Sonja Welsch
@sonjawelsch.bsky.social
Taking care of Electron Microscopy @mpibp.bsky.social. Yay for #cryoEM and #cryoET ❄️🔬but frozen is not always better. Also, #viruses 🦠 rule.
Reposted by Sonja Welsch
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 5:42 PM
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
Reposted by Sonja Welsch
Exciting week in Frankfurt! Our CEOS energy filter and ASI Timepix3 are installed and we're looking forward to running the first tests :) #CryoEM #timepix #REELanalysis #4DSTEM @mpibp.bsky.social
November 5, 2025 at 12:12 PM
Exciting week in Frankfurt! Our CEOS energy filter and ASI Timepix3 are installed and we're looking forward to running the first tests :) #CryoEM #timepix #REELanalysis #4DSTEM @mpibp.bsky.social
Reposted by Sonja Welsch
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 3, 2025 at 4:47 PM
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠
www.uu.nl/en/news/33-m...
Looking for an exciting #cryoEM postdoc position? 🤩 This one is highly recommended! 👇
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Dodonova Group – Organisational principles and 3D architecture of archaeal chromatin
www.embl.org
October 30, 2025 at 2:55 PM
Looking for an exciting #cryoEM postdoc position? 🤩 This one is highly recommended! 👇
Reposted by Sonja Welsch
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by Sonja Welsch
Lauren Alexandrescu et al.: `Mix-it-up': accessible time-resolved cryo-EM on the millisecond timescale ##ElectronMicroscopy##CryoEM##TimeResolvedStudies... ##IUCrhttps://journals.iucr.org/paper?S2052252525008838
`Mix-it-up': accessible time-resolved cryo-EM on the millisecond timescale
The development of methods for low-cost time-resolved cryo-EM using an on-grid mixing strategy is described.
journals.iucr.org
October 28, 2025 at 1:00 AM
Lauren Alexandrescu et al.: `Mix-it-up': accessible time-resolved cryo-EM on the millisecond timescale ##ElectronMicroscopy##CryoEM##TimeResolvedStudies... ##IUCrhttps://journals.iucr.org/paper?S2052252525008838
Reposted by Sonja Welsch
Have you registered to the next EMBO Practical Course on In-situ structural biology by Cryo-FIB and Cryo-ET? 🧊 Join us in Frankfurt for hands-on training on cryo-techniques and networking with experts!
🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
📍 Frankfurt | 📆 April 12–20, 2026
🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
📍 Frankfurt | 📆 April 12–20, 2026
October 23, 2025 at 9:10 AM
Have you registered to the next EMBO Practical Course on In-situ structural biology by Cryo-FIB and Cryo-ET? 🧊 Join us in Frankfurt for hands-on training on cryo-techniques and networking with experts!
🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
📍 Frankfurt | 📆 April 12–20, 2026
🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
📍 Frankfurt | 📆 April 12–20, 2026
Reposted by Sonja Welsch
Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
October 24, 2025 at 8:11 AM
Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
@mpibp.bsky.social’s handsome STEM scan of the day 🤩
Guess the crystal? Hint: S136
Guess the crystal? Hint: S136
October 22, 2025 at 4:11 PM
@mpibp.bsky.social’s handsome STEM scan of the day 🤩
Guess the crystal? Hint: S136
Guess the crystal? Hint: S136
Reposted by Sonja Welsch
Are you interested in #StructuralBiology?
Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel.
A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss.
www.universiteitleiden.nl/en/kroese-du...
Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel.
A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss.
www.universiteitleiden.nl/en/kroese-du...
Kroese-Duijsters Symposium 2025
The Kroese-Duijsters Symposia aim to provide researchers from different fields and different career stages to meet in an informal setting, to stimulate discussions and to start new collaborations. The...
www.universiteitleiden.nl
October 17, 2025 at 9:59 AM
Are you interested in #StructuralBiology?
Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel.
A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss.
www.universiteitleiden.nl/en/kroese-du...
Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel.
A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss.
www.universiteitleiden.nl/en/kroese-du...
Oh! Highly recommended, please consider applying! 👇🏻🤩
ISTA @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology, to develop tools for cryo-EM, cryo-ET, structural prediction methods and protein interaction analysis!
Please spread the word!
ista.ac.at/en/job/tenur...
Please spread the word!
ista.ac.at/en/job/tenur...
Tenure-based Research Staff Scientist Position in Computational Structural Biology
ISTA (www.ista.ac.at) is seeking a highly skilled Staff Scientist in Computational Structural Biology to support and advance the Institute’s structural biology research through the development and imp...
ista.ac.at
October 16, 2025 at 4:54 PM
Oh! Highly recommended, please consider applying! 👇🏻🤩
Reposted by Sonja Welsch
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
beta.ideas.lego.com/product-idea...
Biological Laboratory | LEGO® Ideas
This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…
beta.ideas.lego.com
October 16, 2025 at 8:07 AM
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
beta.ideas.lego.com/product-idea...
Only a few days left to apply for the great PhD Programme of @vbcscitraining.bsky.social 👇🏻
Our PhD program offers many training activities and courses for your future career. Check out the range of fully-funded PhD positions in our Autumn call before 10 October 2025: www.vbcphd.at
October 5, 2025 at 12:14 PM
Only a few days left to apply for the great PhD Programme of @vbcscitraining.bsky.social 👇🏻
Reposted by Sonja Welsch
Correlative MS Imaging for cellular identification and analysis of in situ cryo-ET www.biorxiv.org/content/10.1101/2025.09.16.676641v1 #cryoem
September 19, 2025 at 9:16 AM
Correlative MS Imaging for cellular identification and analysis of in situ cryo-ET www.biorxiv.org/content/10.1101/2025.09.16.676641v1 #cryoem
❗️🤩👇🏻
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
September 30, 2025 at 10:41 AM
❗️🤩👇🏻
Reposted by Sonja Welsch
Since it was published at peak holiday season, I'm taking the liberty to re-introduce our recent review article. We hope it will be a useful overview of RNA virus replication strategies, and how in situ cryo-EM have helped us understand them:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Illuminating druggable dark matter in RNA virus replication using in situ cryo-EM
Viral proteins typically exist in the context of complex virions or in the even more complex host cells in which they replicate. Hence, meaningful ins…
www.sciencedirect.com
September 22, 2025 at 9:26 AM
Since it was published at peak holiday season, I'm taking the liberty to re-introduce our recent review article. We hope it will be a useful overview of RNA virus replication strategies, and how in situ cryo-EM have helped us understand them:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Sonja Welsch
Ever wondered how to position organelles in bacteria? Wonder no more!
Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab.
The avenues this opens in the synthetic biology space are enormous!
Movie: Carboxysomes positioned in E. coli!
Preprint: shorturl.at/D6xVg
Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab.
The avenues this opens in the synthetic biology space are enormous!
Movie: Carboxysomes positioned in E. coli!
Preprint: shorturl.at/D6xVg
September 23, 2025 at 3:31 PM
Ever wondered how to position organelles in bacteria? Wonder no more!
Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab.
The avenues this opens in the synthetic biology space are enormous!
Movie: Carboxysomes positioned in E. coli!
Preprint: shorturl.at/D6xVg
Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab.
The avenues this opens in the synthetic biology space are enormous!
Movie: Carboxysomes positioned in E. coli!
Preprint: shorturl.at/D6xVg
Reposted by Sonja Welsch
We welcome our new faculty member Ramachandra Bhaskara! His group uses simulations and modeling to study complex biological systems at the interface of biology, physics, and data science.
#imprs #imprs_cbp @goetheuni.bsky.social
#imprs #imprs_cbp @goetheuni.bsky.social
September 22, 2025 at 11:26 AM
We welcome our new faculty member Ramachandra Bhaskara! His group uses simulations and modeling to study complex biological systems at the interface of biology, physics, and data science.
#imprs #imprs_cbp @goetheuni.bsky.social
#imprs #imprs_cbp @goetheuni.bsky.social
Reposted by Sonja Welsch
We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.
September 18, 2025 at 3:28 PM
We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.
Reposted by Sonja Welsch
A productive morning with Profs. Dötsch, García-Sáez and Helfrich! We learnt about transcription factors, cellular death and biosynthetic pathways. All before lunch time! #sciencemorning #gradschool @mpibp.bsky.social @goetheuni.bsky.social
September 17, 2025 at 11:18 AM
A productive morning with Profs. Dötsch, García-Sáez and Helfrich! We learnt about transcription factors, cellular death and biosynthetic pathways. All before lunch time! #sciencemorning #gradschool @mpibp.bsky.social @goetheuni.bsky.social
At what number of hidden layers do shallow learning networks cross over to being deep learning? One? More? Depends?🤔
September 16, 2025 at 4:55 PM
At what number of hidden layers do shallow learning networks cross over to being deep learning? One? More? Depends?🤔
Reposted by Sonja Welsch
First webinar on the kit this Thu Sep 18th. You can still register in one of the links below.
Our aim was to create a kit to produce in-house 1.2 holey carbon cryoEM grids, in three simple steps, at less than half of the prize, and without due times. I think we are there. Academic teams that want to know more, receive training or order a kit, please contact grids@puxano.com.
September 16, 2025 at 2:38 PM
First webinar on the kit this Thu Sep 18th. You can still register in one of the links below.
Reposted by Sonja Welsch
Great session with Melanie McDowell today!
She shared exciting insights into how proteins find their way into the ER.
#imprs #imprs_cbp #phd #gradschool #biophysics
She shared exciting insights into how proteins find their way into the ER.
#imprs #imprs_cbp #phd #gradschool #biophysics
September 16, 2025 at 12:55 PM
Great session with Melanie McDowell today!
She shared exciting insights into how proteins find their way into the ER.
#imprs #imprs_cbp #phd #gradschool #biophysics
She shared exciting insights into how proteins find their way into the ER.
#imprs #imprs_cbp #phd #gradschool #biophysics
Reposted by Sonja Welsch
We're very excited to welcome the new generation of #IMPRS students during our Symposium on Cellular Biophysics 🧪 This morning, we heard spokespersons Volker Dötsch and Martin Beck, and coordinator Pamela Ornelas, introduce the doctoral program to the new students!
#imprs_cbp #biophysics #gradschool
#imprs_cbp #biophysics #gradschool
September 15, 2025 at 12:17 PM
We're very excited to welcome the new generation of #IMPRS students during our Symposium on Cellular Biophysics 🧪 This morning, we heard spokespersons Volker Dötsch and Martin Beck, and coordinator Pamela Ornelas, introduce the doctoral program to the new students!
#imprs_cbp #biophysics #gradschool
#imprs_cbp #biophysics #gradschool