Rajesh Mohandas
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rajmohandas.bsky.social
Rajesh Mohandas
@rajmohandas.bsky.social
820 followers 560 following 4 posts
Physician scientist interested in vascular biology of kidney disease. LSU Nephrology NOLA
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rajmohandas.bsky.social
50% risk reduction and curves separating in just a few months ? Insane!
nejm.org NEJM.org @nejm.org · 17d
In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo

@asnkidney.bsky.social | #KidneyWk
American Society of Nephrology Kidney Week 2025 Original Article | Nov. 7, 2025 | NEJM.org Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis Fig. 1A. A Serious Cardiovascular Events The NEJM identity sits at the bottom.
November 7, 2025 at 9:40 PM
Reposted by Rajesh Mohandas
hswapnil.medsky.social
Eli Lilly continuing to hit it out the park

Selective amylin agonist as an alternative to GLP1RAs? #eloralintide

www.thelancet.com/journals/lan... in @thelancet.com

(Yeah I know it’s #KidneyWk but what do we do till Houston wakes up!)

cc @rnflex.bsky.social
Figure 2. Change in bodyweight (A) Mean percent change in bodyweight from baseline to week 48, shown as observed means and bars indicating SEs. The model-based estimates of the mean percent change in bodyweight and differences among treatment groups at week 48 with the corresponding p values (efficacy estimand only) and 95% CIs are shown in (B) (efficacy estimand) and (D) (treatment-regimen estimand); bars indicate SEs. Multiplicity adjustment was not performed, and p values should be interpreted as exploratory. (C) shows the percentage of participants with bodyweight reductions of at least 5%, 10%, 15%, 20%, 25%, and 30% from baseline to week 48. The percentage of participants is annotated above each bar, calculated with the use of Rubin's rules by combining the percentages of participants who met the thresholds in imputed datasets. *The model-based estimates and 95% CIs from a mixed model repeated measures analysis for the efficacy estimand are shown on the right, denoted by 48.
November 6, 2025 at 1:54 PM
Reposted by Rajesh Mohandas
bengoult.bsky.social
Vinculin is a simple adapter protein right? Wrong!

That’s been the prevailing view for the 46 years since it was discovered.

Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.

www.science.org/doi/10.1126/...
The mechanical response of vinculin
Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.
www.science.org
October 31, 2025 at 6:29 PM
Reposted by Rajesh Mohandas
asnpublications.bsky.social
This #ASNCJASN article finds physical exercise prior to hemodialysis provides cardioprotective effects in a randomized controlled trial. kidney.pub/CJASN0767
October 10, 2025 at 5:00 PM
Reposted by Rajesh Mohandas
hswapnil.medsky.social
Orfoglipron in @nejm.org

www.nejm.org/doi/full/10....

See discussion below for why this is significant!

#MedSky #NephSky
Body weight reductions with Oreo
September 19, 2025 at 12:22 AM
Reposted by Rajesh Mohandas
hswapnil.medsky.social
Spironolactone does not work for dialysis

ACHIEVE published in @thelancet.com

@lastwalsh.bsky.social and colleagues

www.thelancet.com/journals/lan...

Coming soon to a #NephJC near you
Spironolactone versus placebo in patients undergoing maintenance dialysis (ACHIEVE): an international, parallel-group, randomised controlled trial
Among patients receiving maintenance dialysis, spironolactone 25 mg daily orally did not reduce the composite outcome of cardiovascular mortality and hospitalisation due to heart failure compared with...
www.thelancet.com
August 14, 2025 at 11:15 PM
Reposted by Rajesh Mohandas
natureportfolio.nature.com
Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level, according to a paper in Nature. go.nature.com/47mxemu #medsky 🧪
This is figure 5, which shows the therapeutic efficacy of a plaque-evading lithium salt.
August 10, 2025 at 4:38 PM
Reposted by Rajesh Mohandas
erictopol.bsky.social
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...
www.nejm.org
August 4, 2025 at 11:38 PM
Reposted by Rajesh Mohandas
asnpublications.bsky.social
Could gene-targeted therapy be coming for autosomal dominant polycystic kidney disease? Farabursen, a new medication acquired by Novartis offers to potentially impact cyst formation and even regression. kidney.pub/KN1707-07 #ASNKidneyNews

@nephrosparks.bsky.social
July 16, 2025 at 4:00 PM
Reposted by Rajesh Mohandas
erictopol.bsky.social
Our means for lowering LDL cholesterol keeps expanding. A new CETP inhibitor adds to the mix of drug options New RCT @nejm.org
(And Lp(a) drugs are not far behind)
www.nejm.org/doi/full/10....
Safety and Efficacy of Obicetrapib in Patients at High Cardiovascular Risk | NEJM
Obicetrapib is a highly selective cholesteryl ester transfer protein inhibitor that reduces low-density lipoprotein (LDL) cholesterol levels. The efficacy and safety of obicetrapib have not been fu...
www.nejm.org
May 7, 2025 at 11:28 AM
Reposted by Rajesh Mohandas
erictopol.bsky.social
To restore the gut microbiome after antibiotics, the right diet (rich in carbohydrates, low in fat) was a better approach than fecal microbial transplants (in the experimental model)
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Diet outperforms microbial transplant to drive microbiome recovery in mice - Nature
Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic interactions th...
www.nature.com
April 30, 2025 at 6:57 PM
Reposted by Rajesh Mohandas
arvindcanchi.bsky.social
Lorundrostat - an aldosterone synthase inhibitor.
Lorundrostat was associated with greater reductions in 24-hr average BP than placebo in pts with uncontrolled & treatment-resistant hypertension.
K level >6.0 occurred in 5 pts (5%) in the stable-dose group.
www.nejm.org/doi/full/10....
@nejm.org
April 27, 2025 at 1:08 AM
Reposted by Rajesh Mohandas
haoyin.bsky.social
ExerGeneDB
A physical exercise-regulated differential gene expression database

Human/mouse/rat >6k samples microarray/bulk/scRNAseq
+ncRNA

+Genes related to interactions b/w Exercise & gender/age/BMI

exergenedb.com

#JSHS_MedHealth 2025
www.sciencedirect.com/science/arti...
February 23, 2025 at 1:51 PM
Reposted by Rajesh Mohandas
erictopol.bsky.social
Suppression of the inflammation that occurs with aging ("inflammaging") by blocking thrombospondin-1 (Thbs1), prevented age-related blood stem cell defects and expanded lifespan in the mouse model (KO-knockout)
www.science.org/doi/10.1126/...
January 3, 2025 at 8:10 PM
Reposted by Rajesh Mohandas
rajmehrotra.bsky.social
As promised, @asnpublications.bsky.social is on the platform. Four publications, one account. Please follow for the best in scientific publishing in nephrology!
December 19, 2024 at 7:34 AM
Reposted by Rajesh Mohandas
science.org
Move over mitochondria, a new organelle called the nitroplast is here.

In a Science study from earlier this year, researchers report that a nitrogen-fixing organelle has been identified in a marine alga. Learn more in this #SciencePerspective:
The nitroplast: A nitrogen-fixing organelle
A bacterial endosymbiont of marine algae evolved to an organelle
scim.ag
December 25, 2024 at 5:06 PM
Reposted by Rajesh Mohandas
jbwallingford.bsky.social
Looking for something fun to read? Here’s a #popsci piece I did on the crazy history of cilia and left/right patterning in embryos. Remember #devbiolwriteclub Bluesky Boot Camp starts Monday Dec. 2! Please RS (re-skeet?)

nautil.us/the-anatomic...
The Anatomical Quirk That Saved Dr. No
A wild tale of how scientists unraveled embryology's most fascinating mystery.
nautil.us
November 27, 2024 at 5:07 PM
Reposted by Rajesh Mohandas
kidneyboy.bsky.social
All modern inpatient hypertension research:

"Whatever you do, don't treat inpatient hypertension"

Current EHRs

Blood pressure of 142/80 in red. With an exclamation point.

🤦🏻‍♂️
Blood pressure of 142/80 in red. with an exclamation point.
November 28, 2024 at 4:04 PM
Reposted by Rajesh Mohandas
washingtonpost.com
People with HIV will be able to receive kidney or liver transplants from donors who also have HIV, federal health officials announced Tuesday.

The landmark move, which takes effect Wednesday, is expected to shorten wait times for organs for all patients.
U.S. okays organ transplants between people with HIV, expanding donor pool
The landmark move is expected to shorten wait times for organs for all patients and reduce hurdles to life-saving care for those with HIV.
www.washingtonpost.com
November 27, 2024 at 2:49 PM
Reposted by Rajesh Mohandas
fperrywilson.bsky.social
"Drink more water!" It's the easiest health advice around. Tired? Headache? Trying to be like Tom Brady? Just drink more water. But as a nephrologist, I get asked all the time: How much is the right amount? And the truth is... we don't really know. 🧵
November 26, 2024 at 6:35 PM
Reposted by Rajesh Mohandas
scientificdiscovery.dev
This month, a phase 3 trial of tirzepatide (a GLP-1 drug) found that it reduced the chances of developing type 2 diabetes by around 90% (!), among people with obesity and pre-diabetes.

That's a reduction if I ever saw one.
www.nejm.org/doi/full/10....
Kaplan Meier curve showing the cumulative incidence of type 2 diabetes in people given tirzepatide vs placebo
November 26, 2024 at 12:11 PM
Reposted by Rajesh Mohandas
kidneyboy.bsky.social
Down goes daprodustat.

The HIF-PHI drugs for CKD anemia will go down as the drug class with the greatest hype that utterly failed in delivering anything of note for patients. Just an epic decades long drama for nothing.
November 26, 2024 at 2:57 PM
Reposted by Rajesh Mohandas
verenaresch.bsky.social
I sometimes forget how flexible proteins are. It becomes really apparent when you use NMR states for an animation. That poor cofactor is getting pushed around a lot 😅

#sciart #blender3d #biocatalysis
November 25, 2024 at 5:14 PM
Reposted by Rajesh Mohandas
swissnephro.bsky.social
“Patients who are diagnosed with ACE inhibitor-induced angioedema should be tested for hereditary angioedema types 1/2“

So far, not something that I have been doing …

#whatilearnedtoday #nephsky #skyneph

onlinelibrary.wiley.com/doi/10.1111/...
The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update
Click on the article title to read more.
onlinelibrary.wiley.com
November 21, 2024 at 12:37 PM