Joaquin Pellegrini
@joaquinpellegrini.bsky.social
🇦🇷 Immunologist in 🇨🇵 interested in host-pathogen interaction and cell biology 🧫
Reposted by Joaquin Pellegrini
🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 (2.5y)
🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project!
🔬 Profile: PhD in microbiology
#Postdoc #Microbiology #YersiniaPestis #ResearchJobs
🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project!
🔬 Profile: PhD in microbiology
#Postdoc #Microbiology #YersiniaPestis #ResearchJobs
October 5, 2025 at 3:08 PM
🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 (2.5y)
🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project!
🔬 Profile: PhD in microbiology
#Postdoc #Microbiology #YersiniaPestis #ResearchJobs
🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project!
🔬 Profile: PhD in microbiology
#Postdoc #Microbiology #YersiniaPestis #ResearchJobs
Reposted by Joaquin Pellegrini
💡Our webinars are back!
Don’t miss our session on macrophage metabolism this September 18th at 1:00 PM CET.
Stoyan Ivanov (Research Director; C3M, Nice) and Malvina Seradj (Postdoc; Institute of Cancer Research, London).
🔗 Register here: tinyurl.com/2feve67c
Don’t miss our session on macrophage metabolism this September 18th at 1:00 PM CET.
Stoyan Ivanov (Research Director; C3M, Nice) and Malvina Seradj (Postdoc; Institute of Cancer Research, London).
🔗 Register here: tinyurl.com/2feve67c
August 21, 2025 at 2:54 PM
💡Our webinars are back!
Don’t miss our session on macrophage metabolism this September 18th at 1:00 PM CET.
Stoyan Ivanov (Research Director; C3M, Nice) and Malvina Seradj (Postdoc; Institute of Cancer Research, London).
🔗 Register here: tinyurl.com/2feve67c
Don’t miss our session on macrophage metabolism this September 18th at 1:00 PM CET.
Stoyan Ivanov (Research Director; C3M, Nice) and Malvina Seradj (Postdoc; Institute of Cancer Research, London).
🔗 Register here: tinyurl.com/2feve67c
Over the last months I've been preparing important presentations. No matter the outcome, I'm very pleased to find many people willing to help and collaborate 🙏🙏 This is the way to build a strong scientific community
June 10, 2025 at 6:34 AM
Over the last months I've been preparing important presentations. No matter the outcome, I'm very pleased to find many people willing to help and collaborate 🙏🙏 This is the way to build a strong scientific community
New in The Journal of Immunology !📢
Neutrophils from tuberculosis patients are polarized toward pro-inflammatory and anti-inflammatory phenotypes according to the disease severity
👉
academic.oup.com/jimmunol/adv...
Neutrophils from tuberculosis patients are polarized toward pro-inflammatory and anti-inflammatory phenotypes according to the disease severity
👉
academic.oup.com/jimmunol/adv...
Neutrophils from tuberculosis patients are polarized toward pro-inflammatory and anti-inflammatory phenotypes according to the disease severity
Abstract. Neutrophils are the first line of defense against pathogens, combating them by using several antimicrobial mechanisms. These cells display a rema
academic.oup.com
April 25, 2025 at 4:41 PM
New in The Journal of Immunology !📢
Neutrophils from tuberculosis patients are polarized toward pro-inflammatory and anti-inflammatory phenotypes according to the disease severity
👉
academic.oup.com/jimmunol/adv...
Neutrophils from tuberculosis patients are polarized toward pro-inflammatory and anti-inflammatory phenotypes according to the disease severity
👉
academic.oup.com/jimmunol/adv...
Reposted by Joaquin Pellegrini
pDCs and antibacterial response? Check out this paper ⬇️
Congratulations @joaquinpellegrini.bsky.social and all the authors involved! @ciml.bsky.social
Congratulations @joaquinpellegrini.bsky.social and all the authors involved! @ciml.bsky.social
The group of Jean-Pierre Gorvel @ciml.bsky.social identify in @jclinical-invest.bsky.social novel roles of SLAMF7 and SLAMF8 in finely tuning human plasmacytoid DC responses to intracellular bacterial infections.
www.jci.org/articles/vie...
www.jci.org/articles/vie...
April 17, 2025 at 1:35 PM
pDCs and antibacterial response? Check out this paper ⬇️
Congratulations @joaquinpellegrini.bsky.social and all the authors involved! @ciml.bsky.social
Congratulations @joaquinpellegrini.bsky.social and all the authors involved! @ciml.bsky.social
Reposted by Joaquin Pellegrini
In a study led by Jean-Pierre Gorvel and Sylvie Mémet, CIML researchers found that SLAMF receptors shape human plasmacytoid dendritic cell responses to intracellular bacteria. Congrats to 1st author Joaquin Pellegrini and collaborators.
www.jci.org/articles/vie...
@jclinical-invest.bsky.social
www.jci.org/articles/vie...
@jclinical-invest.bsky.social
April 16, 2025 at 10:03 AM
In a study led by Jean-Pierre Gorvel and Sylvie Mémet, CIML researchers found that SLAMF receptors shape human plasmacytoid dendritic cell responses to intracellular bacteria. Congrats to 1st author Joaquin Pellegrini and collaborators.
www.jci.org/articles/vie...
@jclinical-invest.bsky.social
www.jci.org/articles/vie...
@jclinical-invest.bsky.social
Proud to share our work! 🧫😍
A special one!
Using Salmonella and Brucella, this study provides the first demonstration of an antibacterial response in pDCs orchestrated by SLAMF7 and SLAMF8, driving cytokine responses and favoring bacterial survival via mtROS control.
www.jci.org/articles/vie...
A special one!
Using Salmonella and Brucella, this study provides the first demonstration of an antibacterial response in pDCs orchestrated by SLAMF7 and SLAMF8, driving cytokine responses and favoring bacterial survival via mtROS control.
www.jci.org/articles/vie...
April 16, 2025 at 7:36 AM
Proud to share our work! 🧫😍
A special one!
Using Salmonella and Brucella, this study provides the first demonstration of an antibacterial response in pDCs orchestrated by SLAMF7 and SLAMF8, driving cytokine responses and favoring bacterial survival via mtROS control.
www.jci.org/articles/vie...
A special one!
Using Salmonella and Brucella, this study provides the first demonstration of an antibacterial response in pDCs orchestrated by SLAMF7 and SLAMF8, driving cytokine responses and favoring bacterial survival via mtROS control.
www.jci.org/articles/vie...
Reposted by Joaquin Pellegrini
April 8, 2025 at 3:54 PM
Reposted by Joaquin Pellegrini
🚨 Groundbreaking study reveals how hypoxia shapes immune cell organization in #Tuberculosis granulomas, promoting Mtb persistence. Targeting these metabolic niches could revolutionize TB treatment strategies. A technical tour de force and a major scientific advance!
📖 shorturl.at/WkTgq
📖 shorturl.at/WkTgq
February 24, 2025 at 6:38 AM
🚨 Groundbreaking study reveals how hypoxia shapes immune cell organization in #Tuberculosis granulomas, promoting Mtb persistence. Targeting these metabolic niches could revolutionize TB treatment strategies. A technical tour de force and a major scientific advance!
📖 shorturl.at/WkTgq
📖 shorturl.at/WkTgq
Join us today!
📢 The next FCYI webinar on Intestinal Immunology is happening on 🗓️ Thursday, Feb 6th at 5 PM on Zoom 👩💻
Speakers:
🎙️ Julien Mambu (Postdoctoral researcher, CIML, Marseille)
🎙️ Valentin Thevin (Postdoctoral researcher, Department for Biomedical Research, Bern)
➤ Register here: tinyurl.com/2ma5d7tv
February 6, 2025 at 7:06 AM
Join us today!
Reposted by Joaquin Pellegrini
📢 The next FCYI webinar on Intestinal Immunology is happening on 🗓️ Thursday, Feb 6th at 5 PM on Zoom 👩💻
Speakers:
🎙️ Julien Mambu (Postdoctoral researcher, CIML, Marseille)
🎙️ Valentin Thevin (Postdoctoral researcher, Department for Biomedical Research, Bern)
➤ Register here: tinyurl.com/2ma5d7tv
January 22, 2025 at 3:30 PM
📢 The next FCYI webinar on Intestinal Immunology is happening on 🗓️ Thursday, Feb 6th at 5 PM on Zoom 👩💻
Speakers:
🎙️ Julien Mambu (Postdoctoral researcher, CIML, Marseille)
🎙️ Valentin Thevin (Postdoctoral researcher, Department for Biomedical Research, Bern)
➤ Register here: tinyurl.com/2ma5d7tv
The French Club of Young Immunologists is now in BlueSky!
Under the aegis of the French Society for Immunology, it aims to bring together young scientists of French nationality or working in France in the field of immunology 💉🇨🇵🧫
@fcyimmuno.bsky.social
Follow the new account!
Under the aegis of the French Society for Immunology, it aims to bring together young scientists of French nationality or working in France in the field of immunology 💉🇨🇵🧫
@fcyimmuno.bsky.social
Follow the new account!
February 5, 2025 at 5:10 PM
The French Club of Young Immunologists is now in BlueSky!
Under the aegis of the French Society for Immunology, it aims to bring together young scientists of French nationality or working in France in the field of immunology 💉🇨🇵🧫
@fcyimmuno.bsky.social
Follow the new account!
Under the aegis of the French Society for Immunology, it aims to bring together young scientists of French nationality or working in France in the field of immunology 💉🇨🇵🧫
@fcyimmuno.bsky.social
Follow the new account!
Reposted by Joaquin Pellegrini
Registration is live!! May 30th deadline for #EMBOTissueImmunity in Basel🇨🇭 (home to Eurocup 2025, Eurovision 2025, Art Basel, world renowned architecture and muuuuuch more!) Be our guest for groundbreaking #immunology discussion, swimming & fun along the Rhine.
meetings.embo.org/event/25-bar...
meetings.embo.org/event/25-bar...
December 19, 2024 at 1:59 PM
Registration is live!! May 30th deadline for #EMBOTissueImmunity in Basel🇨🇭 (home to Eurocup 2025, Eurovision 2025, Art Basel, world renowned architecture and muuuuuch more!) Be our guest for groundbreaking #immunology discussion, swimming & fun along the Rhine.
meetings.embo.org/event/25-bar...
meetings.embo.org/event/25-bar...
Reposted by Joaquin Pellegrini
In a study led by Sylvie Mémet and Jean-Pierre Gorvel, CIML researchers identified a new pathway by which Brucella abortus escapes host immune responses in the visceral fat. Congrats to 1st authors Joaquin Pellegrini, Gabriela González and all collaborators. Check the study: @naturecomms.bsky.social
Brucella abortus impairs T lymphocyte responsiveness by mobilizing IL-1RA-secreting omental neutrophils - Nature Communications
In this study, authors identify the omentum, a tertiary lymphoid organ part of the fat tissue, as a reservoir for Brucella abortus, which promotes bacterial persistence and causes CD4+ and CD8+ T cell...
www.nature.com
January 23, 2025 at 12:48 PM
In a study led by Sylvie Mémet and Jean-Pierre Gorvel, CIML researchers identified a new pathway by which Brucella abortus escapes host immune responses in the visceral fat. Congrats to 1st authors Joaquin Pellegrini, Gabriela González and all collaborators. Check the study: @naturecomms.bsky.social
They're back!
Join us for the next FCYI immuno webinar. Excellent talks for granted!
Join us for the next FCYI immuno webinar. Excellent talks for granted!
January 21, 2025 at 6:38 PM
They're back!
Join us for the next FCYI immuno webinar. Excellent talks for granted!
Join us for the next FCYI immuno webinar. Excellent talks for granted!
Reposted by Joaquin Pellegrini
The omentum, a reservoir for B. abortus, promotes bacterial persistence and causes CD4+ and CD8+ T cell immunosuppression by IL-1RA secreted by PD-L1+Sca-1+ neutrophils
nature.com/articles/s41...
@naturecomms.bsky.social @joaquinpellegrini.bsky.social
nature.com/articles/s41...
@naturecomms.bsky.social @joaquinpellegrini.bsky.social
Brucella abortus impairs T lymphocyte responsiveness by mobilizing IL-1RA-secreting omental neutrophils - Nature Communications
In this study, authors identify the omentum, a tertiary lymphoid organ part of the fat tissue, as a reservoir for Brucella abortus, which promotes bacterial persistence and causes CD4+ and CD8+ T cell...
nature.com
January 21, 2025 at 5:45 PM
The omentum, a reservoir for B. abortus, promotes bacterial persistence and causes CD4+ and CD8+ T cell immunosuppression by IL-1RA secreted by PD-L1+Sca-1+ neutrophils
nature.com/articles/s41...
@naturecomms.bsky.social @joaquinpellegrini.bsky.social
nature.com/articles/s41...
@naturecomms.bsky.social @joaquinpellegrini.bsky.social
I'm very glad to share our last work, now online:
The omentum, a new reservoir for B. abortus, promotes bacterial persistence and causes CD4+ and CD8+ T cell immunosuppression by IL-1RA secreted by PD-L1+Sca-1+ neutrophils.
www.nature.com/articles/s41... @ciml.bsky.social
The omentum, a new reservoir for B. abortus, promotes bacterial persistence and causes CD4+ and CD8+ T cell immunosuppression by IL-1RA secreted by PD-L1+Sca-1+ neutrophils.
www.nature.com/articles/s41... @ciml.bsky.social
Brucella abortus impairs T lymphocyte responsiveness by mobilizing IL-1RA-secreting omental neutrophils - Nature Communications
In this study, authors identify the omentum, a tertiary lymphoid organ part of the fat tissue, as a reservoir for Brucella abortus, which promotes bacterial persistence and causes CD4+ and CD8+ T cell...
www.nature.com
January 21, 2025 at 6:29 PM
I'm very glad to share our last work, now online:
The omentum, a new reservoir for B. abortus, promotes bacterial persistence and causes CD4+ and CD8+ T cell immunosuppression by IL-1RA secreted by PD-L1+Sca-1+ neutrophils.
www.nature.com/articles/s41... @ciml.bsky.social
The omentum, a new reservoir for B. abortus, promotes bacterial persistence and causes CD4+ and CD8+ T cell immunosuppression by IL-1RA secreted by PD-L1+Sca-1+ neutrophils.
www.nature.com/articles/s41... @ciml.bsky.social
Reposted by Joaquin Pellegrini
Pertussis is awful even if you’re not at high risk, but it literally kills and disables babies. The vaccines are not perfect, but keeping up to date and getting boosted in pregnancy is critical.
Your vaccination also protects the lives of babies under 1 who cannot be fully immunized. 10% of adults in NZ’s outbreak vs 2/3 of babies have had to be hospitalized.
Pertussis can make small children stop breathing and even a “mild” case in an adult can mean months of coughing so severe ribs break
Pertussis can make small children stop breathing and even a “mild” case in an adult can mean months of coughing so severe ribs break
New Zealand: Baby with whooping cough dies over holiday period www.rnz.co.nz/news/nationa...
January 21, 2025 at 5:55 AM
Pertussis is awful even if you’re not at high risk, but it literally kills and disables babies. The vaccines are not perfect, but keeping up to date and getting boosted in pregnancy is critical.
Reposted by Joaquin Pellegrini
Insights: Nikhil Jiwrajka & @montserrat-anguera.bsky.social discuss study of plasmacytoid dendritic cells from #SystemicSclerosis patients by Du et al. (https://buff.ly/3Cf8uQ8) that suggests the X chromosome plays a key role in the sex bias of this autoimmune disease. https://buff.ly/4jnpjc2
January 17, 2025 at 6:16 PM
Insights: Nikhil Jiwrajka & @montserrat-anguera.bsky.social discuss study of plasmacytoid dendritic cells from #SystemicSclerosis patients by Du et al. (https://buff.ly/3Cf8uQ8) that suggests the X chromosome plays a key role in the sex bias of this autoimmune disease. https://buff.ly/4jnpjc2
Reposted by Joaquin Pellegrini
Happy to share our latest @biorxiv-plants.bsky.social led by @manuelgonzalezfuen.bsky.social “Effector-triggered processing body formation attenuates host translation via ER stress responses and autophagy upon bacterial infection” #proteostasis #plantimmunity 🧵(1/16)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 14, 2025 at 4:35 PM
Happy to share our latest @biorxiv-plants.bsky.social led by @manuelgonzalezfuen.bsky.social “Effector-triggered processing body formation attenuates host translation via ER stress responses and autophagy upon bacterial infection” #proteostasis #plantimmunity 🧵(1/16)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Representing the @FCYImmuno at the 27th congress of the French Cytometry Association (AFC🇨🇵) in Marseille. Excellent talks this morning during the Young Scientists session.
December 18, 2024 at 4:31 PM
Representing the @FCYImmuno at the 27th congress of the French Cytometry Association (AFC🇨🇵) in Marseille. Excellent talks this morning during the Young Scientists session.
Reposted by Joaquin Pellegrini
Undernutrition is a key driver of TB accounting for 1/5 cases, but relationship is poorly understood. New sys review of this based on 42 studies (>26 million people) by Matt Saunders et al:
papers.ssrn.com/sol3/papers....
@reinhouben.bsky.social
@raclark18.bsky.social
@lshtm-tbmod.bsky.social
papers.ssrn.com/sol3/papers....
@reinhouben.bsky.social
@raclark18.bsky.social
@lshtm-tbmod.bsky.social
Tuberculosis Incidence and Body Mass Index – An Updated Systematic Literature Review and Global Analysis
Background: Undernutrition is the leading population-level determinant of tuberculosis, but the relationship between tuberculosis and nutritional status remains
papers.ssrn.com
December 11, 2024 at 9:14 AM
Undernutrition is a key driver of TB accounting for 1/5 cases, but relationship is poorly understood. New sys review of this based on 42 studies (>26 million people) by Matt Saunders et al:
papers.ssrn.com/sol3/papers....
@reinhouben.bsky.social
@raclark18.bsky.social
@lshtm-tbmod.bsky.social
papers.ssrn.com/sol3/papers....
@reinhouben.bsky.social
@raclark18.bsky.social
@lshtm-tbmod.bsky.social
Antibiotic treatment of pregnant mice reduces the amount of breast milk antibodies (sIgA) and alters the neonatal fecal microbiota, making neonatal mice more susceptible to sepsis
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Prenatal antibiotics reduce breast milk IgA and induce dysbiosis in mouse offspring, increasing neonatal susceptibility to bacterial sepsis
Up to one-third of women receive antibiotics during pregnancy. Pietrasanta et al.
show that antibiotic treatment of pregnant mice reduces the amount of breast milk
antibodies (SIgA) and alters the neo...
www.cell.com
November 26, 2024 at 8:42 PM
Antibiotic treatment of pregnant mice reduces the amount of breast milk antibodies (sIgA) and alters the neonatal fecal microbiota, making neonatal mice more susceptible to sepsis
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Reposted by Joaquin Pellegrini
On this World Antimicrobial Awareness Week, vaccines are a vital tool in the fight against antimicrobial resistance (AMR).
Let’s #Educate on their role in reducing antibiotic use, #Advocate for wider access, and #Act by supporting global immunisation efforts.
Learn more: bit.ly/4eBegZa
Let’s #Educate on their role in reducing antibiotic use, #Advocate for wider access, and #Act by supporting global immunisation efforts.
Learn more: bit.ly/4eBegZa
How do vaccines prevent AMR?
bit.ly
November 18, 2024 at 4:13 PM
On this World Antimicrobial Awareness Week, vaccines are a vital tool in the fight against antimicrobial resistance (AMR).
Let’s #Educate on their role in reducing antibiotic use, #Advocate for wider access, and #Act by supporting global immunisation efforts.
Learn more: bit.ly/4eBegZa
Let’s #Educate on their role in reducing antibiotic use, #Advocate for wider access, and #Act by supporting global immunisation efforts.
Learn more: bit.ly/4eBegZa
Reposted by Joaquin Pellegrini
Recent paper (Nature)-why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? X/Y or hormones? We study adaptation of immune systems in gender-affirming testosterone treatment: nature.com/articles/s41...
Immune system adaptation during gender-affirming testosterone treatment - Nature
Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses...
nature.com
November 17, 2024 at 6:57 AM
Recent paper (Nature)-why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? X/Y or hormones? We study adaptation of immune systems in gender-affirming testosterone treatment: nature.com/articles/s41...