Centre d'Immunologie de Marseille Luminy
@ciml.bsky.social
The Centre d’Immunologie de Marseille-Luminy is all about Immunology in every aspect. CNRS UMR7280, Inserm U1104, AMU UNIV UM2
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Welcome to the BlueSky account of the Centre d’Immunologie de Marseille-Luminy (CIML). 🌟 Founded in 1976, we’re one of Europe’s largest and most prestigious immunology research centers, located in the heart of the Calanques National Park. 🏞️
For the first time, we hosted a CNRS Unusual Visits event: 290 applications → 24 visitors→ A tremendous enthusiasm!! Highlights included immune system talks & hands-on workshops on skin, cholesterol, IgE, and DNA extraction.
October 10, 2025 at 4:10 PM
For the first time, we hosted a CNRS Unusual Visits event: 290 applications → 24 visitors→ A tremendous enthusiasm!! Highlights included immune system talks & hands-on workshops on skin, cholesterol, IgE, and DNA extraction.
🔬 A look back at the 2025 Science Festival in CIML!
On Thursday 9 October, we had the pleasure of opening the doors of our laboratories to middle and high school students as part of the 2025 Science Festival. A day rich in discoveries and exchanges! #FêteDeLaScience #FDS2025
On Thursday 9 October, we had the pleasure of opening the doors of our laboratories to middle and high school students as part of the 2025 Science Festival. A day rich in discoveries and exchanges! #FêteDeLaScience #FDS2025
October 10, 2025 at 4:06 PM
🔬 A look back at the 2025 Science Festival in CIML!
On Thursday 9 October, we had the pleasure of opening the doors of our laboratories to middle and high school students as part of the 2025 Science Festival. A day rich in discoveries and exchanges! #FêteDeLaScience #FDS2025
On Thursday 9 October, we had the pleasure of opening the doors of our laboratories to middle and high school students as part of the 2025 Science Festival. A day rich in discoveries and exchanges! #FêteDeLaScience #FDS2025
🔬 The CIML is proud to be an academic partner of the 11th edition of #MiFoBio2025, the Functional Microscopy in Biology school organized by @gdrimabio.bsky.social taking place from October 10–17, 2025.
The CIML Imaging Platform and researchers will be sharing our expertise in immune system imaging.
The CIML Imaging Platform and researchers will be sharing our expertise in immune system imaging.
October 10, 2025 at 12:47 PM
🔬 The CIML is proud to be an academic partner of the 11th edition of #MiFoBio2025, the Functional Microscopy in Biology school organized by @gdrimabio.bsky.social taking place from October 10–17, 2025.
The CIML Imaging Platform and researchers will be sharing our expertise in immune system imaging.
The CIML Imaging Platform and researchers will be sharing our expertise in immune system imaging.
A new study led by Sandrine Henri is out now in OncoImmunology. Authors characterized the prostate's immune landscape in healthy inidviduals and during cancer progression. Congratulations to 1st author Despoina Pervizou and all collaborators.
Characterization of the immune landscape in healthy mouse prostate and during prostate cancer progression
The immune landscape of healthy prostate and its alterations during prostate cancer (PCa) progression remain poorly characterized. Using scRNA-sequencing and multiparametric flow-cytometry analysis...
www.tandfonline.com
October 2, 2025 at 10:06 AM
A new study led by Sandrine Henri is out now in OncoImmunology. Authors characterized the prostate's immune landscape in healthy inidviduals and during cancer progression. Congratulations to 1st author Despoina Pervizou and all collaborators.
A new study led by Elena Tomasello & Marc Dalod is out now in @natimmunol.nature.com. Through the generation of a novel system lacking plasmacytoid DCs, authors show that pDCs are dispensable or deleterious in respiratory viral infections. Congrats to 1st author Clemence Ngo and all collaborators!
Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections - Nature Immunology
Previous research has suggested that pDCs are required for an effective antiviral immune response, but direct experimental evidence to support this is lacking. Here Ngo et al. develop a pDC knockin mouse model and find that pDCs are dispensable for an antiviral immune response to mouse cytomegalovirus and may be detrimental during influenza or SARS-CoV-2 infection.
www.nature.com
October 2, 2025 at 9:54 AM
A new study led by Elena Tomasello & Marc Dalod is out now in @natimmunol.nature.com. Through the generation of a novel system lacking plasmacytoid DCs, authors show that pDCs are dispensable or deleterious in respiratory viral infections. Congrats to 1st author Clemence Ngo and all collaborators!
Today we had the great honor to welcome Dr Michela Locci from the University of Pennsylvania in our CIML seminar series.
Michela gave an outstanding seminar entitled "Defense decoded: how mRNA vaccines train germinal center responses" and had great exchange with CIML scientists.
Michela gave an outstanding seminar entitled "Defense decoded: how mRNA vaccines train germinal center responses" and had great exchange with CIML scientists.
October 2, 2025 at 9:40 AM
Today we had the great honor to welcome Dr Michela Locci from the University of Pennsylvania in our CIML seminar series.
Michela gave an outstanding seminar entitled "Defense decoded: how mRNA vaccines train germinal center responses" and had great exchange with CIML scientists.
Michela gave an outstanding seminar entitled "Defense decoded: how mRNA vaccines train germinal center responses" and had great exchange with CIML scientists.
It was a pleasure to have Ang Cui presenting her work at CIML.
Ang Cui, from @harvardmed.bsky.social
, invited by @ciml.bsky.social and CENTURI is now holding her talk "Dictionary of immune responses to cytokines at single-celle resolution"!
, invited by @ciml.bsky.social and CENTURI is now holding her talk "Dictionary of immune responses to cytokines at single-celle resolution"!
September 26, 2025 at 12:08 PM
It was a pleasure to have Ang Cui presenting her work at CIML.
Today we had the great honor to welcome Dr Florent Ginhoux from Gustave Roussy Institute in our CIML seminar series.
Florent gave an outstanding seminar entitled "Harnessing Tumor Macrophage Heterogeneity" and had great exchange with CIML scientists.
Florent gave an outstanding seminar entitled "Harnessing Tumor Macrophage Heterogeneity" and had great exchange with CIML scientists.
September 25, 2025 at 9:40 AM
Today we had the great honor to welcome Dr Florent Ginhoux from Gustave Roussy Institute in our CIML seminar series.
Florent gave an outstanding seminar entitled "Harnessing Tumor Macrophage Heterogeneity" and had great exchange with CIML scientists.
Florent gave an outstanding seminar entitled "Harnessing Tumor Macrophage Heterogeneity" and had great exchange with CIML scientists.
Today we had the great honor to welcome Dr Megan MacLeod from the University of Glasgow School of Infection and Immunity.
Megan gave a great talk on"Different faces of immune memory in the lung following influenza virus infection" and had great exchange with CIML scientists. Thanks for visiting us!
Megan gave a great talk on"Different faces of immune memory in the lung following influenza virus infection" and had great exchange with CIML scientists. Thanks for visiting us!
September 10, 2025 at 9:58 AM
Today we had the great honor to welcome Dr Megan MacLeod from the University of Glasgow School of Infection and Immunity.
Megan gave a great talk on"Different faces of immune memory in the lung following influenza virus infection" and had great exchange with CIML scientists. Thanks for visiting us!
Megan gave a great talk on"Different faces of immune memory in the lung following influenza virus infection" and had great exchange with CIML scientists. Thanks for visiting us!
Today we had the great honor to welcome Dr Ed Roberts from the Cancer Research UK-Scotland Institute @cruk-si.bsky.social.
Ed gave a great talk on"Time dependent impact of viral infection on lung tumour development" and had great exchange with CIML scientists. Thanks Ed for visiting us!
Ed gave a great talk on"Time dependent impact of viral infection on lung tumour development" and had great exchange with CIML scientists. Thanks Ed for visiting us!
September 5, 2025 at 9:43 AM
Today we had the great honor to welcome Dr Ed Roberts from the Cancer Research UK-Scotland Institute @cruk-si.bsky.social.
Ed gave a great talk on"Time dependent impact of viral infection on lung tumour development" and had great exchange with CIML scientists. Thanks Ed for visiting us!
Ed gave a great talk on"Time dependent impact of viral infection on lung tumour development" and had great exchange with CIML scientists. Thanks Ed for visiting us!
Today we had the great honor to welcome Dr Francesca Granucci from the University of Milano-Bicocca in our CIML seminar series.
Francesca gave an outstanding seminar entitled "Microbial adhesion promotes mechanotransduction to initiate innate immunity" and had great exchange with CIML scientists.
Francesca gave an outstanding seminar entitled "Microbial adhesion promotes mechanotransduction to initiate innate immunity" and had great exchange with CIML scientists.
September 4, 2025 at 9:44 AM
Today we had the great honor to welcome Dr Francesca Granucci from the University of Milano-Bicocca in our CIML seminar series.
Francesca gave an outstanding seminar entitled "Microbial adhesion promotes mechanotransduction to initiate innate immunity" and had great exchange with CIML scientists.
Francesca gave an outstanding seminar entitled "Microbial adhesion promotes mechanotransduction to initiate innate immunity" and had great exchange with CIML scientists.
🗞️ La Provence newspaper dedicated an article to Réjane Rua's work and career on August 6th, highlighting her expertise and remarkable studies at CIML. Check here:
À Marseille, la scientifique Réjane Rua rêve de faire avancer la recherche contre Alzheimer
À Marseille, la scientifique Réjane Rua rêve de faire avancer la recherche contre Alzheimer
www.laprovence.com
August 14, 2025 at 11:49 AM
🗞️ La Provence newspaper dedicated an article to Réjane Rua's work and career on August 6th, highlighting her expertise and remarkable studies at CIML. Check here:
Big congratulations to Achille Broggi @achillebro.bsky.social, team leader at CIML, who has been awarded the 2025 CNRS Bronze Medal! This distinction honors his research on innate immunity, particularly his discoveries on the role of interferons in tissue protection and repair.
August 5, 2025 at 9:02 AM
Big congratulations to Achille Broggi @achillebro.bsky.social, team leader at CIML, who has been awarded the 2025 CNRS Bronze Medal! This distinction honors his research on innate immunity, particularly his discoveries on the role of interferons in tissue protection and repair.
The CIML mourns the loss of its founding father, Michel Fougereau. In 1976, he founded our institute to bring immunology researchers in France together on one site.
Generations of immunologists were shaped by what he built. His legacy lives on in the curiosity and collaboration that define CIML.
Generations of immunologists were shaped by what he built. His legacy lives on in the curiosity and collaboration that define CIML.
August 5, 2025 at 8:25 AM
The CIML mourns the loss of its founding father, Michel Fougereau. In 1976, he founded our institute to bring immunology researchers in France together on one site.
Generations of immunologists were shaped by what he built. His legacy lives on in the curiosity and collaboration that define CIML.
Generations of immunologists were shaped by what he built. His legacy lives on in the curiosity and collaboration that define CIML.
Last week we had the great honor to welcome Dr Maria Rescigno from Humanitas Research Hospital in our 2025 CIML seminar series.
Maria gave an outstanding seminar on "The microbiota in pregnancy outcome and risk of sepsis in the newborn" and had lots of great exchange with CIML scientists.
Maria gave an outstanding seminar on "The microbiota in pregnancy outcome and risk of sepsis in the newborn" and had lots of great exchange with CIML scientists.
July 16, 2025 at 1:34 PM
Last week we had the great honor to welcome Dr Maria Rescigno from Humanitas Research Hospital in our 2025 CIML seminar series.
Maria gave an outstanding seminar on "The microbiota in pregnancy outcome and risk of sepsis in the newborn" and had lots of great exchange with CIML scientists.
Maria gave an outstanding seminar on "The microbiota in pregnancy outcome and risk of sepsis in the newborn" and had lots of great exchange with CIML scientists.
Last week we had the great honor to welcome Dr Nuria Martínez-Martín from Severo Ochoa Molecular Biology Centre in our 2025 CIML seminar series.
Nuria gave a brillant seminar on "Mitochondria as Gatekeepers of B Cell Function: Internal Regulators and External Gifts"
Thanks Nuria for visiting !
Nuria gave a brillant seminar on "Mitochondria as Gatekeepers of B Cell Function: Internal Regulators and External Gifts"
Thanks Nuria for visiting !
July 9, 2025 at 9:07 AM
Last week we had the great honor to welcome Dr Nuria Martínez-Martín from Severo Ochoa Molecular Biology Centre in our 2025 CIML seminar series.
Nuria gave a brillant seminar on "Mitochondria as Gatekeepers of B Cell Function: Internal Regulators and External Gifts"
Thanks Nuria for visiting !
Nuria gave a brillant seminar on "Mitochondria as Gatekeepers of B Cell Function: Internal Regulators and External Gifts"
Thanks Nuria for visiting !
Yesterday, we had the pleasure to welcome Dr. Vera Pancaldi from Centre de Recherche en Cancérologie de Toulouse in our CIML seminar series.
Vera gave a brillant seminar on "Data-driven mathematical models for simulating the tumour microenvironment"
Thanks for visiting @verapancaldi.bsky.social !
Vera gave a brillant seminar on "Data-driven mathematical models for simulating the tumour microenvironment"
Thanks for visiting @verapancaldi.bsky.social !
June 27, 2025 at 6:29 PM
Yesterday, we had the pleasure to welcome Dr. Vera Pancaldi from Centre de Recherche en Cancérologie de Toulouse in our CIML seminar series.
Vera gave a brillant seminar on "Data-driven mathematical models for simulating the tumour microenvironment"
Thanks for visiting @verapancaldi.bsky.social !
Vera gave a brillant seminar on "Data-driven mathematical models for simulating the tumour microenvironment"
Thanks for visiting @verapancaldi.bsky.social !
Last week we had the great honor to welcome Pr. Ping-Chih Ho from University of Lausanne and Ludwig Cancer Research in our 2025 CIML seminar series.
Ping-Chih gave a brillant seminar on "Mitochondria-tailored T cell dysfunction and opportunity for cancer immunotherapy"
Thanks for visiting !
Ping-Chih gave a brillant seminar on "Mitochondria-tailored T cell dysfunction and opportunity for cancer immunotherapy"
Thanks for visiting !
June 27, 2025 at 6:25 PM
Last week we had the great honor to welcome Pr. Ping-Chih Ho from University of Lausanne and Ludwig Cancer Research in our 2025 CIML seminar series.
Ping-Chih gave a brillant seminar on "Mitochondria-tailored T cell dysfunction and opportunity for cancer immunotherapy"
Thanks for visiting !
Ping-Chih gave a brillant seminar on "Mitochondria-tailored T cell dysfunction and opportunity for cancer immunotherapy"
Thanks for visiting !
Last week we had the great honor to welcome Pr. Tal Arnon from University of Oxford in our 2025 CIML seminar series.
Tal gave an outstanding seminar on "Humoral immunity in the infected lung" and had lots of great exchange with CIML scientists.
Thanks for visiting !
Tal gave an outstanding seminar on "Humoral immunity in the infected lung" and had lots of great exchange with CIML scientists.
Thanks for visiting !
June 18, 2025 at 4:33 PM
Last week we had the great honor to welcome Pr. Tal Arnon from University of Oxford in our 2025 CIML seminar series.
Tal gave an outstanding seminar on "Humoral immunity in the infected lung" and had lots of great exchange with CIML scientists.
Thanks for visiting !
Tal gave an outstanding seminar on "Humoral immunity in the infected lung" and had lots of great exchange with CIML scientists.
Thanks for visiting !
Check this last paper from the Malissen's lab👇. A gain-of-function CARMIL2 variant can substitute for CD28 costimulation, enabling T cells to bypass PD-1 and CTLA-4 checkpoints. This discovery revisits the architecture of the CD28 costimulatory pathway and opens avenues for next-gen immunotherapies.
Zhang, Celis-Gutierrez, Malissen, Malissen et al. @ciml.bsky.social demonstrate that the expression of a mutated CARMIL2 protein in CD28-deficient mice induces most of the developmental and functional consequences known to result from CD28 costimulation rupress.org/jem/article/...
May 27, 2025 at 1:41 PM
Check this last paper from the Malissen's lab👇. A gain-of-function CARMIL2 variant can substitute for CD28 costimulation, enabling T cells to bypass PD-1 and CTLA-4 checkpoints. This discovery revisits the architecture of the CD28 costimulatory pathway and opens avenues for next-gen immunotherapies.
🦠 Check the last study from the team of Philippe Pierre in PNAS @pnas.org. The authors show how a bacterial toxin can hijack our cells’ stress response to trigger immune signals linked to inflammation and infection. Congratulations to all authors!
Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation | PNAS
We demonstrate that exposure to the AB5 subtilase cytotoxin (SubAB) induces the unfolded
protein response (UPR) in human peripheral blood mononucle...
www.pnas.org
May 20, 2025 at 2:05 PM
🦠 Check the last study from the team of Philippe Pierre in PNAS @pnas.org. The authors show how a bacterial toxin can hijack our cells’ stress response to trigger immune signals linked to inflammation and infection. Congratulations to all authors!
Last week we had the great honor to welcome Dr. Eliane Piaggio from Institut Curie in our 2025 CIML seminar series.
Eliane gave an interesting seminar on "Single-Cell Treg Profiling: New Cancer Therapies and Insights into Tumor-Treg Biology" and had great exchanges with CIML scientists.
Eliane gave an interesting seminar on "Single-Cell Treg Profiling: New Cancer Therapies and Insights into Tumor-Treg Biology" and had great exchanges with CIML scientists.
May 19, 2025 at 5:47 PM
Last week we had the great honor to welcome Dr. Eliane Piaggio from Institut Curie in our 2025 CIML seminar series.
Eliane gave an interesting seminar on "Single-Cell Treg Profiling: New Cancer Therapies and Insights into Tumor-Treg Biology" and had great exchanges with CIML scientists.
Eliane gave an interesting seminar on "Single-Cell Treg Profiling: New Cancer Therapies and Insights into Tumor-Treg Biology" and had great exchanges with CIML scientists.
🧠🦠 Check this Review written by the team of Sophie Ugolini @ugolinis.bsky.social on how sensory neurons modulate immune responses. Just out in Immunity @cp-immunity.bsky.social.
Role of specialized sensory neuron subtypes in modulating peripheral immune responses
The immune and sensory nervous systems work in concert to defend against threats and
maintain homeostasis. In this issue of Immunity, Ugolini and colleagues review how
immune signals activate speciali...
www.cell.com
May 5, 2025 at 8:15 AM
🧠🦠 Check this Review written by the team of Sophie Ugolini @ugolinis.bsky.social on how sensory neurons modulate immune responses. Just out in Immunity @cp-immunity.bsky.social.
🔬 🦠 Check this great scientific meeting organized by Carolyn King and CIML's team leader Mauro Gaya.
@immunologyking.bsky.social
@maurogaya.bsky.social
@immunologyking.bsky.social
@maurogaya.bsky.social
🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
Adaptive immunity in barrier tissues
Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…
meetings.embo.org
April 30, 2025 at 3:07 PM
🔬 🦠 Check this great scientific meeting organized by Carolyn King and CIML's team leader Mauro Gaya.
@immunologyking.bsky.social
@maurogaya.bsky.social
@immunologyking.bsky.social
@maurogaya.bsky.social
🧠🛡️ CIML celebrates the International Day of Immunology 2025: When Brain Meets Immunity.
This year, we spotlight two Inserm researchers whose research is transforming our understanding of how the nervous and immune systems interact, paving the way for new therapies for neurological diseases.
This year, we spotlight two Inserm researchers whose research is transforming our understanding of how the nervous and immune systems interact, paving the way for new therapies for neurological diseases.
April 29, 2025 at 8:19 AM
🧠🛡️ CIML celebrates the International Day of Immunology 2025: When Brain Meets Immunity.
This year, we spotlight two Inserm researchers whose research is transforming our understanding of how the nervous and immune systems interact, paving the way for new therapies for neurological diseases.
This year, we spotlight two Inserm researchers whose research is transforming our understanding of how the nervous and immune systems interact, paving the way for new therapies for neurological diseases.