George Chiduza
@gchiduza.bsky.social
Chargé de recherche @ulbruxelles.bsky.social interested in transporters and protein-lipid interactions in autism and autophagy. @crick.ac.uk alumnus. #membrane #proteins #biochemistry #cryoEM #structuralMS
Reposted by George Chiduza
Kangfu Peng, Hong Zhang et al. show that scramblase-attenuated #Celegans ATG-9 mutants rescue the #autophagy defect and lysosome damage caused by nondegradative autolysosomes. This uncovers the role of ATG-9 in regulating #lysosome function & integrity. rupress.org/jcb/article/...
April 9, 2025 at 8:57 PM
Kangfu Peng, Hong Zhang et al. show that scramblase-attenuated #Celegans ATG-9 mutants rescue the #autophagy defect and lysosome damage caused by nondegradative autolysosomes. This uncovers the role of ATG-9 in regulating #lysosome function & integrity. rupress.org/jcb/article/...
Reposted by George Chiduza
Run BioEmu in Colab - just click "Runtime → Run all"! Our notebook uses ColabFold to generate MSAs, BioEmu to predict trajectories, and Foldseek to cluster conformations.
Thanks @jjimenezluna.bsky.social for the help!
🌐 colab.research.google.com/github/sokry...
📄 www.biorxiv.org/content/10.1...
Thanks @jjimenezluna.bsky.social for the help!
🌐 colab.research.google.com/github/sokry...
📄 www.biorxiv.org/content/10.1...
Google Colab
colab.research.google.com
March 29, 2025 at 9:50 AM
Run BioEmu in Colab - just click "Runtime → Run all"! Our notebook uses ColabFold to generate MSAs, BioEmu to predict trajectories, and Foldseek to cluster conformations.
Thanks @jjimenezluna.bsky.social for the help!
🌐 colab.research.google.com/github/sokry...
📄 www.biorxiv.org/content/10.1...
Thanks @jjimenezluna.bsky.social for the help!
🌐 colab.research.google.com/github/sokry...
📄 www.biorxiv.org/content/10.1...
Reposted by George Chiduza
Researchers at the Rosalind Franklin Institute, The Alan Turing Institute, and STFC Scientific Computing have developed a new machine learning model that will improve the detection of proteins in 3D images, such as those obtained by cryo-electron tomography.
Read the full update here: zurl.co/1Z0PZ
Read the full update here: zurl.co/1Z0PZ
March 28, 2025 at 5:09 PM
Researchers at the Rosalind Franklin Institute, The Alan Turing Institute, and STFC Scientific Computing have developed a new machine learning model that will improve the detection of proteins in 3D images, such as those obtained by cryo-electron tomography.
Read the full update here: zurl.co/1Z0PZ
Read the full update here: zurl.co/1Z0PZ
Reposted by George Chiduza
This will never stop blowing my mind.
I know that the mRNA is larger than the protein it codes for but I don't believe it
March 20, 2025 at 12:31 AM
This will never stop blowing my mind.
Reposted by George Chiduza
Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. @minhuanli.bsky.social and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.
February 24, 2025 at 12:23 PM
Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. @minhuanli.bsky.social and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.
Another day another structural biology AI based tool 😎
Can AlphaFold refine structures for X-ray & Cryo-EM/ET data? Now it can! Great collab with @moalquraishi.bsky.social and @randyjread.bsky.social led by @alisiafadini.bsky.social and @minhuanli.bsky.social. 🧵below. Code to follow...
Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. @minhuanli.bsky.social and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.
February 25, 2025 at 11:26 AM
Another day another structural biology AI based tool 😎
Reposted by George Chiduza
Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍
Preprint📜: www.biorxiv.org/content/10.1...
A short thread🧵👇
Preprint📜: www.biorxiv.org/content/10.1...
A short thread🧵👇
January 6, 2025 at 11:19 AM
Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍
Preprint📜: www.biorxiv.org/content/10.1...
A short thread🧵👇
Preprint📜: www.biorxiv.org/content/10.1...
A short thread🧵👇
Reposted by George Chiduza
We are currently advertising our AI #ionchannel modelling PhD Studentship. Fully funded (sadly only for UK based students). Please repost or mention to any potential victims hmmmm, *applicants* you know?
www.findaphd.com/phds/project...
Richardbj.bsky.social
www.findaphd.com/phds/project...
Richardbj.bsky.social
December 29, 2024 at 11:31 AM
We are currently advertising our AI #ionchannel modelling PhD Studentship. Fully funded (sadly only for UK based students). Please repost or mention to any potential victims hmmmm, *applicants* you know?
www.findaphd.com/phds/project...
Richardbj.bsky.social
www.findaphd.com/phds/project...
Richardbj.bsky.social
Reposted by George Chiduza
1/ A new series of #CryoSPARC tutorial videos from this year’s S2C2 #cryoEM image processing workshop are now online! These videos will be interesting to all users and especially those newer to #cryoEM.
www.youtube.com/playlist?lis...
www.youtube.com/playlist?lis...
2024 S2C2 Single-Particle Cryo-EM Image Processing Workshop - YouTube
This playlist contains six recordings covering single particle cryo-EM data processing in CryoSPARC from the 2024 Single-Particle Cryo-EM Image Processing Wo...
www.youtube.com
December 13, 2024 at 6:56 PM
1/ A new series of #CryoSPARC tutorial videos from this year’s S2C2 #cryoEM image processing workshop are now online! These videos will be interesting to all users and especially those newer to #cryoEM.
www.youtube.com/playlist?lis...
www.youtube.com/playlist?lis...
Reposted by George Chiduza
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
December 11, 2024 at 1:53 PM
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!
3 postdoc positions advertised soon.
Reposted by George Chiduza
One of those #cryoEM papers were using "near-atomic resolution" in the title would be entirely ok. 😉
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Visualizing the modification landscape of the human 60S ribosomal subunit at close to atomic resolution
Abstract. Chemical modifications of ribosomal RNAs (rRNAs) and proteins expand their topological repertoire, and together with the plethora of bound ligand
academic.oup.com
December 11, 2024 at 3:54 PM
One of those #cryoEM papers were using "near-atomic resolution" in the title would be entirely ok. 😉
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Reposted by George Chiduza
High-resolution template matching of the human ribosome in situ by Lippincott-Schwartz Lab @hhmijanelia.bsky.social @hhmi.bsky.social. >40 conformations within together reveal molecular dynamics of the elongation cycle with previously unknown bending and “spring-like” motion.
December 3, 2024 at 12:21 PM
High-resolution template matching of the human ribosome in situ by Lippincott-Schwartz Lab @hhmijanelia.bsky.social @hhmi.bsky.social. >40 conformations within together reveal molecular dynamics of the elongation cycle with previously unknown bending and “spring-like” motion.
Reposted by George Chiduza
I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............
November 18, 2024 at 3:09 PM
I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............
Reposted by George Chiduza
I am super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳
Using cryo-electron tomography 🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!
www.biorxiv.org/content/10.1...
Using cryo-electron tomography 🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!
www.biorxiv.org/content/10.1...
September 5, 2024 at 7:49 AM
I am super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳
Using cryo-electron tomography 🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!
www.biorxiv.org/content/10.1...
Using cryo-electron tomography 🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!
www.biorxiv.org/content/10.1...
Reposted by George Chiduza
My first post on Blue Sky - moving over !
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
EMBL Jobs
We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.
www.embl.org
November 18, 2024 at 5:28 PM
My first post on Blue Sky - moving over !
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
Reposted by George Chiduza
An AF3-like model available with an MIT license
“Our model and code are released under MIT License, and can be freely used for both academic and commercial purposes.”
“Our model and code are released under MIT License, and can be freely used for both academic and commercial purposes.”
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
November 17, 2024 at 7:52 PM
An AF3-like model available with an MIT license
“Our model and code are released under MIT License, and can be freely used for both academic and commercial purposes.”
“Our model and code are released under MIT License, and can be freely used for both academic and commercial purposes.”
Reposted by George Chiduza
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/
G. Napolitano,A. Esposito, and A. Ballabio.
G. Napolitano,A. Esposito, and A. Ballabio.
November 16, 2024 at 4:31 PM
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/
G. Napolitano,A. Esposito, and A. Ballabio.
G. Napolitano,A. Esposito, and A. Ballabio.
Reposted by George Chiduza
First bluesky post! About time.
This week, our manuscript revealing the structure, inhibition, and mechanism of human Ceramide Synthase 6 was finally published in NSMB.
We combined cryo-EM and mass spectrometry to reveal its ping-pong mechanism. Check it out!
doi.org/10.1038/s415...
This week, our manuscript revealing the structure, inhibition, and mechanism of human Ceramide Synthase 6 was finally published in NSMB.
We combined cryo-EM and mass spectrometry to reveal its ping-pong mechanism. Check it out!
doi.org/10.1038/s415...
November 13, 2024 at 8:05 PM
First bluesky post! About time.
This week, our manuscript revealing the structure, inhibition, and mechanism of human Ceramide Synthase 6 was finally published in NSMB.
We combined cryo-EM and mass spectrometry to reveal its ping-pong mechanism. Check it out!
doi.org/10.1038/s415...
This week, our manuscript revealing the structure, inhibition, and mechanism of human Ceramide Synthase 6 was finally published in NSMB.
We combined cryo-EM and mass spectrometry to reveal its ping-pong mechanism. Check it out!
doi.org/10.1038/s415...
Reposted by George Chiduza
As my lab's first post on Bluesky. If you are a UK Structural Biologist please come to our one day meeting on Friday 6th December
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ
November 14, 2024 at 10:52 AM
As my lab's first post on Bluesky. If you are a UK Structural Biologist please come to our one day meeting on Friday 6th December
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ
Just recently moved from X/twitter
November 14, 2024 at 1:08 AM
Just recently moved from X/twitter