The Yellow Fever (YF) 17D vaccine, developed in the 1930s, stands as a triumph in vaccinology, recognized as one of the most potent and durable vaccines known. Despite its widespread success, having b...

No matter how elegant the lies, an NIH Director who lacks credibility among the public he serves cannot fulfill his public health mission

Dengue virus (DENV) has been expanding its range to temperate areas that are not usually affected, where the spread of vectors has been facilitated by global trade and climate change. In Europe, th...

In 2024, cases of the mosquito-borne viral disease dengue hit historic highs throughout the Americas. The virus remains a threat in 2025, with more than 477 000 suspected cases already reported in the region as of February 20. The Pan American Health Organization (PAHO) also has issued an epidemiological alert based on growing circulation of 1 of dengue’s 4 distinct serotypes, DENV-3, in the region. Argentina, Brazil, Mexico, and Peru are among the nations currently reporting DENV-3 circulation. According to the alert, such a reappearance of a serotype that has not been in circulation over the past decade increases the probability of severe cases. Although the TAK-003 vaccine is meant to protect against all dengue serotypes, research has shown that it is less effective against DENV-3. In the absence of a US Food and Drug Administration–approved treatment for the virus, the National Institutes of Health has launched a clinical trial to test the efficacy of the investigational monoclonal antibody AV-1 on symptom mitigation. In the meantime, PAHO has urged countries in the southern hemisphere of the Americas “to strengthen their surveillance, early diagnosis, and clinical management” as they prepare for a possible rise in cases. Most people with dengue don’t develop symptoms, but those who do may experience body aches, severe headaches, nausea, fever, and rash, with severe illness progressing to shock, internal bleeding, and death. Back to top Article Information Published Online: March 7, 2025. doi:10.1001/jama.2025.1349

In a controlled lab setting, researchers reveal how the Zika virus modulates human fibroblasts, potentially transforming its host into a “rescue beacon” that emits signals to attract mosquito vectors,...

Numerous orthoflaviviruses transmitted through the bites of different mosquito species infect more than 500 million people annually. Bite-initiated skin infection represents a critical and conserved s...

Government support is essential to science. The Trump administration kneecapped it.

This is a potentially devastating event — not just for the scientific community, but for all Americans.