Ishier Raote
@ishier.bsky.social
Institut Jacques Monod, Paris
@ijmonod.bsky.social
https://www.ijm.fr/raote-lab/
Collagen secretion, membrane trafficking
Formerly @crg.eu
@ijmonod.bsky.social
https://www.ijm.fr/raote-lab/
Collagen secretion, membrane trafficking
Formerly @crg.eu
Reposted by Ishier Raote
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
November 9, 2025 at 6:04 PM
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
Reposted by Ishier Raote
Environmental stiffness regulates neuronal
maturation via Piezo1-mediated transthyretin activity.
My main postdoc paper is finally online!
Thanks to all the co-authors, the entire Franze lab and the Káradóttir lab.
@franzelab.bsky.social
www.nature.com/articles/s41...
maturation via Piezo1-mediated transthyretin activity.
My main postdoc paper is finally online!
Thanks to all the co-authors, the entire Franze lab and the Káradóttir lab.
@franzelab.bsky.social
www.nature.com/articles/s41...
Environmental stiffness regulates neuronal maturation via Piezo1-mediated transthyretin activity - Nature Communications
How the environment regulates neuronal maturation during brain development is poorly understood. Here, Kreysing et al. identify brain stiffness as a key factor and determine a mechanotransduction path...
www.nature.com
November 7, 2025 at 11:48 AM
Environmental stiffness regulates neuronal
maturation via Piezo1-mediated transthyretin activity.
My main postdoc paper is finally online!
Thanks to all the co-authors, the entire Franze lab and the Káradóttir lab.
@franzelab.bsky.social
www.nature.com/articles/s41...
maturation via Piezo1-mediated transthyretin activity.
My main postdoc paper is finally online!
Thanks to all the co-authors, the entire Franze lab and the Káradóttir lab.
@franzelab.bsky.social
www.nature.com/articles/s41...
Reposted by Ishier Raote
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.
Beautiful tomography and microscopy - congrats all 🤩
Beautiful tomography and microscopy - congrats all 🤩
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:56 AM
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.
Beautiful tomography and microscopy - congrats all 🤩
Beautiful tomography and microscopy - congrats all 🤩
Reposted by Ishier Raote
Under two weeks before my #play hits the stage @taratheatre.com ! Can't wait!
Come see it if you're in London- it'll be great to have tons of people there.
Book here: taratheatre.com/whats-on/i-d...
A video of me wittering on about the play in the post below ⬇️
#theatre #newWriting #immigration
Come see it if you're in London- it'll be great to have tons of people there.
Book here: taratheatre.com/whats-on/i-d...
A video of me wittering on about the play in the post below ⬇️
#theatre #newWriting #immigration
I Dream of Theresa May – Tara Theatre
taratheatre.com
November 5, 2025 at 5:58 PM
Under two weeks before my #play hits the stage @taratheatre.com ! Can't wait!
Come see it if you're in London- it'll be great to have tons of people there.
Book here: taratheatre.com/whats-on/i-d...
A video of me wittering on about the play in the post below ⬇️
#theatre #newWriting #immigration
Come see it if you're in London- it'll be great to have tons of people there.
Book here: taratheatre.com/whats-on/i-d...
A video of me wittering on about the play in the post below ⬇️
#theatre #newWriting #immigration
Nice preprint from Gerard Cantero @gercrcat.bsky.social! Loss of ClC-5 function causes Dent’s Disease type 1. In a renal proximal tubule epithelial cell line, ClC-5 mutations disrupt endolysosomal pH and the Golgi via TMEM9 and SEC22B, interesting pathophysiology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
TMEM9 and SEC22B interact with ClC-5 to shape renal proximal tubule function and Dent's Disease type I pathogenesis
Cl-/H+ antiporter ClC-5 is a key regulator of renal proximal tubule function, primarily by controlling endosomal acidification. Loss-of-function mutations in ClC-5 cause Dent's Disease type 1 (DD1), a...
www.biorxiv.org
November 5, 2025 at 8:42 AM
Nice preprint from Gerard Cantero @gercrcat.bsky.social! Loss of ClC-5 function causes Dent’s Disease type 1. In a renal proximal tubule epithelial cell line, ClC-5 mutations disrupt endolysosomal pH and the Golgi via TMEM9 and SEC22B, interesting pathophysiology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ishier Raote
Europe's MSCA postdoctoral fellowships are now attracting many researchers who would have gone to the US. So the payline has dropped below 10% (~1,600 fellowships to 17k applicants). Super tough situation. One more reason to double the next Horizon budget, as proposed by the EU Commission.
Applications for MCSA are up 64%! 50% now come from outside the EU. Trump effect?
The European Research market just got a hell of a lot more crowded.
EU should turn on the tap
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
The European Research market just got a hell of a lot more crowded.
EU should turn on the tap
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
MSCA Postdoctoral Fellowships 2025 receives record number of 17,058 proposals
This year’s annual MSCA Postdoctoral Fellowships call has attracted considerable interest from the research community with 17,058 proposals submitted.
marie-sklodowska-curie-actions.ec.europa.eu
November 3, 2025 at 8:24 AM
Europe's MSCA postdoctoral fellowships are now attracting many researchers who would have gone to the US. So the payline has dropped below 10% (~1,600 fellowships to 17k applicants). Super tough situation. One more reason to double the next Horizon budget, as proposed by the EU Commission.
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
November 3, 2025 at 7:33 PM
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
Reposted by Ishier Raote
I have two open positions @ALMU @crg.eu:
1. Imaging Scientist (permanent position. Deadline 11th Nov.) recruitment.crg.eu/content/jobs...
2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.) recruitment.crg.eu/content/jobs...
Reposts appreciated.
1. Imaging Scientist (permanent position. Deadline 11th Nov.) recruitment.crg.eu/content/jobs...
2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.) recruitment.crg.eu/content/jobs...
Reposts appreciated.
November 3, 2025 at 2:01 PM
I have two open positions @ALMU @crg.eu:
1. Imaging Scientist (permanent position. Deadline 11th Nov.) recruitment.crg.eu/content/jobs...
2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.) recruitment.crg.eu/content/jobs...
Reposts appreciated.
1. Imaging Scientist (permanent position. Deadline 11th Nov.) recruitment.crg.eu/content/jobs...
2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.) recruitment.crg.eu/content/jobs...
Reposts appreciated.
The new Outlook app has achieved peak academic design: less functional, but somehow more confident.
November 3, 2025 at 7:45 AM
The new Outlook app has achieved peak academic design: less functional, but somehow more confident.
Reposted by Ishier Raote
Interested in intracellular organization and membrane trafficking? 🥞 Join us at @melisupf.bsky.social in Barcelona! We’re looking for postdocs to apply for a Juan de la Cierva fellowship (PhD between Jan’24–Dec ’25). If you’d like to work with us, get in touch! www.aei.gob.es/en/announcem...
Ayudas para contratos Juan de la Cierva 2025 | Agencia Estatal de Investigación
Las ayudas Juan de la Cierva tienen como finalidad fomentar la incorporación de jóvenes, en posesión del grado de doctor, con objeto de que completen su formación investigadora postdoctoral en centros...
www.aei.gob.es
November 2, 2025 at 11:08 AM
Interested in intracellular organization and membrane trafficking? 🥞 Join us at @melisupf.bsky.social in Barcelona! We’re looking for postdocs to apply for a Juan de la Cierva fellowship (PhD between Jan’24–Dec ’25). If you’d like to work with us, get in touch! www.aei.gob.es/en/announcem...
Nice preprint from Mondira Kundu lab! Glucose starvation blocks SEC24C-dependent ER-to-Golgi export of some proteins like E-cadherin, reshaping the surface proteome - via AMPK-ULK1-Sec31A signalling. Controls cell migration and metastasis under nutrient stress.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ER-to-Golgi Trafficking is a Nutrient-Sensitive Checkpoint Linking Glucose Starvation to Cell Surface Remodeling
Cancer cells adapt to nutrient stress by remodeling the repertoire of proteins on their surface, enabling survival and progression under starvation conditions. However, the molecular mechanisms by whi...
www.biorxiv.org
November 1, 2025 at 5:54 PM
Nice preprint from Mondira Kundu lab! Glucose starvation blocks SEC24C-dependent ER-to-Golgi export of some proteins like E-cadherin, reshaping the surface proteome - via AMPK-ULK1-Sec31A signalling. Controls cell migration and metastasis under nutrient stress.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ishier Raote
🚨 #PhD Opportunities 🚨
🧵
How does plasma membrane structure underpin tissue development?
Let’s find out!
Opportunity to do a PhD with me, co-supervised by Darius Koester, at Warwick.
Fully funded studentship by #MIBTP.
🔬✨🐟
More info:
www.findaphd.com/phds/project...
Interested? Reach out!
🧵
How does plasma membrane structure underpin tissue development?
Let’s find out!
Opportunity to do a PhD with me, co-supervised by Darius Koester, at Warwick.
Fully funded studentship by #MIBTP.
🔬✨🐟
More info:
www.findaphd.com/phds/project...
Interested? Reach out!
October 31, 2025 at 1:33 PM
🚨 #PhD Opportunities 🚨
🧵
How does plasma membrane structure underpin tissue development?
Let’s find out!
Opportunity to do a PhD with me, co-supervised by Darius Koester, at Warwick.
Fully funded studentship by #MIBTP.
🔬✨🐟
More info:
www.findaphd.com/phds/project...
Interested? Reach out!
🧵
How does plasma membrane structure underpin tissue development?
Let’s find out!
Opportunity to do a PhD with me, co-supervised by Darius Koester, at Warwick.
Fully funded studentship by #MIBTP.
🔬✨🐟
More info:
www.findaphd.com/phds/project...
Interested? Reach out!
Reposted by Ishier Raote
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
October 31, 2025 at 2:42 PM
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
Should I be worried if I can't solve many of the 'are you human' puzzles on the internet?
October 31, 2025 at 5:25 PM
Should I be worried if I can't solve many of the 'are you human' puzzles on the internet?
Reposted by Ishier Raote
Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM url: rupress.org/jcb/article-...
Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM
Nair et al. show an abundance of vesicular ERES in mammalian cells imaged by volume-focused ion beam EM. These findings reconcile diverging models of ERES
rupress.org
October 31, 2025 at 3:03 PM
Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM url: rupress.org/jcb/article-...
Reposted by Ishier Raote
Had the pleasure of working with @mohannad-dardiry.bsky.social to rethink what it means to develop for life. Many thanks to @dev-journal.bsky.social! @embl.org #LifelongDevSI
October 31, 2025 at 11:24 AM
Had the pleasure of working with @mohannad-dardiry.bsky.social to rethink what it means to develop for life. Many thanks to @dev-journal.bsky.social! @embl.org #LifelongDevSI
Reposted by Ishier Raote
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ishier Raote
📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
October 30, 2025 at 1:15 PM
📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!
Reposted by Ishier Raote
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
#JobOffer
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
October 28, 2025 at 1:51 PM
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
Reposted by Ishier Raote
#JobOffer
💼 Postdoctoral Researcher (M/F) in Biophysics of Bacterial Infection
📆 January 1st, 2026
📍Institut Jacques Monod, Bonazzi Lab
Apply before November 6th 🔗 emploi.cnrs.fr/Offres/CDD/U...
💼 Postdoctoral Researcher (M/F) in Biophysics of Bacterial Infection
📆 January 1st, 2026
📍Institut Jacques Monod, Bonazzi Lab
Apply before November 6th 🔗 emploi.cnrs.fr/Offres/CDD/U...
October 27, 2025 at 10:43 AM
#JobOffer
💼 Postdoctoral Researcher (M/F) in Biophysics of Bacterial Infection
📆 January 1st, 2026
📍Institut Jacques Monod, Bonazzi Lab
Apply before November 6th 🔗 emploi.cnrs.fr/Offres/CDD/U...
💼 Postdoctoral Researcher (M/F) in Biophysics of Bacterial Infection
📆 January 1st, 2026
📍Institut Jacques Monod, Bonazzi Lab
Apply before November 6th 🔗 emploi.cnrs.fr/Offres/CDD/U...
Reposted by Ishier Raote
Calling all #Membrane enthusiasts!
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
October 27, 2025 at 5:02 PM
Calling all #Membrane enthusiasts!
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Reposted by Ishier Raote
📢 2 very exciting PhD opportunities, please share!
We use a range of technologies+systems to study #collagen, #ECMatrix, and #fibrosis 👇
1) MRC CASE DTP - #3D #biomaterials, #immune cells alter, #drugscreens
lnkd.in/e6eMqs8M
2) Bicentenary - #macrophages, #circadian, #omics.
lnkd.in/ekZfJfsd
We use a range of technologies+systems to study #collagen, #ECMatrix, and #fibrosis 👇
1) MRC CASE DTP - #3D #biomaterials, #immune cells alter, #drugscreens
lnkd.in/e6eMqs8M
2) Bicentenary - #macrophages, #circadian, #omics.
lnkd.in/ekZfJfsd
October 20, 2025 at 8:41 AM
📢 2 very exciting PhD opportunities, please share!
We use a range of technologies+systems to study #collagen, #ECMatrix, and #fibrosis 👇
1) MRC CASE DTP - #3D #biomaterials, #immune cells alter, #drugscreens
lnkd.in/e6eMqs8M
2) Bicentenary - #macrophages, #circadian, #omics.
lnkd.in/ekZfJfsd
We use a range of technologies+systems to study #collagen, #ECMatrix, and #fibrosis 👇
1) MRC CASE DTP - #3D #biomaterials, #immune cells alter, #drugscreens
lnkd.in/e6eMqs8M
2) Bicentenary - #macrophages, #circadian, #omics.
lnkd.in/ekZfJfsd
Reposted by Ishier Raote
Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium
Abstract. To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms
academic.oup.com
October 17, 2025 at 11:58 AM
Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
Reposted by Ishier Raote
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - MCDB - UOD2016
Closing date: Thursday 6 November 2025, 23:59
www.dundee.ac.uk
October 15, 2025 at 12:53 PM
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
New preprint from Sean Munro @cellbiol-mrclmb.bsky.social! Golgi tether p115 directly binds Sec16A at ER exit sites. Mutations blocking this binding reduce secretion. A rich new mechanistic insight into physical coupling of ERES–ERGIC/Golgi.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Golgi vesicle tether p115/USO1 can bind directly to the ER exit site organiser Sec16A
Newly-made secretory and membrane proteins exit the endoplasmic reticulum (ER) in COPII vesicles that form at specialised ER exit sites. These exit sites are typically near to the early Golgi compartm...
www.biorxiv.org
October 17, 2025 at 7:36 AM
New preprint from Sean Munro @cellbiol-mrclmb.bsky.social! Golgi tether p115 directly binds Sec16A at ER exit sites. Mutations blocking this binding reduce secretion. A rich new mechanistic insight into physical coupling of ERES–ERGIC/Golgi.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...