@qiangguo.bsky.social
We usually learn that centrioles/basal bodies are made of microtubule triplets. But our work on Plasmodium shows its basal body is built from singlets, which then mature into the doublets of a functional cilium. #TEAMTOMO www.nature.com/articles/s41...
A basal body microtubule singlet-to-doublet transition in Plasmodium male gametogenesis - Nature Communications
Yang et al. use cryo-ET and resolve a unique native architecture of microtubule singlet-to-doublet transition in the basal body of Plasmodium. They reveal the key role of δTubulin and ε-Tubulin in thi...
www.nature.com
October 16, 2025 at 8:28 AM
We usually learn that centrioles/basal bodies are made of microtubule triplets. But our work on Plasmodium shows its basal body is built from singlets, which then mature into the doublets of a functional cilium. #TEAMTOMO www.nature.com/articles/s41...
What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...
Translation landscape of stress granules
Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.
www.science.org
October 5, 2025 at 5:22 AM
What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...
Wow, nice story~ This interaction is suprising for me~ Back 2018, after the HTT-HAP40 story, we screened a lot of interactiors of HTT, and none of them really stable enough for structural study. We should try these filamental structuctures as well😀
Cryo-ET visualization of HTT bound to F-actin, highlighted in the yellow square on the left.
On the right, a detailed zoom-in view of the molecular model of the HTT/F-actin complex is shown.
On the right, a detailed zoom-in view of the molecular model of the HTT/F-actin complex is shown.
September 24, 2025 at 1:43 AM
Wow, nice story~ This interaction is suprising for me~ Back 2018, after the HTT-HAP40 story, we screened a lot of interactiors of HTT, and none of them really stable enough for structural study. We should try these filamental structuctures as well😀