Maja Radulovic
@majarad.bsky.social
Project leader at Dept. of Molecular Cell Biology/Stenmark lab, Oslo University Hospital 🧪🔬
https://www.ous-research.no/home/stenmark/Group%20members/16509
https://www.ous-research.no/home/stenmark/Group%20members/16509
Reposted by Maja Radulovic
Autolamellasomes: An Autophagy-Dependent Parallel Pathway for Bulk ER Degradation and Lysosome Biogenesis https://www.biorxiv.org/content/10.1101/2025.11.16.688694v1
November 17, 2025 at 12:30 AM
Autolamellasomes: An Autophagy-Dependent Parallel Pathway for Bulk ER Degradation and Lysosome Biogenesis https://www.biorxiv.org/content/10.1101/2025.11.16.688694v1
Reposted by Maja Radulovic
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
October 29, 2025 at 5:11 PM
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
Reposted by Maja Radulovic
Lipid Landscape of human cells https://www.biorxiv.org/content/10.1101/2025.10.05.680593v1
October 6, 2025 at 3:05 PM
Lipid Landscape of human cells https://www.biorxiv.org/content/10.1101/2025.10.05.680593v1
Reposted by Maja Radulovic
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair https://www.biorxiv.org/content/10.1101/2025.10.23.684214v1
October 24, 2025 at 11:30 PM
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair https://www.biorxiv.org/content/10.1101/2025.10.23.684214v1
Reposted by Maja Radulovic
🚨 We’re hiring a postdoc! 🚨
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
October 14, 2025 at 5:00 PM
🚨 We’re hiring a postdoc! 🚨
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
Reposted by Maja Radulovic
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
September 30, 2025 at 5:50 AM
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Maja Radulovic
Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!
@lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...
September 24, 2025 at 3:49 PM
Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!
Reposted by Maja Radulovic
Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof
CHIP protects lysosomes from CLN4 mutant-induced membrane damage
Nature Cell Biology - Lee et al. use an aggregation-prone CLN4 mutant that causes lysosomal damage in neurons and show that in non-neurons, the ubiquitin ligase CHIP prevents CLN4-dependent...
rdcu.be
August 25, 2025 at 1:23 PM
Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof
Reposted by Maja Radulovic
LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...
LYVAC/PDZD8 is a lysosomal vacuolator
Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...
www.science.org
August 21, 2025 at 11:19 PM
LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...
Reposted by Maja Radulovic
Nature research paper: Quantitative imaging of lipid transport in mammalian cells
go.nature.com/4mmSygd
go.nature.com/4mmSygd
Quantitative imaging of lipid transport in mammalian cells - Nature
Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
go.nature.com
August 21, 2025 at 12:58 PM
Nature research paper: Quantitative imaging of lipid transport in mammalian cells
go.nature.com/4mmSygd
go.nature.com/4mmSygd
Interested in lysosome damage and repair pathways? Check out the latest updates.
New Online! Lysosomal membrane homeostasis and its importance in physiology and disease
Lysosomal membrane homeostasis and its importance in physiology and disease
Nature Reviews Molecular Cell Biology, Published online: 04 August 2025; doi:10.1038/s41580-025-00873-wLysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.
bit.ly
August 5, 2025 at 1:02 PM
Interested in lysosome damage and repair pathways? Check out the latest updates.
Reposted by Maja Radulovic
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
meetings.embo.org
July 4, 2025 at 3:50 PM
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
Reposted by Maja Radulovic
What a fantastic ESCRT meeting, the field is going strong and full of exciting science. Many thanks to @rouxlab.bsky.social @cellarchlab.com @jujumathieu.bsky.social @magromayor.bsky.social @majarad.bsky.social for organising such a a great event
June 27, 2025 at 12:59 PM
What a fantastic ESCRT meeting, the field is going strong and full of exciting science. Many thanks to @rouxlab.bsky.social @cellarchlab.com @jujumathieu.bsky.social @magromayor.bsky.social @majarad.bsky.social for organising such a a great event
Reposted by Maja Radulovic
The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem
The expanding repertoire of ESCRT functions in cell biology and disease - Nature
This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.
tinyurl.com
June 25, 2025 at 6:24 PM
The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem
Reposted by Maja Radulovic
A short reminder that registrations for the EMBO ESCRT meeting 2025 in Montreux June 23rd-June27th are still opened! Please register online at meetings.embo.org/event/25-escrt
ESCRT function, evolutionary diversity and mechanism of action
The ESCRTs (Endosomal Sorting Complexes Required for Transport) were discovered in 2002 and became one of the most dynamic fields of research in membrane cell biology. ESCRTs are protein complexes fo…
meetings.embo.org
March 28, 2025 at 12:24 PM
A short reminder that registrations for the EMBO ESCRT meeting 2025 in Montreux June 23rd-June27th are still opened! Please register online at meetings.embo.org/event/25-escrt