The chemicals stay closer to the ground and may become less effective, though using tear gas outdoors is questionable practice in any weather.

Organelles are the internal batteries, gears, actuators, 3D printers and transmitters that drive cell function. Their composition and activity vary between cell types depending on functional demands. In T cells, which are key mediators of immunosurveillance and tumour eradication, organelles are relatively few and function at basal levels when cells are at rest. However, upon activation, they increase in number and size and undergo extensive remodelling to support rapid proliferation, effector differentiation and adaptation to diverse microenvironments, including the tumour microenvironment, thereby enabling efficient clearance of target cells. In this Review, we provide an overview of recent advances in our understanding of how various organelles contribute to T cell-mediated antitumour immunity. We also discuss emerging strategies to modulate organelle functions — from organelle-targeted therapies and their use as cargo delivery systems to the transfer or transplantation of nati

An engineer and musician teaches an octopus to play the piano.

Ig Nobel-winning research could one day be used to treat people with blocked airways or clogged lungs.

By shifting water to a higher elevation, the giant Three Gorges Dam caused the Earth to spin more slowly.