@pilarcossio.bsky.social
Checkout our cryo-EM simulator in JAX: paving the way for cryo-EM probabilistic modelling & statistical structural biology #cryoEM with @m0bri3n.bsky.social @miroastore.bsky.social + Harvard, Flatiron & Cornell!
hey bsky! excited to share what i've been working on for a few years now.
cryoJAX: A Cryo-EM Image Simulation Library In JAX
www.biorxiv.org/content/10.1...
cryoJAX is a modular framework for implementing forward models of cryo-EM image formation. these can be used to build powerful data analyses!
cryoJAX: A Cryo-EM Image Simulation Library In JAX
www.biorxiv.org/content/10.1...
cryoJAX is a modular framework for implementing forward models of cryo-EM image formation. these can be used to build powerful data analyses!
www.biorxiv.org
November 15, 2025 at 4:03 PM
Checkout our cryo-EM simulator in JAX: paving the way for cryo-EM probabilistic modelling & statistical structural biology #cryoEM with @m0bri3n.bsky.social @miroastore.bsky.social + Harvard, Flatiron & Cornell!
**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: pcossio@flatironinstitute.org
October 22, 2025 at 2:55 PM
**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: pcossio@flatironinstitute.org
Submit your BPS T&C subgroup nominations::!!
Hello @biophysicalsoc.bsky.social Theory & Computation Subgroup! Please consider volunteering as an officer for our subgroup for the 2026-2028 cycle. Submit your nomination(s) by November 17th.
Looking forward to seeing you next Annual Meeting in San Francisco next year!!
Looking forward to seeing you next Annual Meeting in San Francisco next year!!
October 21, 2025 at 2:20 PM
Submit your BPS T&C subgroup nominations::!!
*Job Alert*: postdoc positions available @flatironinstitute.org in Computational Mathematics: apply.interfolio.com/173401
Apply - Interfolio
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apply.interfolio.com
September 19, 2025 at 10:40 AM
*Job Alert*: postdoc positions available @flatironinstitute.org in Computational Mathematics: apply.interfolio.com/173401
Check out our latest preprint for the first community #cryoEM heterogeneity challenge 🎆🎇 @sonyahanson.bsky.social @miroastore.bsky.social + method developers and participants! @flatironinstitute.org
That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
biorxiv.org/content/10.110
biorxiv.org/content/10.110
biorxiv.org
July 24, 2025 at 12:30 AM
Check out our latest preprint for the first community #cryoEM heterogeneity challenge 🎆🎇 @sonyahanson.bsky.social @miroastore.bsky.social + method developers and participants! @flatironinstitute.org
#BPS2026 submit your nomination for the Theory and computation awards!!!
Submit your nominations for the 2026 T&C Subgroup Awards. Recipients get a cash award and speak at the next @biophysicalsoc.bsky.social Annual Meeting in San Francisco, CA.
Deadline: August 1, 2025
biophysics.org/awards-fundi...
Deadline: August 1, 2025
biophysics.org/awards-fundi...
July 10, 2025 at 2:23 PM
#BPS2026 submit your nomination for the Theory and computation awards!!!
Check out our recent preprint 👇on counting particles to estimate populations in #cryoem: noise can bias the estimates; with Luke Evans & a great team.
Counting particles could give wrong probabilities in Cryo-Electron Microscopy https://www.biorxiv.org/content/10.1101/2025.03.27.644168v1
March 30, 2025 at 1:29 PM
Check out our recent preprint 👇on counting particles to estimate populations in #cryoem: noise can bias the estimates; with Luke Evans & a great team.
Reposted
If you care about how to use cryoEM to estimate conformational ensembles and populations of different states you should read this from @pilarcossio.bsky.social and team ❄️ 🔬
Counting particles could give wrong probabilities in Cryo-Electron Microscopy https://www.biorxiv.org/content/10.1101/2025.03.27.644168v1
March 29, 2025 at 4:01 PM
If you care about how to use cryoEM to estimate conformational ensembles and populations of different states you should read this from @pilarcossio.bsky.social and team ❄️ 🔬
#APSSummit25 come to our session in generative modeling and machine learning in chem phys! Chaired with @GrantRotskoff and an amazing set of speakers 🎉 starting Thursday 11:30am room 204A
March 20, 2025 at 5:58 PM
#APSSummit25 come to our session in generative modeling and machine learning in chem phys! Chaired with @GrantRotskoff and an amazing set of speakers 🎉 starting Thursday 11:30am room 204A
#BPS2025 waiting for the national lecture 🥳 @giuliapalermo.bsky.social @labvanni.bsky.social @sriraksha.bsky.social @sesamedusa.bsky.social
February 18, 2025 at 4:01 AM
#BPS2025 waiting for the national lecture 🥳 @giuliapalermo.bsky.social @labvanni.bsky.social @sriraksha.bsky.social @sesamedusa.bsky.social
Reposted
Thanks to all who attended the #BPS2025 #cryoem symposium yesterday, and the happy hour last night!
We heard some superb science at the symposium and had some great discussions which were continued in the evening.
And congratulations to Dr. Elizabeth Wright, our inaugural Almeida Award winner!
We heard some superb science at the symposium and had some great discussions which were continued in the evening.
And congratulations to Dr. Elizabeth Wright, our inaugural Almeida Award winner!
February 17, 2025 at 12:12 AM
Reposted
Nice time catching up with folks from @foldingathome.org at #bps2025
February 16, 2025 at 11:55 PM
Nice time catching up with folks from @foldingathome.org at #bps2025
Reposted
We are hiring a Flatiron Research Fellow in the Structural Molecular Biophysics team! Experience with cryoEM and/or membrane protein simulations are a plus! Happy to chat in person with anyone at #bps2025 ! apply.interfolio.com/160227
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
February 17, 2025 at 1:55 AM
We are hiring a Flatiron Research Fellow in the Structural Molecular Biophysics team! Experience with cryoEM and/or membrane protein simulations are a plus! Happy to chat in person with anyone at #bps2025 ! apply.interfolio.com/160227
Checkout the Flatiron Institute Structural and Molecular Biophysics at #BPS2025 @sonyahanson.bsky.social @miroastore.bsky.social @samsl.io
February 15, 2025 at 8:44 PM
Checkout the Flatiron Institute Structural and Molecular Biophysics at #BPS2025 @sonyahanson.bsky.social @miroastore.bsky.social @samsl.io
For those at #BPS2025 come to the #cryoem subgroup symposium Saturday 8:30-12:30am Room 515B. 🔬❄️There are also tickets available for the happy hour!
Can't wait to see you all at #BPS2025 for the #cryoem subgroup symposium!
8:30am-12:30pm, Sat Feb 15, Room 515B
See detailed program at the link below. We have some superb science lined up, so please join us for what I hope will be a fantastic morning of science!
8:30am-12:30pm, Sat Feb 15, Room 515B
See detailed program at the link below. We have some superb science lined up, so please join us for what I hope will be a fantastic morning of science!
www.dropbox.com
February 15, 2025 at 4:05 PM
Reposted
Looking forward to great science and cool scientists at #BPS25 next week
And before that a stopover in NYC 🍎 to give a talk at the Flatiron Institute and meet @pilarcossio.bsky.social and colleagues
And before that a stopover in NYC 🍎 to give a talk at the Flatiron Institute and meet @pilarcossio.bsky.social and colleagues
February 10, 2025 at 6:00 PM
Looking forward to great science and cool scientists at #BPS25 next week
And before that a stopover in NYC 🍎 to give a talk at the Flatiron Institute and meet @pilarcossio.bsky.social and colleagues
And before that a stopover in NYC 🍎 to give a talk at the Flatiron Institute and meet @pilarcossio.bsky.social and colleagues
Reposted
New metric for calling significant detections of proteins in cryoEM images with 2DTM. Driven by Kexin Zhang in @grigoriefflab.bsky.social in collaboration with @pilarcossio.bsky.social
Kexin Zhang et al.: A new statistical metric for robust target detection in cryo-EM using 2D template matching ##3DReconstructionAndImageProcessing##SingleParticleCryoEM##Imaging@umassboston...##IUCrhttps://journals.iucr.org/paper?S2052252524011771
A new statistical metric for robust target detection in cryo-EM using 2D template matching
A novel statistical metric for 2D template matching (2DTM), the 2DTM p-value, has been developed to improve the detection of targets in cryo-EM images under various imaging and sample conditions, particularly for smaller and aspherical targets.
journals.iucr.org
January 18, 2025 at 3:04 AM
New metric for calling significant detections of proteins in cryoEM images with 2DTM. Driven by Kexin Zhang in @grigoriefflab.bsky.social in collaboration with @pilarcossio.bsky.social
Reposted
1/ Thrilled to announce Dr. Elizabeth Wright as the inaugural winner of the June Almeida Award for #cryoem! 🎉Elizabeth’s pioneering work in both cryo-ET methods and structural virology made her a perfect fit for this award. Congrats, Elizabeth!
December 17, 2024 at 7:27 PM
1/ Thrilled to announce Dr. Elizabeth Wright as the inaugural winner of the June Almeida Award for #cryoem! 🎉Elizabeth’s pioneering work in both cryo-ET methods and structural virology made her a perfect fit for this award. Congrats, Elizabeth!
Reposted
As a current IDEA scholar, I can thoroughly recommend the program! Interact with bright minds, kind, inclusive scientists via visits to @flatironinstitute.org in New York City. What’s not to like?
Applications are still open for our 2025 – 2026 Flatiron Institute Inclusion, Diversity, Equity, Advocacy (IDEA) Scholar Program! Learn more and apply here by 1/3/2025: www.simonsfoundation.org/2024/11/01/a... #science #math
Applications Open for 2025 – 2026 Flatiron Institute Inclusion, Diversity, Equity, Advocacy (IDEA) Scholar Program
Applications Open for 2025 – 2026 Flatiron Institute Inclusion, Diversity, Equity, Advocacy (IDEA) Scholar Program on Simons Foundation
www.simonsfoundation.org
December 17, 2024 at 8:10 PM
As a current IDEA scholar, I can thoroughly recommend the program! Interact with bright minds, kind, inclusive scientists via visits to @flatironinstitute.org in New York City. What’s not to like?
#NeurIPS2024 check out our work: Cryo-EM images are intrinsically low dimensional at the MLSB workshop with
Luke Evans, Octavian-Vlad Murad @larsdingeldein.bsky.social
@rocovino.bsky.social & Marina Meila www.mlsb.io/papers_2024/...
Luke Evans, Octavian-Vlad Murad @larsdingeldein.bsky.social
@rocovino.bsky.social & Marina Meila www.mlsb.io/papers_2024/...
www.mlsb.io
December 13, 2024 at 2:48 PM
#NeurIPS2024 check out our work: Cryo-EM images are intrinsically low dimensional at the MLSB workshop with
Luke Evans, Octavian-Vlad Murad @larsdingeldein.bsky.social
@rocovino.bsky.social & Marina Meila www.mlsb.io/papers_2024/...
Luke Evans, Octavian-Vlad Murad @larsdingeldein.bsky.social
@rocovino.bsky.social & Marina Meila www.mlsb.io/papers_2024/...
Happy to be part of this & my first post on 🦋 👋
📢 New #preprint describing our community effort to share #plumed tutorials arxiv.org/abs/2412.03595 ! Explore the tutorials at www.plumed-tutorials.org
PLUMED Tutorials: a collaborative, community-driven learning ecosystem
In computational physics, chemistry, and biology, the implementation of new techniques in a shared and open source software lowers barriers to entry and promotes rapid scientific progress. However, ef...
arxiv.org
December 7, 2024 at 12:30 AM
Happy to be part of this & my first post on 🦋 👋