Prof John Gordon
@profcelentyx.bsky.social
B Cell Enthusiast; Immunology Prof (Emeritus, but Still Breathing); Big on Immunotherapy; Love Herefordshire; & Curries 😃
Any views and comments are strictly personal
Any views and comments are strictly personal
Wild!!
EVs aren’t just tiny, they’re powerful! 🦇
These nanoparticles could unlock secrets of immune responses in bats, revealing viral tolerance mechanisms.
Read the article: https://bit.ly/4dXLgfE
##WildImmunology
These nanoparticles could unlock secrets of immune responses in bats, revealing viral tolerance mechanisms.
Read the article: https://bit.ly/4dXLgfE
##WildImmunology
October 31, 2025 at 4:26 PM
Wild!!
Thrilled and honoured to be invited onto the Scientific Advisory Panel of the Centre for Human-Specific Research 😊
humanspecificresearch.org
humanspecificresearch.org
October 31, 2025 at 7:53 AM
Thrilled and honoured to be invited onto the Scientific Advisory Panel of the Centre for Human-Specific Research 😊
humanspecificresearch.org
humanspecificresearch.org
HuBIE: The Human Blood Immunome Encyclopedia Of TCRs and BCRs in Bloodstream Infections and Cancer https://www.biorxiv.org/content/10.1101/2025.10.22.678684v1
October 24, 2025 at 10:41 AM
#cancersky #immunosky #antibodysky
Major #CD40 #TherapeuticAntibody Success now breaking
@cp-cancercell.bsky.social
First-in-Human study of Fc-optimised CD40 agonistic Antibody elicits #TertiaryLymphoidStructures & systemic anti-Tumor #Immunity in Metastatic #Cancer
Fantastic work 👏
Major #CD40 #TherapeuticAntibody Success now breaking
@cp-cancercell.bsky.social
First-in-Human study of Fc-optimised CD40 agonistic Antibody elicits #TertiaryLymphoidStructures & systemic anti-Tumor #Immunity in Metastatic #Cancer
Fantastic work 👏
Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer
Osorio et al. report a first-in-human study of intratumoral 2141-V11, an Fc-engineered
CD40 agonistic antibody, showing it is safe and induces systemic and durable antitumor
immunity in patients with ...
www.cell.com
August 14, 2025 at 4:00 PM
#cancersky #immunosky #antibodysky
Major #CD40 #TherapeuticAntibody Success now breaking
@cp-cancercell.bsky.social
First-in-Human study of Fc-optimised CD40 agonistic Antibody elicits #TertiaryLymphoidStructures & systemic anti-Tumor #Immunity in Metastatic #Cancer
Fantastic work 👏
Major #CD40 #TherapeuticAntibody Success now breaking
@cp-cancercell.bsky.social
First-in-Human study of Fc-optimised CD40 agonistic Antibody elicits #TertiaryLymphoidStructures & systemic anti-Tumor #Immunity in Metastatic #Cancer
Fantastic work 👏
Dr Neil Bodie (June 13, 1955 - July 19, 2025)
It is with a heavy heart that I report the sad news that my "LinkedIn Friend" & Colleague Dr Neil Martin Bodie, passed away on July 19th.
For more about Neil please see: www.linkedin.com/feed/update/...
R.I.P. Dear Friend
Thoughts are with his family
It is with a heavy heart that I report the sad news that my "LinkedIn Friend" & Colleague Dr Neil Martin Bodie, passed away on July 19th.
For more about Neil please see: www.linkedin.com/feed/update/...
R.I.P. Dear Friend
Thoughts are with his family
July 30, 2025 at 10:53 AM
Dr Neil Bodie (June 13, 1955 - July 19, 2025)
It is with a heavy heart that I report the sad news that my "LinkedIn Friend" & Colleague Dr Neil Martin Bodie, passed away on July 19th.
For more about Neil please see: www.linkedin.com/feed/update/...
R.I.P. Dear Friend
Thoughts are with his family
It is with a heavy heart that I report the sad news that my "LinkedIn Friend" & Colleague Dr Neil Martin Bodie, passed away on July 19th.
For more about Neil please see: www.linkedin.com/feed/update/...
R.I.P. Dear Friend
Thoughts are with his family
Major study, great work 👍
🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back.
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity
Cole et al. report that adoptively transferred, tumor-specific Th17 cells engage host
B cells and drive B cell proliferation and differentiation. These Th17 cells require
B cells for sustained immunit...
www.cell.com
July 26, 2025 at 7:23 AM
Major study, great work 👍
#immunosky #cancersky #climatechangesky
#PsychoNeuroImmunology
#ClimateChange / #SocialDivision: A Perfect Storm for Chronic #Inflammation to Seedbed #Cancer?
Intriguing, OPEN ACCESS Opinion Piece now breaking at @wiley.com #Immunology
#PsychoNeuroImmunology
#ClimateChange / #SocialDivision: A Perfect Storm for Chronic #Inflammation to Seedbed #Cancer?
Intriguing, OPEN ACCESS Opinion Piece now breaking at @wiley.com #Immunology
Inflammation Perfect Storm: Cancer, Climate and Polarisation
Interplay between major global challenges and human health. Climate change and sociopolitical polarisation act as overarching amplifiers, driving specific environmental and psychosocial/policy-relate...
onlinelibrary.wiley.com
June 11, 2025 at 6:11 PM
#immunosky #cancersky #climatechangesky
#PsychoNeuroImmunology
#ClimateChange / #SocialDivision: A Perfect Storm for Chronic #Inflammation to Seedbed #Cancer?
Intriguing, OPEN ACCESS Opinion Piece now breaking at @wiley.com #Immunology
#PsychoNeuroImmunology
#ClimateChange / #SocialDivision: A Perfect Storm for Chronic #Inflammation to Seedbed #Cancer?
Intriguing, OPEN ACCESS Opinion Piece now breaking at @wiley.com #Immunology
A Perfect Selection 😉
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Replaying germinal center evolution on a quantified affinity landscape
Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
www.biorxiv.org
June 7, 2025 at 3:17 PM
A Perfect Selection 😉
Fantastic advance 👏
'Here, we report that Fc-optimized anti-CTLA-4 antibodies are potent remodelers of tumor vasculature that increase tumor-associated high endothelial venules (TA-HEVs), specialized blood vessels supporting lymphocyte entry into tumors'
#Immunology #Immunotherapy
www.cell.com/cell-reports...
#Immunology #Immunotherapy
www.cell.com/cell-reports...
Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade
Blanchard et al. reveal that Fc-optimized anti-CTLA-4 antibodies remodel tumor vasculature
and increase tumor-associated high endothelial venules (TA-HEVs) that support T cell
recruitment into tumors....
www.cell.com
June 7, 2025 at 11:23 AM
Fantastic advance 👏
Clucking Awesome 🐓
How do chickens generate antibody diversity? 🐔🔬
This study maps over 1 million gene conversion events in chicken antibodies, shedding light on how birds diversify their immune response.
🔗 https://bit.ly/45wSe95
#Immunology #VetImmunology #GeneConversion
This study maps over 1 million gene conversion events in chicken antibodies, shedding light on how birds diversify their immune response.
🔗 https://bit.ly/45wSe95
#Immunology #VetImmunology #GeneConversion
May 30, 2025 at 3:28 PM
Clucking Awesome 🐓
A fantastic #MS resource from @britsocimm.bsky.social 👍
🧡 Today is #WorldMSDay - a global moment to raise awareness and stand with everyone affected by multiple sclerosis.
Curious about how the immune system plays a role in MS? Explore our easy-to-digest BiteSized Immunology section on MS.
📖Learn more here: https://bit.ly/4dFYj5i
Curious about how the immune system plays a role in MS? Explore our easy-to-digest BiteSized Immunology section on MS.
📖Learn more here: https://bit.ly/4dFYj5i
May 30, 2025 at 1:34 PM
A fantastic #MS resource from @britsocimm.bsky.social 👍
#Immunosky #Cancersky
Antidepressants: A “Dead SERT” for #Immunotherapy!
Open Access @cellpress.bsky.social
@gilliangrafton.bsky.social 😎
Antidepressants: A “Dead SERT” for #Immunotherapy!
Open Access @cellpress.bsky.social
@gilliangrafton.bsky.social 😎
Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis
Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral
serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants
enhance CD8 T cell ...
www.cell.com
May 22, 2025 at 5:39 PM
#Immunosky #Cancersky
Antidepressants: A “Dead SERT” for #Immunotherapy!
Open Access @cellpress.bsky.social
@gilliangrafton.bsky.social 😎
Antidepressants: A “Dead SERT” for #Immunotherapy!
Open Access @cellpress.bsky.social
@gilliangrafton.bsky.social 😎
#CancerSky #MedSky
"When #Cancer #Therapy faces STIFF competition"
OPEN ACCESS Review @cp-trendscancer.bsky.social
"When #Cancer #Therapy faces STIFF competition"
OPEN ACCESS Review @cp-trendscancer.bsky.social
Tissue mechanics in tumor heterogeneity and aggression
Tumorigenesis ensues within a heterogeneous tissue microenvironment that promotes
malignant transformation, metastasis and treatment resistance. A major feature of
the tumor microenvironment is the he...
www.cell.com
May 2, 2025 at 8:29 AM
#CancerSky #MedSky
"When #Cancer #Therapy faces STIFF competition"
OPEN ACCESS Review @cp-trendscancer.bsky.social
"When #Cancer #Therapy faces STIFF competition"
OPEN ACCESS Review @cp-trendscancer.bsky.social
#ImmunoSky #MedSky #CancerSky
"Strengthening the #GLUT5" for #ACT vs Solid #Tumours"
Breaking OPEN ACCESS Study @britsocimm.bsky.social journal @imtadvances.bsky.social 👏
"Strengthening the #GLUT5" for #ACT vs Solid #Tumours"
Breaking OPEN ACCESS Study @britsocimm.bsky.social journal @imtadvances.bsky.social 👏
GLUT5 armouring enhances adoptive T cell therapy anti-tumour activity under glucose-limiting conditions
AbstractBackground. Cancer immunotherapy with engineered T cells has become a standard treatment for certain haematological cancers. However, clinical tria
academic.oup.com
May 1, 2025 at 7:32 AM
#ImmunoSky #MedSky #CancerSky
"Strengthening the #GLUT5" for #ACT vs Solid #Tumours"
Breaking OPEN ACCESS Study @britsocimm.bsky.social journal @imtadvances.bsky.social 👏
"Strengthening the #GLUT5" for #ACT vs Solid #Tumours"
Breaking OPEN ACCESS Study @britsocimm.bsky.social journal @imtadvances.bsky.social 👏
#ImmunoSky #InflammationSky #DietSky
#ILC3s #Immunity #Inflammation #Mucosa #Metabolism #Nutrition #Diet #IL22
"Trust Your #Gut" & Stay Off those Big Macs 🍔
@wehi-research.bsky.social researchers Cyril Seillet & Friends "Chew the #Fat" in Breaking OPEN ACCESS Study @cp-immunity.bsky.social
#ILC3s #Immunity #Inflammation #Mucosa #Metabolism #Nutrition #Diet #IL22
"Trust Your #Gut" & Stay Off those Big Macs 🍔
@wehi-research.bsky.social researchers Cyril Seillet & Friends "Chew the #Fat" in Breaking OPEN ACCESS Study @cp-immunity.bsky.social
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut
microbial and immune environment, disrupting tissue homeostasis. IL-22 production
by group 3 innate lymphoid cells (I...
www.cell.com
April 14, 2025 at 3:34 PM
#ImmunoSky #InflammationSky #DietSky
#ILC3s #Immunity #Inflammation #Mucosa #Metabolism #Nutrition #Diet #IL22
"Trust Your #Gut" & Stay Off those Big Macs 🍔
@wehi-research.bsky.social researchers Cyril Seillet & Friends "Chew the #Fat" in Breaking OPEN ACCESS Study @cp-immunity.bsky.social
#ILC3s #Immunity #Inflammation #Mucosa #Metabolism #Nutrition #Diet #IL22
"Trust Your #Gut" & Stay Off those Big Macs 🍔
@wehi-research.bsky.social researchers Cyril Seillet & Friends "Chew the #Fat" in Breaking OPEN ACCESS Study @cp-immunity.bsky.social
#ImmunoSky #MedSky #CancerSky #PharmaSky #DrugSky
**BREAKING: Massive layoffs hit the rodent workforce!**
In a historic shift, the FDA is exploring a future without animal studies for drug approvals.
BRILLIANT Joseph Arboleda Velasquez @harvard.edu 🤩👍👏
www.linkedin.com/posts/joseph...
**BREAKING: Massive layoffs hit the rodent workforce!**
In a historic shift, the FDA is exploring a future without animal studies for drug approvals.
BRILLIANT Joseph Arboleda Velasquez @harvard.edu 🤩👍👏
www.linkedin.com/posts/joseph...
April 13, 2025 at 1:11 PM
#ImmunoSky #MedSky #CancerSky #PharmaSky #DrugSky
**BREAKING: Massive layoffs hit the rodent workforce!**
In a historic shift, the FDA is exploring a future without animal studies for drug approvals.
BRILLIANT Joseph Arboleda Velasquez @harvard.edu 🤩👍👏
www.linkedin.com/posts/joseph...
**BREAKING: Massive layoffs hit the rodent workforce!**
In a historic shift, the FDA is exploring a future without animal studies for drug approvals.
BRILLIANT Joseph Arboleda Velasquez @harvard.edu 🤩👍👏
www.linkedin.com/posts/joseph...
#CancerSky #ImmunoSky #MedSky
#Cancer #Aging #Metabolism
#TIME to Watch you Eat'
#Age- & #Diet- instructed Metabolic Rewiring of the #TumorImmuneMicroEnvironment
#TIME-ly review from @unil.bsky.social authors now breaking at @jem.org
rupress.org/jem/article/...
#Cancer #Aging #Metabolism
#TIME to Watch you Eat'
#Age- & #Diet- instructed Metabolic Rewiring of the #TumorImmuneMicroEnvironment
#TIME-ly review from @unil.bsky.social authors now breaking at @jem.org
rupress.org/jem/article/...
April 11, 2025 at 2:42 PM
#CancerSky #ImmunoSky #MedSky
#Cancer #Aging #Metabolism
#TIME to Watch you Eat'
#Age- & #Diet- instructed Metabolic Rewiring of the #TumorImmuneMicroEnvironment
#TIME-ly review from @unil.bsky.social authors now breaking at @jem.org
rupress.org/jem/article/...
#Cancer #Aging #Metabolism
#TIME to Watch you Eat'
#Age- & #Diet- instructed Metabolic Rewiring of the #TumorImmuneMicroEnvironment
#TIME-ly review from @unil.bsky.social authors now breaking at @jem.org
rupress.org/jem/article/...
#ImmunoSky #MedSky
#drugrepurposing
#Inflammation: "Time to halt the #Dopamine rush"
An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis
Now @science.org signaling
#drugrepurposing
#Inflammation: "Time to halt the #Dopamine rush"
An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis
Now @science.org signaling
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis
Macrophages perform repeated rounds of phagocytosis in response to an FDA-approved dopamine blocker.
www.science.org
April 10, 2025 at 7:43 AM
#ImmunoSky #MedSky
#drugrepurposing
#Inflammation: "Time to halt the #Dopamine rush"
An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis
Now @science.org signaling
#drugrepurposing
#Inflammation: "Time to halt the #Dopamine rush"
An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis
Now @science.org signaling
#ImmunoSky
#Immunotherapy
#ImmuneRelatedAdverseEvents
#Biomarkers
#ICOS+ CD4 #Tcells define #Susceptibility to anti-PD1-induced #Lung #Pathology in the #Aged
#Bcells #Antibodies #TertiaryLymphoidStructures
Breaking Open Access Study @jci-insight.bsky.social
insight.jci.org/articles/vie...
#Immunotherapy
#ImmuneRelatedAdverseEvents
#Biomarkers
#ICOS+ CD4 #Tcells define #Susceptibility to anti-PD1-induced #Lung #Pathology in the #Aged
#Bcells #Antibodies #TertiaryLymphoidStructures
Breaking Open Access Study @jci-insight.bsky.social
insight.jci.org/articles/vie...
April 9, 2025 at 8:28 AM
#ImmunoSky
#Immunotherapy
#ImmuneRelatedAdverseEvents
#Biomarkers
#ICOS+ CD4 #Tcells define #Susceptibility to anti-PD1-induced #Lung #Pathology in the #Aged
#Bcells #Antibodies #TertiaryLymphoidStructures
Breaking Open Access Study @jci-insight.bsky.social
insight.jci.org/articles/vie...
#Immunotherapy
#ImmuneRelatedAdverseEvents
#Biomarkers
#ICOS+ CD4 #Tcells define #Susceptibility to anti-PD1-induced #Lung #Pathology in the #Aged
#Bcells #Antibodies #TertiaryLymphoidStructures
Breaking Open Access Study @jci-insight.bsky.social
insight.jci.org/articles/vie...
Maximizing activity & selectivity of #TherapeuticAntibodies mediated effector functions using Antibody mixtures
Breaking Open Access Study* @tandfresearch.bsky.social #mAbs
*https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2480666?src=exp-la#abstract
Breaking Open Access Study* @tandfresearch.bsky.social #mAbs
*https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2480666?src=exp-la#abstract
April 4, 2025 at 8:02 AM
Maximizing activity & selectivity of #TherapeuticAntibodies mediated effector functions using Antibody mixtures
Breaking Open Access Study* @tandfresearch.bsky.social #mAbs
*https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2480666?src=exp-la#abstract
Breaking Open Access Study* @tandfresearch.bsky.social #mAbs
*https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2480666?src=exp-la#abstract
#Bcells & #VaccinesSaveLives
Towards a pan- #Flu #Vaccine
Identification of a seasonal influenza vaccine–induced broadly protective neuraminidase antibody
Breaking Open Access Study* @jem.org
*https://rupress.org/jem/article/222/6/e20241930/277361/Identification-of-a-seasonal-influenza-vaccine
Towards a pan- #Flu #Vaccine
Identification of a seasonal influenza vaccine–induced broadly protective neuraminidase antibody
Breaking Open Access Study* @jem.org
*https://rupress.org/jem/article/222/6/e20241930/277361/Identification-of-a-seasonal-influenza-vaccine
#flu #vaccine #protective #antibody #jem #bcells #vaccinessavelives | John Gordon
Towards a pan-#Flu #Vaccine | Identification of a Seasonal Influenza Vaccine-induced Broadly #Protective Neuraminidase #Antibody | Breaking Open Access Study at Rockefeller University Press #JEM | #Bc...
www.linkedin.com
April 3, 2025 at 2:58 PM
#Bcells & #VaccinesSaveLives
Towards a pan- #Flu #Vaccine
Identification of a seasonal influenza vaccine–induced broadly protective neuraminidase antibody
Breaking Open Access Study* @jem.org
*https://rupress.org/jem/article/222/6/e20241930/277361/Identification-of-a-seasonal-influenza-vaccine
Towards a pan- #Flu #Vaccine
Identification of a seasonal influenza vaccine–induced broadly protective neuraminidase antibody
Breaking Open Access Study* @jem.org
*https://rupress.org/jem/article/222/6/e20241930/277361/Identification-of-a-seasonal-influenza-vaccine
Frontiers | Decoding plasma cell maturation dynamics with BCMA
www.frontiersin.org
April 1, 2025 at 11:17 AM
Targeting the #FcRn in #AutoimmuneDiseases: Pipeline & Progress
Torleif Tollefsrud Gjølberg & Colleagues Dig Deep into the Biology of the Neonatal Fc Receptor & its Antagonism in Superlative Breaking Open Access Review
Torleif Tollefsrud Gjølberg & Colleagues Dig Deep into the Biology of the Neonatal Fc Receptor & its Antagonism in Superlative Breaking Open Access Review
Targeting the Neonatal Fc Receptor in Autoimmune Diseases: Pipeline and Progress - BioDrugs
Autoimmune diseases are highly prevalent and affect people at all ages, women more often than men. The most prominent immunological manifestation is the production of antibodies directed against self-...
link.springer.com
March 31, 2025 at 9:15 AM
Targeting the #FcRn in #AutoimmuneDiseases: Pipeline & Progress
Torleif Tollefsrud Gjølberg & Colleagues Dig Deep into the Biology of the Neonatal Fc Receptor & its Antagonism in Superlative Breaking Open Access Review
Torleif Tollefsrud Gjølberg & Colleagues Dig Deep into the Biology of the Neonatal Fc Receptor & its Antagonism in Superlative Breaking Open Access Review