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hoeferlab.bsky.social
Höfer Lab
@hoeferlab.bsky.social
1.1K followers 460 following 13 posts
The Höfer lab studies the epitranscriptomic mechanisms of gene regulation based on NAD-capped RNAs in bacteria and bacteriophages. We are located at the Max Planck Institute for terrestrial Microbiology, Marburg, Germany and area Member of SYNMIKRO
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Reposted by Höfer Lab
frunzkelab.bsky.social
Please RT:
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...

Interested candidates are encouraged to contact me via email for further details.

@spp2330.bsky.social; @mibinet.bsky.social
Junior Group Leader - Phage Biology & Biotechnology
As a leading research institution for microbial biotechnology the Institute of Bio- and Geosciences - Biotechnology (IBG-1, https://www.fz-juelich.de/de/ibg/ibg-1 ) at the Forschungszentrum Jülich foc...
www.fz-juelich.de
October 8, 2025 at 6:50 AM
Reposted by Höfer Lab
s-lab.bsky.social
Many thanks to Katharina Höfer @hoeferlab.bsky.social for giving an inspiring presentation about RNAylation at our annual "Early-Career Microbiologists Symposium" @johninnescentre.bsky.social. Many thanks also to #EMBO @embo.org for supporting this "Young Investigator Seminar".
September 16, 2025 at 6:45 AM
Reposted by Höfer Lab
philipcball.bsky.social
Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA.
www.cell.com/cell/fulltex...
Rethinking RNA-binding proteins: Riboregulation challenges prevailing views
The advent of system-wide proteomic approaches has largely expanded the number of RNA-binding proteins (RBPs). This review discusses how recent discoveries are transforming our understanding of biolog...
www.cell.com
September 5, 2025 at 3:49 PM
Reposted by Höfer Lab
mpimarinemicrobio.bsky.social
This demanding fieldwork is coming to an end – we are excited to dig into the collected samples and data!

Learn more about the research behind the fieldwork here:
mpi-bremen.de/en/Max-Planc...

#CAPSOLUTION @fischerlab.bsky.social @sumayrasultanji.bsky.social @hoeferlab.bsky.social
August 18, 2025 at 11:21 AM
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fischerlab.bsky.social
Lac de Louvie (2213 m elevation) was an incredibly stunning place to sample for microbes! Many thanks to altis.swiss for letting us use their maintenance cable car :)
#CAPSOLUTION
@mpimarinemicrobio.bsky.social
@erc.europa.eu
@hoeferlab.bsky.social
@maxemilschon.bsky.social
Lac de Louvie with the snow-covered Grand Combin in the background. Merci beaucoup à ALTIS et M. Olivier! A somewhat tricky location for our setup, but it worked! The samples are all bagged and cooled.
August 12, 2025 at 7:34 PM
Reposted by Höfer Lab
fischerlab.bsky.social
Switzerland welcomed us with summer weather and beautiful mountains! We started with the Lac de Champex (1467 m) which is influenced by human activity, and then hiked up to the Lacs de Fenêtre (2465 m) the next day.
#CAPSOLUTION
@mpimarinemicrobio.bsky.social @erc.europa.eu @hoeferlab.bsky.social
Lac de Champex in Champex-Lac, a popular tourist destination in summer and winter. Keeping the samples cool was a new, but weclome challenge for us on this trip. The largest one of the lacs de Fenêtre, with the Mont Blanc massif just visible on the far right. Our fantastic sampling crew for the Swiss leg!
August 10, 2025 at 3:07 PM
Reposted by Höfer Lab
philholliger.bsky.social
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).
Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
www.jobs.ac.uk
July 14, 2025 at 12:10 PM
Reposted by Höfer Lab
ki.se
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
June 25, 2025 at 10:01 AM
Reposted by Höfer Lab
leokiss.bsky.social
Excited about #ubiquitin and #TPD ?
Then join us tomorrow for the latest instalment of the @danafarber.bsky.social ‬ Targeted Protein Degradation Webinar where Kimberly Stegmaier and I will present our latest work.
dfci.zoom.us/webinar/regi...
June 25, 2025 at 9:08 PM
Reposted by Höfer Lab
mjendrusch.bsky.social
Happy to announce the first paper from my PhD at Korbel group at @embl.org has finally been published:
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵
June 19, 2025 at 8:10 AM
Reposted by Höfer Lab
parthbibekar.bsky.social
Presenting RISoTTo, a molecular context-aware model for RNA sequence design, building on our work with PeSTo (for protein binding interface prediction) and CARBonAra (for protein design).

📄 Preprint: www.biorxiv.org/content/10.1...
💻 Code & more coming soon!

#RNAdesign #RNAbiology #AI4Science
www.biorxiv.org
June 22, 2025 at 9:02 AM
Reposted by Höfer Lab
vivekmutalik.bsky.social
#phage #phagesky
landongetz.bsky.social Landon Getz @landongetz.bsky.social · Jun 10
I'm excited to share our new review in Current Opinion in Microbiology: “A solution to the post‑antibiotic era: phages as precision medicine.”

Here, we explore how engineered bacteriophages could be the next generation of anti-bacterials!
A solution to the postantibiotic era: phages as precision medicine
Antibiotic-resistant bacterial infections pose a significant global health challenge. Phage therapy provides a promising alternative to antibiotics th…
www.sciencedirect.com
June 12, 2025 at 12:34 PM
Reposted by Höfer Lab
proloewe.bsky.social
🔛LOEWE-RobuCop ist online, auch bei proloewe.de !🎯 Ziel von RobuCop @unimarburg.bsky.social ist es, die natürlich Mecha­nis­men d. CO2-Fixierung, Stressantwort-+Resilienz-Mechanismen im Chloro­plasten grundleg. zu🔬untersuchen, um robuste Photo­synthese zu ermöglichen.
➡️ proloewe.de/de/loewe-vor...
June 10, 2025 at 8:05 AM
Reposted by Höfer Lab
drmikebooth.bsky.social
What do you call a group of nucleic acid chemists?

Suggestions welcome 🧬❤️

#SCNAC2025
@cjserpell.bsky.social @hoeferlab.bsky.social @boekhovenlab.bsky.social @rentmeisterlab.bsky.social @kgoepfrich.bsky.social @chlab.bsky.social
Picture of a lot of us nucleic acid chemists in cesky krumlov
June 10, 2025 at 7:30 AM
Reposted by Höfer Lab
drmikebooth.bsky.social
The #SCNAC2025 nucleic acid chemistry conference starting off in Czech-style by @hoceklab.bsky.social 🧬🗡
Michal Hocek telling us a (very big) sword will be used if we go over time on our talks...
June 9, 2025 at 7:01 AM
Reposted by Höfer Lab
rnacanada.bsky.social
Attention RNA Artists! That includes *you*!
The RNA Canada ARN Outreach Committee is hosting a design contest for RNA-themed merchandise, which will be showcased at future RNA Canada ARN meetings and sold in the RNA Canada ARN online store. Deadline June 30th
www.rnacanada.ca/rna-canada-a...
RNA Canada ARN 2025: Design Contest! - RNA Canada ARN
Attention RNA Artists! We have exciting news for the RNA Canada! The Outreach Committee is hosting a design contest for RNA-themed merchandise, which will be showcased at future RNA Canada ARN meeting...
www.rnacanada.ca
June 3, 2025 at 7:46 PM
Reposted by Höfer Lab
nature.com
Manufacturing CAR T cells in the laboratory is expensive and time-consuming.

An in vivo approach could get this powerful therapy to more people
https://go.nature.com/45w5A5w
Cancer-fighting immune cells could soon be engineered inside our bodies
Nature - Manufacturing CAR T cells in the laboratory is expensive and time-consuming. An in vivo approach could get the powerful therapy to more people.
go.nature.com
May 31, 2025 at 3:16 PM
Reposted by Höfer Lab
olallalab.bsky.social
YES!!!Excellent initiative #Microbes-for-Climate #M4C🦠FUNDED💲💰☺️🤩
The best?🤔The people❤️
Endless gratitude to Tobi & Anke - amazing role models❤️ Love the "thanks BBQ no matter what" spirit from the "Präsidium"! @unimarburg.bsky.social - sure it tasted better as we got it😉😂 #ProfLife #LovelyMarburg🏰❤️
May 24, 2025 at 8:11 AM
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dfg.de
Wir starten in den Auswahltag der #Exzellenzcluster. Heute kommt das Expertengremium u. die für Wissenschaft und Forschung zuständigen Minister*innen von Bund und Ländern zusammen. Ab ca. 17 Uhr geben GWK-Vorsitzender Falko Mohrs u. Forschungsministerin Dorothee Bär die Ergebnisse bekannt.
Gruppenbild aus der Exzellenzkommission: GWK-Vorsitzender Falko Mohrs, Bundesforschungsministerin Dorothee Bär, DFG-Präsidentin Katja Becker, Wissenschaftsratsvorsitzender Wolfgang Wick. Blick in die Exzellenzkommission.
May 22, 2025 at 7:54 AM
Reposted by Höfer Lab
robucop.bsky.social
What a lovely time at @synmikro.bsky.social!

PIs, PhD students, PostDocs and associated members of RobuCop met at the kick off meeting to share ideas, discuss projects and connect with each other🌱🫰
Can't wait for our next meeting!

Thank you @ramona-zuelch.bsky.social for the picture.
May 22, 2025 at 7:31 AM
Reposted by Höfer Lab
asaflevylab.bsky.social
A new preprint from the lab in collaboration with Feng Jiang.
www.biorxiv.org/content/10.1...
This is a thread for you if you're interested in secretion systems, phages, and evolution.

The extracellular contractile injection system (eCIS) is a mysterious microbial toxin delivery system.
May 14, 2025 at 11:14 AM
Reposted by Höfer Lab
buzzbaum.bsky.social
Excited to announce the Molecular Biology of Archaea (MBoA) 2026!

Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.
April 18, 2025 at 1:56 PM
Reposted by Höfer Lab
tinearnvig.bsky.social
Registration is open, look forward to seeing you!
microbialrnameeting.com
April 15, 2025 at 10:49 AM
Reposted by Höfer Lab
mpi-nat.bsky.social
What does it mean to be a woman in science 👩‍🔬?
It’s up to you: Join the 9th Women’s Careers and Networks symposium on June 4 and 5 on our Fassberg Campus to explore career opportunities and engage with experts and peers.

Learn more about #WoCaNet2025 here 👉 uni-goettingen.de/de/203891.html
April 15, 2025 at 10:52 AM
Reposted by Höfer Lab
plosbiology.org
PHORCE allows measurement of lytic #phage amplification rates in bacterial populations. @yuvalmulla.bsky.social & co use PHORCE to reveal phenotypic diversity among #Ecoli & #Paeruginosa phages; phage- #antibiotic interactions are mainly determined by the drug @plosbiology.org 🧪 plos.io/3G2myhf
A mathematical model of phage infection allows the extraction of key phage amplification parameters (PHORCE). Top and middle: E. coli growth curves measured by bioluminescence in the presence of the phage Bas04 at all combinations of eight different initial bacterial concentrations (1.1 × 104–1.4 × 106 mL−1, orange to blue) and 10 different initial phage concentrations (2.5 × 103–1.3 × 106 mL−1, light to dark). Bottom left: Schematic of minimal model of phage amplification. Bottom right: Comparison of observed collapse times and collapse times from the model.
April 9, 2025 at 1:20 PM