Joan Chang
@tranejoan.bsky.social
Chasing the👩🏻🔬dream: HKG-EDI-LDN-CPH-RDU-MAN| Matrix/⏰ biology | Disease microenvironment | MRC CDA Fellow @mcrcellmatrix.bsky.social @mcf-uom.bsky.social, University of Manchester | Mass Spec aficionado
Pinned
Joan Chang
@tranejoan.bsky.social
· Mar 5
Macrophages promote collagen deposition through circadian regulation of fibroblasts
Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...
www.biorxiv.org
Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
Had a wonderful time as usual! Really fantastic to see so many new #ECMatrix young scientists from diverse institutions, with exciting projects 💪🏻 and superb hosting (and organisation) from @ccstorytime.bsky.social of course (should've taken more food photos)!
Day 2 of the Matrix Biology PhD course and we’re in the new Fælleshuset building starting our group work brain storming. Thanks to @douglaspdyer.bsky.social and @tranejoan.bsky.social for laying the foundations of ECM biology in yesterday’s lectures!
November 6, 2025 at 8:19 AM
Had a wonderful time as usual! Really fantastic to see so many new #ECMatrix young scientists from diverse institutions, with exciting projects 💪🏻 and superb hosting (and organisation) from @ccstorytime.bsky.social of course (should've taken more food photos)!
📢 2 very exciting PhD opportunities, please share!
We use a range of technologies+systems to study #collagen, #ECMatrix, and #fibrosis 👇
1) MRC CASE DTP - #3D #biomaterials, #immune cells alter, #drugscreens
lnkd.in/e6eMqs8M
2) Bicentenary - #macrophages, #circadian, #omics.
lnkd.in/ekZfJfsd
We use a range of technologies+systems to study #collagen, #ECMatrix, and #fibrosis 👇
1) MRC CASE DTP - #3D #biomaterials, #immune cells alter, #drugscreens
lnkd.in/e6eMqs8M
2) Bicentenary - #macrophages, #circadian, #omics.
lnkd.in/ekZfJfsd
October 20, 2025 at 8:41 AM
📢 2 very exciting PhD opportunities, please share!
We use a range of technologies+systems to study #collagen, #ECMatrix, and #fibrosis 👇
1) MRC CASE DTP - #3D #biomaterials, #immune cells alter, #drugscreens
lnkd.in/e6eMqs8M
2) Bicentenary - #macrophages, #circadian, #omics.
lnkd.in/ekZfJfsd
We use a range of technologies+systems to study #collagen, #ECMatrix, and #fibrosis 👇
1) MRC CASE DTP - #3D #biomaterials, #immune cells alter, #drugscreens
lnkd.in/e6eMqs8M
2) Bicentenary - #macrophages, #circadian, #omics.
lnkd.in/ekZfJfsd
My office for the next week or so, good to be back at HKU.
October 20, 2025 at 3:07 AM
My office for the next week or so, good to be back at HKU.
Reposted by Joan Chang
Looking for a PhD ? Don’t miss ⬇️
12 PhDs available in the REMOD-HEALING European doctoral network, funded by Horizon Europe's MCSA-DN program, in Europe and Costa Rica !
www.euraxess.fr/jobs/375945
@themeshwork.bsky.social @matrixbiologie.bsky.social
#ECM #collagen #WoundHealing
#proteases
12 PhDs available in the REMOD-HEALING European doctoral network, funded by Horizon Europe's MCSA-DN program, in Europe and Costa Rica !
www.euraxess.fr/jobs/375945
@themeshwork.bsky.social @matrixbiologie.bsky.social
#ECM #collagen #WoundHealing
#proteases
October 4, 2025 at 9:31 AM
Looking for a PhD ? Don’t miss ⬇️
12 PhDs available in the REMOD-HEALING European doctoral network, funded by Horizon Europe's MCSA-DN program, in Europe and Costa Rica !
www.euraxess.fr/jobs/375945
@themeshwork.bsky.social @matrixbiologie.bsky.social
#ECM #collagen #WoundHealing
#proteases
12 PhDs available in the REMOD-HEALING European doctoral network, funded by Horizon Europe's MCSA-DN program, in Europe and Costa Rica !
www.euraxess.fr/jobs/375945
@themeshwork.bsky.social @matrixbiologie.bsky.social
#ECM #collagen #WoundHealing
#proteases
Reposted by Joan Chang
Thoughtful (and hopeful) reflections on the state-of-play for #ResearchCulture assessment as part of #REF2029 and the #REFPCE indicators project:
wonkhe.com/blogs/is-res...
"We don’t need all the answers for 2029, but we shouldn’t discard the tangible progress made"
wonkhe.com/blogs/is-res...
"We don’t need all the answers for 2029, but we shouldn’t discard the tangible progress made"
Is research culture really too hard to assess?
Yolana Pringle and Ben Tatler make the case that the REF pause should be the moment to build on the most substantial sector-wide collaboration ever undertaken on research environments
wonkhe.com
October 1, 2025 at 3:33 PM
Thoughtful (and hopeful) reflections on the state-of-play for #ResearchCulture assessment as part of #REF2029 and the #REFPCE indicators project:
wonkhe.com/blogs/is-res...
"We don’t need all the answers for 2029, but we shouldn’t discard the tangible progress made"
wonkhe.com/blogs/is-res...
"We don’t need all the answers for 2029, but we shouldn’t discard the tangible progress made"
Reposted by Joan Chang
Become part of our new MRC Centre, working across Manchester and Oxford to solve a major challenge of our time - how does the immune system become dysregulated by environmental exposures to cause chronic disease.
www.manchester.ac.uk/exposome-jobs
@exposomeimmunology.bsky.social
www.manchester.ac.uk/exposome-jobs
@exposomeimmunology.bsky.social
www.bmh.manchester.ac.uk
September 30, 2025 at 10:57 AM
Become part of our new MRC Centre, working across Manchester and Oxford to solve a major challenge of our time - how does the immune system become dysregulated by environmental exposures to cause chronic disease.
www.manchester.ac.uk/exposome-jobs
@exposomeimmunology.bsky.social
www.manchester.ac.uk/exposome-jobs
@exposomeimmunology.bsky.social
Reposted by Joan Chang
The liver #transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein #OGlcNAcylation in mouse #liver during the day, @joanna-chiu.bsky.social &co show how shifts in a nutrient-sensitive #PTM may shape transcriptional regulation @plosbiology.org 🧪 plos.io/3KuS7m1
September 29, 2025 at 1:15 PM
The liver #transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein #OGlcNAcylation in mouse #liver during the day, @joanna-chiu.bsky.social &co show how shifts in a nutrient-sensitive #PTM may shape transcriptional regulation @plosbiology.org 🧪 plos.io/3KuS7m1
New review! Towards a unified framework for the function of ER exit sites
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
September 30, 2025 at 12:37 PM
New review! Towards a unified framework for the function of ER exit sites
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Joan Chang
🎉 Happy Postdoc Appreciation Week 2025! 🎉
At ASMB, we’re celebrating the innovators of tomorrow — our incredible PhD students & postdocs who are driving discovery every day.
👉ASMB members, want to be featured?: We are still accepting Submissions!
#ASMBPAW2025 #ASMBTrainees #ECMatrix
At ASMB, we’re celebrating the innovators of tomorrow — our incredible PhD students & postdocs who are driving discovery every day.
👉ASMB members, want to be featured?: We are still accepting Submissions!
#ASMBPAW2025 #ASMBTrainees #ECMatrix
September 18, 2025 at 6:23 PM
🎉 Happy Postdoc Appreciation Week 2025! 🎉
At ASMB, we’re celebrating the innovators of tomorrow — our incredible PhD students & postdocs who are driving discovery every day.
👉ASMB members, want to be featured?: We are still accepting Submissions!
#ASMBPAW2025 #ASMBTrainees #ECMatrix
At ASMB, we’re celebrating the innovators of tomorrow — our incredible PhD students & postdocs who are driving discovery every day.
👉ASMB members, want to be featured?: We are still accepting Submissions!
#ASMBPAW2025 #ASMBTrainees #ECMatrix
It's been a great conference hearing all the other research findings and lots of new ideas - food for thought for everyone! Wish I didn't have to leave earlier...
Terrific talk from @tranejoan.bsky.social on collagen homeostasis and turnover. Still a lot of things to be learned about collagen.
July 29, 2025 at 11:21 AM
It's been a great conference hearing all the other research findings and lots of new ideas - food for thought for everyone! Wish I didn't have to leave earlier...
Reposted by Joan Chang
Great to meet with @tranejoan.bsky.social
July 28, 2025 at 10:28 AM
Great to meet with @tranejoan.bsky.social
Awesome talk (as expected) by @stockmannlab.bsky.social on targeting fibrogenesis, at the #SclerodermaWorkshop - first reunion since #KeystoneFobrosis2022!
July 27, 2025 at 1:03 PM
Awesome talk (as expected) by @stockmannlab.bsky.social on targeting fibrogenesis, at the #SclerodermaWorkshop - first reunion since #KeystoneFobrosis2022!
Yesterday I attended the #graduation of my #firstPhD student Katie Lowles. What a moment! No longer her PI but still feeling very proud @mcf-uom.bsky.social @mcrcellmatrix.bsky.social
(Oh and I also attended my first ever #GRCCollagen...it was awesome even though I had to leave early!)
(Oh and I also attended my first ever #GRCCollagen...it was awesome even though I had to leave early!)
July 11, 2025 at 1:28 PM
Yesterday I attended the #graduation of my #firstPhD student Katie Lowles. What a moment! No longer her PI but still feeling very proud @mcf-uom.bsky.social @mcrcellmatrix.bsky.social
(Oh and I also attended my first ever #GRCCollagen...it was awesome even though I had to leave early!)
(Oh and I also attended my first ever #GRCCollagen...it was awesome even though I had to leave early!)
Reposted by Joan Chang
Our final online seminar of the season is just around the corner!!! Save the date: June 25, 3pm CET. Register for FREE now and join us next week to discuss all things Hyaluronan in Medicine with Dr Laura Alaniz!!! Follow the QR code or click here: forms.gle/iSjnrLBVZmkD... @amsocmatbio.bsky.social
June 18, 2025 at 6:53 AM
Our final online seminar of the season is just around the corner!!! Save the date: June 25, 3pm CET. Register for FREE now and join us next week to discuss all things Hyaluronan in Medicine with Dr Laura Alaniz!!! Follow the QR code or click here: forms.gle/iSjnrLBVZmkD... @amsocmatbio.bsky.social
Reposted by Joan Chang
📢 IMPORTANT DATE ALLERT!
Excited for the ASMB 2025 Biennial Meeting in Baltimore, Nov 16–19! Early Bird Registrations and Abstract submission deadline approaching—Don't forget to sign up first, then submit your abstract. See you there!
#ASMB2025 #ASMBaltimore2025 #ECMatrix
Excited for the ASMB 2025 Biennial Meeting in Baltimore, Nov 16–19! Early Bird Registrations and Abstract submission deadline approaching—Don't forget to sign up first, then submit your abstract. See you there!
#ASMB2025 #ASMBaltimore2025 #ECMatrix
June 2, 2025 at 4:22 PM
📢 IMPORTANT DATE ALLERT!
Excited for the ASMB 2025 Biennial Meeting in Baltimore, Nov 16–19! Early Bird Registrations and Abstract submission deadline approaching—Don't forget to sign up first, then submit your abstract. See you there!
#ASMB2025 #ASMBaltimore2025 #ECMatrix
Excited for the ASMB 2025 Biennial Meeting in Baltimore, Nov 16–19! Early Bird Registrations and Abstract submission deadline approaching—Don't forget to sign up first, then submit your abstract. See you there!
#ASMB2025 #ASMBaltimore2025 #ECMatrix
Looking forwards to talking about #collagen and #circadian (or otherwise!) tomorrow!
Don't forget to join us tomorrow for an exciting talk by
@tranejoan.bsky.social on Circadian control of collagen homeostasis. In case you didn't have the chance to register, follow the QR code below or the link: upatras-gr.zoom.us/j/9408054408...
@tranejoan.bsky.social on Circadian control of collagen homeostasis. In case you didn't have the chance to register, follow the QR code below or the link: upatras-gr.zoom.us/j/9408054408...
May 27, 2025 at 6:23 PM
Looking forwards to talking about #collagen and #circadian (or otherwise!) tomorrow!
Not sure I'm the expert, but definitely we're all about the #ECMatrix with a dabble of #CircadianRhythms 😆
This month we are bringing the circadian rhythm in focus with a talk by @tranejoan.bsky.social on "(Circadian) control of collagen homeostasis – new paradigms and tools" Register now and don't miss a stimulating talk with all the latest updates from the expert herself: forms.gle/peLbQr5AiF2R...
May 12, 2025 at 8:37 AM
Not sure I'm the expert, but definitely we're all about the #ECMatrix with a dabble of #CircadianRhythms 😆
Reposted by Joan Chang
Are you into cryo-ET, in-cell discovery, protein translocation and folding or just cool integration of structural biology, proteomics and bioinformatics? Then see our new work:
www.biorxiv.org/content/10.1...
Thank you to all coauthors for your amazing work!
www.biorxiv.org/content/10.1...
Thank you to all coauthors for your amazing work!
www.biorxiv.org
April 28, 2025 at 4:43 AM
Are you into cryo-ET, in-cell discovery, protein translocation and folding or just cool integration of structural biology, proteomics and bioinformatics? Then see our new work:
www.biorxiv.org/content/10.1...
Thank you to all coauthors for your amazing work!
www.biorxiv.org/content/10.1...
Thank you to all coauthors for your amazing work!
April 14, 2025 at 11:51 AM
So professional (until it got to my part, so flustered!) - it's been a wonderful meeting and it's exciting to see a YouTube channel!! #ECMatrix #ScienceNoBoundaries
🎬 New video just dropped! Tag along for a mini vlog from the Matrix Nexus with surprise guests in rapid-fire Qs we asked around the floor! Catch the Young Investigator sneak peeks and behind-the-scenes vibes 👀Watch now: youtu.be/GkqB_Pk4hBQ Like/Subscribe for more
Matrix Nexus Vlog + Bonus Q&A
YouTube video by The Meshwork
youtu.be
April 10, 2025 at 11:28 AM
So professional (until it got to my part, so flustered!) - it's been a wonderful meeting and it's exciting to see a YouTube channel!! #ECMatrix #ScienceNoBoundaries
Incredible.
"David Liu – a professor at the Broad Institute of MIT and Harvard, a biomedical research facility in Massachusetts – has marked Thanksgiving by handing over his entire annual salary to the staff and students in his laboratory."
www.theguardian.com/science/2025...
"David Liu – a professor at the Broad Institute of MIT and Harvard, a biomedical research facility in Massachusetts – has marked Thanksgiving by handing over his entire annual salary to the staff and students in his laboratory."
www.theguardian.com/science/2025...
Biologist whose innovation saved the life of British teenager wins $3m Breakthrough prize
Prof David Liu is among the winners of 2025’s ‘Oscars of science’, with honours also going to researchers for landmark work on multiple sclerosis, particle physics and ‘skinny jabs’
www.theguardian.com
April 6, 2025 at 9:12 AM
Incredible.
"David Liu – a professor at the Broad Institute of MIT and Harvard, a biomedical research facility in Massachusetts – has marked Thanksgiving by handing over his entire annual salary to the staff and students in his laboratory."
www.theguardian.com/science/2025...
"David Liu – a professor at the Broad Institute of MIT and Harvard, a biomedical research facility in Massachusetts – has marked Thanksgiving by handing over his entire annual salary to the staff and students in his laboratory."
www.theguardian.com/science/2025...
Reposted by Joan Chang
Join us 3/26!
#MeetTheSpeaker #2: Dr. Simona Plesselova (@simastatina), postdoc in @delapuente_lab who will share here latest work on Targeting #ECM to Reprogram Hypoxic Immunologically Cold #OvarianTumor
Info & registration: asmb.net/e-symposia #ECMatrixIsEverywhere #WomensHealth
#MeetTheSpeaker #2: Dr. Simona Plesselova (@simastatina), postdoc in @delapuente_lab who will share here latest work on Targeting #ECM to Reprogram Hypoxic Immunologically Cold #OvarianTumor
Info & registration: asmb.net/e-symposia #ECMatrixIsEverywhere #WomensHealth
March 17, 2025 at 6:48 PM
Join us 3/26!
#MeetTheSpeaker #2: Dr. Simona Plesselova (@simastatina), postdoc in @delapuente_lab who will share here latest work on Targeting #ECM to Reprogram Hypoxic Immunologically Cold #OvarianTumor
Info & registration: asmb.net/e-symposia #ECMatrixIsEverywhere #WomensHealth
#MeetTheSpeaker #2: Dr. Simona Plesselova (@simastatina), postdoc in @delapuente_lab who will share here latest work on Targeting #ECM to Reprogram Hypoxic Immunologically Cold #OvarianTumor
Info & registration: asmb.net/e-symposia #ECMatrixIsEverywhere #WomensHealth
Reposted by Joan Chang
Don't forget to join our next #eSymposium organized by @delapuente_lab & @GonzalezPLab on the Intersection of Women’s Health & the ECM.
#MeetTheSpeaker: Brandon J Vogt (www.linkedin.com/in/brandon-vogt-1028/)
Info & registration: www.asmb.net/e-symposia
#ECMatrixIsEverywhere #WomensHealth
#MeetTheSpeaker: Brandon J Vogt (www.linkedin.com/in/brandon-vogt-1028/)
Info & registration: www.asmb.net/e-symposia
#ECMatrixIsEverywhere #WomensHealth
March 14, 2025 at 8:41 PM
Don't forget to join our next #eSymposium organized by @delapuente_lab & @GonzalezPLab on the Intersection of Women’s Health & the ECM.
#MeetTheSpeaker: Brandon J Vogt (www.linkedin.com/in/brandon-vogt-1028/)
Info & registration: www.asmb.net/e-symposia
#ECMatrixIsEverywhere #WomensHealth
#MeetTheSpeaker: Brandon J Vogt (www.linkedin.com/in/brandon-vogt-1028/)
Info & registration: www.asmb.net/e-symposia
#ECMatrixIsEverywhere #WomensHealth
We're ready for #BritishScienceWeek @ManchesterMuseum! All about #secretion, #ECMatrix assembly, from cells to #zebrafish! @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
March 11, 2025 at 9:43 AM
We're ready for #BritishScienceWeek @ManchesterMuseum! All about #secretion, #ECMatrix assembly, from cells to #zebrafish! @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
Standing in spirit with my US colleagues 💪🏻 #ScienceNoBoundaries #ECMatrix
EVERYONE: #standupforscience2025 this Friday, March 7, 2025 - Because science is for and impacts everyone!
Find your local rally site and other ways to get involve at standupforscience2025.org
#ScienceNotSilence
#ScienceForAll
#ECMatrixIsEverywhere
Find your local rally site and other ways to get involve at standupforscience2025.org
#ScienceNotSilence
#ScienceForAll
#ECMatrixIsEverywhere
March 7, 2025 at 6:42 AM
Standing in spirit with my US colleagues 💪🏻 #ScienceNoBoundaries #ECMatrix