Jake Wintermute
@synbio1.bsky.social
Synthetic Biologist - Foundry Theorist
foundrytheory.substack.com
stay humble biodesigners
foundrytheory.substack.com
stay humble biodesigners
Science is an attention economy. “Novelty” is “Virality.” Citations are Likes. Editors are content curators. Prestige journals are the “For You” page.
Yes, scientists prefer fact-based content. But facts need to earn attention before they can drive discoveries or make careers
Yes, scientists prefer fact-based content. But facts need to earn attention before they can drive discoveries or make careers
December 28, 2025 at 4:49 PM
Science is an attention economy. “Novelty” is “Virality.” Citations are Likes. Editors are content curators. Prestige journals are the “For You” page.
Yes, scientists prefer fact-based content. But facts need to earn attention before they can drive discoveries or make careers
Yes, scientists prefer fact-based content. But facts need to earn attention before they can drive discoveries or make careers
Scientists be like “ah the holidays a chance to take a break from the grind” and then read 87 journal articles about the gila monster pancreas
December 27, 2025 at 7:21 PM
Scientists be like “ah the holidays a chance to take a break from the grind” and then read 87 journal articles about the gila monster pancreas
My new startup will genetically engineer bay leafs that actually do something when you add them to a recipe
December 23, 2025 at 7:51 PM
My new startup will genetically engineer bay leafs that actually do something when you add them to a recipe
Is anyone building doordash for that tube of Proteinase K that you need for a time-sensitive experiment but your inconsiderate labmate used it all and didn’t reorder
December 20, 2025 at 7:51 PM
Is anyone building doordash for that tube of Proteinase K that you need for a time-sensitive experiment but your inconsiderate labmate used it all and didn’t reorder
High throughput screens be like
December 19, 2025 at 1:35 PM
High throughput screens be like
It is actually amazing to see in 2025 a political focus group of normal Americans who are 100% happy about something.
Democrat & Republican. Men & Women. White, Black, Latino, Asian.
What are they happy about? Weight loss drugs. Politicians take note.
www.nytimes.com/interactive/...
Democrat & Republican. Men & Women. White, Black, Latino, Asian.
What are they happy about? Weight loss drugs. Politicians take note.
www.nytimes.com/interactive/...
December 18, 2025 at 10:48 PM
It is actually amazing to see in 2025 a political focus group of normal Americans who are 100% happy about something.
Democrat & Republican. Men & Women. White, Black, Latino, Asian.
What are they happy about? Weight loss drugs. Politicians take note.
www.nytimes.com/interactive/...
Democrat & Republican. Men & Women. White, Black, Latino, Asian.
What are they happy about? Weight loss drugs. Politicians take note.
www.nytimes.com/interactive/...
This but I unfurl the Roche Biochemical Pathways chart and stick a dagger right in the center of the Krebs Cycle
December 17, 2025 at 5:50 PM
This but I unfurl the Roche Biochemical Pathways chart and stick a dagger right in the center of the Krebs Cycle
Sometimes trying to be good at both engineering and biology feels like one of those Fraser episodes where Fraser goes on two dates at the same time
December 15, 2025 at 3:30 PM
Sometimes trying to be good at both engineering and biology feels like one of those Fraser episodes where Fraser goes on two dates at the same time
At this point I’m hoping google cracks agi pretty soon because maybe the agi will be able to add a gmail feature whereby searching your emails for a keyword reliably returns a list of emails that contain that keyword
December 12, 2025 at 12:39 AM
At this point I’m hoping google cracks agi pretty soon because maybe the agi will be able to add a gmail feature whereby searching your emails for a keyword reliably returns a list of emails that contain that keyword
“I have looked upon all that the universe has to hold of horror, and even the skies of spring and the flowers of summer must ever afterward be poison to me.” - H.P. Lovecraft
December 11, 2025 at 2:22 PM
“I have looked upon all that the universe has to hold of horror, and even the skies of spring and the flowers of summer must ever afterward be poison to me.” - H.P. Lovecraft
Product is hard in biotech
December 9, 2025 at 1:24 PM
Product is hard in biotech
I miss the good old days when academics would post twitter threads for all their papers I just find it so much easier to pay attention to things when they're on my phone
December 6, 2025 at 7:33 PM
I miss the good old days when academics would post twitter threads for all their papers I just find it so much easier to pay attention to things when they're on my phone
This is why people go to grad school
December 5, 2025 at 9:27 PM
This is why people go to grad school
Telling my nieces and nephews that this is a labubu
December 4, 2025 at 6:38 PM
Telling my nieces and nephews that this is a labubu
What you're a blob of neurons that became self-aware piloting a mech suit made of meat?
That's crazy me too we have so much in common
That's crazy me too we have so much in common
December 4, 2025 at 1:52 PM
What you're a blob of neurons that became self-aware piloting a mech suit made of meat?
That's crazy me too we have so much in common
That's crazy me too we have so much in common
Reposted by Jake Wintermute
🌱🚨 Funded PhD for UK students 🇬🇧🌿
Take a look at this Plant BioDesign Doctoral Training Program.
Come work with me and @michaelwebster.bsky.social to study plant rubiscos. High throughput biochem at Cambridge and Cryo-EM techniques at the John Innes Centre.
www.findaphd.com/phds/project...
Take a look at this Plant BioDesign Doctoral Training Program.
Come work with me and @michaelwebster.bsky.social to study plant rubiscos. High throughput biochem at Cambridge and Cryo-EM techniques at the John Innes Centre.
www.findaphd.com/phds/project...
Engineering plant rubisco enzymes through high-throughput enzyme assays and cryo-EM (Plant BioDesign Cambridge project) at University of York on FindAPhD.com
PhD Project - Engineering plant rubisco enzymes through high-throughput enzyme assays and cryo-EM (Plant BioDesign Cambridge project) at University of York, listed on FindAPhD.com
www.findaphd.com
December 3, 2025 at 11:22 AM
🌱🚨 Funded PhD for UK students 🇬🇧🌿
Take a look at this Plant BioDesign Doctoral Training Program.
Come work with me and @michaelwebster.bsky.social to study plant rubiscos. High throughput biochem at Cambridge and Cryo-EM techniques at the John Innes Centre.
www.findaphd.com/phds/project...
Take a look at this Plant BioDesign Doctoral Training Program.
Come work with me and @michaelwebster.bsky.social to study plant rubiscos. High throughput biochem at Cambridge and Cryo-EM techniques at the John Innes Centre.
www.findaphd.com/phds/project...
This is the kind of elevated biohacking content that YouTube needs more of
December 2, 2025 at 3:27 PM
This is the kind of elevated biohacking content that YouTube needs more of
I love the ritual of putting on a pot of coffee if you and me are ever in an 80s sci-fi thriller where we have to pull an all-nighter to decode a message from aliens I will be the guy who puts on the pot of coffee
December 1, 2025 at 2:02 PM
I love the ritual of putting on a pot of coffee if you and me are ever in an 80s sci-fi thriller where we have to pull an all-nighter to decode a message from aliens I will be the guy who puts on the pot of coffee
If human genetics becomes more engineerable in the future many social conventions about the human body (race, gender, beauty, parenthood) will become untenable and, I suppose, be replaced with other social conventions that we cannot see from this side of history
November 29, 2025 at 2:47 PM
If human genetics becomes more engineerable in the future many social conventions about the human body (race, gender, beauty, parenthood) will become untenable and, I suppose, be replaced with other social conventions that we cannot see from this side of history
Americans make great biologists because we are forged by the hardest challenge in all of biotech: getting flavor from a turkey
November 27, 2025 at 2:35 PM
Americans make great biologists because we are forged by the hardest challenge in all of biotech: getting flavor from a turkey
You can't judge a scientific discipline by it's cover
November 26, 2025 at 11:21 PM
You can't judge a scientific discipline by it's cover
Amplicon sequencing is getting close to the price point where it starts to makes sense to just sequence your PCR product instead of running an agarose gel to see if it worked.
Imagine a future without agarose gels. What will grad students do all day?
Imagine a future without agarose gels. What will grad students do all day?
November 26, 2025 at 5:20 PM
Amplicon sequencing is getting close to the price point where it starts to makes sense to just sequence your PCR product instead of running an agarose gel to see if it worked.
Imagine a future without agarose gels. What will grad students do all day?
Imagine a future without agarose gels. What will grad students do all day?
Given that GLP-1 drugs were found in gila monster venom it's not totally unrealistic to imagine that one day a breakthrough drug will be discovered in literal snake oil and a biotech startup will be like "ok how do we market this"
November 25, 2025 at 4:42 PM
Given that GLP-1 drugs were found in gila monster venom it's not totally unrealistic to imagine that one day a breakthrough drug will be discovered in literal snake oil and a biotech startup will be like "ok how do we market this"
I dare you to put this in your next talk instead of the slide acknowledging funding sources
November 24, 2025 at 6:52 PM
I dare you to put this in your next talk instead of the slide acknowledging funding sources
"We should keep saying how AI can enable biomedical breakthroughs people seem to like that"
November 24, 2025 at 1:42 AM
"We should keep saying how AI can enable biomedical breakthroughs people seem to like that"