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gladstoneinst.bsky.social
Gladstone Institutes
@gladstoneinst.bsky.social
580 followers 130 following 450 posts
To drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and diverse environment.
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gladstoneinst.bsky.social
Azalea grew out of collaborative research conducted at the Innovative Genomics Institute in Jennifer Doudna’s lab and in Justin Eyquem’s lab as part of the Gladstone-UCSF Institute of Genomic Immunology.

@j-eyquem.bsky.social
@innovativegenomics.bsky.social
Azalea Therapeutics Launches with $82 Million Financing to Redefine Precision Genomic Medicines by Engineering Cells Directly Inside Each Patient
Azalea Therapeutics launches with $82M to advance precision in vivo genome engineering, creating therapeutic cells directly inside patients....
www.globenewswire.com
November 14, 2025 at 9:10 PM
gladstoneinst.bsky.social
🚨NEW PUBLICATION 🚨 "FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry"

@cp-immunity.bsky.social
@ucsanfrancisco.bsky.social
@parkerici.bsky.social
@innovativegenomics.bsky.social
@arcinstitute.org

https://bit.ly/4paigFO
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
FOXP3 is a transcription factor critical for immune homeostasis. Using a broad CRISPR toolkit, Umhoefer et al. elucidate the cis- and trans-regulatory circuitry governing FOXP3 expression in human Tre...
www.cell.com
November 14, 2025 at 6:53 PM
Reposted by Gladstone Institutes
innovativegenomics.bsky.social
New from IGI's Alex Marson!
November 13, 2025 at 9:24 PM
Reposted by Gladstone Institutes
labwaggoner.bsky.social
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @gladstoneinst.bsky.social
November 14, 2025 at 3:29 AM
gladstoneinst.bsky.social
Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.
@cp-immunity.bsky.social
@ucsanfrancisco.bsky.social
@parkerici.bsky.social
@innovativegenomics.bsky.social
https://bit.ly/4nUtpcT
Researchers Reveal Intricate Control System for Key Immune Gene
Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.
gladstone.org
November 13, 2025 at 8:51 PM
gladstoneinst.bsky.social
Discover the future of medicine as Gladstone President Deepak Srivastava takes the stage at the Global Wellness Summit! Don’t miss his insights on groundbreaking cures.

Learn more: https://bit.ly/3Jna8mn
November 12, 2025 at 5:08 PM
gladstoneinst.bsky.social
Virtual cell models hold potential to transform biomedicine, and Gladstone's Christina Theodoris has been at the forefront with her platfom for predicting gene interactions.

https://bit.ly/49esW1C
Can AI capture the mind-boggling complexity of a human cell?
Researchers are competing to make “virtual cells” that could transform biomedicine by predicting gene activity and more
bit.ly
November 11, 2025 at 8:14 PM
gladstoneinst.bsky.social
Epigenetic editors create enhanced T cells that show improved survival in cancer models, without the risk of DNA damage.

@arcinstitute.org

https://bit.ly/3JphFBa
Epigenetic Reprogramming Safely Modifies Multiple Genes in T Cells Simultaneously for CAR-T Therapies | Arc Institute
Arc Institute, Gladstone Institutes, and University of California, San Francisco, scientists have developed an epigenetic editing platform that enables safe modification of multiple genes in primary h...
arcinstitute.org
November 10, 2025 at 6:11 PM
gladstoneinst.bsky.social
To commemorate #AlzheimersAwarenessMonth, Lennart Mucke, director of the Gladstone Institute for Neurological Disease, shares his ultimate goal for Alzheimer’s research and the groundbreaking efforts being made to find a cure.
https://bit.ly/4hUQLOn
Lennart Mucke’s Vision for Alzheimer’s Research | Gladstone's Mission to Cure Alzheimer’s Disease
YouTube video by Gladstone Institutes
www.youtube.com
November 10, 2025 at 4:51 PM
gladstoneinst.bsky.social
In this episode of the @epigeneticspod.bsky.social, Ryan Corces talks about his work on the impact of chromatin architecture on Alzheimer's and Parkinson's Disease.

https://www.activemotif.com/podcasts-ryan-corces
The Impact of Chromatin Architecture on Alzheimer's and Parkinson's Disease (Ryan Corces)
In this episode of the Epigenetics Podcast, we talked with Ryan Corces from the Gladstone Institutes about his work on the impact of chromatin architecture on Alzheimer's and Parkinson's Disease.
www.activemotif.com
November 9, 2025 at 6:37 PM
gladstoneinst.bsky.social
A team of scientists at Gladstone Institutes and UCSF that includes Yadong Huang used human data to identify existing drugs that could be repurposed to treat Alzheimer’s disease.
From risk to resilience - Drug Discovery World (DDW)
Peng Fu, CEO, and Estrid Jakobsen, Communications Lead at Conscience, explore how creativity and open science are transforming drug discovery.
www.ddw-online.com
November 8, 2025 at 7:20 PM
gladstoneinst.bsky.social
Gladstone President Deepak Srivastava will be speaking at the Global Wellness Summit.

Learn more: https://bit.ly/3Jna8mn
November 7, 2025 at 7:18 PM
gladstoneinst.bsky.social
Looking back at unforgettable moments from past Ogawa-Yamanaka Stem Cell Prize Ceremonies as we get excited for 2025! ✨

#throwbackthursday
November 6, 2025 at 5:09 PM
gladstoneinst.bsky.social
Science meets tech in this captivating podcast featuring Gladstone's Alex Marson. He chats about Car T-Cell Therapy, using #CRISPR to edit T-Cells, biotech, and his collaboration with Sean Parker, cofounder of Napster 🧪🚀
CRISPR T-Cells: Programming the Future of Medicine with Dr. Alexander Marson
In this episode, I talked to Dr. Alexander Marson, cofounder of Arsenal Biosciences and director of the Gladstone-UCSF Institute of Genomic Immunology. He is on
bit.ly
November 6, 2025 at 3:47 PM
gladstoneinst.bsky.social
Deepak Srivastava will present at the American Heart Association's Scientific Sessions 2025 in New Orleans. The lectureship is a major recognition of excellence by the association.
Deepak Srivastava Selected to Deliver American Heart Association's Distinguished Scientist Lecture
Srivastava will present at the American Heart Association's Scientific Sessions 2025 in New Orleans; the lectureship is a major recognition of excellence by the association.
gladstone.org
November 5, 2025 at 6:12 PM
gladstoneinst.bsky.social
Shoudout to to Conklin lab members Colby Fagan, Manasi Kumar, Bazilco Jean Simon, and Hannah Watry, who volunteered at the Bay Area Science Festival where kids became junior scientists as they learned how to extract real DNA from strawberries. 🍓 🧬
November 5, 2025 at 4:22 PM
gladstoneinst.bsky.social
This podcast episode kicks off with a deep dive into the new Nature study from Deepak Srivastava and Katie Pollard.
https://bit.ly/3WClnKA
Ep. 307: “Vascular Biology” Featuring Dr. Juan Melero-Martin - The Stem Cell Podcast
Dr. Juan Melero-Martin is an Associate Professor and the Endowed Chair in Cardiac Surgery at Boston Children's Hospital. His lab uses bioengineering principles to understand how vascular networks are ...
bit.ly
November 4, 2025 at 6:10 PM
gladstoneinst.bsky.social
In this video, Gladstone scientists share how they used stem cells, gene editing, and AI to identify a gene driving heart defects in Down syndrome—and how reducing its levels in mice restored normal heart development, offering hope for future treatments.

https://bit.ly/3JrLelx
Science in Seconds | Researchers Pinpoint Key Gene Behind Heart Defects in Down Syndrome
In this video, Gladstone scientists share how they used stem cells, gene editing, and AI to identify a gene driving heart defects in Down syndrome—and how reducing its levels in mice restored normal h...
bit.ly
November 4, 2025 at 5:22 PM
gladstoneinst.bsky.social
Meet Shijie Wang, a postdoctoral scholar in Steve Finkbeiner’s lab at Gladstone Institutes. Originally from Shenzhen, China, Shijie uses artificial intelligence, robotics, and stem cell technologies to study why brain cells die in diseases like Alzheimer’s and Parkinson’s.

https://bit.ly/47x1LfP
Meet Gladstone: Shijie Wang | Using AI to Unlock the Mysteries of the Brain
YouTube video by Gladstone Institutes
www.youtube.com
November 3, 2025 at 6:09 PM
gladstoneinst.bsky.social
Congratulations to Nadia Roan who received an HIV cure-focused target grant from @amfarofficial.bsky.social
amfAR Awards New HIV Cure-Focused Research Grants Totaling $2.4 Million
amfAR awards new research grants totaling $2.4 million for projects focused on a global HIV cure: scalable, accessible, and applicable for all.
bit.ly
November 2, 2025 at 7:41 PM
gladstoneinst.bsky.social
Researchers from the Arc Institute, Gladstone, and UCSF have developed an epigenetic editing platform capable of safely modifying multiple genes in primary human T cells.
Epigenetic Editing Platform Developed to Modify Multiple Genes in Human T Cells for CAR-T Therapy - GeneOnline News
Researchers from the Arc Institute, Gladstone Institute [...]
bit.ly
November 1, 2025 at 8:46 PM
gladstoneinst.bsky.social
In a stunning leap forward for immunotherapy, researchers from the Arc Institute, Gladstone, and UCSF have unveiled a groundbreaking epigenetic editing platform that redefines the genetic programming of human T cells.

@arcinstitute.org
@ucsanfrancisco.bsky.social
Safe Epigenetic Reprogramming Enables Simultaneous Multi-Gene Editing in T
In a stunning leap forward for immunotherapy, researchers from the Arc Institute, Gladstone Institutes, and the University of California, San Francisco have unveiled a groundbreaking epigenetic
bioengineer.org
October 31, 2025 at 8:54 PM
gladstoneinst.bsky.social
Nobel Prize-winning scientist Shinya Yamanaka shares the deeply personal and touching story behind the prestigious Ogawa-Yamanaka Stem Cell Prize.

https://bit.ly/4on39co
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October 30, 2025 at 4:55 PM
gladstoneinst.bsky.social
In October's newsletter, discover how scientists used stem cell technology and AI to uncover a gene that interferes with heart development in people with Down syndrome, learn how scientists have trained a microscope to conduct experiments by itself, and don’t miss this spooky cellfie.
Cell Signals│Scientists Pinpoint a Key Gene Behind Heart Defects in Down Syndrome
Discover how scientists used stem cell technology and AI to uncover a gene that interferes with heart development in babies with Down syndrome, learn how scientists have trained a microscope to conduct experiments by itself, and don't miss this spooky c...
mailchi.mp
October 30, 2025 at 4:05 PM
Reposted by Gladstone Institutes
stemcell.com
Researchers from @gladstoneinst.bsky.social have discovered that by removing an extra copy of the HMGN1 gene from mice models with Down syndrome, heart defects disappeared. 🧬

@sanjeevranade.bsky.social
Scientists Pinpoint a Key Gene Behind Heart Defects in Down Syndrome
After decades of mystery, Gladstone researchers identify a gene that can derail heart formation—and show that fixing it prevents the problem in mice.
gladstone.org
October 30, 2025 at 3:33 PM