Chrystal Paulos
@chrystalpaulos.bsky.social
Tumor immunologist, Director of Translational Medicine, Cutaneous Malignancies. Assoc. Professor of Surgery/Microbiology & Immunology at Emory. Fitness is fun @PaulosLab
Reposted by Chrystal Paulos
Check out our new research on developing a model for tumor infiltrating lymphocyte (TIL) therapy for cholangiocarcinoma (CCA) by the Lesinski and Paulos Labs!
@lesinskilab.bsky.social
@chrystalpaulos.bsky.social
academic.oup.com/jimmunol/adv...
@lesinskilab.bsky.social
@chrystalpaulos.bsky.social
academic.oup.com/jimmunol/adv...
Development of a murine tumor-infiltrating lymphocyte therapy model for cholangiocarcinoma
Abstract. Tumor-infiltrating lymphocyte (TIL) therapy is a promising approach, earning U.S. Food and Drug Administration approval in patients with anti–PD-
academic.oup.com
September 24, 2025 at 1:00 PM
Check out our new research on developing a model for tumor infiltrating lymphocyte (TIL) therapy for cholangiocarcinoma (CCA) by the Lesinski and Paulos Labs!
@lesinskilab.bsky.social
@chrystalpaulos.bsky.social
academic.oup.com/jimmunol/adv...
@lesinskilab.bsky.social
@chrystalpaulos.bsky.social
academic.oup.com/jimmunol/adv...
Reposted by Chrystal Paulos
The City of Atlanta is opening its first municipal grocery store today.
The city is spending $3.5 million in partnership with a neighborhood grocery chain in an effort to eliminate a downtown food desert.
www.wsbtv.com/news/local/a...
The city is spending $3.5 million in partnership with a neighborhood grocery chain in an effort to eliminate a downtown food desert.
www.wsbtv.com/news/local/a...
City of Atlanta opening grocery store to clear up downtown food desert
The Azalea Fresh Market opens on Friday.
www.wsbtv.com
August 29, 2025 at 2:33 PM
The City of Atlanta is opening its first municipal grocery store today.
The city is spending $3.5 million in partnership with a neighborhood grocery chain in an effort to eliminate a downtown food desert.
www.wsbtv.com/news/local/a...
The city is spending $3.5 million in partnership with a neighborhood grocery chain in an effort to eliminate a downtown food desert.
www.wsbtv.com/news/local/a...
Reposted by Chrystal Paulos
www.v.org/grants/chrys...
Honored to be awarded the All-Star V Foundation grant! Inspired by great team efforts between #Paulos and #Lesinski labs! Props to cell therapy gurus @megen-w.bsky.social #AnnaCole @meganmw.bsky.social and crew @winshipcancer.emory.edu
Honored to be awarded the All-Star V Foundation grant! Inspired by great team efforts between #Paulos and #Lesinski labs! Props to cell therapy gurus @megen-w.bsky.social #AnnaCole @meganmw.bsky.social and crew @winshipcancer.emory.edu
Chrystal Paulos, PhD - V Foundation
Melanoma is a serious and often deadly type of skin cancer. Although immunotherapy has saved many lives, it still doesn’t work for every patient. Our lab is developing ways to give the immune system a...
www.v.org
August 1, 2025 at 11:24 AM
www.v.org/grants/chrys...
Honored to be awarded the All-Star V Foundation grant! Inspired by great team efforts between #Paulos and #Lesinski labs! Props to cell therapy gurus @megen-w.bsky.social #AnnaCole @meganmw.bsky.social and crew @winshipcancer.emory.edu
Honored to be awarded the All-Star V Foundation grant! Inspired by great team efforts between #Paulos and #Lesinski labs! Props to cell therapy gurus @megen-w.bsky.social #AnnaCole @meganmw.bsky.social and crew @winshipcancer.emory.edu
🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back.
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity
Cole et al. report that adoptively transferred, tumor-specific Th17 cells engage host
B cells and drive B cell proliferation and differentiation. These Th17 cells require
B cells for sustained immunit...
www.cell.com
July 25, 2025 at 2:51 PM
🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back.
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!
Reposted by Chrystal Paulos
Check out our new paper in Hepatology on how myeloid cells limit immunotherapy in preclinical cholangiocarcinoma models!
Disease site matters! @chrystalpaulos.bsky.social @megen-w.bsky.social @winshipcancer.emory.edu many others!
pubmed.ncbi.nlm.nih.gov/40590857/
Disease site matters! @chrystalpaulos.bsky.social @megen-w.bsky.social @winshipcancer.emory.edu many others!
pubmed.ncbi.nlm.nih.gov/40590857/
Tumor site influences efficacy of MEKi and immunotherapy combinations in pre-clinical model of cholangiocarcinoma - PubMed
These findings identify myeloid cells as key mediators of both immunotherapy resistance and toxicity in CCA, highlighting the critical importance of tumor site and use of physiologically relevant pre-...
pubmed.ncbi.nlm.nih.gov
July 3, 2025 at 1:06 PM
Check out our new paper in Hepatology on how myeloid cells limit immunotherapy in preclinical cholangiocarcinoma models!
Disease site matters! @chrystalpaulos.bsky.social @megen-w.bsky.social @winshipcancer.emory.edu many others!
pubmed.ncbi.nlm.nih.gov/40590857/
Disease site matters! @chrystalpaulos.bsky.social @megen-w.bsky.social @winshipcancer.emory.edu many others!
pubmed.ncbi.nlm.nih.gov/40590857/
Amazing talk by Dr. Ayana Ruffin @winship on the importance of CD2 in adoptive immunotherapy of cancer. It’s a T:B thing. #2025SIS on the UVA campus.
June 6, 2025 at 7:21 PM
Amazing talk by Dr. Ayana Ruffin @winship on the importance of CD2 in adoptive immunotherapy of cancer. It’s a T:B thing. #2025SIS on the UVA campus.
Not a trend I will partake in. :/
The latest drinking craze? Dropping a few jalapeño slices into a chilled glass of white wine.
Jalapeño Wine Delights TikTok but Confuses Bartenders
www.nytimes.com
May 15, 2025 at 11:43 AM
Not a trend I will partake in. :/
Reposted by Chrystal Paulos
This week I will be attending the @helloeacr.bsky.social conference, entitled "Defense is the Best Attack," where we'll catch up on the latest advances in immuno-oncology and advanced therapies. It's always a great opportunity to meet people and learn from the best. Hoping to meet you all there! 😁🧪
May 12, 2025 at 8:18 PM
This week I will be attending the @helloeacr.bsky.social conference, entitled "Defense is the Best Attack," where we'll catch up on the latest advances in immuno-oncology and advanced therapies. It's always a great opportunity to meet people and learn from the best. Hoping to meet you all there! 😁🧪
Excited to present at the first Breast Center Translational Research Seminar Series @winshipcancer.emory.edu Thank Dr. Shipra Gandhi for the invite.
May 13, 2025 at 1:19 AM
Excited to present at the first Breast Center Translational Research Seminar Series @winshipcancer.emory.edu Thank Dr. Shipra Gandhi for the invite.
What is the most important unanswered questions to address in the field of cancer immunotherapy?
May 3, 2025 at 1:17 AM
What is the most important unanswered questions to address in the field of cancer immunotherapy?
Delighted to present our labs exciting work on T cell metabolism and cancer immunotherapy today at AACR by Guillermo Rangel Rivera and Soundharya Kumaresan!
April 28, 2025 at 10:06 AM
Delighted to present our labs exciting work on T cell metabolism and cancer immunotherapy today at AACR by Guillermo Rangel Rivera and Soundharya Kumaresan!
Our findings highlight the critical role of T cell trafficking to the lymph nodes in shaping neoantigen-specific antitumor responses and offers insight for improving adoptive cellular therapies www.biorxiv.org/content/10.1...
Neoantigens drive adoptively transferred CD8 T cells to long-lived effectors mediated by lymph node trafficking
Adoptive transfer of neoantigen-reactive T lymphocytes mediates potent responses against solid tumors in patients while often limiting toxicity to normal tissues; however, the mechanisms governing the...
www.biorxiv.org
April 25, 2025 at 12:15 AM
Our findings highlight the critical role of T cell trafficking to the lymph nodes in shaping neoantigen-specific antitumor responses and offers insight for improving adoptive cellular therapies www.biorxiv.org/content/10.1...
Check out this awesome body of elegant work by @lesinskilab.bsky.social @winshipatemory.bsky.social on the immune landscape of primary vs metastatic tumor of patients with pancreatic cancer. Must read!!!!
www.biorxiv.org/content/10.1...
Excited to share our preprint on comparing Human Primary and metastatic #pancreaticcancer!!!
Excited to share our preprint on comparing Human Primary and metastatic #pancreaticcancer!!!
High-Dimensional Protein Analysis Uncovers Distinct Immunological and Stromal Signatures Between Primary and Metastatic Pancreatic Ductal Adenocarcinoma
Our understanding of the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) primarily stems from murine models or primary patient tumors. While metastatic tumors have generally less ...
www.biorxiv.org
April 19, 2025 at 12:35 PM
Check out this awesome body of elegant work by @lesinskilab.bsky.social @winshipatemory.bsky.social on the immune landscape of primary vs metastatic tumor of patients with pancreatic cancer. Must read!!!!
Stellar team!!
So very proud of our newly minted Dr. Maggie Phillips! @winshipatemory.bsky.social
She showcased her amazing translational oncology experience in today’s public defense!
She showcased her amazing translational oncology experience in today’s public defense!
April 18, 2025 at 3:40 PM
Stellar team!!
Reposted by Chrystal Paulos
Inspiring (as always) @cholangiocarcinoma.bsky.social annual meeting comes to a close. Our @winshipatemory.bsky.social team returns motivated by survivors, patients and caregivers to make a difference! @megen-w.bsky.social @chrystalpaulos.bsky.social
April 12, 2025 at 1:31 AM
Inspiring (as always) @cholangiocarcinoma.bsky.social annual meeting comes to a close. Our @winshipatemory.bsky.social team returns motivated by survivors, patients and caregivers to make a difference! @megen-w.bsky.social @chrystalpaulos.bsky.social
Excited to present our labs work on novel T cell therapies @clevelandclinic.bsky.social virtually @winshipatemory.bsky.social Thank you for the invite #LilyWang!
March 27, 2025 at 12:09 PM
Excited to present our labs work on novel T cell therapies @clevelandclinic.bsky.social virtually @winshipatemory.bsky.social Thank you for the invite #LilyWang!
💥Cheers to Megen Wittling @megen-w.bsky.social @winshipatemory.bsky.social for presenting exciting work on the distinct trafficking & activation patterns of adoptively transferred CD8 T cells that recognize non-mutated va mutated tumors.
March 27, 2025 at 1:42 AM
💥Cheers to Megen Wittling @megen-w.bsky.social @winshipatemory.bsky.social for presenting exciting work on the distinct trafficking & activation patterns of adoptively transferred CD8 T cells that recognize non-mutated va mutated tumors.
Going to talk about antitumorT cell prowess at KUMC today. Thanks to Dr. Kalyani Pyaram for inviting me to visit and talk about our labs work @winshipatemory.bsky.social
March 26, 2025 at 12:34 PM
Going to talk about antitumorT cell prowess at KUMC today. Thanks to Dr. Kalyani Pyaram for inviting me to visit and talk about our labs work @winshipatemory.bsky.social
Reposted by Chrystal Paulos
A study in Nature Immunology finds that a single injection of CAR T cells, designed to target drivers of allergic reactions, represses the signs and symptoms of allergic asthma in mice for at least a year. go.nature.com/3VeWuVg 🧪
May 28, 2024 at 2:01 PM
A study in Nature Immunology finds that a single injection of CAR T cells, designed to target drivers of allergic reactions, represses the signs and symptoms of allergic asthma in mice for at least a year. go.nature.com/3VeWuVg 🧪
Reposted by Chrystal Paulos
#CUAnschutz researchers have developed a supercharged iteration of CAR-T cell therapy that can enhance the effectiveness and longevity of the cells, particularly against #cancer cells that are harder for prior CAR-T therapies to detect and fight. 🗞️⬇️
New CAR-T Cell Therapy Shows Promise for Hard-to-Treat Cancers
New CAR-T Cell Therapy Shows Promise for Hard-to-Treat Cancers
news.cuanschutz.edu
March 11, 2025 at 4:33 PM
#CUAnschutz researchers have developed a supercharged iteration of CAR-T cell therapy that can enhance the effectiveness and longevity of the cells, particularly against #cancer cells that are harder for prior CAR-T therapies to detect and fight. 🗞️⬇️