The morphodynamical plasticity of the endolysosomal system supports the formation and function of specialized intracellular compartments, as exemplified by the pigment organelles in skin cells. In ep....

CLEM-Reg automates the three-dimensional alignment of volume correlative light and electron microscopy datasets by leveraging probabilistic point cloud registration techniques for fast and accurate re...

Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...

Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.

Nature Reviews Molecular Cell Biology, Published online: 04 August 2025; doi:10.1038/s41580-025-00873-wLysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.

Da Graça et al. identify ER-endosome contact sites as critical hubs for autophagosome biogenesis, where starvation triggers sequential endosome tethering to ER exit sites. This spatiotemporal coordina...

Lysosomes are damaged in quiescent cells, and UPR regulators, IRE-1/XBP-1, promote lysosome repair for cell-cycle re-entry. Lysosome damage in quiescent cells is caused in part by macroautophagy and i...

Epithelial tubulogenesis shapes internal organs by transforming flat epithelial sheets or unpolarized cords into hollow tubes with central lumens. A key example is the formation of the posterior neura...

Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

T cell receptors co-recognizing both MHC and antigenic peptide for a tri-party specific interaction has been a central dogma of T cell-mediated responses. Here the authors use X-ray crystallography to...