Petter Brodin
@petterbrodin.bsky.social
Pediatrician &
Professor of Pediatric Immunology
Human Systems Immunology
MRC LMS, Imperial College London
& Karolinska Institutet
Professor of Pediatric Immunology
Human Systems Immunology
MRC LMS, Imperial College London
& Karolinska Institutet
Pinned
Petter Brodin
@petterbrodin.bsky.social
· Nov 17
Immune system adaptation during gender-affirming testosterone treatment - Nature
Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses...
nature.com
Recent paper (Nature)-why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? X/Y or hormones? We study adaptation of immune systems in gender-affirming testosterone treatment: nature.com/articles/s41...
Reposted by Petter Brodin
Recap 2023 via @petterbrodin.bsky.social
@theguardian.com
www.theguardian.com/science/2023...
The term “immunity debt” was first introduced by French researchers in 2021. It refers to a population-wide effect rather than an individual-level one.
@theguardian.com
www.theguardian.com/science/2023...
The term “immunity debt” was first introduced by French researchers in 2021. It refers to a population-wide effect rather than an individual-level one.
Immunity debt: does it really exist?
Some claim the rise in winter infections has been caused by the reduction of seasonal bugs during lockdowns. But experts are sceptical about these oversimplified explanations
www.theguardian.com
November 9, 2025 at 5:44 AM
Recap 2023 via @petterbrodin.bsky.social
@theguardian.com
www.theguardian.com/science/2023...
The term “immunity debt” was first introduced by French researchers in 2021. It refers to a population-wide effect rather than an individual-level one.
@theguardian.com
www.theguardian.com/science/2023...
The term “immunity debt” was first introduced by French researchers in 2021. It refers to a population-wide effect rather than an individual-level one.
Reposted by Petter Brodin
Why are more and more people suffering from #allergies and autoimmune diseases? The answer may lie in the development of the immune system in newborns @petterbrodin.bsky.social @ki.se has developed a technique to map #immunesystem development from a single drop of blood.
tinyurl.com/3j22dyw8
tinyurl.com/3j22dyw8
How the immune system develops in newborn babies | Knut and Alice Wallenberg Foundation
Why are more and more people suffering from allergies and autoimmune diseases? The answer may lie in the development of the immune system in newborns. Wallenberg Scholar Petter Brodin has developed a ...
tinyurl.com
October 15, 2025 at 7:39 AM
Why are more and more people suffering from #allergies and autoimmune diseases? The answer may lie in the development of the immune system in newborns @petterbrodin.bsky.social @ki.se has developed a technique to map #immunesystem development from a single drop of blood.
tinyurl.com/3j22dyw8
tinyurl.com/3j22dyw8
Reposted by Petter Brodin
In new review @jhumimmunity.org, Andreakos et al. report the progress of the COVID Human Genetic Effort since its launch 5 years ago, with the aim to understand clinical variability, from resistance to severe outcomes, among individuals exposed to #SARSCoV2. rupress.org/jhi/article/...
October 24, 2025 at 5:45 PM
In new review @jhumimmunity.org, Andreakos et al. report the progress of the COVID Human Genetic Effort since its launch 5 years ago, with the aim to understand clinical variability, from resistance to severe outcomes, among individuals exposed to #SARSCoV2. rupress.org/jhi/article/...
Hehe, Thanks Grant!
Great to see my friend @petterbrodin.bsky.social at #ACR25 and hear about his work on hormones, chromosomes, and autoimmunity in this aptly named session
November 7, 2025 at 10:00 PM
Hehe, Thanks Grant!
Reposted by Petter Brodin
The seven enigmas of #SARSCoV2: From the past to the future. New review from Evangelos Andreakos, Helen Su, Jean-Laurent Casanova (@casanovalab.bsky.social) and colleagues: rupress.org/jhi/article/...
#InbornErrorsOfImmunity #InfectiousDiseases #PopulationGenetics
#InbornErrorsOfImmunity #InfectiousDiseases #PopulationGenetics
October 31, 2025 at 2:45 PM
The seven enigmas of #SARSCoV2: From the past to the future. New review from Evangelos Andreakos, Helen Su, Jean-Laurent Casanova (@casanovalab.bsky.social) and colleagues: rupress.org/jhi/article/...
#InbornErrorsOfImmunity #InfectiousDiseases #PopulationGenetics
#InbornErrorsOfImmunity #InfectiousDiseases #PopulationGenetics
The American Association of Immunologists AAI meeting will be in Boston, April 15-19, 2026. Come join me and @chrysothemisbrown.bsky.social at this exciting Symposium on Early life immune development. Submit your abstracts by October 15th! immunology2026.aai.org/session/earl...
Early Life Immune Development and Function - IMMUNOLOGY2026™
Time: 8:00 - 11:30 AM Chairs: Chrysothemis C. Brown, Memorial Sloan Kettering Cancer Ctr., USA Petter Brodin, Imperial Col. London and Karolinska Inst., GBR, SWE
immunology2026.aai.org
September 22, 2025 at 3:23 PM
The American Association of Immunologists AAI meeting will be in Boston, April 15-19, 2026. Come join me and @chrysothemisbrown.bsky.social at this exciting Symposium on Early life immune development. Submit your abstracts by October 15th! immunology2026.aai.org/session/earl...
Reposted by Petter Brodin
#Medsky🧪 #IDsky #immunosky #publichealth @petterbrodin.bsky.social , @casanovalab.bsky.social et al
To determine the underlying genetic causes & other modifying factors like sex hormones , interferon responses impacting restrained #Tcell responses to #SARSCoV2 & #viralpersistence in #LongCOVID.
To determine the underlying genetic causes & other modifying factors like sex hormones , interferon responses impacting restrained #Tcell responses to #SARSCoV2 & #viralpersistence in #LongCOVID.
September 10, 2025 at 9:04 PM
#Medsky🧪 #IDsky #immunosky #publichealth @petterbrodin.bsky.social , @casanovalab.bsky.social et al
To determine the underlying genetic causes & other modifying factors like sex hormones , interferon responses impacting restrained #Tcell responses to #SARSCoV2 & #viralpersistence in #LongCOVID.
To determine the underlying genetic causes & other modifying factors like sex hormones , interferon responses impacting restrained #Tcell responses to #SARSCoV2 & #viralpersistence in #LongCOVID.
Thx for highlighting @sun-in-winter12.bsky.social
Hey everyone, ICYMI I wanted to highlight this groundbreaking #LongCOVID preprint.
Personally, I've found there may be a lot of truth to this idea:
**High anti-spike antibodies that don’t wane 6 months after infection may be a sign of viral persistence**
1/
👇
www.medrxiv.org/content/10.1...
Personally, I've found there may be a lot of truth to this idea:
**High anti-spike antibodies that don’t wane 6 months after infection may be a sign of viral persistence**
1/
👇
www.medrxiv.org/content/10.1...
Restrained memory CD8+ T cell responses favors viral persistence and elevated IgG responses in patients with severe Long COVID
During the COVID-19 pandemic it was widely described that certain individuals infected by SARS-CoV-2 experience persistent disease signs and symptoms, Long COVID, which in some cases is very severe wi...
www.medrxiv.org
August 25, 2025 at 7:48 PM
Thx for highlighting @sun-in-winter12.bsky.social
Reposted by Petter Brodin
Variation in the human immune system is largely driven by non-heritable influences
@petterbrodin.bsky.social P. Brodin et al. Cell. 2015.
@petterbrodin.bsky.social P. Brodin et al. Cell. 2015.
Variation in the human immune system is largely driven by non-heritable influences - PubMed
There is considerable heterogeneity in immunological parameters between individuals, but its sources are largely unknown. To assess the relative contribution of heritable versus non-heritable factors,...
pubmed.ncbi.nlm.nih.gov
August 7, 2025 at 7:35 PM
Variation in the human immune system is largely driven by non-heritable influences
@petterbrodin.bsky.social P. Brodin et al. Cell. 2015.
@petterbrodin.bsky.social P. Brodin et al. Cell. 2015.
Weight loss improves health but What happens to cells in the fat during weight loss? Intriguingly, immune cell numbers decrease but their activated states persist w chronic inflammatory potential. Beautiful work from neighbors @mrc-lms.bsky.social Will Scott et al www.nature.com/articles/s41...
Selective remodelling of the adipose niche in obesity and weight loss - Nature
An atlas study of adipose tissue in people with obesity undergoing weight loss and their lean counterparts reveals that weight loss reduces cell senescence but cannot reverse all the metabolic problem...
www.nature.com
July 11, 2025 at 10:06 AM
Weight loss improves health but What happens to cells in the fat during weight loss? Intriguingly, immune cell numbers decrease but their activated states persist w chronic inflammatory potential. Beautiful work from neighbors @mrc-lms.bsky.social Will Scott et al www.nature.com/articles/s41...
New paper 📣! Pixelgen reports its incredible new Proximity Network Assay (PNA)->3D maps of 155 proteins in single cells by sequencing by barcoded antibodies and in situ rolling circle amplification yields >40,000 spatial nodes/cell: www.biorxiv.org/content/10.1...
June 25, 2025 at 1:45 PM
New paper 📣! Pixelgen reports its incredible new Proximity Network Assay (PNA)->3D maps of 155 proteins in single cells by sequencing by barcoded antibodies and in situ rolling circle amplification yields >40,000 spatial nodes/cell: www.biorxiv.org/content/10.1...
No evidence for neutralizing IL1RN autoantibodies in our cohorts of MIS-C, SARS-CoV2 pneumonia or vaccine-induced myocarditis. onlinelibrary.wiley.com/doi/10.1111/... Great work by Anish Behere in Nils Landegren lab, Uppsala university
Evaluating IL1RA‐Autoantibodies Across SARS‐CoV‐2‐Related Diseases
Click on the article title to read more.
onlinelibrary.wiley.com
June 25, 2025 at 6:59 AM
No evidence for neutralizing IL1RN autoantibodies in our cohorts of MIS-C, SARS-CoV2 pneumonia or vaccine-induced myocarditis. onlinelibrary.wiley.com/doi/10.1111/... Great work by Anish Behere in Nils Landegren lab, Uppsala university
Exciting new cell state model from @arcinstitute.org
Introducing Arc Institute’s first virtual cell model: STATE
June 23, 2025 at 5:35 PM
Exciting new cell state model from @arcinstitute.org
Absolute pleasure to be teaching human systems immunology @efis-immunology.bsky.social summer school in beautiful Alghero, Sardinia.
May 27, 2025 at 2:50 PM
Absolute pleasure to be teaching human systems immunology @efis-immunology.bsky.social summer school in beautiful Alghero, Sardinia.
Reposted by Petter Brodin
"Children should be included in ongoing and future clinical trials for Long Covid
Age-related protections & regulations must be incorporated, including obtaining institutional review board/research ethics approval along with paediatric assent & parental
publications.ersnet.org/content/erj/...
Age-related protections & regulations must be incorporated, including obtaining institutional review board/research ethics approval along with paediatric assent & parental
publications.ersnet.org/content/erj/...
May 23, 2025 at 7:23 AM
"Children should be included in ongoing and future clinical trials for Long Covid
Age-related protections & regulations must be incorporated, including obtaining institutional review board/research ethics approval along with paediatric assent & parental
publications.ersnet.org/content/erj/...
Age-related protections & regulations must be incorporated, including obtaining institutional review board/research ethics approval along with paediatric assent & parental
publications.ersnet.org/content/erj/...
Reposted by Petter Brodin
Reminder to join us June 5/6 in Paris if you're interested in pediatric immunity and cancer development ! @institutcurie.bsky.social @gustaveroussy.fr @hopitalnecker.bsky.social @institutimagine.bsky.social
Interested in the relationship between the developing immune system and pediatric cancer ? Come join us for the first Paris Kids Cancer symposium June 5/6 institut-curie.org/symposium-pa... @institutcurie.bsky.social @aphp.bsky.social @gustaveroussy.fr @institutimagine.bsky.social
Symposium Paris Kids Cancer 2025 - Institut Curie
Find Symposium Paris Kids Cancer 2025. The Institut Curie is the leading center for research and the fight against cancer in France.
institut-curie.org
April 30, 2025 at 6:59 AM
Reminder to join us June 5/6 in Paris if you're interested in pediatric immunity and cancer development ! @institutcurie.bsky.social @gustaveroussy.fr @hopitalnecker.bsky.social @institutimagine.bsky.social
Reposted by Petter Brodin
New in @jumimmunity.org:
Human #InbornErrorsOfImmunity: 2024 update on the classification from the @iuis-online.bsky.social Expert Committee: rupress.org/jhi/article/...
See also the accompanying diagnostic guide by Bousfiha et al.: rupress.org/jhi/article/...
Human #InbornErrorsOfImmunity: 2024 update on the classification from the @iuis-online.bsky.social Expert Committee: rupress.org/jhi/article/...
See also the accompanying diagnostic guide by Bousfiha et al.: rupress.org/jhi/article/...
April 23, 2025 at 2:19 PM
New in @jumimmunity.org:
Human #InbornErrorsOfImmunity: 2024 update on the classification from the @iuis-online.bsky.social Expert Committee: rupress.org/jhi/article/...
See also the accompanying diagnostic guide by Bousfiha et al.: rupress.org/jhi/article/...
Human #InbornErrorsOfImmunity: 2024 update on the classification from the @iuis-online.bsky.social Expert Committee: rupress.org/jhi/article/...
See also the accompanying diagnostic guide by Bousfiha et al.: rupress.org/jhi/article/...
Human inborn errors of immunity: 2024 update on the classification from the International Union of Immunological Societies Expert Committee url:https://rupress.org/jhi/article/1/1/e20250003/277390/Human-inborn-errors-of-immunity-2024-update-on-the
April 15, 2025 at 6:01 PM
Human inborn errors of immunity: 2024 update on the classification from the International Union of Immunological Societies Expert Committee url:https://rupress.org/jhi/article/1/1/e20250003/277390/Human-inborn-errors-of-immunity-2024-update-on-the
Reposted by Petter Brodin
Amazing study showing protective effect of herpes zoster vaccination against dementia with interesting sex differences @sexdiffimmunity.bsky.social
#vaccines work! #immunosky #medsky
#vaccines work! #immunosky #medsky
Vaccination against shingles might also prevent dementia, such as that caused by Alzheimer’s disease, according to a study of health records from around 300,000 people in Wales.
https://go.nature.com/446nriQ
https://go.nature.com/446nriQ
Does shingles vaccination cut dementia risk? Large study hints at a link
Analysis of nearly 300,000 people finds an association between the shingles jab and a lower rate of dementia — but questions linger.
go.nature.com
April 3, 2025 at 9:48 AM
Amazing study showing protective effect of herpes zoster vaccination against dementia with interesting sex differences @sexdiffimmunity.bsky.social
#vaccines work! #immunosky #medsky
#vaccines work! #immunosky #medsky
Reposted by Petter Brodin
Co-senior author from this study Prof Coziana Ciurtin will be talking alongside @petterbrodin.bsky.social in a RITA webinar on Sex Biases on Autoimmunity next Tuesday - should be a great discussion. Register 👇 #ImmunoSky #sexdifferences
register.gotowebinar.com/register/822...
register.gotowebinar.com/register/822...
March 28, 2025 at 6:04 PM
Co-senior author from this study Prof Coziana Ciurtin will be talking alongside @petterbrodin.bsky.social in a RITA webinar on Sex Biases on Autoimmunity next Tuesday - should be a great discussion. Register 👇 #ImmunoSky #sexdifferences
register.gotowebinar.com/register/822...
register.gotowebinar.com/register/822...
Reposted by Petter Brodin
🔥1/3. Next in the Fireside Chat series from The #LongCovid Clinic - What You CAN Do!
‘Covid & the Immune System’
🗓️ Wednesday 12th March 2025 at 6pm GMT
@binitakane.bsky.social & @helenoakleigh.bsky.social are joined by Consultant Immunologist @petterbrodin.bsky.social!
Link ⬇️
‘Covid & the Immune System’
🗓️ Wednesday 12th March 2025 at 6pm GMT
@binitakane.bsky.social & @helenoakleigh.bsky.social are joined by Consultant Immunologist @petterbrodin.bsky.social!
Link ⬇️
March 10, 2025 at 6:52 PM
🔥1/3. Next in the Fireside Chat series from The #LongCovid Clinic - What You CAN Do!
‘Covid & the Immune System’
🗓️ Wednesday 12th March 2025 at 6pm GMT
@binitakane.bsky.social & @helenoakleigh.bsky.social are joined by Consultant Immunologist @petterbrodin.bsky.social!
Link ⬇️
‘Covid & the Immune System’
🗓️ Wednesday 12th March 2025 at 6pm GMT
@binitakane.bsky.social & @helenoakleigh.bsky.social are joined by Consultant Immunologist @petterbrodin.bsky.social!
Link ⬇️
Thx so much for highlighting!
Childhood solid tumors shape immune responses differently by age and type. Systems-level study of 191 pediatric patients reveals key variations, paving the way for precision immunotherapy. Great work by the one-and-only @petterbrodin.bsky.social and teams.
doi.org/10.1016/j.ce... 🧪
doi.org/10.1016/j.ce... 🧪
March 10, 2025 at 8:44 PM
Thx so much for highlighting!
Reposted by Petter Brodin
#Medsky🧪#oncosky #pedsky @petterbrodin.bsky.social et al . A systems-level analysis of immune responses in 191 children within a population-based cohort with diverse tumors & reveal that age & tumor type shape immune responses differently.#immunotherapies for childhood cancer.
March 9, 2025 at 5:16 PM
#Medsky🧪#oncosky #pedsky @petterbrodin.bsky.social et al . A systems-level analysis of immune responses in 191 children within a population-based cohort with diverse tumors & reveal that age & tumor type shape immune responses differently.#immunotherapies for childhood cancer.
Reposted by Petter Brodin
How do immune responses vary across different childhood ages and tumor types?
A crucial study from @petterbrodin.bsky.social’s lab freshly baked on #SystemsImmunology, advancing precision medicine in pediatric diseases!
www.cell.com/cell/fulltex...
A crucial study from @petterbrodin.bsky.social’s lab freshly baked on #SystemsImmunology, advancing precision medicine in pediatric diseases!
www.cell.com/cell/fulltex...
Systems-level immunomonitoring in children with solid tumors to enable precision medicine
In a population-based cohort of 191 children with diverse solid tumors, systems-level
analyses unravel immune variation with age and tumor type and provide a reference
for future precision immunothera...
www.cell.com
March 7, 2025 at 9:04 AM
How do immune responses vary across different childhood ages and tumor types?
A crucial study from @petterbrodin.bsky.social’s lab freshly baked on #SystemsImmunology, advancing precision medicine in pediatric diseases!
www.cell.com/cell/fulltex...
A crucial study from @petterbrodin.bsky.social’s lab freshly baked on #SystemsImmunology, advancing precision medicine in pediatric diseases!
www.cell.com/cell/fulltex...
Reposted by Petter Brodin
#Paediatrics | #Cancer | #ImmuneSystem | #Immunotherapy |
Yet Another Phenomenal Resource from @petterbrodin.bsky.social & Friends |
Breaking OPEN ACCESS Study Online at @cellpress.bsky.social |
#immunogenicity | #Tcells | #inflammation |
Yet Another Phenomenal Resource from @petterbrodin.bsky.social & Friends |
Breaking OPEN ACCESS Study Online at @cellpress.bsky.social |
#immunogenicity | #Tcells | #inflammation |
Systems-level immunomonitoring in children with solid tumors to enable precision medicine
In a population-based cohort of 191 children with diverse solid tumors, systems-level
analyses unravel immune variation with age and tumor type and provide a reference
for future precision immunothera...
www.cell.com
March 6, 2025 at 10:42 PM
#Paediatrics | #Cancer | #ImmuneSystem | #Immunotherapy |
Yet Another Phenomenal Resource from @petterbrodin.bsky.social & Friends |
Breaking OPEN ACCESS Study Online at @cellpress.bsky.social |
#immunogenicity | #Tcells | #inflammation |
Yet Another Phenomenal Resource from @petterbrodin.bsky.social & Friends |
Breaking OPEN ACCESS Study Online at @cellpress.bsky.social |
#immunogenicity | #Tcells | #inflammation |