Marcus Säemann
@marcussaemann.bsky.social
Nephrology - Internal Medicine, Diabetes survivor, Tennis - R. Federer, T. Mann, J. Haydn Afficionado @oegnephro MARKUS@HOMe
Reposted by Marcus Säemann
SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
SGLT-2 I in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller
YouTube video by MARKUS at HOMe
youtu.be
October 10, 2025 at 6:21 PM
SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
Reposted by Marcus Säemann
Reposted by Marcus Säemann
Reposted by Marcus Säemann
New in #ASNJASN: Remote volume monitoring in heart failure has big potential. Implantable hemodynamic sensors offer early, actionable data vital for patients with kidney diseases. kidney.pub/JASN0843
August 24, 2025 at 4:00 PM
New in #ASNJASN: Remote volume monitoring in heart failure has big potential. Implantable hemodynamic sensors offer early, actionable data vital for patients with kidney diseases. kidney.pub/JASN0843
Reposted by Marcus Säemann
Kidney function trajectories before and after hospitalization for HFrEF by Drs. Kobayashi, Girerd et al.
academic.oup.com/eurheartj/ar...
In HFrEF, kidney function decline may precede a HF events by up to one year. Monitoring eGFR slopes may allow early detection of patients at risk.
academic.oup.com/eurheartj/ar...
In HFrEF, kidney function decline may precede a HF events by up to one year. Monitoring eGFR slopes may allow early detection of patients at risk.
August 5, 2025 at 7:42 PM
Kidney function trajectories before and after hospitalization for HFrEF by Drs. Kobayashi, Girerd et al.
academic.oup.com/eurheartj/ar...
In HFrEF, kidney function decline may precede a HF events by up to one year. Monitoring eGFR slopes may allow early detection of patients at risk.
academic.oup.com/eurheartj/ar...
In HFrEF, kidney function decline may precede a HF events by up to one year. Monitoring eGFR slopes may allow early detection of patients at risk.
Reposted by Marcus Säemann
Today at #WTC2025:
A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: nej.md/3TXVgwp
@ttsorg.bsky.social
A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: nej.md/3TXVgwp
@ttsorg.bsky.social
August 4, 2025 at 3:40 PM
Today at #WTC2025:
A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: nej.md/3TXVgwp
@ttsorg.bsky.social
A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: nej.md/3TXVgwp
@ttsorg.bsky.social
Reposted by Marcus Säemann
One big outcome is the change in GFR slope. Tirzepatide slowed GFR decline by 3.54ml/min at 36 months which is absolutely fantastic! I imagine this has something to do with the reduction in mortality given how much mortality is caused by kidney disease in diabetics.
July 31, 2025 at 12:57 PM
One big outcome is the change in GFR slope. Tirzepatide slowed GFR decline by 3.54ml/min at 36 months which is absolutely fantastic! I imagine this has something to do with the reduction in mortality given how much mortality is caused by kidney disease in diabetics.
Reposted by Marcus Säemann
SURPASS CVOT #T2D #Tirzepatide Non inferior but numerically superior for some endpoints #CVD investor.lilly.com/news-release...
July 31, 2025 at 11:21 AM
SURPASS CVOT #T2D #Tirzepatide Non inferior but numerically superior for some endpoints #CVD investor.lilly.com/news-release...
Reposted by Marcus Säemann
Reposted by Marcus Säemann
Could gene-targeted therapy be coming for autosomal dominant polycystic kidney disease? Farabursen, a new medication acquired by Novartis offers to potentially impact cyst formation and even regression. kidney.pub/KN1707-07 #ASNKidneyNews
@nephrosparks.bsky.social
@nephrosparks.bsky.social
July 16, 2025 at 4:00 PM
Could gene-targeted therapy be coming for autosomal dominant polycystic kidney disease? Farabursen, a new medication acquired by Novartis offers to potentially impact cyst formation and even regression. kidney.pub/KN1707-07 #ASNKidneyNews
@nephrosparks.bsky.social
@nephrosparks.bsky.social
Reposted by Marcus Säemann
SGLT2i in CKD: impact beyond kidneys
🔻 15% all-cause hospitalizations
✅ Consistent regardless of eGFR, UACR & diabetes
🏥 ~36 fewer hospitalizations per 1000 pt-years
Large absolute gains for patients & health systems
Meta-analysis in @asnpublications.bsky.social
journals.lww.com/cjasn/pages/...
🔻 15% all-cause hospitalizations
✅ Consistent regardless of eGFR, UACR & diabetes
🏥 ~36 fewer hospitalizations per 1000 pt-years
Large absolute gains for patients & health systems
Meta-analysis in @asnpublications.bsky.social
journals.lww.com/cjasn/pages/...
July 15, 2025 at 3:40 AM
SGLT2i in CKD: impact beyond kidneys
🔻 15% all-cause hospitalizations
✅ Consistent regardless of eGFR, UACR & diabetes
🏥 ~36 fewer hospitalizations per 1000 pt-years
Large absolute gains for patients & health systems
Meta-analysis in @asnpublications.bsky.social
journals.lww.com/cjasn/pages/...
🔻 15% all-cause hospitalizations
✅ Consistent regardless of eGFR, UACR & diabetes
🏥 ~36 fewer hospitalizations per 1000 pt-years
Large absolute gains for patients & health systems
Meta-analysis in @asnpublications.bsky.social
journals.lww.com/cjasn/pages/...
Reposted by Marcus Säemann
Mechanistic target of rapamycin (mTOR) inhibitor–based immunosuppression was associated with an improved T-cell response to vaccination in kidney transplant recipients. Read more in #ASNJASN: kidney.pub/JASN0716
@chengshengchai.bsky.social @griffithperkins.bsky.social
@chengshengchai.bsky.social @griffithperkins.bsky.social
July 19, 2025 at 5:00 PM
Mechanistic target of rapamycin (mTOR) inhibitor–based immunosuppression was associated with an improved T-cell response to vaccination in kidney transplant recipients. Read more in #ASNJASN: kidney.pub/JASN0716
@chengshengchai.bsky.social @griffithperkins.bsky.social
@chengshengchai.bsky.social @griffithperkins.bsky.social
Reposted by Marcus Säemann
Uromodulin and Risk of Upper Urinary Tract Infections: A Mendelian Randomization Study
bit.ly/Liyanarachi2... #OpenAccess
#VisualAbstract
bit.ly/Liyanarachi2... #OpenAccess
#VisualAbstract
Uromodulin and Risk of Upper Urinary Tract Infections: A Mendelian Randomization Study
bit.ly
July 18, 2025 at 10:03 PM
Uromodulin and Risk of Upper Urinary Tract Infections: A Mendelian Randomization Study
bit.ly/Liyanarachi2... #OpenAccess
#VisualAbstract
bit.ly/Liyanarachi2... #OpenAccess
#VisualAbstract
Reposted by Marcus Säemann
A bold guideline from the beginning!
“We suggest that all individuals with hypertension be screened for primary aldosteronism”
“We suggest that all individuals with hypertension be screened for primary aldosteronism”
July 16, 2025 at 10:52 PM
A bold guideline from the beginning!
“We suggest that all individuals with hypertension be screened for primary aldosteronism”
“We suggest that all individuals with hypertension be screened for primary aldosteronism”
Reposted by Marcus Säemann
In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone production, and hypokalemia. Full SPARK study results: nej.md/40Js1kz
#ENDO2025
#ENDO2025
July 13, 2025 at 10:06 PM
In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone production, and hypokalemia. Full SPARK study results: nej.md/40Js1kz
#ENDO2025
#ENDO2025
Reposted by Marcus Säemann
New Primary Aldosteronism Guidelines - simpler, streamlined, and hopefully more pragmatic
academic.oup.com/jcem/advance...
academic.oup.com/jcem/advance...
July 15, 2025 at 1:06 PM
New Primary Aldosteronism Guidelines - simpler, streamlined, and hopefully more pragmatic
academic.oup.com/jcem/advance...
academic.oup.com/jcem/advance...
Reposted by Marcus Säemann
This is new. Higher vitamin D levels associated with higher prostate cancer prevalence 🤦🏻♂️
I'm sure the "taking vitamin D couldn't hurt" crowd will have an explanation forthcoming
I'm sure the "taking vitamin D couldn't hurt" crowd will have an explanation forthcoming
particularly those subgroups & individuals with #CVD . Regulating serum 25(OH)D levels may contribute to mitigating PCa prevalence.
bmccancer.biomedcentral.com/articles/10....
@biomedcentral.bsky.social
bmccancer.biomedcentral.com/articles/10....
@biomedcentral.bsky.social
Association between serum 25-hydroxyvitamin D and prostate cancer in middle-aged and elderly Americans: a national population-based analysis of NHANES 2001–2018 - BMC Cancer
Background The impact of serum 25-hydroxyvitamin D [25(OH)D] on prostate cancer (PCa) development remains inconclusive. This investigation aimed to evaluate the association between 25(OH)D concentrati...
bmccancer.biomedcentral.com
June 23, 2025 at 11:35 AM
This is new. Higher vitamin D levels associated with higher prostate cancer prevalence 🤦🏻♂️
I'm sure the "taking vitamin D couldn't hurt" crowd will have an explanation forthcoming
I'm sure the "taking vitamin D couldn't hurt" crowd will have an explanation forthcoming
Reposted by Marcus Säemann
Using an MRA empiricially or renin-guided therapy in apparent treatment resistant hypertension?
academic.oup.com/ajh/article/...
#WeekendReads from the #EditorsChoice archives
academic.oup.com/ajh/article/...
#WeekendReads from the #EditorsChoice archives
June 22, 2025 at 10:20 AM
Using an MRA empiricially or renin-guided therapy in apparent treatment resistant hypertension?
academic.oup.com/ajh/article/...
#WeekendReads from the #EditorsChoice archives
academic.oup.com/ajh/article/...
#WeekendReads from the #EditorsChoice archives
Reposted by Marcus Säemann
The 62nd ERA congress Allstars: Late-breaking studies 2025
Our guests:
@lonniepyne.bsky.social
@lastwalsh.bsky.social
Vianda Stel
Fadi Fakhouri
Hans Mann
Natalie Staplin
Jonathan Barratt
@rosertorra.bsky.social
@katestevens.bsky.social
youtu.be/HbUEh8oLB2M?...
Our guests:
@lonniepyne.bsky.social
@lastwalsh.bsky.social
Vianda Stel
Fadi Fakhouri
Hans Mann
Natalie Staplin
Jonathan Barratt
@rosertorra.bsky.social
@katestevens.bsky.social
youtu.be/HbUEh8oLB2M?...
62nd ERA Congress - Profs. L. Pyne, F. Fakhouri, M. Walsh, H. Mann, N. Staplin, V. Stel & J. Barratt
YouTube video by MARKUS at HOMe
youtu.be
June 13, 2025 at 5:31 PM
The 62nd ERA congress Allstars: Late-breaking studies 2025
Our guests:
@lonniepyne.bsky.social
@lastwalsh.bsky.social
Vianda Stel
Fadi Fakhouri
Hans Mann
Natalie Staplin
Jonathan Barratt
@rosertorra.bsky.social
@katestevens.bsky.social
youtu.be/HbUEh8oLB2M?...
Our guests:
@lonniepyne.bsky.social
@lastwalsh.bsky.social
Vianda Stel
Fadi Fakhouri
Hans Mann
Natalie Staplin
Jonathan Barratt
@rosertorra.bsky.social
@katestevens.bsky.social
youtu.be/HbUEh8oLB2M?...
Reposted by Marcus Säemann
Best of ERA 25 @markusathome.bsky.social with
@lonniepyne.bsky.social @lastwalsh.bsky.social
Dr. Stel Dr. Staplin Dr. Mann Dr. Fakhouri
@rosertorra.bsky.social @katestevens.bsky.social @marcussaemann.bsky.social @sarahelena.bsky.social
@dgfn.bsky.social @sfndt.bsky.social
youtu.be/HbUEh8oLB2M?...
@lonniepyne.bsky.social @lastwalsh.bsky.social
Dr. Stel Dr. Staplin Dr. Mann Dr. Fakhouri
@rosertorra.bsky.social @katestevens.bsky.social @marcussaemann.bsky.social @sarahelena.bsky.social
@dgfn.bsky.social @sfndt.bsky.social
youtu.be/HbUEh8oLB2M?...
62nd ERA Congress - Profs. L. Pyne, F. Fakhouri, M. Walsh, H. Mann, N. Staplin, V. Stel & J. Barratt
YouTube video by MARKUS at HOMe
youtu.be
June 13, 2025 at 11:48 AM
Best of ERA 25 @markusathome.bsky.social with
@lonniepyne.bsky.social @lastwalsh.bsky.social
Dr. Stel Dr. Staplin Dr. Mann Dr. Fakhouri
@rosertorra.bsky.social @katestevens.bsky.social @marcussaemann.bsky.social @sarahelena.bsky.social
@dgfn.bsky.social @sfndt.bsky.social
youtu.be/HbUEh8oLB2M?...
@lonniepyne.bsky.social @lastwalsh.bsky.social
Dr. Stel Dr. Staplin Dr. Mann Dr. Fakhouri
@rosertorra.bsky.social @katestevens.bsky.social @marcussaemann.bsky.social @sarahelena.bsky.social
@dgfn.bsky.social @sfndt.bsky.social
youtu.be/HbUEh8oLB2M?...
Reposted by Marcus Säemann
youtu.be/s-iglqVIp2s?...
With @marcussaemann.bsky.social @sarahelena.bsky.social @rosertorra.bsky.social Prof. Anders Prof. Stevens
With @marcussaemann.bsky.social @sarahelena.bsky.social @rosertorra.bsky.social Prof. Anders Prof. Stevens
Post ERA 2025 - NDT / MARKUS at HOMe Special
YouTube video by MARKUS at HOMe
youtu.be
June 9, 2025 at 8:33 AM
youtu.be/s-iglqVIp2s?...
With @marcussaemann.bsky.social @sarahelena.bsky.social @rosertorra.bsky.social Prof. Anders Prof. Stevens
With @marcussaemann.bsky.social @sarahelena.bsky.social @rosertorra.bsky.social Prof. Anders Prof. Stevens
Reposted by Marcus Säemann
"The perfect storm to support the darkest forces. ...If we don’t engage this crisis with the courage of those who fought on this continent in WW2, then I sense we risk the eventual ramp up to carnage that could easily surpass that."
Speech to legislators yesterday.
www.linkedin.com/pulse/addres...
Speech to legislators yesterday.
www.linkedin.com/pulse/addres...
May 12, 2025 at 4:32 AM
"The perfect storm to support the darkest forces. ...If we don’t engage this crisis with the courage of those who fought on this continent in WW2, then I sense we risk the eventual ramp up to carnage that could easily surpass that."
Speech to legislators yesterday.
www.linkedin.com/pulse/addres...
Speech to legislators yesterday.
www.linkedin.com/pulse/addres...
Reposted by Marcus Säemann
📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan www.kireports.org/ar...
May 9, 2025 at 6:00 AM
📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan www.kireports.org/ar...
Reposted by Marcus Säemann
Kidney disease should be recognised on WHO's priority list of non-communicable diseases, alongside cancer, cardiovascular disease, and diabetes
https://go.nature.com/4lLJ5iY
https://go.nature.com/4lLJ5iY
Kidney disease is a worldwide killer. Treat it that way
The international community has a golden opportunity to start reining in the escalating, mostly ignored global burden of chronic kidney disease.
go.nature.com
April 22, 2025 at 4:26 PM
Kidney disease should be recognised on WHO's priority list of non-communicable diseases, alongside cancer, cardiovascular disease, and diabetes
https://go.nature.com/4lLJ5iY
https://go.nature.com/4lLJ5iY
Reposted by Marcus Säemann
Fascism is now in the algorithms, the neural pathways, the social interactions. How did we fail to see all this? “We wanted to see Trump in terms of his absences, so that our way of seeing the world would go unchallenged,” Timothy Snyder writes.
What Does It Mean That Donald Trump Is a Fascist?
Trump takes the tools of dictators and adapts them for the Internet. We should expect him to try to cling to power until death, and create a cult of January 6th martyrs.
www.newyorker.com
April 19, 2025 at 8:47 PM
Fascism is now in the algorithms, the neural pathways, the social interactions. How did we fail to see all this? “We wanted to see Trump in terms of his absences, so that our way of seeing the world would go unchallenged,” Timothy Snyder writes.