Gautam Dey
@gautamdey.bsky.social
Evolutionary cell biology @EMBL
evonuclab.org
evonuclab.org
Pinned
Gautam Dey
@gautamdey.bsky.social
· Nov 11
So happy to see that energy and community vibe from the early days in the old place, looks like #SciSky is reaching critical mass 😍
Reporting for duty with tales of the weird and wonderful cell biology you never knew you needed to know 🫡
🧪🌏🦠
Reporting for duty with tales of the weird and wonderful cell biology you never knew you needed to know 🫡
🧪🌏🦠
Reposted by Gautam Dey
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 13, 2025 at 4:20 PM
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Gautam Dey
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 13, 2025 at 8:14 PM
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Reposted by Gautam Dey
November 13, 2025 at 7:23 PM
Reposted by Gautam Dey
Wound healing is a hallmark feature of all life, including single cells. In a new preprint, Ambika Nadkarni @biochembika.bsky.social investigates a new dimension in cellular wound healing: how cells recover AFTER the wound has been closed
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 10, 2025 at 5:47 PM
Wound healing is a hallmark feature of all life, including single cells. In a new preprint, Ambika Nadkarni @biochembika.bsky.social investigates a new dimension in cellular wound healing: how cells recover AFTER the wound has been closed
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Gautam Dey
Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!
Main - Cell Dynamics and Fragmentation Lab
The Cell Dynamics and Fragmentation lab at We study how single cells move and fragment in complex environments using microfluidics. We bring tools and concep...
celldynamicslab.com
November 11, 2025 at 5:10 PM
Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!
Reposted by Gautam Dey
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted by Gautam Dey
🚀 New in @natmicrobiol.nature.com
EMCG — droplet-based single-particle genomics method 🧬⚠️Sequencing marine microbes one by one — in nL of seawater!
Ultra-high resolution — no culture, no bulk averaging. A new way to see the invisible 🫥 🌊 rdcu.be/eOsUF #protistsonsky @bigelowlab.bsky.social
EMCG — droplet-based single-particle genomics method 🧬⚠️Sequencing marine microbes one by one — in nL of seawater!
Ultra-high resolution — no culture, no bulk averaging. A new way to see the invisible 🫥 🌊 rdcu.be/eOsUF #protistsonsky @bigelowlab.bsky.social
Single-particle genomics uncovers abundant non-canonical marine viruses from nanolitre volumes
Nature Microbiology - Environmental micro-compartment genomics provides efficient and high-throughput single-particle DNA sequencing that captures overlooked members of microbial communities.
rdcu.be
November 5, 2025 at 8:34 PM
🚀 New in @natmicrobiol.nature.com
EMCG — droplet-based single-particle genomics method 🧬⚠️Sequencing marine microbes one by one — in nL of seawater!
Ultra-high resolution — no culture, no bulk averaging. A new way to see the invisible 🫥 🌊 rdcu.be/eOsUF #protistsonsky @bigelowlab.bsky.social
EMCG — droplet-based single-particle genomics method 🧬⚠️Sequencing marine microbes one by one — in nL of seawater!
Ultra-high resolution — no culture, no bulk averaging. A new way to see the invisible 🫥 🌊 rdcu.be/eOsUF #protistsonsky @bigelowlab.bsky.social
Reposted by Gautam Dey
www.nature.com/articles/s42...
Latest from the lab. The conclusion is in the title!
Basically, we found that the KMN complex (outer kinetochore) is fully conserved between plants and fungi/animals, showing deep origin. (reminder, you are closer to a mushroom than a mushroom is to a plant.)
Latest from the lab. The conclusion is in the title!
Basically, we found that the KMN complex (outer kinetochore) is fully conserved between plants and fungi/animals, showing deep origin. (reminder, you are closer to a mushroom than a mushroom is to a plant.)
The composition and structure of the outer kinetochore KMN complex is conserved across kingdoms - Communications Biology
Affinity purification in Arabidopsis identified all key subunits of the outer kinetochore KMN complex. Functional analyses revealed a striking conservation of its composition and organization across k...
www.nature.com
November 7, 2025 at 7:02 PM
www.nature.com/articles/s42...
Latest from the lab. The conclusion is in the title!
Basically, we found that the KMN complex (outer kinetochore) is fully conserved between plants and fungi/animals, showing deep origin. (reminder, you are closer to a mushroom than a mushroom is to a plant.)
Latest from the lab. The conclusion is in the title!
Basically, we found that the KMN complex (outer kinetochore) is fully conserved between plants and fungi/animals, showing deep origin. (reminder, you are closer to a mushroom than a mushroom is to a plant.)
Reposted by Gautam Dey
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
wi.mit.edu/news/alterna...
Alternate proteins from the same gene contribute differently to health and rare disease | Whitehead Institute
Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients thro...
wi.mit.edu
November 7, 2025 at 4:14 PM
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
wi.mit.edu/news/alterna...
Reposted by Gautam Dey
This is a glimpse of the cytoskeletal structures we found doing U-ExM in more than 200 species, now in Cell🤩: shorturl.at/6oHvi
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
November 7, 2025 at 1:35 PM
This is a glimpse of the cytoskeletal structures we found doing U-ExM in more than 200 species, now in Cell🤩: shorturl.at/6oHvi
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
Reposted by Gautam Dey
Just read this great quote from one of my scientific heroes: Franklin Harold: ‘The way of science is for the best of our achievements to endure in substance but lose their individuality, like raindrops falling into a pond.’
November 7, 2025 at 10:38 AM
Just read this great quote from one of my scientific heroes: Franklin Harold: ‘The way of science is for the best of our achievements to endure in substance but lose their individuality, like raindrops falling into a pond.’
Reposted by Gautam Dey
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.
Beautiful tomography and microscopy - congrats all 🤩
Beautiful tomography and microscopy - congrats all 🤩
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:56 AM
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.
Beautiful tomography and microscopy - congrats all 🤩
Beautiful tomography and microscopy - congrats all 🤩
Reposted by Gautam Dey
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Gautam Dey
Laurence Wilson and Martin Bees use high-speed 3D holographic imaging to capture the flagellar beat of single algal cells, revealing changes in the ‘handedness’ of the flagellar shapes at different points in their cycle.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 6, 2025 at 9:05 AM
Laurence Wilson and Martin Bees use high-speed 3D holographic imaging to capture the flagellar beat of single algal cells, revealing changes in the ‘handedness’ of the flagellar shapes at different points in their cycle.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Reposted by Gautam Dey
(1/10) I am excited to share this signature review from our lab published @jxbotany.bsky.social
Congratulations to @ohazel.bsky.social and @jessicaa-orr.bsky.social (first published paper for Jessica!)
Nuclear positioning and cell division site specification in plants
doi.org/10.1093/jxb/...
Congratulations to @ohazel.bsky.social and @jessicaa-orr.bsky.social (first published paper for Jessica!)
Nuclear positioning and cell division site specification in plants
doi.org/10.1093/jxb/...
July 22, 2025 at 11:40 PM
(1/10) I am excited to share this signature review from our lab published @jxbotany.bsky.social
Congratulations to @ohazel.bsky.social and @jessicaa-orr.bsky.social (first published paper for Jessica!)
Nuclear positioning and cell division site specification in plants
doi.org/10.1093/jxb/...
Congratulations to @ohazel.bsky.social and @jessicaa-orr.bsky.social (first published paper for Jessica!)
Nuclear positioning and cell division site specification in plants
doi.org/10.1093/jxb/...
Reposted by Gautam Dey
My god this is for real one of the most incredible speeches I’ve ever seen by an elected US politician: ‘And if there is any way to terrify a despot, it is to dismantle the very conditions that allowed him to accumulate power. This not only how we stop Trump, it’s how we stop the next one.’
Mamdani: "We can respond to oligarchy and authoritarianism with the strength it fears, not the appeasement it craves. After all, if anyone can show a nation betrayed by Donald Trump how to defeat him, it is the city that gave rise to him."
November 5, 2025 at 4:52 AM
My god this is for real one of the most incredible speeches I’ve ever seen by an elected US politician: ‘And if there is any way to terrify a despot, it is to dismantle the very conditions that allowed him to accumulate power. This not only how we stop Trump, it’s how we stop the next one.’
Reposted by Gautam Dey
Language models cannot reliably distinguish belief from knowledge and fact #AI
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Language models cannot reliably distinguish belief from knowledge and fact - Nature Machine Intelligence
Suzgun et al. find that current large language models cannot reliably distinguish between belief, knowledge and fact, raising concerns for their use in healthcare, law and journalism, where such disti...
www.nature.com
November 4, 2025 at 10:13 AM
Language models cannot reliably distinguish belief from knowledge and fact #AI
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Reposted by Gautam Dey
Janaki Ammal was born 128 years ago today! A legend of botanical genetics, she studied how polyploidy plays into the resilience of agricultural crops, compiled a sprawling chromosomal atlas of plants, and fought for the preservation of India's natural legacy.
tinyurl.com/2j9hxmjb
#WomenInSTEM
tinyurl.com/2j9hxmjb
#WomenInSTEM
Janaki Ammal And the Fight for India’s Botanical Future.
Caste. Race. Gender. These were the three categories that, in early twentieth century Madras, combined to determine the boundaries of an individual’s potential. Being of an undesirable categorizat...
tinyurl.com
November 4, 2025 at 3:13 PM
Janaki Ammal was born 128 years ago today! A legend of botanical genetics, she studied how polyploidy plays into the resilience of agricultural crops, compiled a sprawling chromosomal atlas of plants, and fought for the preservation of India's natural legacy.
tinyurl.com/2j9hxmjb
#WomenInSTEM
tinyurl.com/2j9hxmjb
#WomenInSTEM
Reposted by Gautam Dey
Europe's MSCA postdoctoral fellowships are now attracting many researchers who would have gone to the US. So the payline has dropped below 10% (~1,600 fellowships to 17k applicants). Super tough situation. One more reason to double the next Horizon budget, as proposed by the EU Commission.
Applications for MCSA are up 64%! 50% now come from outside the EU. Trump effect?
The European Research market just got a hell of a lot more crowded.
EU should turn on the tap
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
The European Research market just got a hell of a lot more crowded.
EU should turn on the tap
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
MSCA Postdoctoral Fellowships 2025 receives record number of 17,058 proposals
This year’s annual MSCA Postdoctoral Fellowships call has attracted considerable interest from the research community with 17,058 proposals submitted.
marie-sklodowska-curie-actions.ec.europa.eu
November 3, 2025 at 8:24 AM
Europe's MSCA postdoctoral fellowships are now attracting many researchers who would have gone to the US. So the payline has dropped below 10% (~1,600 fellowships to 17k applicants). Super tough situation. One more reason to double the next Horizon budget, as proposed by the EU Commission.
Reposted by Gautam Dey
Scaling back DEI isn’t just a moral setback—it’s a loss of innovation.
Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”
doi.org/10.1038/s415...
Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”
doi.org/10.1038/s415...
November 3, 2025 at 2:05 PM
Scaling back DEI isn’t just a moral setback—it’s a loss of innovation.
Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”
doi.org/10.1038/s415...
Bhalla, Trejo & @marymunson4.bsky.social in Nature Cell Biology: limiting who can participate in science “weakens research capacity and stifles discovery.”
doi.org/10.1038/s415...
Reposted by Gautam Dey
NEW Publication🥳
Rapid #evolution is thought to be disadvantageous due to the accumulation of deleterious #mutations. We identify multiple lineages of rapidly evolving and stable #yeast that are many millions of years old
🔗: academic.oup.com/mbe/advance-...
Rapid #evolution is thought to be disadvantageous due to the accumulation of deleterious #mutations. We identify multiple lineages of rapidly evolving and stable #yeast that are many millions of years old
🔗: academic.oup.com/mbe/advance-...
November 3, 2025 at 6:29 PM
NEW Publication🥳
Rapid #evolution is thought to be disadvantageous due to the accumulation of deleterious #mutations. We identify multiple lineages of rapidly evolving and stable #yeast that are many millions of years old
🔗: academic.oup.com/mbe/advance-...
Rapid #evolution is thought to be disadvantageous due to the accumulation of deleterious #mutations. We identify multiple lineages of rapidly evolving and stable #yeast that are many millions of years old
🔗: academic.oup.com/mbe/advance-...
Reposted by Gautam Dey
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.
journals.biologists.com
November 3, 2025 at 5:32 PM
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Reposted by Gautam Dey
Very excited to finally share my PhD paper, about advancing #chloroplast #synbio through high-throughput plastome engineering of #Chlamydomonas.
Huge thanks to the whole team!
www.nature.com/articles/s41...
Huge thanks to the whole team!
www.nature.com/articles/s41...
November 3, 2025 at 4:26 PM
Very excited to finally share my PhD paper, about advancing #chloroplast #synbio through high-throughput plastome engineering of #Chlamydomonas.
Huge thanks to the whole team!
www.nature.com/articles/s41...
Huge thanks to the whole team!
www.nature.com/articles/s41...
Reposted by Gautam Dey
In French - Virginie on Swiss radio! 🎙️ She talks about our latest collab with @dudinlab.bsky.social and @gautamdey.bsky.social #UExM #ProtistsOnSky
📻 Interview de Virginie Hamel du @centriolelab.bsky.social pour CQFD de la #RTS: Une méthode ouvre lʹaccès à lʹarchitecture interne du #plancton #microscopie #expansion www.rts.ch/audio-podcas... @mocel.bsky.social @sciencesunige.bsky.social @dudinlab.bsky.social
Une méthode ouvre lʹaccès à lʹarchitecture interne du plancton | RTS
Une étude majeure menée par l’Université de Genève et le Laboratoire européen de biologie moléculaire, publiée dans la revue Cell, révèle l’architecture interne de plus de deux cents espèces de planct...
www.rts.ch
November 3, 2025 at 5:13 PM
In French - Virginie on Swiss radio! 🎙️ She talks about our latest collab with @dudinlab.bsky.social and @gautamdey.bsky.social #UExM #ProtistsOnSky