TM9SF3 is a Golgi-resident ATG8-binding protein essential for Golgi-selective autophagy: Developmental Cell www.cell.com/developmenta...
TM9SF3 is a Golgi-resident ATG8-binding protein essential for Golgi-selective autophagy
Yang et al. identify TM9SF3 as a Golgi-resident receptor essential for selective autophagy
of the Golgi (Golgiphagy). TM9SF3 binds ATG8 proteins via its LIR motifs and controls
the degradation of Golg...
www.cell.com
November 3, 2025 at 6:56 PM
TM9SF3 is a Golgi-resident ATG8-binding protein essential for Golgi-selective autophagy: Developmental Cell www.cell.com/developmenta...
Bridge-like lipid transfer protein 3A (BLTP3A) participates in endomembrane repair as an effector of #ATG8 conjugation to single membranes (CASM) - helping repair or minimize #lysosome damage
@mike-hanna.bsky.social et al, @pdc-lab.bsky.social
www.embopress.org/doi/full/10....
@mike-hanna.bsky.social et al, @pdc-lab.bsky.social
www.embopress.org/doi/full/10....
September 12, 2025 at 11:10 AM
Bridge-like lipid transfer protein 3A (BLTP3A) participates in endomembrane repair as an effector of #ATG8 conjugation to single membranes (CASM) - helping repair or minimize #lysosome damage
@mike-hanna.bsky.social et al, @pdc-lab.bsky.social
www.embopress.org/doi/full/10....
@mike-hanna.bsky.social et al, @pdc-lab.bsky.social
www.embopress.org/doi/full/10....
Just planted in @jcellsci.bsky.social 🌳 😍
An A. thaliana mutant lacking all nine #ATG8 isoforms provides genetic evidence for functional specialization of #ATG8 in plants
forest.biologists.com/landscape/?i...
An A. thaliana mutant lacking all nine #ATG8 isoforms provides genetic evidence for functional specialization of #ATG8 in plants
forest.biologists.com/landscape/?i...
Landscape - The Forest of Biologists
forest.biologists.com
September 11, 2025 at 7:09 AM
Just planted in @jcellsci.bsky.social 🌳 😍
An A. thaliana mutant lacking all nine #ATG8 isoforms provides genetic evidence for functional specialization of #ATG8 in plants
forest.biologists.com/landscape/?i...
An A. thaliana mutant lacking all nine #ATG8 isoforms provides genetic evidence for functional specialization of #ATG8 in plants
forest.biologists.com/landscape/?i...
In vascular plants, ATG8 gene family is expanded. Previously, we proposed expansion may help compartmentalize different autophagy pathways that happen at the same time in the same cell (See👇 autophagosomes labelled by different ATG8s) pubmed.ncbi.nlm.nih.gov/28038982/
December 10, 2024 at 8:47 PM
In vascular plants, ATG8 gene family is expanded. Previously, we proposed expansion may help compartmentalize different autophagy pathways that happen at the same time in the same cell (See👇 autophagosomes labelled by different ATG8s) pubmed.ncbi.nlm.nih.gov/28038982/
ATG8 delipidation is dispensable for plant autophagy https://www.biorxiv.org/content/10.1101/2023.08.23.554513v1
August 25, 2023 at 9:03 PM
ATG8 delipidation is dispensable for plant autophagy https://www.biorxiv.org/content/10.1101/2023.08.23.554513v1
ATG8 delipidation is dispensable for plant autophagy https://www.biorxiv.org/content/10.1101/2023.08.23.554513v1
August 25, 2023 at 9:03 PM
ATG8 delipidation is dispensable for plant autophagy https://www.biorxiv.org/content/10.1101/2023.08.23.554513v1
We investigated whether autophagy is required for organelle breakdown in conidial cells. Using a ∆atg8:Scad2-paGFP strain lacking autophagy, we found that only the apical cell transported mitochondria to the appressorium, while those in distal and middle cells remained intact. (8/13)
October 11, 2025 at 10:25 PM
We investigated whether autophagy is required for organelle breakdown in conidial cells. Using a ∆atg8:Scad2-paGFP strain lacking autophagy, we found that only the apical cell transported mitochondria to the appressorium, while those in distal and middle cells remained intact. (8/13)
Targeted glycophagy ATG8 therapy for diabetic heart disease https://www.biorxiv.org/content/10.1101/2024.11.28.625926v1
Targeted glycophagy ATG8 therapy for diabetic heart disease https://www.biorxiv.org/content/10.1101/2024.11.28.625926v1
Diabetic heart disease is highly prevalent and is associated with the early development of impaired
www.biorxiv.org
December 3, 2024 at 10:02 PM
Targeted glycophagy ATG8 therapy for diabetic heart disease https://www.biorxiv.org/content/10.1101/2024.11.28.625926v1
オートファジーマトリクス解析から見えてきた宿主の6つのAtg8 パラログと細胞内で肺炎球菌が産生するH2O2の新たな機能 - 厚生労働省-戸山研究庁舎
news.google.com/rss/articles/CBMiUGh0dHBzOi8vd3d3Lm5paWQuZ28uanAvbmlpZC9qYS9iYXNpYy1zY2llbmNlL2JhY3RlcmlvbG9neS8xMjY1Ni1iYWMtMjAyNC0wMy5odG1s0gEA?oc=5
news.google.com/rss/articles/CBMiUGh0dHBzOi8vd3d3Lm5paWQuZ28uanAvbmlpZC9qYS9iYXNpYy1zY2llbmNlL2JhY3RlcmlvbG9neS8xMjY1Ni1iYWMtMjAyNC0wMy5odG1s0gEA?oc=5
April 26, 2024 at 6:09 AM
オートファジーマトリクス解析から見えてきた宿主の6つのAtg8 パラログと細胞内で肺炎球菌が産生するH2O2の新たな機能 - 厚生労働省-戸山研究庁舎
news.google.com/rss/articles/CBMiUGh0dHBzOi8vd3d3Lm5paWQuZ28uanAvbmlpZC9qYS9iYXNpYy1zY2llbmNlL2JhY3RlcmlvbG9neS8xMjY1Ni1iYWMtMjAyNC0wMy5odG1s0gEA?oc=5
news.google.com/rss/articles/CBMiUGh0dHBzOi8vd3d3Lm5paWQuZ28uanAvbmlpZC9qYS9iYXNpYy1zY2llbmNlL2JhY3RlcmlvbG9neS8xMjY1Ni1iYWMtMjAyNC0wMy5odG1s0gEA?oc=5
New online: Recruitment of Atg1 to the phagophore by Atg8 orchestrates autophagy machineries
Recruitment of Atg1 to the phagophore by Atg8 orchestrates autophagy machineries
Nature Structural & Molecular Biology, Published online: 28 April 2025; doi:10.1038/s41594-025-01546-0Here, Song and Li et al. show that autophagy-related 8 (Atg8) recruits Atg1 to the surface of autophagosomes to coordinate membrane expansion of the autophagy machinery. Artificial tethering of the Atg1 kinase domain to autophagosomal membranes boosts autophagy in multiple species.
go.nature.com
April 28, 2025 at 10:45 AM
New online: Recruitment of Atg1 to the phagophore by Atg8 orchestrates autophagy machineries
Nuestro laboratorio es como recursos humanos celular: ponemos a prueba el estilo de liderazgo de cada “jefa de turno” (ATG4) con animales que solo tienen 1 tipo de “jefa” para comprobar si es capaz de despertar y liberar correctamente a las “basureras” (ATG8).
June 17, 2025 at 9:45 PM
Nuestro laboratorio es como recursos humanos celular: ponemos a prueba el estilo de liderazgo de cada “jefa de turno” (ATG4) con animales que solo tienen 1 tipo de “jefa” para comprobar si es capaz de despertar y liberar correctamente a las “basureras” (ATG8).
Another important step to understanding why they are so many ATG8 family members and what they are all doing. Great work @plantophagy.bsky.social and team!
September 3, 2025 at 9:18 AM
Another important step to understanding why they are so many ATG8 family members and what they are all doing. Great work @plantophagy.bsky.social and team!
Plant cells maintain structural integrity by relocating ATG8 to the vacuole membrane upon cell wall damage, preventing vacuole rupture and cell death, highlighting a crucial protective mechanism. doi.org/g838sv
Balancing the pressure: How plant cells protect their vacuoles
Plants droop and shed their leaves when parched, but with a splash of water, their stems regain strength and their leaves unfurl.
phys.org
February 7, 2025 at 10:32 AM
Plant cells maintain structural integrity by relocating ATG8 to the vacuole membrane upon cell wall damage, preventing vacuole rupture and cell death, highlighting a crucial protective mechanism. doi.org/g838sv
📜 Nonuple atg8 mutant provides genetic evidence for
functional specialization of ATG8 isoforms in Arabidopsis thaliana
🧑🔬 Alessia Del Chiaro, Nenad Grujic, @plantophagy.bsky.social, et al.
📙 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #Autophagy #PlantDevelopment
functional specialization of ATG8 isoforms in Arabidopsis thaliana
🧑🔬 Alessia Del Chiaro, Nenad Grujic, @plantophagy.bsky.social, et al.
📙 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #Autophagy #PlantDevelopment
Nonuple atg8 mutant provides genetic evidence for functional specialization of ATG8 isoforms in Arabidopsis thaliana
Autophagy sustains cellular health by recycling damaged or excess components through autophagosomes. It is mediated by conserved ATG proteins, which coordinate autophagosome biogenesis and selective c...
www.biorxiv.org
December 12, 2024 at 1:24 PM
📜 Nonuple atg8 mutant provides genetic evidence for
functional specialization of ATG8 isoforms in Arabidopsis thaliana
🧑🔬 Alessia Del Chiaro, Nenad Grujic, @plantophagy.bsky.social, et al.
📙 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #Autophagy #PlantDevelopment
functional specialization of ATG8 isoforms in Arabidopsis thaliana
🧑🔬 Alessia Del Chiaro, Nenad Grujic, @plantophagy.bsky.social, et al.
📙 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #Autophagy #PlantDevelopment
Have you noticed any discernible difference in autophagosome size pending on the atg8 isoform?
December 11, 2024 at 3:53 PM
Have you noticed any discernible difference in autophagosome size pending on the atg8 isoform?
New online: Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression
Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression
Nature Structural & Molecular Biology, Published online: 16 September 2025; doi:10.1038/s41594-025-01678-3Fujioka et al. show that, under starvation, yeast Atg1 forms droplets that concentrate autophagy factors, boosting Atg8 lipidation and clustering vesicles. These droplets likely serve as hubs that generate membrane seeds for autophagosome formation.
go.nature.com
September 16, 2025 at 12:00 PM
New online: Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression
Targeted glycophagy ATG8 therapy for diabetic heart disease https://www.biorxiv.org/content/10.1101/2024.11.28.625926v1
Targeted glycophagy ATG8 therapy for diabetic heart disease https://www.biorxiv.org/content/10.1101/2024.11.28.625926v1
Diabetic heart disease is highly prevalent and is associated with the early development of impaired
www.biorxiv.org
December 3, 2024 at 10:02 PM
Targeted glycophagy ATG8 therapy for diabetic heart disease https://www.biorxiv.org/content/10.1101/2024.11.28.625926v1
Recruitment of Atg1 to the phagophore by Atg8 orchestrates autophagy machineries
->Nature | More info from EcoSearch
->Nature | More info from EcoSearch
Recruitment of Atg1 to the phagophore by Atg8 orchestrates autophagy machineries
Morishita, H. & Mizushima, N. Diverse cellular roles of autophagy. Annu. Rev. Cell Dev. Biol. 35, 453–475 (2019). Nguyen, T. N. & Lazarou, M. A unifying model for the role of the ATG8 system in autophagy. J. Cell Sci. 135,...
www.nature.com
April 28, 2025 at 6:07 PM
Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues https:// rdcu.be/eIEN4
Interest | Match | Feed
Interest | Match | Feed
Origin
tomkahe.com
October 1, 2025 at 5:39 AM
Phase separation promotes Atg8 lipidation for autophagy progression https://www.biorxiv.org/content/10.1101/2024.08.29.610189v1
Phase separation promotes Atg8 lipidation for autophagy progression https://www.biorxiv.org/content/10.1101/2024.08.29.610189v1
Upon starvation, the autophagy-initiating Atg1 complex undergoes phase separation to organize the pr
www.biorxiv.org
August 30, 2024 at 5:30 PM
Phase separation promotes Atg8 lipidation for autophagy progression https://www.biorxiv.org/content/10.1101/2024.08.29.610189v1
For the first time in plants, we used APEX-based electron microscopy to map the precise localization of ATG8 at the vacuolar membrane after stress! 🚀
Pushing the boundaries of plant cell biology—one EM image at a time. ⚡👀
#PlantScience #ElectronMicroscopy #Autophagy #Vacuole #NaturePlants
Pushing the boundaries of plant cell biology—one EM image at a time. ⚡👀
#PlantScience #ElectronMicroscopy #Autophagy #Vacuole #NaturePlants
February 7, 2025 at 11:11 AM
For the first time in plants, we used APEX-based electron microscopy to map the precise localization of ATG8 at the vacuolar membrane after stress! 🚀
Pushing the boundaries of plant cell biology—one EM image at a time. ⚡👀
#PlantScience #ElectronMicroscopy #Autophagy #Vacuole #NaturePlants
Pushing the boundaries of plant cell biology—one EM image at a time. ⚡👀
#PlantScience #ElectronMicroscopy #Autophagy #Vacuole #NaturePlants
オートファジーマトリクス解析から見えてきた宿主の6つのAtg8 パラログと細胞内で肺炎球菌が産生するH2O2の新たな機能 - 厚生労働省-戸山研究庁舎
news.google.com/rss/articles/CBMiUGh0dHBzOi8vd3d3Lm5paWQuZ28uanAvbmlpZC9qYS9iYXNpYy1zY2llbmNlL2JhY3RlcmlvbG9neS8xMjY1Ni1iYWMtMjAyNC0wMy5odG1s0gEA?oc=5
news.google.com/rss/articles/CBMiUGh0dHBzOi8vd3d3Lm5paWQuZ28uanAvbmlpZC9qYS9iYXNpYy1zY2llbmNlL2JhY3RlcmlvbG9neS8xMjY1Ni1iYWMtMjAyNC0wMy5odG1s0gEA?oc=5
April 26, 2024 at 7:09 AM
オートファジーマトリクス解析から見えてきた宿主の6つのAtg8 パラログと細胞内で肺炎球菌が産生するH2O2の新たな機能 - 厚生労働省-戸山研究庁舎
news.google.com/rss/articles/CBMiUGh0dHBzOi8vd3d3Lm5paWQuZ28uanAvbmlpZC9qYS9iYXNpYy1zY2llbmNlL2JhY3RlcmlvbG9neS8xMjY1Ni1iYWMtMjAyNC0wMy5odG1s0gEA?oc=5
news.google.com/rss/articles/CBMiUGh0dHBzOi8vd3d3Lm5paWQuZ28uanAvbmlpZC9qYS9iYXNpYy1zY2llbmNlL2JhY3RlcmlvbG9neS8xMjY1Ni1iYWMtMjAyNC0wMy5odG1s0gEA?oc=5
@nature.com identify a mechanism that separates the 2 responses: during chronic but not acute inflammation, chromatin remodelling is influenced by nuclear #autophagy, in which the WSTF protein of the ISWI chromatin-remodelling complex interacts with the ATG8 autophagy protein family in the nucleus.
WSTF nuclear autophagy regulates chronic but not acute inflammation - Nature
During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent...
www.nature.com
July 4, 2025 at 12:37 PM
@nature.com identify a mechanism that separates the 2 responses: during chronic but not acute inflammation, chromatin remodelling is influenced by nuclear #autophagy, in which the WSTF protein of the ISWI chromatin-remodelling complex interacts with the ATG8 autophagy protein family in the nucleus.
NEW #Preprint on #ATG8 specialization in #autophagy in #plants: www.biorxiv.org/content/10.1... #plantscience A short 🧵
Nonuple atg8 mutant provides genetic evidence for functional specialization of ATG8 isoforms in Arabidopsis thaliana
Autophagy sustains cellular health by recycling damaged or excess components through autophagosomes. It is mediated by conserved ATG proteins, which coordinate autophagosome biogenesis and selective c...
www.biorxiv.org
December 10, 2024 at 8:47 PM
NEW #Preprint on #ATG8 specialization in #autophagy in #plants: www.biorxiv.org/content/10.1... #plantscience A short 🧵
In this new #Yeast research article, Yumiko Oba, Miyuki Higuchi, Naoka Takahashi, Haruko Katsuta, Naoki Koike, Takashi Ushimaru & Yoko Kimura investigated the cooperative role of ATG8 and TORC1 in Saccharomyces cerevisiae.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Cooperative Function of Atg8‐ and TORC1‐Mediated Activities in Yeast
The atg8Δ mutant is sensitive to rapamycin, and both lipidation-dependent and -independent functions of Atg8 are necessary for survival during impaired TORC1 activity. Atg8- and TORC1-mediated functi...
onlinelibrary.wiley.com
July 3, 2025 at 7:56 AM
In this new #Yeast research article, Yumiko Oba, Miyuki Higuchi, Naoka Takahashi, Haruko Katsuta, Naoki Koike, Takashi Ushimaru & Yoko Kimura investigated the cooperative role of ATG8 and TORC1 in Saccharomyces cerevisiae.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...