Here the authors show that persistent antigen stimulation drives the generation of CD8+ tissue-resident exhausted T cells with distinct developmental origins, function and therapeutic responsiveness w...

"Local governments have a substantial amount of leverage," an IU professor said. "They are well aware of what people want and the concerns people have about data centers. Design choices

From glowing neurons to newborn memories, here are the most fascinating brain discoveries of 2025

The discovery of Shimao city (around 2300–1800 bce1), a premier state-level Neolithic fortified settlement in Shaanxi, China2, played an important role in helping us understand the emergence of socially stratified urban societies. However, key questions remain regarding how ancestry and kinship shaped the hierarchy of this class-based society characterized by human sacrifice. The origin of the founding populations of Shimao and other Loess Plateau settlements, and their interactions within the broader ancestral landscape, have yet to be determined. Here we present, by sequencing 144 ancient genomes from Shimao city and its satellites, pedigrees among tomb owners spanning up to four generations. These findings reveal a predominantly patrilineal descent structure across Shimao communities, and possibly sex-specific sacrificial rituals. We also characterize the population history, revealing that Shimao culture-related populations originated mostly from a Yangshao culture-related populatio

Research & Innovation New Partnership Will Revitalize Ocean Research Off the Jersey Shore Research & Innovation New Gilded Age Christmas Cookbook Whisks Readers Back in Time Research & Innovation Health Policy Experts Identify Promising Strategies for P...

We are hiring! Join the Knoblich lab as a Master’s student and work on a project in neuronal network development.

Snow is expected to impact roads Thursday evening, especially south of U.S. 30, with more expected over the weekend amid extremely cold temperatures.

Snow and Slick Travel Expected This Morning

Roger Highfield, Science Director, describes the first real stride toward writing human genomes from scratch.

The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) t...

This will be Our First Sanctioned Event Located at the Laporte County Fairgrounds In Indiana.

The era of plump, cuddly pets may soon be over, as overweight animals are being prescribed a version of Ozempic. What will this do to their love for food?

This cohort study uses data from the Framingham Heart Study to evaluate whether higher physical activity levels in early adult life, midlife, or late life are associated with lower risk of all-cause o...