Michael O’Brien
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m0bri3n.bsky.social
Michael O’Brien
@m0bri3n.bsky.social
39 followers 74 following 5 posts
phd student @ harvard. microtubules + molecular motors and cryo-EM informed biophysical modeling. silly person presenting serious 🥸
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Reposted by Michael O’Brien
pilarcossio.bsky.social
Happy to share our cryoEM Ensemble Optimization method! 🎉It infers optimal structures and their weights directly from individual cryoEM images - no maps just physics! with David Sliva-Sánchez, @erikhthiede.bsky.social & Roy Lederman www.biorxiv.org/content/10.6...
Cryo-electron microscopy ensemble optimization using individual particles and physical constraints
Biomolecules are inherently dynamic, and understanding their conformational ensemble distributions is essential for understanding their dynamics and biological roles. Cryo-electron microscopy (cryo-EM...
www.biorxiv.org
December 5, 2025 at 4:13 PM
m0bri3n.bsky.social
hey bsky! excited to share what i've been working on for a few years now.

cryoJAX: A Cryo-EM Image Simulation Library In JAX
www.biorxiv.org/content/10.1...

cryoJAX is a modular framework for implementing forward models of cryo-EM image formation. these can be used to build powerful data analyses!
www.biorxiv.org
November 14, 2025 at 5:33 PM