Peng Xu
@pengxu.bsky.social
Cellular and molecular biologist investigating neurodegeneration @ De Camilli lab Yale. Previously @ The Rockefeller University and @ National University of Singapore.
Reposted by Peng Xu
Do you like following rules… but also breaking them?
So does your dopaminergic synapse! 😎🧠
Our new Trends in Neurosciences review dives into the non-classical side of dopamine signaling, notably the tools reshaping how we see it (CLEM, cryo-CLEM, serial EM + more).
So does your dopaminergic synapse! 😎🧠
Our new Trends in Neurosciences review dives into the non-classical side of dopamine signaling, notably the tools reshaping how we see it (CLEM, cryo-CLEM, serial EM + more).
October 15, 2025 at 1:46 PM
Do you like following rules… but also breaking them?
So does your dopaminergic synapse! 😎🧠
Our new Trends in Neurosciences review dives into the non-classical side of dopamine signaling, notably the tools reshaping how we see it (CLEM, cryo-CLEM, serial EM + more).
So does your dopaminergic synapse! 😎🧠
Our new Trends in Neurosciences review dives into the non-classical side of dopamine signaling, notably the tools reshaping how we see it (CLEM, cryo-CLEM, serial EM + more).
Reposted by Peng Xu
Excited to share our latest manuscript by @saikat2025.bsky.social and an international team, reporting variants in the EARP- and GARP-interacting protein EIPR1 associated with a neurodevelopmental disorder. Will send you the PDF if you can’t access the article: academic.oup.com/brain/articl...
EIPR1 variants cause a neurodevelopmental disorder with endolysosomal and dense core vesicle defects
Abstract. EIPR1 (EARP-interacting protein 1, formerly known as TSSC1) is a WD40-domain protein that interacts with the EARP (endosome-associated recycling
academic.oup.com
October 8, 2025 at 3:33 PM
Excited to share our latest manuscript by @saikat2025.bsky.social and an international team, reporting variants in the EARP- and GARP-interacting protein EIPR1 associated with a neurodevelopmental disorder. Will send you the PDF if you can’t access the article: academic.oup.com/brain/articl...
Reposted by Peng Xu
Interesting synthetic lethality during mouse development of two bridge-like lipid transfer proteins that are thought to localize in distinct compartments...new work from @pdc-lab.bsky.social in collaboration with @dianekrause.bsky.social:
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C
VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...
journals.plos.org
September 30, 2025 at 9:19 PM
Interesting synthetic lethality during mouse development of two bridge-like lipid transfer proteins that are thought to localize in distinct compartments...new work from @pdc-lab.bsky.social in collaboration with @dianekrause.bsky.social:
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Peng Xu
"Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C" out now in PLOS Biology
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C
VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...
journals.plos.org
September 29, 2025 at 1:47 PM
"Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C" out now in PLOS Biology
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Peng Xu
Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!
@lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...
September 24, 2025 at 3:49 PM
Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!
Reposted by Peng Xu
Proud to present our new paper in @natmetabolism.nature.com
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
September 22, 2025 at 11:02 AM
Proud to present our new paper in @natmetabolism.nature.com
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
Reposted by Peng Xu
VPS13A & VPS13C are lipid transport proteins linked to #ChoreaAcanthocytosis & #ParkinsonsDisease. @pengxu.bsky.social @pdc-lab.bsky.social &co shows that mice lacking either protein are viable but absence of both results in defective #hematopoiesis & lethality @plosbiology.org 🧪 plos.io/46rTEAy
September 18, 2025 at 2:03 PM
VPS13A & VPS13C are lipid transport proteins linked to #ChoreaAcanthocytosis & #ParkinsonsDisease. @pengxu.bsky.social @pdc-lab.bsky.social &co shows that mice lacking either protein are viable but absence of both results in defective #hematopoiesis & lethality @plosbiology.org 🧪 plos.io/46rTEAy
Reposted by Peng Xu
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
September 15, 2025 at 6:03 PM
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Reposted by Peng Xu
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
September 17, 2025 at 5:38 PM
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
Reposted by Peng Xu
This month’s Discover ASAP episode features @danacobblewis.bsky.social talking with Miguel Gonzalez-Lozano, PhD, about EndoMap, a new open-access tool mapping the endosomal system in #Parkinsons 🗺️ 🧪
🔗 Learn how this resource accelerates discovery and supports drug development: bit.ly/4njfGfM
🔗 Learn how this resource accelerates discovery and supports drug development: bit.ly/4njfGfM
September 12, 2025 at 4:19 PM
This month’s Discover ASAP episode features @danacobblewis.bsky.social talking with Miguel Gonzalez-Lozano, PhD, about EndoMap, a new open-access tool mapping the endosomal system in #Parkinsons 🗺️ 🧪
🔗 Learn how this resource accelerates discovery and supports drug development: bit.ly/4njfGfM
🔗 Learn how this resource accelerates discovery and supports drug development: bit.ly/4njfGfM
Reposted by Peng Xu
New paper alert! I’m very excited to share our paper published in @embojournal.org! @pdc-lab.bsky.social @yaleneuro.bsky.social
Bridge-like lipid transfer protein 3A (BLTP3A) participates in endomembrane repair as an effector of #ATG8 conjugation to single membranes (CASM) - helping repair or minimize #lysosome damage
@mike-hanna.bsky.social et al, @pdc-lab.bsky.social
www.embopress.org/doi/full/10....
@mike-hanna.bsky.social et al, @pdc-lab.bsky.social
www.embopress.org/doi/full/10....
September 12, 2025 at 2:04 PM
New paper alert! I’m very excited to share our paper published in @embojournal.org! @pdc-lab.bsky.social @yaleneuro.bsky.social
Reposted by Peng Xu
Just published: the @pdc-lab.bsky.social, led by @anbangdai.bsky.social, sheds light on the localization and function of BLTP2, a bridge-like lipid transfer protein: BLTP2 is found at contacts between the endoplasmic reticulum (ER) & plasma membrane (PM), and plays a key role in PM dynamics.
Multiple interactions recruit BLTP2 to ER-PM contacts to control plasma membrane dynamics - PubMed
BLTP2/KIAA0100, a bridge-like lipid transfer protein, was reported to localize at contacts of the ER with either the plasma membrane (PM) or recycling tubular endosomes depending on the cell type. Our...
pubmed.ncbi.nlm.nih.gov
September 4, 2025 at 4:36 PM
Just published: the @pdc-lab.bsky.social, led by @anbangdai.bsky.social, sheds light on the localization and function of BLTP2, a bridge-like lipid transfer protein: BLTP2 is found at contacts between the endoplasmic reticulum (ER) & plasma membrane (PM), and plays a key role in PM dynamics.
Reposted by Peng Xu
🚨 JOB ALERT!
Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack
Register 👇 www.cognitoforms.com/Ntu18/NTUSin...
Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack
Register 👇 www.cognitoforms.com/Ntu18/NTUSin...
September 2, 2025 at 11:45 AM
🚨 JOB ALERT!
Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack
Register 👇 www.cognitoforms.com/Ntu18/NTUSin...
Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack
Register 👇 www.cognitoforms.com/Ntu18/NTUSin...
Reposted by Peng Xu
@anbangdai.bsky.social et al. @pdc-lab.bsky.social report the localization of BLTP2 in different human cell types & reveal binding partners that mediate its tethering to the PM & to PM-connected structures including certain #endosomes & #macropinosomes undergoing fusion rupress.org/jcb/article/...
September 3, 2025 at 4:15 PM
@anbangdai.bsky.social et al. @pdc-lab.bsky.social report the localization of BLTP2 in different human cell types & reveal binding partners that mediate its tethering to the PM & to PM-connected structures including certain #endosomes & #macropinosomes undergoing fusion rupress.org/jcb/article/...
Reposted by Peng Xu
👏 We’re recognizing Ben Johnson (CRN Team De Camilli) as this month’s Open Science Champion!
Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben!
Check out the manual: bit.ly/46DuL6R
Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben!
Check out the manual: bit.ly/46DuL6R
August 28, 2025 at 3:29 PM
👏 We’re recognizing Ben Johnson (CRN Team De Camilli) as this month’s Open Science Champion!
Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben!
Check out the manual: bit.ly/46DuL6R
Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben!
Check out the manual: bit.ly/46DuL6R
Reposted by Peng Xu
One for the Apicomplexa peeps:
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
July 26, 2025 at 5:16 PM
One for the Apicomplexa peeps:
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
Reposted by Peng Xu
New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...
EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature
A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.
www.nature.com
May 28, 2025 at 3:52 PM
New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...
Reposted by Peng Xu
In 1️⃣ week! On May 20th, we are delighted to host Erika Holzbaur, PhD, from @pennmedicine.bsky.social, who will give the 2025 @kavliatyale.bsky.social Distinguished Lecture ✨
This event is open to all Yale affiliates, and a reception will follow.
This event is open to all Yale affiliates, and a reception will follow.
May 13, 2025 at 5:57 PM
In 1️⃣ week! On May 20th, we are delighted to host Erika Holzbaur, PhD, from @pennmedicine.bsky.social, who will give the 2025 @kavliatyale.bsky.social Distinguished Lecture ✨
This event is open to all Yale affiliates, and a reception will follow.
This event is open to all Yale affiliates, and a reception will follow.
Reposted by Peng Xu
mTORC1 is activated when cells are fed with amino acids. New preprint with @robzonculab.bsky.social led by Rachel Jansen shows how the massive "CastiGATOR" complex is formed when arginine-free CASTOR1 binds to the GATOR2 complex to antagonize mTORC1 starved cells. tinyurl.com/yr6en6f4
May 14, 2025 at 3:30 PM
mTORC1 is activated when cells are fed with amino acids. New preprint with @robzonculab.bsky.social led by Rachel Jansen shows how the massive "CastiGATOR" complex is formed when arginine-free CASTOR1 binds to the GATOR2 complex to antagonize mTORC1 starved cells. tinyurl.com/yr6en6f4
Reposted by Peng Xu
tinyurl.com/mrce6bbb Fun to write this N&V together with Regina @hrshin.bsky.social, on the several cryoEM papers that build on her discovery of the fascinating LYCHOS protein and its role in cholesterol sensing and mTORC1 regulation!
Cholesterol finds its pocket in LYCHOS - Nature Structural & Molecular Biology
The lysosomal transmembrane protein LYCHOS enables activation of the master growth regulator mTORC1 kinase by cholesterol. Here we summarize recent structural findings that shed light on the LYCHOS ch...
tinyurl.com
April 28, 2025 at 3:42 PM
tinyurl.com/mrce6bbb Fun to write this N&V together with Regina @hrshin.bsky.social, on the several cryoEM papers that build on her discovery of the fascinating LYCHOS protein and its role in cholesterol sensing and mTORC1 regulation!
Reposted by Peng Xu
mScarlet3-H (aka mYongHong), a highly stable monomeric red fluorescent protein, works well for long-term super-resolution imaging, rapid tissue clearing, and CLEM www.nature.com/articles/s41...
A highly stable monomeric red fluorescent protein for advanced microscopy - Nature Methods
The red fluorescent protein mScarlet3-H is bright, photostable and very robust to high temperature, chaotropic conditions and oxidative environments. mScarlet3-H works well in correlative light and el...
www.nature.com
April 18, 2025 at 2:10 AM
mScarlet3-H (aka mYongHong), a highly stable monomeric red fluorescent protein, works well for long-term super-resolution imaging, rapid tissue clearing, and CLEM www.nature.com/articles/s41...
Reposted by Peng Xu
Earlier this month I had the honor of interviewing Dr. Zoncu @robzonculab.bsky.social during his visit to Yale. It was so inspiring- and also fun! Here is a link: medicine.yale.edu/cellbio/news...
Meet our Speakers: Dr. Roberto Zoncu
As a scientist, starting from my postdoc and continuing in my own lab, we have helped redefine the role of the lysosome. Historically, it was considered a
medicine.yale.edu
April 19, 2025 at 1:00 AM
Earlier this month I had the honor of interviewing Dr. Zoncu @robzonculab.bsky.social during his visit to Yale. It was so inspiring- and also fun! Here is a link: medicine.yale.edu/cellbio/news...
Reposted by Peng Xu
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
December 20, 2024 at 9:13 PM
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.