José Díaz Maldonado
@josediazm.bsky.social
PhD student at Harvard MCO| BS. Biochemistry @UC Chile 🇨🇱 | Interested in #mitochondria #RNA
Reposted by José Díaz Maldonado
Mitochondrial pull-out controls mitochondrial structure in response to mitochondrial activity https://www.biorxiv.org/content/10.1101/2025.11.25.690431v1
November 28, 2025 at 9:30 PM
Mitochondrial pull-out controls mitochondrial structure in response to mitochondrial activity https://www.biorxiv.org/content/10.1101/2025.11.25.690431v1
Reposted by José Díaz Maldonado
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by
the synergy of innate immune activation and metabolic stress. This process is regulated
by mTORC2 and involves persis...
www.cell.com
November 28, 2025 at 4:18 PM
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by José Díaz Maldonado
Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
November 17, 2025 at 2:28 PM
Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
Reposted by José Díaz Maldonado
The proton motive force maintains mtDNA euploidy by balancing mtDNA replication with cell proliferation https://www.biorxiv.org/content/10.1101/2025.10.27.684790v1
October 28, 2025 at 2:30 AM
The proton motive force maintains mtDNA euploidy by balancing mtDNA replication with cell proliferation https://www.biorxiv.org/content/10.1101/2025.10.27.684790v1
Reposted by José Díaz Maldonado
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by José Díaz Maldonado
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
October 14, 2025 at 11:50 AM
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
Long-read sequencing-based atlas of tissue-specific expression of Drp1 transcript variants
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
October 8, 2025 at 3:28 AM
Long-read sequencing-based atlas of tissue-specific expression of Drp1 transcript variants
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by José Díaz Maldonado
Online now: The energy resistance principle
The energy resistance principle
Picard and Murugan introduce the energy resistance principle (ERP), a testable framework outlining how resistance to energy flow sustains life and shapes health. Excess resistance (éR) promotes hallmarks of disease, whereas restorative states minimize éR, thus linking the biophysics of energy to human health, aging, and healing.
dlvr.it
October 6, 2025 at 3:42 PM
Online now: The energy resistance principle
Reposted by José Díaz Maldonado
What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...
Translation landscape of stress granules
Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.
www.science.org
October 5, 2025 at 5:22 AM
What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...
Reposted by José Díaz Maldonado
I am excited to share the second half of my postdoctoral work in the Yeo lab at UCSD! We found that neuronal aging leads to the accumulation of mitochondrial double-stranded RNA, which triggers the chronic stress response. 1/ www.biorxiv.org/content/10.1...
August 5, 2025 at 5:16 PM
I am excited to share the second half of my postdoctoral work in the Yeo lab at UCSD! We found that neuronal aging leads to the accumulation of mitochondrial double-stranded RNA, which triggers the chronic stress response. 1/ www.biorxiv.org/content/10.1...
Reposted by José Díaz Maldonado
SARCOMERES divide! Mechanism how muscles grow while contracting - daughter sarcomeres appear everywhere. Seen live, registered on our cover. Pioneered by @clementrodier.bsky.social @friedrich-group.bsky.social Ian Estabrook @ibdm.bsky.social $ by @hfspo.bsky.social www.science.org/doi/10.1126/...
July 10, 2025 at 10:16 AM
SARCOMERES divide! Mechanism how muscles grow while contracting - daughter sarcomeres appear everywhere. Seen live, registered on our cover. Pioneered by @clementrodier.bsky.social @friedrich-group.bsky.social Ian Estabrook @ibdm.bsky.social $ by @hfspo.bsky.social www.science.org/doi/10.1126/...
Reposted by José Díaz Maldonado
Our latest issue is out now www.cell.com/molecular-ce...
June 19, 2025 at 3:00 PM
Our latest issue is out now www.cell.com/molecular-ce...
Reposted by José Díaz Maldonado
Online Now: DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation Online now:
DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation
Wang et al. reveal a role of DNMT1, traditionally known for DNA methylation, in regulating mitochondrial health through RNA modification. Their findings explain how the mutation in DNMT1 disrupts cellular energy metabolism, contributing to neurological disorders, and suggest therapeutic potential targeting RNA methylation in neurodegenerative diseases.
dlvr.it
May 7, 2025 at 3:20 PM
Online Now: DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation Online now:
Transgenerational inheritance of mitochondrial hormetic oxidative stress mediated by histone H3K4me3 and H3K27me3 modifications.
Transgenerational inheritance of mitochondrial hormetic oxidative stress mediated by histone H3K4me3 and H3K27me3 modifications
Mitochondrial hormetic oxidative stress (mtHOS) is crucial in physiology and disease; however, its effects on epigenetic inheritance and organism fitn…
www.sciencedirect.com
March 20, 2025 at 11:29 PM
Transgenerational inheritance of mitochondrial hormetic oxidative stress mediated by histone H3K4me3 and H3K27me3 modifications.
Reposted by José Díaz Maldonado
@science.org A subcellular map of translational machinery composition and regulation at the single-molecule level | Science www.science.org/doi/10.1126/...
A subcellular map of translational machinery composition and regulation at the single-molecule level
Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...
www.science.org
March 7, 2025 at 4:28 PM
@science.org A subcellular map of translational machinery composition and regulation at the single-molecule level | Science www.science.org/doi/10.1126/...
Reposted by José Díaz Maldonado
I am excited to finally be able to share with you our work reporting the first Extracellular Vesicle with a personality! This video does not show a cell, it is a Blebbisome! #CellBiology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 21, 2025 at 12:59 PM
I am excited to finally be able to share with you our work reporting the first Extracellular Vesicle with a personality! This video does not show a cell, it is a Blebbisome! #CellBiology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by José Díaz Maldonado
Cancer cells can poison attacking immune cells by filling them with defective mitochondria ― dampening the body’s defensive forces and helping the tumour to evade eradication
https://go.nature.com/42qye6G
https://go.nature.com/42qye6G
Cancer cells ‘poison’ the immune system with tainted mitochondria
Immune cells lose their cancer-fighting prowess after taking tumours’ organelles on board.
go.nature.com
January 22, 2025 at 5:14 PM
Cancer cells can poison attacking immune cells by filling them with defective mitochondria ― dampening the body’s defensive forces and helping the tumour to evade eradication
https://go.nature.com/42qye6G
https://go.nature.com/42qye6G
Reposted by José Díaz Maldonado
Combining in vivo 2-photon imaging with photoactivatable fluorescent labeling reveals strikingly low rates of mitochondrial dynamics in skeletal muscle
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Combining in vivo 2-photon imaging with photoactivatable fluorescent labeling reveals strikingly low rates of mitochondrial dynamics in skeletal muscle
Mitochondrial dynamics involve two distinct and opposing processes, fusion and fission. Traditionally we assess fusion and fission by snapshots of protein markers at distinct time points or in vitro m...
www.biorxiv.org
December 26, 2024 at 1:40 AM
Combining in vivo 2-photon imaging with photoactivatable fluorescent labeling reveals strikingly low rates of mitochondrial dynamics in skeletal muscle
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by José Díaz Maldonado
Pearling Drives Mitochondrial DNA Nucleoid Distribution https://www.biorxiv.org/content/10.1101/2024.12.21.629917v1
December 22, 2024 at 8:30 PM
Pearling Drives Mitochondrial DNA Nucleoid Distribution https://www.biorxiv.org/content/10.1101/2024.12.21.629917v1
Reposted by José Díaz Maldonado
How to improve memory and cognitive function in aged mice
Fix the mitochondrial EC (excitation-coupling)
@science.org
representing a new potential path for replenishing neuronal energy reserves to counter brain aging
www.science.org/doi/10.1126/...
Fix the mitochondrial EC (excitation-coupling)
@science.org
representing a new potential path for replenishing neuronal energy reserves to counter brain aging
www.science.org/doi/10.1126/...
December 19, 2024 at 10:57 PM
How to improve memory and cognitive function in aged mice
Fix the mitochondrial EC (excitation-coupling)
@science.org
representing a new potential path for replenishing neuronal energy reserves to counter brain aging
www.science.org/doi/10.1126/...
Fix the mitochondrial EC (excitation-coupling)
@science.org
representing a new potential path for replenishing neuronal energy reserves to counter brain aging
www.science.org/doi/10.1126/...
Reposted by José Díaz Maldonado
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance - Nature Chemical Biology
The MBD2c splicing variant of MBD2 that is essential for nuclear transcription translocates to the mitochondria to regulate mitochondrial DNA transcription and respiration and is linked to drug resist...
www.nature.com
November 29, 2024 at 2:32 PM
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by José Díaz Maldonado
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice https://www.biorxiv.org/content/10.1101/2024.11.14.623694v1
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice https://www.biorxiv.org/content/10.1101/2024.11.14.623694v1
Somatic mitochondrial DNA (mtDNA) mutations are heavily implicated as important drivers of ageing an
www.biorxiv.org
November 18, 2024 at 2:33 PM
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice https://www.biorxiv.org/content/10.1101/2024.11.14.623694v1