Annabel Quinet Lab
@quinet.bsky.social
Our team 🇧🇷🇱🇧🇳🇱🇫🇷 investigates DNA replication stress responses with a focus on gaps using tailored single-cell and single-molecule microscopy approaches.
In Paris region 🇫🇷
Lab site: https://shorturl.at/rGHau
In Paris region 🇫🇷
Lab site: https://shorturl.at/rGHau
Back home after a truly inspiring trip where I had the honor to present at the Asian meeting on radiobiology at Hiroshima and at the VII Farm-DNA in São Paulo! Had the chance to connect with amazing scientists, old and new friends! Thanks so much to the organizers for these wonderful opportunities!
November 18, 2025 at 8:22 AM
Back home after a truly inspiring trip where I had the honor to present at the Asian meeting on radiobiology at Hiroshima and at the VII Farm-DNA in São Paulo! Had the chance to connect with amazing scientists, old and new friends! Thanks so much to the organizers for these wonderful opportunities!
Super proud of Léa Girard who graduated from her Master with a really high grade and of Tiya Jahjah who defended her qualifying exams brilliantly !! You rock!!
June 27, 2025 at 8:52 PM
Super proud of Léa Girard who graduated from her Master with a really high grade and of Tiya Jahjah who defended her qualifying exams brilliantly !! You rock!!
Reposted by Annabel Quinet Lab
Join us NEXT WEEK for the #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," featuring a workshop lead by Drs. Laurie Sanders and Tobias Dansen, a keynote talk by Dr. Karlene Cimprich, and more!
Register Today: emgs-us.org/event/OxiDNA...
Register Today: emgs-us.org/event/OxiDNA...
June 3, 2025 at 7:20 PM
Join us NEXT WEEK for the #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," featuring a workshop lead by Drs. Laurie Sanders and Tobias Dansen, a keynote talk by Dr. Karlene Cimprich, and more!
Register Today: emgs-us.org/event/OxiDNA...
Register Today: emgs-us.org/event/OxiDNA...
Reposted by Annabel Quinet Lab
Two year postdoc position available in the Sparte lab at IGDR to investigate the crosstalk between ADP-ribosylation and SUMOylation signaling at stressed replication forks
May 27, 2025 at 2:30 PM
Two year postdoc position available in the Sparte lab at IGDR to investigate the crosstalk between ADP-ribosylation and SUMOylation signaling at stressed replication forks
Reposted by Annabel Quinet Lab
Don't miss the next #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," presented by the EMGS DNA Repair SIG. 🧬
Register Today: emgs-us.org/event/OxiDNA...
Register Today: emgs-us.org/event/OxiDNA...
May 20, 2025 at 6:46 PM
Don't miss the next #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," presented by the EMGS DNA Repair SIG. 🧬
Register Today: emgs-us.org/event/OxiDNA...
Register Today: emgs-us.org/event/OxiDNA...
Reposted by Annabel Quinet Lab
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
May 8, 2025 at 10:12 AM
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
Back home truly inspired by this fantastic meeting! Thanks so much to the organizers for putting it together!!
Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together!
May 3, 2025 at 7:39 AM
Back home truly inspired by this fantastic meeting! Thanks so much to the organizers for putting it together!!
Reposted by Annabel Quinet Lab
Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together!
May 2, 2025 at 7:50 AM
Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together!
Really honored to have contributed with a review to this super special issue!!
Thanks @albertociccia.bsky.social and @vindignilab.bsky.social for the initiative of putting together this issue on hot topics in the replication stress field!
Thanks @albertociccia.bsky.social and @vindignilab.bsky.social for the initiative of putting together this issue on hot topics in the replication stress field!
Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social.
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
DNA Repair | The replication stress response: mechanisms and functions | ScienceDirect.com by ElsevierScienceDirect
High-fidelity DNA replication is constantly challenged by a diverse range of obstacles, including endogenous lesions and secondary structures in the DNA template, tightly bound protein-DNA complexes, ...
www.sciencedirect.com
April 19, 2025 at 3:48 PM
Really honored to have contributed with a review to this super special issue!!
Thanks @albertociccia.bsky.social and @vindignilab.bsky.social for the initiative of putting together this issue on hot topics in the replication stress field!
Thanks @albertociccia.bsky.social and @vindignilab.bsky.social for the initiative of putting together this issue on hot topics in the replication stress field!
Reposted by Annabel Quinet Lab
Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways
www.biorxiv.org
April 1, 2025 at 5:58 PM
Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways
Reposted by Annabel Quinet Lab
📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
March 30, 2025 at 9:54 AM
📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
Reposted by Annabel Quinet Lab
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
March 17, 2025 at 9:58 PM
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
Reposted by Annabel Quinet Lab
SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
DNA replication and genome maintenance: from basic biology to disease
www.embl.org
February 26, 2025 at 3:22 PM
SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
Reposted by Annabel Quinet Lab
Nature research paper: Mechanism for local attenuation of DNA replication at double-strand breaks
https://go.nature.com/4k8AdCX
https://go.nature.com/4k8AdCX
Mechanism for local attenuation of DNA replication at double-strand breaks - Nature
DNA double-strand breaks induce local genome maintenance and inhibition of replication initiation at nearby topologically associating domains without affecting global DNA synthesis.
go.nature.com
February 20, 2025 at 6:57 PM
Nature research paper: Mechanism for local attenuation of DNA replication at double-strand breaks
https://go.nature.com/4k8AdCX
https://go.nature.com/4k8AdCX
Reposted by Annabel Quinet Lab
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability
Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.
tinyurl.com
February 19, 2025 at 7:35 PM
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Reposted by Annabel Quinet Lab
🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)
The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.
tinyurl.com
February 12, 2025 at 2:53 PM
🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
Reposted by Annabel Quinet Lab
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 12, 2025 at 6:28 AM
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Annabel Quinet Lab
Dear all,
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk
February 10, 2025 at 2:45 PM
Dear all,
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk
Reposted by Annabel Quinet Lab
Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td
Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability
Nature Cancer - Whalen et al. report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to DNA nicks, limiting tumor formation in...
rdcu.be
January 21, 2025 at 5:26 PM
Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td
Reposted by Annabel Quinet Lab
It's craaazy that chemo has been in the clinic for so long, yet its therapeutic index remains incompletely understood. In this #Perspective, Letai & de The explore existing models + knowledge gaps, & suggest principles for optimizing dosing + scheduling.
@natrevcancer.bsky.social
bit.ly/3C53w8g
@natrevcancer.bsky.social
bit.ly/3C53w8g
Conventional chemotherapy: millions of cures, unresolved therapeutic index - Nature Reviews Cancer
Conventional chemotherapy has successfully cured millions of patients with cancer, yet the mechanisms of action for this remain unclear. In this Perspective, Letai and de The assess the existing mecha...
bit.ly
January 6, 2025 at 8:54 AM
It's craaazy that chemo has been in the clinic for so long, yet its therapeutic index remains incompletely understood. In this #Perspective, Letai & de The explore existing models + knowledge gaps, & suggest principles for optimizing dosing + scheduling.
@natrevcancer.bsky.social
bit.ly/3C53w8g
@natrevcancer.bsky.social
bit.ly/3C53w8g
Reposted by Annabel Quinet Lab
Please RT. Join the sixth edition of our Training Unit @institut_curie
international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...
international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...
January 4, 2025 at 11:42 AM
Please RT. Join the sixth edition of our Training Unit @institut_curie
international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...
international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...
Celebrating 2024 and feeling super excited with the upcoming new year with this amazing group of terrific scientists I am so lucky to work with!! 🤩🤩
Happy holidays everyone and that 2025 be an awesome year for all of us !
Happy holidays everyone and that 2025 be an awesome year for all of us !
December 20, 2024 at 8:30 PM
Celebrating 2024 and feeling super excited with the upcoming new year with this amazing group of terrific scientists I am so lucky to work with!! 🤩🤩
Happy holidays everyone and that 2025 be an awesome year for all of us !
Happy holidays everyone and that 2025 be an awesome year for all of us !
Reposted by Annabel Quinet Lab
Please join this starter pack for everyone working from chromatin replication to epigenetic inheritance and cell fate! Now still small, but we hope to gather everyone interested in joining. Please message us to be added, go.bsky.app/ALFFRUN
November 26, 2024 at 12:43 PM
Please join this starter pack for everyone working from chromatin replication to epigenetic inheritance and cell fate! Now still small, but we hope to gather everyone interested in joining. Please message us to be added, go.bsky.app/ALFFRUN
Reposted by Annabel Quinet Lab
ok, Genome Stability people. Here are our two starter packs - since I can't pin them both independently to my profile, have to make a new post. Still adding new people to the second pack. As usual, please reach out if you would like to be added!
bsky.app/starter-pack...
bsky.app/starter-pack...
bsky.app/starter-pack...
bsky.app/starter-pack...
November 20, 2024 at 8:09 PM
ok, Genome Stability people. Here are our two starter packs - since I can't pin them both independently to my profile, have to make a new post. Still adding new people to the second pack. As usual, please reach out if you would like to be added!
bsky.app/starter-pack...
bsky.app/starter-pack...
bsky.app/starter-pack...
bsky.app/starter-pack...