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spartelab.bsky.social
SP@RTE
@spartelab.bsky.social
240 followers 140 following 9 posts
#DNA repair, #Chromatin, #PARP, #Fluorescence #Microscopy and more in #Rennes
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spartelab.bsky.social
PhD in Rennes! Study how OGG1 repairs oxidative DNA damage using advanced microscopy. Join Sébastien Huet’s team at IGDR (Oct 2026). Master’s in cell biology/biophysics? Apply: sebastien.huet@univ-rennes.fr #PhD #CancerResearch #Microscopy
February 14, 2026 at 10:39 AM
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bouvraish.bsky.social
We are offering a 24-month post-doctoral position in our team, based in Rennes, France (@IGDR, @cedre-lab). Looking for a highly motivated researcher with expertise in deep learning and image analysis.
emploi.cnrs.fr/Offres/CDD/U...
#PostDoc #DeepLearning #ImageAnalysis #ResearchOpportunity
Portail Emploi CNRS - Offre d'emploi - Chercheur post-doctoral (H/F) : utilisation de l’apprentissage profond et de la simulation pour extraire les paramètres géométriques de filaments dans des imag...
emploi.cnrs.fr
January 3, 2025 at 1:31 PM
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spartelab.bsky.social
In this study, we reveal that OGG1’s association with DNA during lesion searching involves local DNA distortion, promoting base unstacking. This process is tightly regulated by conserved amino acids encircling the double helix, ensuring stable binding without compromising rapid scanning.
February 12, 2026 at 10:20 AM
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spartelab.bsky.social
We are thrilled to share our latest publication in Cell Reports (Cell Press)!

A huge thank you to everyone involved in this work!

📖 Read the full paper here: www.cell.com/cell-reports...
February 12, 2026 at 10:20 AM
spartelab.bsky.social
We are thrilled to share our latest publication in Cell Reports (Cell Press)!

A huge thank you to everyone involved in this work!

📖 Read the full paper here: www.cell.com/cell-reports...
February 12, 2026 at 10:20 AM
spartelab.bsky.social
"Exciting opportunity! Our team is offering two PhD projects for this doctoral competition. Explore our innovative research topics and join us in pushing scientific boundaries. Applications open—don’t miss out! #PhD #Research #JoinUs"
igdrennes.bsky.social Institut de Génétique & Développement de Rennes @igdrennes.bsky.social · 28d
📢 Are you planning to do a #PhD in #Biology? Our doctoral competition is now open!

Apply before 16 April, 11:59 p.m.
5 to 10 positions available

ℹ️https://igdr.univ-rennes.fr/en/application-igdr-phd-program

cc @cnrs-bretagneloire.bsky.social
@insermgrandouest.bsky.social
@rennesuniv.bsky.social
Want to do a PhD in biology? Find out about thesis projects and teams recruiting PhD students. Applications are now open for the IGDR doctoral competition. The files must be submitted by 11:59 p.m. (Paris time) on 16 April 2026 at the latest. Between 5 and 10 positions are available within the IGDR teams, on projects in the following two areas of research: ➟ Genetics, genomics and cancer ➟ Cell biology, development and biophysics Full details and the application portal are available on the link.
January 23, 2026 at 11:05 AM
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spartelab.bsky.social
The IGDR @igdrennes.bsky.social and the Faculty of Sciences at the University of Rennes announce an opening for a University Professor position in CNU Section 65 "Genetic and Epigenetic Regulations" with the opportunity to join our team @spartelab.bsky.social #PU #CNU65.
December 18, 2025 at 9:56 AM
spartelab.bsky.social
L'IGDR @igdrennes.bsky.social et la Faculté des Sciences de l'Université de Rennes annoncent l'ouverture d'un poste de Professeur des Universités en section CNU 65 "Régulations génétiques et épigénétiques" avec l'opportunité de rejoindre notre équipe @spartelab.bsky.social #PU #CNU65
December 18, 2025 at 9:56 AM
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nicolab.bsky.social
L'IGDR @igdrennes.bsky.social et la Faculté des Sciences de l'Université de Rennes annoncent l'ouverture d'un poste de Professeur des Universités en section CNU 65 "Régulations génétiques et épigénétiques" avec l'opportunité de rejoindre l'équipe SP@RTE @spartelab.bsky.social #PU #CNU65
December 18, 2025 at 9:38 AM
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nicolab.bsky.social
The IGDR @igdrennes.bsky.social and the Faculty of Sciences at the University of Rennes announce an opening for a University Professor position in CNU Section 65 "Genetic and Epigenetic Regulations" with the opportunity to join the SP@RTE team @spartelab.bsky.social #PU #CNU65.
December 18, 2025 at 9:38 AM
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msuskiewicz.bsky.social
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
November 17, 2025 at 11:37 AM
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izeddinresearch.bsky.social
October 13, 2025 at 2:34 PM
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izeddinresearch.bsky.social
SPT of DNA repair proteins after cell irradiation by Ashli Kobayashi @asaki-kobayashi.bsky.social and Romane Riou. Setup by Abbelight @abbelight.bsky.social and irradiator by Errol Laser @errol-laser.bsky.social. Look at that recruitment!
#Mifobio2025 @gdrimabio.bsky.social
October 13, 2025 at 2:32 PM
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ahellab.bsky.social
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...
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my.corehr.com
May 24, 2025 at 5:29 AM
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ahellab.bsky.social
We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required.
my.corehr.com/pls/uoxrecru...
'
my.corehr.com
June 6, 2025 at 4:48 AM
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msuskiewicz.bsky.social
Very happy that our SIAH1 article - published online in February - was now chosen for the cover of the new issue of the @febsj.bsky.social . Thank you @spartelab.bsky.social for the wonderful collaboration and the lovely cellular images. febs.onlinelibrary.wiley.com/toc/17424658...
June 5, 2025 at 5:49 AM
spartelab.bsky.social
Two year postdoc position available in the Sparte lab at IGDR to investigate the crosstalk between ADP-ribosylation and SUMOylation signaling at stressed replication forks
May 27, 2025 at 2:30 PM
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igdrennes.bsky.social
#ScientificResult | A collaborative work by the Huet group at IGDR and the Suskiewicz team at CBM discovers how SIAH1 polymerization could improve the clearing of protein aggregates involved in certain neurodegenerative diseases.

igdr.univ-rennes.fr/en/proteins-...
pubmed.ncbi.nlm.nih.gov/39910688/
Team building among proteins: how oligomerisation of SIAH1 promotes its ubiquitin ligase activity. By describing how SIAH1 forms polymers within cells, a collaborative work by the Huet group at IGDR and the Suskiewicz team at CBM, improves our understanding of the mechanisms by which protein aggregates involved in certain neurodegenerative diseases get cleared by the cells.
March 17, 2025 at 1:40 PM
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igdrennes.bsky.social
📢Are you planning to do a #PhD in #Biology? There's still a month to apply at #IGDR PhD call!

Apply before April 21st, 1:00 pm
7 to 9 positions

ℹ️https://igdr.univ-rennes.fr/en/application-igdr-phd-program
cc @cnrs-bretagneloire.bsky.social @insermgrandouest.bsky.social @rennesuniv.bsky.social
IGDR PhD Call | Exploring living for tomorrow's health Applications up to april 21st 2025 13:00 am This year, about 7 to 9 positions will be available to conduct a PhD project within one of the teams of the IGDR on topics encompassing our two research axes "Genetics, Ganomics and Cancer" and "Cell Biology, Development and Biophysics". Apply online now https://igdr.univ-rennes.fr
March 21, 2025 at 11:43 AM
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msuskiewicz.bsky.social
Here is a link to the article: onlinelibrary.wiley.com/share/author...

We're very happy to see it published in a society journal, The FEBS J.

It's another great collaboration with the team from Rennes led by Sébastien Huet @spartelab.bsky.social .

Thanks to @ercresearch.bsky.social for funding.
February 6, 2025 at 9:34 AM
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msuskiewicz.bsky.social
Happy to share our new study showing that the Ub E3 ligase SIAH1, known to dimerise via its C-term SBD, also dimerises via its N-term RING. When these tendencies combine, full-length SIAH1 forms multimers, which might explain its clustering in cells & preference for aggregated/multimeric substrates.
February 6, 2025 at 9:29 AM
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msuskiewicz.bsky.social
This is a cover design that wasn't accepted, showing SIAH1 multimers on top of cells (SIAH1 red, actin green). We were not able to visualise SIAH1 chains in vitro, as we could only purify N- or C-term halves of SIAH1 separately: the blue chains are made from combined dimeric structures of each half.
February 6, 2025 at 10:17 AM
spartelab.bsky.social
What better occasion for our first post on Bluesky than this? Congratulations to Dr. Eva Pinto for successfully defending her thesis, "Study of ADP-ribose-dependent chromatin remodeling processes occurring at early stages of the DNA damage response." 🧬🔬
December 3, 2024 at 1:59 PM