenttse.bsky.social @maxine.science @trishavv.bsky.social
Cortical astrocyte histamine-1-receptors regulate intracellular calcium and extracellular adenosine dynamics across sleep and wake
While histamine-1-receptor (H1R) signaling in neurons regulates arousal, these receptors are also abundant on cortical astrocytes. This study shows that astrocytic H1R signaling modulates calcium acti...
dx.plos.org
October 2, 2025 at 6:02 PM
Congrats to Charlotte Taylor and team for dissecting how astrocyte networks integrate histamine to modulate adenosine over sleep and wake in unexpected ways:
dx.plos.org/10.1371/jour...
@vincenttse.bsky.social @maxine.science @trishavv.bsky.social
dx.plos.org/10.1371/jour...
@vincenttse.bsky.social @maxine.science @trishavv.bsky.social
Reposted by Vincent Tse
Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
September 8, 2025 at 4:25 PM
Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
Reposted by Vincent Tse
Postdocs: Apply now for the SYNAPSES series @kavliatyale.bsky.social @yaleneuro.bsky.social! Deadline to apply is September 7th
August 8, 2025 at 6:27 PM
Postdocs: Apply now for the SYNAPSES series @kavliatyale.bsky.social @yaleneuro.bsky.social! Deadline to apply is September 7th
Reposted by Vincent Tse
Yale School of Medicine seeks a tenure track faculty member to research neuroinflammation in Alzheimer’s, bridging disciplines within a vibrant, collaborative community. Closing date: 31st October
www.dementiaresearcher.nihr.ac.uk/job/associat...
www.dementiaresearcher.nihr.ac.uk/job/associat...
August 5, 2025 at 9:17 PM
Yale School of Medicine seeks a tenure track faculty member to research neuroinflammation in Alzheimer’s, bridging disciplines within a vibrant, collaborative community. Closing date: 31st October
www.dementiaresearcher.nihr.ac.uk/job/associat...
www.dementiaresearcher.nihr.ac.uk/job/associat...
Reposted by Vincent Tse
The Sirota & Huang labs identified a novel letrozole–irinotecan combination therapy that improves memory and reduces pathology in Alzheimer's disease models—showcasing a transformative drug discovery approach rooted in human transcriptomics and real-world clinical data www.cell.com/cell/fulltex...
Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
A multi-cell-type drug discovery strategy targeting dysregulated gene networks in
neurons and glia identified letrozole and irinotecan as a combination therapy that
significantly improved memory and r...
www.cell.com
July 28, 2025 at 9:32 PM
The Sirota & Huang labs identified a novel letrozole–irinotecan combination therapy that improves memory and reduces pathology in Alzheimer's disease models—showcasing a transformative drug discovery approach rooted in human transcriptomics and real-world clinical data www.cell.com/cell/fulltex...
Reposted by Vincent Tse
In collaboration with @pebyale.bsky.social, WTI presents the 2025 Undergraduate Poster Symposium. Join us at 100 College Street on Wednesday, July 30, from 2-4 pm.
Faculty, students + trainees are encouraged to attend! Learn more: wti.yale.edu/event/2025-0...
#KnowTogether
Faculty, students + trainees are encouraged to attend! Learn more: wti.yale.edu/event/2025-0...
#KnowTogether
July 28, 2025 at 2:57 PM
In collaboration with @pebyale.bsky.social, WTI presents the 2025 Undergraduate Poster Symposium. Join us at 100 College Street on Wednesday, July 30, from 2-4 pm.
Faculty, students + trainees are encouraged to attend! Learn more: wti.yale.edu/event/2025-0...
#KnowTogether
Faculty, students + trainees are encouraged to attend! Learn more: wti.yale.edu/event/2025-0...
#KnowTogether
Reposted by Vincent Tse
Now on bioRxiv! Astrocytes in one brain region (cyan) communicate in expansive networks (magenta). Through tool development, tissue clearing, and many hours on our @zeiss-microscopy.bsky.social Z1, we now know these networks are repeatable across mice, plastic, and specific.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
July 22, 2025 at 8:54 PM
Now on bioRxiv! Astrocytes in one brain region (cyan) communicate in expansive networks (magenta). Through tool development, tissue clearing, and many hours on our @zeiss-microscopy.bsky.social Z1, we now know these networks are repeatable across mice, plastic, and specific.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Vincent Tse
Very proud of our new #SingleCell work on #PTSD and #MDD out in @nature.com today.
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD - Nature
A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.
www.nature.com
June 18, 2025 at 4:53 PM
Very proud of our new #SingleCell work on #PTSD and #MDD out in @nature.com today.
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...
Reposted by Vincent Tse
I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!
May 22, 2025 at 11:42 AM
I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!
Reposted by Vincent Tse
I have seen folks waste so much time by not properly planning research. Missed literature, missing controls, ignored hypotheses, etc. Lack of planning also produces bad science (e.g. analysis until significant). So I am writing an app. Looking for feedback. scientific-paper-planner-test.vercel.app
Scientific Paper Planner
Scientific Paper Planner Application
scientific-paper-planner-test.vercel.app
May 15, 2025 at 2:28 PM
I have seen folks waste so much time by not properly planning research. Missed literature, missing controls, ignored hypotheses, etc. Lack of planning also produces bad science (e.g. analysis until significant). So I am writing an app. Looking for feedback. scientific-paper-planner-test.vercel.app
Reposted by Vincent Tse
Extremely proud to finally be able to present this work in the open🍾✨ We identify and manipulate astrocytic calcium-dependent ensembles in the NAc ✨✨ It gathers new tools, intense experiments and results that blowed our minds in the process at Navarrete's lab 🤯 Check it out! rdcu.be/d8qJi
Astrocyte ensembles manipulated with AstroLight tune cue-motivated behavior
Nature Neuroscience - Using the AstroLight system, the authors reveal that astrocytic ensembles in the nucleus accumbens regulate cue-motivated reward behavior, demonstrating that selective...
rdcu.be
February 3, 2025 at 12:17 PM
Extremely proud to finally be able to present this work in the open🍾✨ We identify and manipulate astrocytic calcium-dependent ensembles in the NAc ✨✨ It gathers new tools, intense experiments and results that blowed our minds in the process at Navarrete's lab 🤯 Check it out! rdcu.be/d8qJi
Reposted by Vincent Tse
Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.
Thread below: (1/11)
Thread below: (1/11)
Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease
The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying
cerebral plaque burden depending on the parental source of the transgene. Mice inheriting
the transgene paternally...
www.cell.com
January 20, 2025 at 3:49 PM
Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.
Thread below: (1/11)
Thread below: (1/11)
Reposted by Vincent Tse
Our lab at Yale U/Wu Tsai Institute has a postdoctoral position on neurodegeneration, neuro-glial-vascular biology using 2photon, calcium/voltage imaging, gene editing,transcriptome/proteome, 3D EM, translational neurosci/chemistry. Email me if interested. Forward to those interested pls
January 8, 2025 at 10:08 PM
Our lab at Yale U/Wu Tsai Institute has a postdoctoral position on neurodegeneration, neuro-glial-vascular biology using 2photon, calcium/voltage imaging, gene editing,transcriptome/proteome, 3D EM, translational neurosci/chemistry. Email me if interested. Forward to those interested pls
Reposted by Vincent Tse
Adding @tamarajafar.bsky.social
@schandralab.bsky.social
@toddc.bsky.social
@vincenttse.bsky.social
If you’re interested in understanding cognition and Neuroscience at Yale follow our starter pack .
If there are others that should be added let me know !
go.bsky.app/CqNL4be
@schandralab.bsky.social
@toddc.bsky.social
@vincenttse.bsky.social
If you’re interested in understanding cognition and Neuroscience at Yale follow our starter pack .
If there are others that should be added let me know !
go.bsky.app/CqNL4be
December 16, 2024 at 3:46 PM
Adding @tamarajafar.bsky.social
@schandralab.bsky.social
@toddc.bsky.social
@vincenttse.bsky.social
If you’re interested in understanding cognition and Neuroscience at Yale follow our starter pack .
If there are others that should be added let me know !
go.bsky.app/CqNL4be
@schandralab.bsky.social
@toddc.bsky.social
@vincenttse.bsky.social
If you’re interested in understanding cognition and Neuroscience at Yale follow our starter pack .
If there are others that should be added let me know !
go.bsky.app/CqNL4be
Reposted by Vincent Tse
I would appreciate it if you could share this invitation and respond if you would like to join this group.
go.bsky.app/DXdNa8k
go.bsky.app/DXdNa8k
November 18, 2024 at 10:15 AM
I would appreciate it if you could share this invitation and respond if you would like to join this group.
go.bsky.app/DXdNa8k
go.bsky.app/DXdNa8k
Reposted by Vincent Tse
some great starter packs for the #glia, #astrocyte, #oligodendrocyte, #microglia, #neuro researcher: gliasky, astrocytesky, microglia
But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed?
go.bsky.app/MHtJzeC
But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed?
go.bsky.app/MHtJzeC
November 17, 2024 at 8:35 PM
some great starter packs for the #glia, #astrocyte, #oligodendrocyte, #microglia, #neuro researcher: gliasky, astrocytesky, microglia
But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed?
go.bsky.app/MHtJzeC
But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed?
go.bsky.app/MHtJzeC
Reposted by Vincent Tse
There are lots of us missing, but so many joining so quickly
Please do share, and comment below to be added
go.bsky.app/5f2V6L6
(microglia starter pack also here by @mancusorenzo.bsky.social - bsky.app/starter-pack...)
Please do share, and comment below to be added
go.bsky.app/5f2V6L6
(microglia starter pack also here by @mancusorenzo.bsky.social - bsky.app/starter-pack...)
November 17, 2024 at 7:10 PM
There are lots of us missing, but so many joining so quickly
Please do share, and comment below to be added
go.bsky.app/5f2V6L6
(microglia starter pack also here by @mancusorenzo.bsky.social - bsky.app/starter-pack...)
Please do share, and comment below to be added
go.bsky.app/5f2V6L6
(microglia starter pack also here by @mancusorenzo.bsky.social - bsky.app/starter-pack...)