Research & Innovation New Partnership Will Revitalize Ocean Research Off the Jersey Shore Research & Innovation New Gilded Age Christmas Cookbook Whisks Readers Back in Time Research & Innovation Health Policy Experts Identify Promising Strategies for P...

We are hiring! Join the Knoblich lab as a Master’s student and work on a project in neuronal network development.

Snow is expected to impact roads Thursday evening, especially south of U.S. 30, with more expected over the weekend amid extremely cold temperatures.

Snow and Slick Travel Expected This Morning

Roger Highfield, Science Director, describes the first real stride toward writing human genomes from scratch.

The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) t...

This will be Our First Sanctioned Event Located at the Laporte County Fairgrounds In Indiana.

The era of plump, cuddly pets may soon be over, as overweight animals are being prescribed a version of Ozempic. What will this do to their love for food?

This cohort study uses data from the Framingham Heart Study to evaluate whether higher physical activity levels in early adult life, midlife, or late life are associated with lower risk of all-cause o...

Base editing is a CRISPR-based technology that enables high-throughput, nucleotide-level functional interrogation of the genome that is essential for understanding the genetic basis of human disease and informing therapeutic development. Base editing screens have emerged as a powerful experimental approach, yet significant cell-to-cell variability in editing efficiency introduces noise that may obscure meaningful results. Here we develop a co-selection method that enriches for cells with high base editing activity, substantially increasing editing efficiency at a target locus. We evaluate this activity-based selection method against a traditional screening approach by tiling guide RNAs across TP53, demonstrating its enhanced capacity to pinpoint specific mutations and protein regions of functional importance. We anticipate that this modular selection method will enhance the resolution of base editing screens across many applications. This study presents a splice-based selection method

This review discusses the pathophysiology, clinical presentation, diagnosis, and treatment of length-dependent peripheral neuropathy.

A new study looks at how the mouth-on-mouth smooch came into being, and concludes that Neanderthals also kissed.

Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.

Shabana Mahmood is expected to say the era of permanent protection for refugees is over, in major changes to the UK's asylum and immigration system.