Marcus Säemann
@marcussaemann.bsky.social
Nephrology - Internal Medicine, Diabetes survivor, Tennis - R. Federer, T. Mann, J. Haydn Afficionado @oegnephro MARKUS@HOMe
I am happy with the result😊
November 22, 2025 at 7:01 PM
I am happy with the result😊
For nuance: while leucine is framed as proinflammatory by augmenting atherosclerosis in mice via macrophages supposedly via mTOR, mTOR activation is actually the most prominent anti-inflammatory signaling mediator in myeloid cells such as macrophages (also via AA). Yes nature is complicated…
August 31, 2025 at 8:45 PM
For nuance: while leucine is framed as proinflammatory by augmenting atherosclerosis in mice via macrophages supposedly via mTOR, mTOR activation is actually the most prominent anti-inflammatory signaling mediator in myeloid cells such as macrophages (also via AA). Yes nature is complicated…
Eagerly waiting!
August 31, 2025 at 11:23 AM
Eagerly waiting!
Personal experience: no issues at all incl. Tac levels, side effects similar to the non-Tx population
August 4, 2025 at 3:11 PM
Personal experience: no issues at all incl. Tac levels, side effects similar to the non-Tx population
Reposted by Marcus Säemann
One big outcome is the change in GFR slope. Tirzepatide slowed GFR decline by 3.54ml/min at 36 months which is absolutely fantastic! I imagine this has something to do with the reduction in mortality given how much mortality is caused by kidney disease in diabetics.
July 31, 2025 at 12:57 PM
One big outcome is the change in GFR slope. Tirzepatide slowed GFR decline by 3.54ml/min at 36 months which is absolutely fantastic! I imagine this has something to do with the reduction in mortality given how much mortality is caused by kidney disease in diabetics.