Josh Waitzman
@jwaitz.bsky.social
Kidney doc, biochemist, and dad, taking life one kinesin-sized step at a time. He/him. Employed by Vertex Pharmaceuticals | BIDMC Nephrology | opinions my own
Reposted by Josh Waitzman
If you read only one obit of James Watson, read this one
www.statnews.com/2025/11/07/j...
(From the late Sharon Begley, for @statnews.com )
www.statnews.com/2025/11/07/j...
(From the late Sharon Begley, for @statnews.com )
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 9, 2025 at 11:56 AM
If you read only one obit of James Watson, read this one
www.statnews.com/2025/11/07/j...
(From the late Sharon Begley, for @statnews.com )
www.statnews.com/2025/11/07/j...
(From the late Sharon Begley, for @statnews.com )
Reposted by Josh Waitzman
Shocking first high impact trial of the day. Fish oil reduces CV events in dialysis patients! #Pisces #kidneywk
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
November 7, 2025 at 4:45 PM
Shocking first high impact trial of the day. Fish oil reduces CV events in dialysis patients! #Pisces #kidneywk
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
Reposted by Josh Waitzman
Today’s trials at #KidneyWk
In the morning a LBCT session at 10:30
featuring
PISCES (fish oil in dialysis!)
LIBERATE in AKI
Another AKI alerts from @fperrywilson.bsky.social
A Transplant trial
GLP1 and a Flozin analyses
And
In the morning a LBCT session at 10:30
featuring
PISCES (fish oil in dialysis!)
LIBERATE in AKI
Another AKI alerts from @fperrywilson.bsky.social
A Transplant trial
GLP1 and a Flozin analyses
And
November 7, 2025 at 10:39 AM
Today’s trials at #KidneyWk
In the morning a LBCT session at 10:30
featuring
PISCES (fish oil in dialysis!)
LIBERATE in AKI
Another AKI alerts from @fperrywilson.bsky.social
A Transplant trial
GLP1 and a Flozin analyses
And
In the morning a LBCT session at 10:30
featuring
PISCES (fish oil in dialysis!)
LIBERATE in AKI
Another AKI alerts from @fperrywilson.bsky.social
A Transplant trial
GLP1 and a Flozin analyses
And
Reposted by Josh Waitzman
New to the #KidneyWk Opening Plenary: two High-Impact Clinical Trials debut this morning, presenting pivotal data in CKD and IgAN. These groundbreaking studies take the main stage at Kidney Week for the first time—you don’t want to miss this.
November 6, 2025 at 1:42 PM
New to the #KidneyWk Opening Plenary: two High-Impact Clinical Trials debut this morning, presenting pivotal data in CKD and IgAN. These groundbreaking studies take the main stage at Kidney Week for the first time—you don’t want to miss this.
Reposted by Josh Waitzman
Don’t forget to support #FOAMed and #NephJC with our annual fundraiser. Every donation helps keep us going (even as unpaid volunteers). 🫶🫶🫶
www.nephjc.com
www.nephjc.com
October 29, 2025 at 1:53 AM
Don’t forget to support #FOAMed and #NephJC with our annual fundraiser. Every donation helps keep us going (even as unpaid volunteers). 🫶🫶🫶
www.nephjc.com
www.nephjc.com
Reposted by Josh Waitzman
If treatments are available that can help at early stages of most causes of CKD (RAASi, SGLT2i, etc), why WOULDN’T we screen? Economics? How much does saving 20 years of dialysis get you? What about human costs?
www.kireports.org/article/S246...
www.kireports.org/article/S246...
Urine screening to early diagnose young individuals with CKD: a call for action
Alport syndrome is an inherited disorder of basement membranes leading to progressive
chronic kidney disease, hearing loss, and ocular abnormalities in many affected patients.
When the authors started...
www.kireports.org
October 25, 2025 at 11:39 AM
If treatments are available that can help at early stages of most causes of CKD (RAASi, SGLT2i, etc), why WOULDN’T we screen? Economics? How much does saving 20 years of dialysis get you? What about human costs?
www.kireports.org/article/S246...
www.kireports.org/article/S246...
In case folks missed this, ACGME Transplant Nephrology accreditation is now a thing!
If folks are Program Directors, they may need to start the process of accreditation soon.
Requirements here:
www.acgme.org/globalassets...
If folks are Program Directors, they may need to start the process of accreditation soon.
Requirements here:
www.acgme.org/globalassets...
www.acgme.org
October 15, 2025 at 7:33 PM
In case folks missed this, ACGME Transplant Nephrology accreditation is now a thing!
If folks are Program Directors, they may need to start the process of accreditation soon.
Requirements here:
www.acgme.org/globalassets...
If folks are Program Directors, they may need to start the process of accreditation soon.
Requirements here:
www.acgme.org/globalassets...
In this house we drink liquids and support #nephjc
(Maybe I should get a backpack next time)
Donate at: www.nephjc.com/news/2025/9/...
(Maybe I should get a backpack next time)
Donate at: www.nephjc.com/news/2025/9/...
October 13, 2025 at 3:53 PM
In this house we drink liquids and support #nephjc
(Maybe I should get a backpack next time)
Donate at: www.nephjc.com/news/2025/9/...
(Maybe I should get a backpack next time)
Donate at: www.nephjc.com/news/2025/9/...
Reposted by Josh Waitzman
This is a powerful account from a PhD student whose fellowship was terminated by NIH because it was part of a "diversity" program without any other considerations or understanding of what the program or the students were actually doing.
undark.org/2025/10/09/o...
1/2
undark.org/2025/10/09/o...
1/2
NIH Student Grant Cancellation Will Weaken Scientific Innovation
The termination of federal F31 diversity fellowships puts many graduate students in a bind — and U.S. science at risk.
undark.org
October 13, 2025 at 2:41 PM
This is a powerful account from a PhD student whose fellowship was terminated by NIH because it was part of a "diversity" program without any other considerations or understanding of what the program or the students were actually doing.
undark.org/2025/10/09/o...
1/2
undark.org/2025/10/09/o...
1/2
Pre #nephjc bias: Team pro protein
All these studies are deeply confounded and based in the pre-kidney-preserving therapy era.
Let them eat steak!
(Actually, let them eat vegetable sources of protein, but beans, lentils, and soy don’t rhyme with cake)
All these studies are deeply confounded and based in the pre-kidney-preserving therapy era.
Let them eat steak!
(Actually, let them eat vegetable sources of protein, but beans, lentils, and soy don’t rhyme with cake)
October 13, 2025 at 3:43 PM
Pre #nephjc bias: Team pro protein
All these studies are deeply confounded and based in the pre-kidney-preserving therapy era.
Let them eat steak!
(Actually, let them eat vegetable sources of protein, but beans, lentils, and soy don’t rhyme with cake)
All these studies are deeply confounded and based in the pre-kidney-preserving therapy era.
Let them eat steak!
(Actually, let them eat vegetable sources of protein, but beans, lentils, and soy don’t rhyme with cake)
Loved watching @kidneyrebel.bsky.social grand rounds at @nu-nephrology.bsky.social!!
Thank you for the PKD mega blocks shout out #nephjc (1), happy to be at the right overlap in my Venn diagram (2), and trying to build toward a medical specialty in a hill (3)
www.youtube.com/watch?v=RlTC...
Thank you for the PKD mega blocks shout out #nephjc (1), happy to be at the right overlap in my Venn diagram (2), and trying to build toward a medical specialty in a hill (3)
www.youtube.com/watch?v=RlTC...
October 13, 2025 at 3:28 PM
Loved watching @kidneyrebel.bsky.social grand rounds at @nu-nephrology.bsky.social!!
Thank you for the PKD mega blocks shout out #nephjc (1), happy to be at the right overlap in my Venn diagram (2), and trying to build toward a medical specialty in a hill (3)
www.youtube.com/watch?v=RlTC...
Thank you for the PKD mega blocks shout out #nephjc (1), happy to be at the right overlap in my Venn diagram (2), and trying to build toward a medical specialty in a hill (3)
www.youtube.com/watch?v=RlTC...
Reposted by Josh Waitzman
New episode of Channel Your Enthusiasm, part 2 of 3 on metabolic acidosis. Episode with chapter art, chapters, and fully referenced
www.rosebook.club/episodes/202...
www.rosebook.club/episodes/202...
October 11, 2025 at 8:05 PM
New episode of Channel Your Enthusiasm, part 2 of 3 on metabolic acidosis. Episode with chapter art, chapters, and fully referenced
www.rosebook.club/episodes/202...
www.rosebook.club/episodes/202...
Reposted by Josh Waitzman
My op-ed just came out discussing how NIH leadership is failing early career researchers and, importantly, how we can push back and take our future into our own hands.
NIH Leadership Is Failing Early Career Researchers
Halted training programs, funding chaos, and hiring freezes jeopardize advancement options for early career researchers.
www.the-scientist.com
October 10, 2025 at 11:23 AM
My op-ed just came out discussing how NIH leadership is failing early career researchers and, importantly, how we can push back and take our future into our own hands.
Reposted by Josh Waitzman
Thought-provoking, well-written @nejm.org blog article by Dr. Paul Farmer's wife on the (third) anniversary of his passing: www.nejm.org/doi/10.1056/...
cc: @jwaitz.bsky.social
#nephjc summer book club chat
cc: @jwaitz.bsky.social
#nephjc summer book club chat
In Paul Farmer’s Beautiful Garden of Global Health Equity: Reflections on the Third Remembrance of His Passing | NEJM
On the third anniversary of Paul Farmer’s death, Didi Bertrand Farmer reflects on his “beautiful garden” — a vision of social justice in health care, with deep roots in the fertile soil of equity.
www.nejm.org
October 8, 2025 at 11:04 PM
Thought-provoking, well-written @nejm.org blog article by Dr. Paul Farmer's wife on the (third) anniversary of his passing: www.nejm.org/doi/10.1056/...
cc: @jwaitz.bsky.social
#nephjc summer book club chat
cc: @jwaitz.bsky.social
#nephjc summer book club chat
Reposted by Josh Waitzman
Reposted by Josh Waitzman
rdcu.be/eJHTr
rdcu.be/eJHU8
www.sciencedirect.com/science/arti...
www.annualreviews.org/content/jour...
rdcu.be/eJHU8
www.sciencedirect.com/science/arti...
www.annualreviews.org/content/jour...
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
Nature Reviews Immunology - In this Review, the authors discuss the origins of regulatory T (Treg) cells in the periphery and the mechanisms by which Treg cells are induced, as well as the...
rdcu.be
October 6, 2025 at 1:15 PM
I guess this means it’s time for me to try to understand what Tregs do…
(Thanks @enirenberg.bsky.social for the great explainer!)
(Thanks @enirenberg.bsky.social for the great explainer!)
This year's Nobel Prize in Physiology or Medicine was just announced:
www.nobelprize.org/prizes/medic...
This seems like a good opportunity for me to explain a bit about peripheral immune tolerance and where the prizewinners' work comes in 🧵
www.nobelprize.org/prizes/medic...
This seems like a good opportunity for me to explain a bit about peripheral immune tolerance and where the prizewinners' work comes in 🧵
October 6, 2025 at 1:10 PM
I guess this means it’s time for me to try to understand what Tregs do…
(Thanks @enirenberg.bsky.social for the great explainer!)
(Thanks @enirenberg.bsky.social for the great explainer!)
Reposted by Josh Waitzman
PARASOL Project is expanding focus to include biomarkers & endpoints in APOL1 kidney disease and primary MN as well as FSGS. Learn more: eu1.hubs.ly/H0nr8Lv0
@tobias-b-huber.bsky.social @miktmc.bsky.social @jarcyzphd.bsky.social @ohiostatemed.bsky.social @utoronto.ca @nu-nephrology.bsky.social
@tobias-b-huber.bsky.social @miktmc.bsky.social @jarcyzphd.bsky.social @ohiostatemed.bsky.social @utoronto.ca @nu-nephrology.bsky.social
PARASOL Project Expands Focus to APOL1, Membranous Nephropathy
PARASOL Project expands to focus on APOL1 kidney disease and primary membranous nephropathy, aiming to improve clinical trial endpoints for these conditions.
eu1.hubs.ly
October 3, 2025 at 1:26 PM
PARASOL Project is expanding focus to include biomarkers & endpoints in APOL1 kidney disease and primary MN as well as FSGS. Learn more: eu1.hubs.ly/H0nr8Lv0
@tobias-b-huber.bsky.social @miktmc.bsky.social @jarcyzphd.bsky.social @ohiostatemed.bsky.social @utoronto.ca @nu-nephrology.bsky.social
@tobias-b-huber.bsky.social @miktmc.bsky.social @jarcyzphd.bsky.social @ohiostatemed.bsky.social @utoronto.ca @nu-nephrology.bsky.social
Reposted by Josh Waitzman
Today is #C3GAwarenessDay! At ISGD, we stand with people living with this rare kidney disease. As a medical society for #GlomerularDisease experts, we're committed to raising awareness and moving the science forward to bring more hope and solutions to the C3G community. #C3G #ISGD
September 25, 2025 at 3:34 PM
Today is #C3GAwarenessDay! At ISGD, we stand with people living with this rare kidney disease. As a medical society for #GlomerularDisease experts, we're committed to raising awareness and moving the science forward to bring more hope and solutions to the C3G community. #C3G #ISGD
Reposted by Josh Waitzman
Excellent thread below
I will also plug this talk by Paola Romagnani on podocytopathies
youtu.be/bRMeqaGgA9I?...
#GlomCon #NephGR
I will also plug this talk by Paola Romagnani on podocytopathies
youtu.be/bRMeqaGgA9I?...
#GlomCon #NephGR
September 24, 2025 at 12:00 AM
Excellent thread below
I will also plug this talk by Paola Romagnani on podocytopathies
youtu.be/bRMeqaGgA9I?...
#GlomCon #NephGR
I will also plug this talk by Paola Romagnani on podocytopathies
youtu.be/bRMeqaGgA9I?...
#GlomCon #NephGR
Reposted by Josh Waitzman
Reposted by Josh Waitzman
September 17, 2025 at 1:50 AM
Reposting a q I had re the lower treatment threshold/goal for #nephjc
Congrats Jordy and team on this enormous effort!
I love a good risk score as much as the next guy, but does this overcomplicate things for those around 130/80? Even the commentary says that most folks with who start lifestyle change will need meds, and ARBs are better tolerated than placebo.
I love a good risk score as much as the next guy, but does this overcomplicate things for those around 130/80? Even the commentary says that most folks with who start lifestyle change will need meds, and ARBs are better tolerated than placebo.
September 17, 2025 at 1:30 AM
Reposting a q I had re the lower treatment threshold/goal for #nephjc