Jessica König
@jessicakoenig.bsky.social
Interested in SMCs, microscopy, biophysics, hiking, ...
working at MPI for biophysics, FFM
working at MPI for biophysics, FFM
Reposted by Jessica König
Wonderful, thought-provoking review by Sir Adrian Bird on cohesin loop extrusion as disrupter of chromatin organisation rather than generator. Great read!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Cohesin as an essential disruptor of chromosome organization
Cohesin is a multi-subunit molecular machine that is able to create lateral chromatin loops within a linear chromosome fiber. Despite intense study, a…
www.sciencedirect.com
March 25, 2025 at 7:43 AM
Wonderful, thought-provoking review by Sir Adrian Bird on cohesin loop extrusion as disrupter of chromatin organisation rather than generator. Great read!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Jessica König
This is terrifying. I am worried for the non-citizens who will be showing up to the science rallies this week. Please be smart. It’s unlikely institutions will be able to save you.
March 4, 2025 at 6:04 PM
This is terrifying. I am worried for the non-citizens who will be showing up to the science rallies this week. Please be smart. It’s unlikely institutions will be able to save you.
Reposted by Jessica König
Are you an undergraduate student considering a career in academic research?
Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications!
Apply by 30th March.
More info: www2.mrc-lmb.cam.ac.uk/students/stu...
Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications!
Apply by 30th March.
More info: www2.mrc-lmb.cam.ac.uk/students/stu...
March 4, 2025 at 9:48 AM
Are you an undergraduate student considering a career in academic research?
Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications!
Apply by 30th March.
More info: www2.mrc-lmb.cam.ac.uk/students/stu...
Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications!
Apply by 30th March.
More info: www2.mrc-lmb.cam.ac.uk/students/stu...
Reposted by Jessica König
A new PhD position is available in my lab to explore DNA replication mechanisms using single-molecule approaches. Apply by 19th of March:
www.crick.ac.uk/careers-stud...
www.crick.ac.uk/careers-stud...
Yardimci Lab | Single-molecule visualisation of the eukaryotic replication machinery
www.crick.ac.uk
March 4, 2025 at 11:39 AM
A new PhD position is available in my lab to explore DNA replication mechanisms using single-molecule approaches. Apply by 19th of March:
www.crick.ac.uk/careers-stud...
www.crick.ac.uk/careers-stud...
Reposted by Jessica König
Criminalizing protest is a hallmark of authoritarian regimes
March 4, 2025 at 3:16 PM
Criminalizing protest is a hallmark of authoritarian regimes
Reposted by Jessica König
Not surprised…but bitterly disappointed all the same.
Perhaps time for members to resign en masse. #RoyalSociety
Perhaps time for members to resign en masse. #RoyalSociety
Elon Musk survives as fellow of Royal Society despite anger among scientists
Elon Musk survives as fellow of Royal Society despite anger among scientists
Questions remain over whether further action will be taken after resignations and calls for the Tesla CEO to be expelled
Elon Musk’s fellowship of the Royal Society remains intact after a meeting of the scientific body, the Guardian has learned, but…
www.theguardian.com
March 4, 2025 at 2:33 AM
Not surprised…but bitterly disappointed all the same.
Perhaps time for members to resign en masse. #RoyalSociety
Perhaps time for members to resign en masse. #RoyalSociety
Reposted by Jessica König
Bought a while ago, only start reading now, seems timely!!!
“French resistance by night, experiments (on lac operon) by day!!!”
“French resistance by night, experiments (on lac operon) by day!!!”
March 2, 2025 at 5:04 PM
Bought a while ago, only start reading now, seems timely!!!
“French resistance by night, experiments (on lac operon) by day!!!”
“French resistance by night, experiments (on lac operon) by day!!!”
Reposted by Jessica König
Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
February 27, 2025 at 8:13 PM
Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Reposted by Jessica König
This, by Jan Böhmermann is excellent: on Germany's persistent Nazis. Now, please, mein Herr, do America and its new Nazis in power.
Gift link video:
The Far Right is Rising in the Land of ‘Never Again’ www.nytimes.com/2025/02/20/o...
Gift link video:
The Far Right is Rising in the Land of ‘Never Again’ www.nytimes.com/2025/02/20/o...
Opinion | Germany’s Far-Right Comeback (Gift Article)
Germany’s attempts to “remember away” its Nazi past has instead paved the way for an extremist resurgence.
www.nytimes.com
February 20, 2025 at 11:52 AM
This, by Jan Böhmermann is excellent: on Germany's persistent Nazis. Now, please, mein Herr, do America and its new Nazis in power.
Gift link video:
The Far Right is Rising in the Land of ‘Never Again’ www.nytimes.com/2025/02/20/o...
Gift link video:
The Far Right is Rising in the Land of ‘Never Again’ www.nytimes.com/2025/02/20/o...
Reposted by Jessica König
So much happening in the segmentation space for bioimage analysis. These two papers that were published online today really stood out to me as noteworthy (a thread).
February 12, 2025 at 2:39 PM
So much happening in the segmentation space for bioimage analysis. These two papers that were published online today really stood out to me as noteworthy (a thread).
Reposted by Jessica König
Every scientist should read this. Unbelievable, utterly insane, and outrageous. There is a significant fear that this could also reach Germany with the impending conservative-fascist government (CDU/NSAfD), which Germany is highly likely to have by early summer.
February 4, 2025 at 9:49 PM
Every scientist should read this. Unbelievable, utterly insane, and outrageous. There is a significant fear that this could also reach Germany with the impending conservative-fascist government (CDU/NSAfD), which Germany is highly likely to have by early summer.
Reposted by Jessica König
DeepSeek's open AI model is giving scientists worldwide the opportunity to train custom reasoning models designed to solve problems in their disciplines.
https://go.nature.com/4hxoRGD
https://go.nature.com/4hxoRGD
Scientists flock to DeepSeek: how they’re using the blockbuster AI model
Researchers are testing how well the open model can perform scientific tasks — in topics from mathematics to cognitive neuroscience.
go.nature.com
February 2, 2025 at 3:12 PM
DeepSeek's open AI model is giving scientists worldwide the opportunity to train custom reasoning models designed to solve problems in their disciplines.
https://go.nature.com/4hxoRGD
https://go.nature.com/4hxoRGD
Reposted by Jessica König
Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed
I’m very scared to see what happens to PubMed
January 31, 2025 at 8:44 PM
Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed
Reposted by Jessica König
Friedrich Merz, the leader of the German CDU, just claimed in parliament that gang rapes are committed on a daily basis by asylum seekers in Germany. It is pure far right propaganda. The mainstreaming of the far right is happening on steroids in Germany right now.
January 31, 2025 at 1:53 PM
Friedrich Merz, the leader of the German CDU, just claimed in parliament that gang rapes are committed on a daily basis by asylum seekers in Germany. It is pure far right propaganda. The mainstreaming of the far right is happening on steroids in Germany right now.
Reposted by Jessica König
We’ve updated the #AlphaFold 3 code, see below for details!
AlphaFold v3.0.1 is out! Contains various efficiency and usability improvements alongside a collection of minor bug fixes. See the release notes for more detail - github.com/google-deepm...
Release AlphaFold v3.0.1 · google-deepmind/alphafold3
Version 3.0.1 provides new features, improves performance, improves documentation, and fixes bugs. We thank everyone who reported issues, proposed new features, and submitted PRs!
Change log
Below ...
github.com
January 30, 2025 at 3:18 PM
We’ve updated the #AlphaFold 3 code, see below for details!
Reposted by Jessica König
Researchers used AlphaFold alone (no wet-lab experiments; no cryo-EM etc.) to build a structural model and predict how a huge complex in cells, made of 17 proteins, spans across the bacterial cell envelope to transduce force for motility.
Can anyone tell me if this is a first?
Can anyone tell me if this is a first?
January 30, 2025 at 4:10 PM
Researchers used AlphaFold alone (no wet-lab experiments; no cryo-EM etc.) to build a structural model and predict how a huge complex in cells, made of 17 proteins, spans across the bacterial cell envelope to transduce force for motility.
Can anyone tell me if this is a first?
Can anyone tell me if this is a first?
Reposted by Jessica König
Too many AI projects begin at the wrong starting point. They start with an existing dataset, and ask “what can we do with this data?”
The harder question is, “what are the biggest questions in your area, and what data would be useful to answering them?” 5/
The harder question is, “what are the biggest questions in your area, and what data would be useful to answering them?” 5/
January 24, 2025 at 10:25 PM
Too many AI projects begin at the wrong starting point. They start with an existing dataset, and ask “what can we do with this data?”
The harder question is, “what are the biggest questions in your area, and what data would be useful to answering them?” 5/
The harder question is, “what are the biggest questions in your area, and what data would be useful to answering them?” 5/
Reposted by Jessica König
🇭🇳 Contribute to the community
🇮🇪 Publish papers, but also be publicly visible
🇺🇸 Publication record, impact, and research quality
This is how to become a professor where you are
https://go.nature.com/3WpESGE
🇮🇪 Publish papers, but also be publicly visible
🇺🇸 Publication record, impact, and research quality
This is how to become a professor where you are
https://go.nature.com/3WpESGE
Want to become a professor? Here’s how hiring criteria differ by country
Huge analysis identifies regional variations in the criteria that institutions use to move researchers up the ranks.
go.nature.com
January 22, 2025 at 4:58 PM
🇭🇳 Contribute to the community
🇮🇪 Publish papers, but also be publicly visible
🇺🇸 Publication record, impact, and research quality
This is how to become a professor where you are
https://go.nature.com/3WpESGE
🇮🇪 Publish papers, but also be publicly visible
🇺🇸 Publication record, impact, and research quality
This is how to become a professor where you are
https://go.nature.com/3WpESGE
Reposted by Jessica König
Genome-wide absolute quantification of chromatin looping https://www.biorxiv.org/content/10.1101/2025.01.13.632736v1
January 16, 2025 at 4:34 AM
Genome-wide absolute quantification of chromatin looping https://www.biorxiv.org/content/10.1101/2025.01.13.632736v1
Reposted by Jessica König
Mechanisms of chromatin remodeling by a Snf2-type ATPase https://www.biorxiv.org/content/10.1101/2024.12.31.630910v1
January 2, 2025 at 4:53 PM
Mechanisms of chromatin remodeling by a Snf2-type ATPase https://www.biorxiv.org/content/10.1101/2024.12.31.630910v1
Reposted by Jessica König
Differential effect of supercoiling on bacterial transcription in topological domains https://www.biorxiv.org/content/10.1101/2025.01.02.631060v1
January 2, 2025 at 4:52 PM
Differential effect of supercoiling on bacterial transcription in topological domains https://www.biorxiv.org/content/10.1101/2025.01.02.631060v1
Reposted by Jessica König
If your new year resolution is doing a PhD, there is still time left to apply for a project in my group looking at how the condensin complex undergoes such large conformational changes while making loops. I mean look at how cool the starting model is:
January 2, 2025 at 4:04 PM
If your new year resolution is doing a PhD, there is still time left to apply for a project in my group looking at how the condensin complex undergoes such large conformational changes while making loops. I mean look at how cool the starting model is:
Reposted by Jessica König
"I began to see my time off not as a failure, but as a necessary pause." #ScienceWorkingLife scim.ag/3PxSewJ
I took a break from work to protect my health. This should be more accepted in academia
Better support structures would “lead to a more inclusive, productive, and humane workplace for everyone,” this physician-scientist writes
scim.ag
December 26, 2024 at 4:59 PM
"I began to see my time off not as a failure, but as a necessary pause." #ScienceWorkingLife scim.ag/3PxSewJ
Reposted by Jessica König
