#TertiaryLymphoidStructures
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abhishekgarglab.bsky.social
We discuss how #tumour's #spatialweb supports T cells or causes #dysfunction/#exclusion e.g., supportive #perivascular or pro-#immunogenic/#antigenic niches & #tertiarylymphoidstructures vs. #hypoxic cores, #wound #healing & #myeloid, #stromal or #fibroblastic #barriers. 4/6🧵
April 11, 2025 at 5:31 PM
profcelentyx.bsky.social
#ImmunoSky

#Immunotherapy
#ImmuneRelatedAdverseEvents
#Biomarkers

#ICOS+ CD4 #Tcells define #Susceptibility to anti-PD1-induced #Lung #Pathology in the #Aged

#Bcells #Antibodies #TertiaryLymphoidStructures

Breaking Open Access Study @jci-insight.bsky.social

insight.jci.org/articles/vie...
April 9, 2025 at 8:28 AM
bionewscentral.com
New research shows that peripheral #HelperTCells (Tph cells) in #RheumatoidArthritis include stem-like Tph cells that reside in joint #TertiaryLymphoidStructures and give rise to effector Tph cells that drive #inflammation—suggesting that targeting stem-like Tph cells could improve treatment. 
Hidden immune “hubs” drive joint damage in rheumatoid arthritis – BioNews Central
New research shows that peripheral helper T (Tph) cells in rheumatoid arthritis include stem-like Tph cells that reside in joint tertiary lymphoid structures and give rise to effector Tph cells that exit those structures and drive inflammation—sugges
sbee.link
August 16, 2025 at 6:46 PM
msklibrary.bsky.social
Featured today by @MSKLibrary: IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer

#IL33 #ILC2 #TertiaryLymphoidStructures #PancreaticCancer #CancerImmunology

www.nature.com/articles/s41...
March 7, 2025 at 4:31 PM
profcelentyx.bsky.social
#cancersky #immunosky #antibodysky

Major #CD40 #TherapeuticAntibody Success now breaking
@cp-cancercell.bsky.social

First-in-Human study of Fc-optimised CD40 agonistic Antibody elicits #TertiaryLymphoidStructures & systemic anti-Tumor #Immunity in Metastatic #Cancer

Fantastic work 👏
Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer
Osorio et al. report a first-in-human study of intratumoral 2141-V11, an Fc-engineered CD40 agonistic antibody, showing it is safe and induces systemic and durable antitumor immunity in patients with ...
www.cell.com
August 14, 2025 at 4:00 PM