Gladstone Institutes
@gladstoneinst.bsky.social
To drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and diverse environment.
A discovery about the consequence of neuron overactivity could lead to new methods of treating or preventing Parkinson’s disease.
Overworked Brain Cells May Burn Out in Parkinson’s Disease
A discovery about the consequence of neuron overactivity could lead to new methods of treating or preventing Parkinson’s disease.
gladstone.org
January 3, 2026 at 7:54 PM
A discovery about the consequence of neuron overactivity could lead to new methods of treating or preventing Parkinson’s disease.
This past year was filled with scientific progress, meaningful connections, and moments that reminded us why research matters. Thank you to everyone who followed along, supported our work, and championed science with us.
We can’t wait to see what the new year brings.
We can’t wait to see what the new year brings.
January 1, 2026 at 3:53 PM
This past year was filled with scientific progress, meaningful connections, and moments that reminded us why research matters. Thank you to everyone who followed along, supported our work, and championed science with us.
We can’t wait to see what the new year brings.
We can’t wait to see what the new year brings.
Bringing complex science into clear view. Check out this animated explainer that shows how scientists reprogram cells to study disease and design new therapies.
It’s one of our favorite videos because it highlights not just what we do, but how science works.
https://bit.ly/4oHjWHc
It’s one of our favorite videos because it highlights not just what we do, but how science works.
https://bit.ly/4oHjWHc
Visualizing Stem Cell Technology: An Animated Explainer
In this animated short, Deepak Srivastava explains how scientists can reprogram ordinary skin or blood cells back in time—turning them into induced pluripotent stem cells which are capable of becoming...
bit.ly
December 31, 2025 at 5:50 PM
Bringing complex science into clear view. Check out this animated explainer that shows how scientists reprogram cells to study disease and design new therapies.
It’s one of our favorite videos because it highlights not just what we do, but how science works.
https://bit.ly/4oHjWHc
It’s one of our favorite videos because it highlights not just what we do, but how science works.
https://bit.ly/4oHjWHc
🧠💡 Revolutionizing scientific research: Our very own Steve Finkbeiner and his team have developed the world's first "thinking microscope"! This AI-powered marvel can design and conduct experiments all on its own. Imagine the possibilities for advancing our understanding of complex diseases!
Science in Seconds | The Thinking Microscope: Research Powered by an AI Brain
In this video, Steve Finkbeiner and Jeremy Linsley showcase Gladstone’s groundbreaking “thinking microscope”—an AI-powered system that can design, conduct, and analyze experiments autonomously to uncover new insights into diseases like Alzheimer’s, Parkinson’s, and ALS.
gladstone.org
December 29, 2025 at 5:50 PM
🧠💡 Revolutionizing scientific research: Our very own Steve Finkbeiner and his team have developed the world's first "thinking microscope"! This AI-powered marvel can design and conduct experiments all on its own. Imagine the possibilities for advancing our understanding of complex diseases!
A new documentary, featuring Gladstone scientists, follows Jim Dunn’s end-of-life decision to donate his tissues to HIV research.
https://bit.ly/4p3hIRO
https://bit.ly/4p3hIRO
One Person's Final Gift to Science Gets Us Closer to an HIV Cure
A new documentary follows Jim Dunn's end-of-life decision to donate his tissues to HIV research.
bit.ly
December 27, 2025 at 8:10 PM
A new documentary, featuring Gladstone scientists, follows Jim Dunn’s end-of-life decision to donate his tissues to HIV research.
https://bit.ly/4p3hIRO
https://bit.ly/4p3hIRO
Nearly half of babies born with Down syndrome face serious heart defects. Scientists used stem cells, gene editing, and AI to identify a key gene behind these defects—and showed that reducing its levels restored normal heart development in mice. Watch this video with the researchers to learn more.
Science in Seconds | Researchers Pinpoint Key Gene Behind Heart Defects in Down Syndrome
In this video, Gladstone scientists share how they used stem cells, gene editing, and AI to identify a gene driving heart defects in Down syndrome--and how reducing its levels in mice restored normal heart development, offering hope for future treatments
gladstone.org
December 26, 2025 at 8:58 PM
Nearly half of babies born with Down syndrome face serious heart defects. Scientists used stem cells, gene editing, and AI to identify a key gene behind these defects—and showed that reducing its levels restored normal heart development in mice. Watch this video with the researchers to learn more.
✨ Happy Holidays from all of us at Gladstone! ✨
As the year comes to a close, we’re grateful for our scientists, staff, collaborators, and supporters who help drive discovery forward every day. Wishing you a joyful season and a healthy, bright year ahead.
As the year comes to a close, we’re grateful for our scientists, staff, collaborators, and supporters who help drive discovery forward every day. Wishing you a joyful season and a healthy, bright year ahead.
December 25, 2025 at 4:06 PM
✨ Happy Holidays from all of us at Gladstone! ✨
As the year comes to a close, we’re grateful for our scientists, staff, collaborators, and supporters who help drive discovery forward every day. Wishing you a joyful season and a healthy, bright year ahead.
As the year comes to a close, we’re grateful for our scientists, staff, collaborators, and supporters who help drive discovery forward every day. Wishing you a joyful season and a healthy, bright year ahead.
Have you seen our latest Science in Seconds video?
Seth Shipman and his team recently identified seven new retrons from environmental bacteria by sampling soil and water in nature
Seth Shipman and his team recently identified seven new retrons from environmental bacteria by sampling soil and water in nature
Science in Seconds | Researchers Discover New Bacterial Immune Systems
Seth Shipman and his team recently identified seven new retrons from environmental bacteria by sampling soil and water in nature.
bit.ly
December 23, 2025 at 6:10 PM
Have you seen our latest Science in Seconds video?
Seth Shipman and his team recently identified seven new retrons from environmental bacteria by sampling soil and water in nature
Seth Shipman and his team recently identified seven new retrons from environmental bacteria by sampling soil and water in nature
Here's what's inside our latest issue of Cell Signals
1️⃣ New genomic maps help scientists untangle the complex roots of disease
2️⃣ An inside look into how bacterial immune systems are inspiring new genome-editing tools
3️⃣ Some of Gladstone’s biggest discoveries from 2025
1️⃣ New genomic maps help scientists untangle the complex roots of disease
2️⃣ An inside look into how bacterial immune systems are inspiring new genome-editing tools
3️⃣ Some of Gladstone’s biggest discoveries from 2025
Cell Signals│Genomic Maps Untangle the Complex Roots of Disease
In today’s newsletter, learn how new genomic maps are helping scientists untangle the complex roots of disease, get an inside look into how bacterial immune systems are inspiring new genome-editing to...
mailchi.mp
December 22, 2025 at 5:53 PM
Here's what's inside our latest issue of Cell Signals
1️⃣ New genomic maps help scientists untangle the complex roots of disease
2️⃣ An inside look into how bacterial immune systems are inspiring new genome-editing tools
3️⃣ Some of Gladstone’s biggest discoveries from 2025
1️⃣ New genomic maps help scientists untangle the complex roots of disease
2️⃣ An inside look into how bacterial immune systems are inspiring new genome-editing tools
3️⃣ Some of Gladstone’s biggest discoveries from 2025
Year In Review: From a list of 1,300 drugs, a team of scientists—including Yadong Huang—identified two FDA-approved cancer medications that reduced brain degeneration in mice.
Read more about this study on our website: https://bit.ly/4kOFte4
Read more about this study on our website: https://bit.ly/4kOFte4
December 21, 2025 at 6:44 PM
Year In Review: From a list of 1,300 drugs, a team of scientists—including Yadong Huang—identified two FDA-approved cancer medications that reduced brain degeneration in mice.
Read more about this study on our website: https://bit.ly/4kOFte4
Read more about this study on our website: https://bit.ly/4kOFte4
A powerful collaboration is helping unlock new clues in the fight against Alzheimer’s disease. Gladstone scientists joined a multi-institution team that discovered a rare gene mutation that appears to protect the brain’s immune cells from the damage typically caused by the disease.
Inspired by a Family's Struggle, a Scientist Helps Uncover Defense Against Alzheimer's Disease
Research & Innovation New Partnership Will Revitalize Ocean Research Off the Jersey Shore Research & Innovation New Gilded Age Christmas Cookbook Whisks Readers Back in Time Research & Innovation Health Policy Experts Identify Promising Strategies for P...
www.rutgers.edu
December 20, 2025 at 8:12 PM
A powerful collaboration is helping unlock new clues in the fight against Alzheimer’s disease. Gladstone scientists joined a multi-institution team that discovered a rare gene mutation that appears to protect the brain’s immune cells from the damage typically caused by the disease.
A team of scientists including Bruce Conklin and Jennifer Doudna discovered why CRISPR works differently in neurons than in other cells, opening the door to more accurate gene-editing therapies.
How nondividing cells respond to CRISPR-Cas9
Insights into how nondividing cells respond to CRISPR-Cas9 could potentially influence how gene editing therapies are designed.
bit.ly
December 19, 2025 at 9:19 PM
A team of scientists including Bruce Conklin and Jennifer Doudna discovered why CRISPR works differently in neurons than in other cells, opening the door to more accurate gene-editing therapies.
Gladstone researchers share how they’re tackling Charcot-Marie-Tooth disease, a rare inherited neurological disorder that affects movement. In this video, scientists highlight innovative approaches to understand the disease at its roots and identify new paths toward potential treatments.
Science in Seconds | Gladstone Researchers Tackle Charcot-Marie-Tooth (CMT) Disease
Bruce Conklin and his team at Gladstone are tackling Charcot-Marie-Tooth (CMT) disease, the most common inherited neurological disorders--for which there is currently no cure.
gladstone.org
December 18, 2025 at 4:07 PM
Gladstone researchers share how they’re tackling Charcot-Marie-Tooth disease, a rare inherited neurological disorder that affects movement. In this video, scientists highlight innovative approaches to understand the disease at its roots and identify new paths toward potential treatments.
🚨 NEW PUBLICATION 🚨 "Haplotype editing with CRISPR-Cas9 as a therapeutic approach for dominant-negative missense mutations in NEFL"
https://bit.ly/3N54576
https://bit.ly/3N54576
Redirecting
linkinghub.elsevier.com
December 17, 2025 at 5:50 PM
🚨 NEW PUBLICATION 🚨 "Haplotype editing with CRISPR-Cas9 as a therapeutic approach for dominant-negative missense mutations in NEFL"
https://bit.ly/3N54576
https://bit.ly/3N54576
Understanding how the heart forms is key to unraveling congenital heart defects.
In this video, Gladstone scientist Jon Muncie-Vasic explains how scientists in the Bruneau lab explore the earliest steps of heart development in hopes of finding ways to prevent congenital heart defects.
In this video, Gladstone scientist Jon Muncie-Vasic explains how scientists in the Bruneau lab explore the earliest steps of heart development in hopes of finding ways to prevent congenital heart defects.
December 17, 2025 at 4:52 PM
Understanding how the heart forms is key to unraveling congenital heart defects.
In this video, Gladstone scientist Jon Muncie-Vasic explains how scientists in the Bruneau lab explore the earliest steps of heart development in hopes of finding ways to prevent congenital heart defects.
In this video, Gladstone scientist Jon Muncie-Vasic explains how scientists in the Bruneau lab explore the earliest steps of heart development in hopes of finding ways to prevent congenital heart defects.
Scientists at Gladstone show the new method could treat the majority of patients with Charcot-Marie-Tooth disease.
Gene Editing Strategy Could Treat Hundreds of Inherited Diseases More Effectively
Scientists at Gladstone show the new method could treat the majority of patients with Charcot-Marie-Tooth disease.
bit.ly
December 16, 2025 at 8:05 PM
Scientists at Gladstone show the new method could treat the majority of patients with Charcot-Marie-Tooth disease.
From AI to gene editing — our scientists pushed boundaries in 2025. Explore the highlights.
https://bit.ly/4qa9Wqc
https://bit.ly/4qa9Wqc
Gladstone's Scientific Highlights of 2025
From fundamental insights to translational advances, here's how Gladstone researchers moved science forward in 2025.
bit.ly
December 16, 2025 at 6:11 PM
From AI to gene editing — our scientists pushed boundaries in 2025. Explore the highlights.
https://bit.ly/4qa9Wqc
https://bit.ly/4qa9Wqc
Year In Review: In this commentary, Deepak Srivastava shares why federal funding for scientific research is crucial for medical breakthroughs.
Read more: https://bit.ly/4cqwqNW
Read more: https://bit.ly/4cqwqNW
December 15, 2025 at 6:13 PM
Year In Review: In this commentary, Deepak Srivastava shares why federal funding for scientific research is crucial for medical breakthroughs.
Read more: https://bit.ly/4cqwqNW
Read more: https://bit.ly/4cqwqNW
A study led by Ken Nakamura reveals how mitochondrial failure can set off the chain of events that leads to Parkinson’s disease.
https://bit.ly/48G4hRx
https://bit.ly/48G4hRx
Mitochondria may be the spark that ignites Parkinson’s disease
A new study shows how failing mitochondria and rising oxidative stress may set off key steps in Parkinson’s disease.
bit.ly
December 14, 2025 at 6:40 PM
A study led by Ken Nakamura reveals how mitochondrial failure can set off the chain of events that leads to Parkinson’s disease.
https://bit.ly/48G4hRx
https://bit.ly/48G4hRx
Research led by Bruce Conklin and Jennifer Doudna reveals that neurons respond to gene editing differently than dividing cells—insights that could help scientists design safer, more precise therapies.
Exploring the Outcomes of Genome Editing in Non-Dividing Cells | Cell And Molecular Biology
The CRISPR gene editing technique has had a dramatic influence on biomedical research, and has even been applied to a few humans to treat disease. Since it | Cell And Molecular Biology
bit.ly
December 13, 2025 at 8:54 PM
Research led by Bruce Conklin and Jennifer Doudna reveals that neurons respond to gene editing differently than dividing cells—insights that could help scientists design safer, more precise therapies.
Among his myriad accomplishments, Rudolf Jaenisch—winner of the 2025 Ogawa-Yamanaka Stem Cell Prize—was the first to demonstrate the potential of induced pluripotent stem cells to treat disease.
A Sculptor of Modern Regenerative Medicine
Among his myriad accomplishments, Rudolf Jaenisch--winner of the 2025 Ogawa-Yamanaka Stem Cell Prize--was the first to demonstrate the potential of induced pluripotent stem cells to treat disease.
bit.ly
December 13, 2025 at 7:46 PM
Among his myriad accomplishments, Rudolf Jaenisch—winner of the 2025 Ogawa-Yamanaka Stem Cell Prize—was the first to demonstrate the potential of induced pluripotent stem cells to treat disease.
🚨 NEW PUBLICATION 🚨 "Causal modelling of gene effects from regulators to programs to traits"
@nature.com
@marsonlab.bsky.social
@stanford.edu
https://go.nature.com/4rRRdBi
@nature.com
@marsonlab.bsky.social
@stanford.edu
https://go.nature.com/4rRRdBi
Causal modelling of gene effects from regulators to programs to traits - Nature
Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.
go.nature.com
December 12, 2025 at 9:12 PM
🚨 NEW PUBLICATION 🚨 "Causal modelling of gene effects from regulators to programs to traits"
@nature.com
@marsonlab.bsky.social
@stanford.edu
https://go.nature.com/4rRRdBi
@nature.com
@marsonlab.bsky.social
@stanford.edu
https://go.nature.com/4rRRdBi
#YearInReview: Isha Jain and her team developed a drug that mimics the effects of breathing low oxygen, which could be life-saving for people with mitochondrial diseases who rarely survive past childhood.
Watch this video to learn more about their research.
Watch this video to learn more about their research.
Science in Seconds | Gladstone Researchers Develop a New Low-Oxygen Therapy
Isha Jain and Skyler Blume explain the science behind their discovery and the impact it could have for mitochondrial diseases.
gladstone.org
December 12, 2025 at 7:53 PM
#YearInReview: Isha Jain and her team developed a drug that mimics the effects of breathing low oxygen, which could be life-saving for people with mitochondrial diseases who rarely survive past childhood.
Watch this video to learn more about their research.
Watch this video to learn more about their research.
Check out our latest Science in Seconds! In this video, @seth-shipman.bsky.social and his team share how they identified seven new retrons from environmental bacteria by sampling soil and water in nature.
Science in Seconds | Researchers Discover New Bacterial Immune Systems
Seth Shipman and his team recently identified seven new retrons from environmental bacteria by sampling soil and water in nature.
gladstone.org
December 11, 2025 at 4:12 PM
Check out our latest Science in Seconds! In this video, @seth-shipman.bsky.social and his team share how they identified seven new retrons from environmental bacteria by sampling soil and water in nature.
Nalini Rao is a bioinformatics fellow in the Yang Lab and 2025 AFAR Glenn Foundation Postdoctoral Fellow (@afar.org). Her research is tackling a big question: how aging impairs the brain’s ability to clear toxic proteins — a key factor in neurodegenerative diseases.
Nalini Rao - American Federation for Aging Research
Postdoctoral Fellow, Gladstone Institutes. Elucidating how aging impairs brain proteostasis and protein clearance.. Brain health relies on a delicate
bit.ly
December 11, 2025 at 3:47 PM
Nalini Rao is a bioinformatics fellow in the Yang Lab and 2025 AFAR Glenn Foundation Postdoctoral Fellow (@afar.org). Her research is tackling a big question: how aging impairs the brain’s ability to clear toxic proteins — a key factor in neurodegenerative diseases.