Nicola Osgood
@thebiochemist.bsky.social
PhD student leveraging next-generation gene editing technologies to study functional genomics
🧬🧬🧬🧬🧬🧬🧬🧬🧬🧬🧬
Kenyan born 🇰🇪 | US Marine Veteran 🇺🇸
Biochemist 🔬| STEM PhD 👩🏼🔬
Wife 💍 | Mother 🩷
Safe space 💙
🧬🧬🧬🧬🧬🧬🧬🧬🧬🧬🧬
Kenyan born 🇰🇪 | US Marine Veteran 🇺🇸
Biochemist 🔬| STEM PhD 👩🏼🔬
Wife 💍 | Mother 🩷
Safe space 💙
Reposted by Nicola Osgood
Is it happening again? 🌊🪸
Millions of years ago, coral reefs collapsed as the planet overheated
And now, it’s happening once more.
Fossils reveal both warning and hope: reefs can recover, but only if we slow change enough to let them.
🧪 #SciComm
🎥 Watch or read:
buff.ly/jlGRYIF
Millions of years ago, coral reefs collapsed as the planet overheated
And now, it’s happening once more.
Fossils reveal both warning and hope: reefs can recover, but only if we slow change enough to let them.
🧪 #SciComm
🎥 Watch or read:
buff.ly/jlGRYIF
Earth’s First Climate Tipping Point? Fossils Warn What Happens Next
The deep-time story of coral reefs shows both the danger of warming seas and the power of resilience Beneath the waves, something irreversible may have...
climateages.com
October 29, 2025 at 12:37 PM
Is it happening again? 🌊🪸
Millions of years ago, coral reefs collapsed as the planet overheated
And now, it’s happening once more.
Fossils reveal both warning and hope: reefs can recover, but only if we slow change enough to let them.
🧪 #SciComm
🎥 Watch or read:
buff.ly/jlGRYIF
Millions of years ago, coral reefs collapsed as the planet overheated
And now, it’s happening once more.
Fossils reveal both warning and hope: reefs can recover, but only if we slow change enough to let them.
🧪 #SciComm
🎥 Watch or read:
buff.ly/jlGRYIF
This is a phenomenal interview given by my PI’s post-doctoral advisor, Professor David Liu. I encourage you all to watch it and share!
The first bit talks about technology that I use in my research and how these technologies are being applied to treat and cure diseases.
youtu.be/8YhJM6zxYDw?...
The first bit talks about technology that I use in my research and how these technologies are being applied to treat and cure diseases.
youtu.be/8YhJM6zxYDw?...
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
youtu.be
May 24, 2025 at 2:22 AM
This is a phenomenal interview given by my PI’s post-doctoral advisor, Professor David Liu. I encourage you all to watch it and share!
The first bit talks about technology that I use in my research and how these technologies are being applied to treat and cure diseases.
youtu.be/8YhJM6zxYDw?...
The first bit talks about technology that I use in my research and how these technologies are being applied to treat and cure diseases.
youtu.be/8YhJM6zxYDw?...
I am ecstatic to share this work, which involved functional interrogation of MUTYH variants using base editing. I enjoyed working with Dr. Carlos Vasquez on this project and look forward to seeing this expanded for high throughput!
#baseediting #womeninstem 🧪
academic.oup.com/nar/article/...
#baseediting #womeninstem 🧪
academic.oup.com/nar/article/...
Precision genome editing and in-cell measurements of oxidative DNA damage repair enable functional and mechanistic characterization of cancer-associated MUTYH variants
Abstract. Functional characterization of genetic variants has the potential to advance the field of precision medicine by enhancing the efficacy of current
academic.oup.com
March 31, 2025 at 5:47 PM
I am ecstatic to share this work, which involved functional interrogation of MUTYH variants using base editing. I enjoyed working with Dr. Carlos Vasquez on this project and look forward to seeing this expanded for high throughput!
#baseediting #womeninstem 🧪
academic.oup.com/nar/article/...
#baseediting #womeninstem 🧪
academic.oup.com/nar/article/...
🧪I am thrilled to share that our work was just published in Methods in Enzymology!
HUGE thank you to all who contributed to this, but especially to my phenomenal co-first author, @natalie-z.bsky.social, and our mentor, Dr. Alexis Komor.
#baseediting #genomeediting #SciSky #AcademicSky
HUGE thank you to all who contributed to this, but especially to my phenomenal co-first author, @natalie-z.bsky.social, and our mentor, Dr. Alexis Komor.
#baseediting #genomeediting #SciSky #AcademicSky
Genome editing with programmable base editors in human cells
Genome editing has garnered significant attention over the last decade, resulting in a massive expansion of the genome engineering toolbox. Base edito…
www.sciencedirect.com
February 6, 2025 at 2:48 AM
🧪I am thrilled to share that our work was just published in Methods in Enzymology!
HUGE thank you to all who contributed to this, but especially to my phenomenal co-first author, @natalie-z.bsky.social, and our mentor, Dr. Alexis Komor.
#baseediting #genomeediting #SciSky #AcademicSky
HUGE thank you to all who contributed to this, but especially to my phenomenal co-first author, @natalie-z.bsky.social, and our mentor, Dr. Alexis Komor.
#baseediting #genomeediting #SciSky #AcademicSky
Reposted by Nicola Osgood
#AMIA2024 WELCOME TO BLUESKY! 🦋
I'm so excited to see people finally arrive at the shores of Bluesky!
I want to make sure you stick around so let me give you a guided tour on how to maximize your fun and engagement here! 🧵
I'm so excited to see people finally arrive at the shores of Bluesky!
I want to make sure you stick around so let me give you a guided tour on how to maximize your fun and engagement here! 🧵
November 12, 2024 at 3:02 PM
#AMIA2024 WELCOME TO BLUESKY! 🦋
I'm so excited to see people finally arrive at the shores of Bluesky!
I want to make sure you stick around so let me give you a guided tour on how to maximize your fun and engagement here! 🧵
I'm so excited to see people finally arrive at the shores of Bluesky!
I want to make sure you stick around so let me give you a guided tour on how to maximize your fun and engagement here! 🧵
Constant hypocrisy from conservatives is exhausting, but perhaps more exhausting are the mental gymnastics of their supporters.
January 20, 2025 at 4:20 PM
Constant hypocrisy from conservatives is exhausting, but perhaps more exhausting are the mental gymnastics of their supporters.
This captures what I’ve been thinking, almost exactly.
I've been trying to understand why I feel the particular flavor of distressed that I do right now. I think it's because we can no longer discuss the lessons we should be learning from any kind of disaster without the worst chucklefucks coming out of the woodwork to wreck everything.
January 12, 2025 at 4:23 PM
This captures what I’ve been thinking, almost exactly.
Reposted by Nicola Osgood
You will read countless times today that the LA mayor cut the LA Fire Department's budget by $23 million.
That is a lie.
The budget was actually *increased* by $50 million.
That is a lie.
The budget was actually *increased* by $50 million.
January 9, 2025 at 3:05 PM
You will read countless times today that the LA mayor cut the LA Fire Department's budget by $23 million.
That is a lie.
The budget was actually *increased* by $50 million.
That is a lie.
The budget was actually *increased* by $50 million.
Given his recent announcement about pending changes to Facebook, it would appear Mark Zuckerberg has followed Elon Musk’s direction. This poses a new, significant challenge in combatting misinformation.
Frankly, I’m exhausted, so this is incredibly disappointing. Thoughts?
Frankly, I’m exhausted, so this is incredibly disappointing. Thoughts?
January 9, 2025 at 1:54 PM
Given his recent announcement about pending changes to Facebook, it would appear Mark Zuckerberg has followed Elon Musk’s direction. This poses a new, significant challenge in combatting misinformation.
Frankly, I’m exhausted, so this is incredibly disappointing. Thoughts?
Frankly, I’m exhausted, so this is incredibly disappointing. Thoughts?
Reposted by Nicola Osgood
Download/read "Solving Climate Change" as an eBook now. Link below: 🧪
I wrote one of the endorsements for @jgkoomey.bsky.social and Monroe’s Solving #ClimateChange, which you can download for free through December 20th.
www.solveclimate.org
www.solveclimate.org
December 14, 2024 at 3:25 PM
Download/read "Solving Climate Change" as an eBook now. Link below: 🧪
Reposted by Nicola Osgood
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...
www.nytimes.com/2024/12/09/h...
December 9, 2024 at 11:19 PM
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...
www.nytimes.com/2024/12/09/h...
Reposted by Nicola Osgood
I want men in science to think about this. Think about the biases you have grown up with so much you're probably not even aware you have them. 🧪 #WomenInSTEM
What surprised me the most was how *early* these divergences by STEM fields emerge.
By age 6, kids already see girls as worse at computer science and engineering. But...there's no early male bias for math. (I made this graph for a broader audience).
Six-year-olds have quite nuanced beliefs!
By age 6, kids already see girls as worse at computer science and engineering. But...there's no early male bias for math. (I made this graph for a broader audience).
Six-year-olds have quite nuanced beliefs!
December 10, 2024 at 2:28 AM
I want men in science to think about this. Think about the biases you have grown up with so much you're probably not even aware you have them. 🧪 #WomenInSTEM
Reposted by Nicola Osgood
Phenomenal work - 3 year relapse-free rates moved from 80-85% up to 97.5% in kids with average risk of relapse. This type of leukemia is the leading type of cancer in children. 🧪
December 10, 2024 at 3:10 AM
Phenomenal work - 3 year relapse-free rates moved from 80-85% up to 97.5% in kids with average risk of relapse. This type of leukemia is the leading type of cancer in children. 🧪
Reposted by Nicola Osgood
yeah but I'm sure they'll be sooooo concerned about the wages and welfare of working class Americans
There are 14 BILLIONAIRES that are part of the second Trump administration
December 7, 2024 at 12:38 PM
yeah but I'm sure they'll be sooooo concerned about the wages and welfare of working class Americans
Reposted by Nicola Osgood
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research.
A Place of Joy.
A Place of Joy.
December 3, 2024 at 2:10 PM
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
Reposted by Nicola Osgood
In #NextGenSequencing news, updated the #NGS #specs w/ two upcoming Illumina $ILMN NovaSeqX 25B kits, for 100cycles and 200cycles.
Now the cheapest $/Gb short-read runs are:
(1) NovaSeq X 25B (300 cycles) = $2.22/Gb
(2) NovaSeq X 25B (200 cycles) = $2.72/Gb
(3) NovaSeq X 10B (300 cycles) = $3.54/Gb
Now the cheapest $/Gb short-read runs are:
(1) NovaSeq X 25B (300 cycles) = $2.22/Gb
(2) NovaSeq X 25B (200 cycles) = $2.72/Gb
(3) NovaSeq X 10B (300 cycles) = $3.54/Gb
December 3, 2024 at 12:20 PM
In #NextGenSequencing news, updated the #NGS #specs w/ two upcoming Illumina $ILMN NovaSeqX 25B kits, for 100cycles and 200cycles.
Now the cheapest $/Gb short-read runs are:
(1) NovaSeq X 25B (300 cycles) = $2.22/Gb
(2) NovaSeq X 25B (200 cycles) = $2.72/Gb
(3) NovaSeq X 10B (300 cycles) = $3.54/Gb
Now the cheapest $/Gb short-read runs are:
(1) NovaSeq X 25B (300 cycles) = $2.22/Gb
(2) NovaSeq X 25B (200 cycles) = $2.72/Gb
(3) NovaSeq X 10B (300 cycles) = $3.54/Gb
Reposted by Nicola Osgood
Thread on need to fight for evidence-based policy - a response to Trump's cabinet picks.
Based on new @bmj.com article by me, @martinmckee.bsky.social & @kentbuse.bsky.social
TLDR: Now is the time to stand up for science, not appease those in power attacking it
www.bmj.com/content/387/... 1/14
Based on new @bmj.com article by me, @martinmckee.bsky.social & @kentbuse.bsky.social
TLDR: Now is the time to stand up for science, not appease those in power attacking it
www.bmj.com/content/387/... 1/14
November 28, 2024 at 11:58 PM
Thread on need to fight for evidence-based policy - a response to Trump's cabinet picks.
Based on new @bmj.com article by me, @martinmckee.bsky.social & @kentbuse.bsky.social
TLDR: Now is the time to stand up for science, not appease those in power attacking it
www.bmj.com/content/387/... 1/14
Based on new @bmj.com article by me, @martinmckee.bsky.social & @kentbuse.bsky.social
TLDR: Now is the time to stand up for science, not appease those in power attacking it
www.bmj.com/content/387/... 1/14
Reposted by Nicola Osgood
But RFK Jr. wrote on X "The main problem with hydroxychloroquine was that it is a generic drug with little profit potential. " When in fact, the main problem is that it doesn't work and actually can hurt people.
November 25, 2024 at 5:13 PM
But RFK Jr. wrote on X "The main problem with hydroxychloroquine was that it is a generic drug with little profit potential. " When in fact, the main problem is that it doesn't work and actually can hurt people.
Interesting…
BREAKING: Dr. Oz invested in businesses regulated by the agency Trump wants him to lead.
For example, he has a stake in UnitedHealth Group, $UNH, worth as much as $600,000, as well as shares in pharmaceutical firms.
Oz’s investments total tens of millions of dollars.
For example, he has a stake in UnitedHealth Group, $UNH, worth as much as $600,000, as well as shares in pharmaceutical firms.
Oz’s investments total tens of millions of dollars.
November 25, 2024 at 12:16 AM
Interesting…
This is useful!!
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 24, 2024 at 8:16 PM
This is useful!!
Reposted by Nicola Osgood
A recent AHA scientific session linked redlined areas with poor food access to higher rates of type 2 diabetes, heart disease, hypertension, and obesity. Improving food access could address these disparities. 🩺 🛟
Food access in formerly redlined neighborhoods tied to poor cardiometabolic health
CHICAGO — People living in historically redlined neighborhoods with poor access to healthy foods were more likely to have type 2 diabetes, hypertension, coronary heart disease and obesity, resea...
www.healio.com
November 20, 2024 at 7:28 PM
A recent AHA scientific session linked redlined areas with poor food access to higher rates of type 2 diabetes, heart disease, hypertension, and obesity. Improving food access could address these disparities. 🩺 🛟
Reposted by Nicola Osgood
Great to see so many new people here! Explore Starter Packs to get started!
I made one of scientists with a focus on #ChemBio, #Chemistry, (Chemical) #Proteomics and #DrugDiscovery:
bsky.app/starter-pac...
As well as a short version of the 25 most recommended accounts: bsky.app/starter-pac...
(1/8)
I made one of scientists with a focus on #ChemBio, #Chemistry, (Chemical) #Proteomics and #DrugDiscovery:
bsky.app/starter-pac...
As well as a short version of the 25 most recommended accounts: bsky.app/starter-pac...
(1/8)
Scientists to follow
Join the conversation
bsky.app
November 18, 2024 at 1:38 PM
Great to see so many new people here! Explore Starter Packs to get started!
I made one of scientists with a focus on #ChemBio, #Chemistry, (Chemical) #Proteomics and #DrugDiscovery:
bsky.app/starter-pac...
As well as a short version of the 25 most recommended accounts: bsky.app/starter-pac...
(1/8)
I made one of scientists with a focus on #ChemBio, #Chemistry, (Chemical) #Proteomics and #DrugDiscovery:
bsky.app/starter-pac...
As well as a short version of the 25 most recommended accounts: bsky.app/starter-pac...
(1/8)
Reposted by Nicola Osgood
⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
November 17, 2024 at 6:48 PM
⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
Reposted by Nicola Osgood
One thing I hope we can do as Bluesky gets larger is be less tolerant of the resistance grifters who will try to hack the platform for engagement and growth without any interest in adding anything substantive or meaningful
It’s a different kind of troll.
It’s a different kind of troll.
November 19, 2024 at 1:40 AM
One thing I hope we can do as Bluesky gets larger is be less tolerant of the resistance grifters who will try to hack the platform for engagement and growth without any interest in adding anything substantive or meaningful
It’s a different kind of troll.
It’s a different kind of troll.
Hi, Bluesky! I’m curious to hear from other scientists: what is your field of study and what sparked your interest in it?
#science #scientists
#science #scientists
November 19, 2024 at 1:56 PM
Hi, Bluesky! I’m curious to hear from other scientists: what is your field of study and what sparked your interest in it?
#science #scientists
#science #scientists