Jenna Guthmiller
@guthmillerjenna.bsky.social
Assistant Professor at the University of Colorado Anschutz Medical Campus. Studying all things humoral immunity, influenza viruses, and vaccines.
Reposted by Jenna Guthmiller
A person hospitalized in Washington has tested positive for H5N1, pending confirmatory testing (because that's the system).
First *KNOWN* case this year. Under the Trump admin, the CDC has barely tested any farmworkers for H5N1.
First *KNOWN* case this year. Under the Trump admin, the CDC has barely tested any farmworkers for H5N1.
Preliminary human bird flu case reported in Washington state
If confirmed, it will be the first human bird flu case in the United States since February.
www.cidrap.umn.edu/a...
If confirmed, it will be the first human bird flu case in the United States since February.
www.cidrap.umn.edu/a...
November 14, 2025 at 6:55 PM
A person hospitalized in Washington has tested positive for H5N1, pending confirmatory testing (because that's the system).
First *KNOWN* case this year. Under the Trump admin, the CDC has barely tested any farmworkers for H5N1.
First *KNOWN* case this year. Under the Trump admin, the CDC has barely tested any farmworkers for H5N1.
Reposted by Jenna Guthmiller
Our lab's first paper is out! Led by Jordan Ort, we developed NextClade datasets that enable rapid H5 clade assignment via NextClade. We deployed these during the start of the H5 cattle outbreak, and we finally published the paper in Virus Evolution academic.oup.com/ve/article/1...
Development of avian influenza A(H5) virus datasets for Nextclade enables rapid and accurate clade assignment
Abstract. The 2022 panzootic of highly pathogenic avian influenza (HPAI) A(H5) viruses has led to unprecedented transmission to multiple mammalian species.
academic.oup.com
October 15, 2025 at 3:44 PM
Our lab's first paper is out! Led by Jordan Ort, we developed NextClade datasets that enable rapid H5 clade assignment via NextClade. We deployed these during the start of the H5 cattle outbreak, and we finally published the paper in Virus Evolution academic.oup.com/ve/article/1...
Reposted by Jenna Guthmiller
The paradox of maternal antibodies; protection v interference. Our first paper in this fascinating field is out! www.embopress.org/doi/full/10....
Mechanisms of maternal antibody interference with rotavirus vaccination | The EMBO Journal
imageimageMaternal antibodies are correlated with a reduced ability of infants to produce antibodies
following oral rotavirus vaccination. This interference is attributed in this study
primarily to va...
www.embopress.org
October 14, 2025 at 11:49 AM
The paradox of maternal antibodies; protection v interference. Our first paper in this fascinating field is out! www.embopress.org/doi/full/10....
Reposted by Jenna Guthmiller
What causes viral transmission bottlenecks? This study uses barcoded virions to show that in the case of #influenza A #virus, early within-host replication dynamics (rather than a reduced inoculum population) drive loss of diversity during transmission @plosbiology.org 🧪 plos.io/4ngicDK
September 3, 2025 at 12:56 PM
What causes viral transmission bottlenecks? This study uses barcoded virions to show that in the case of #influenza A #virus, early within-host replication dynamics (rather than a reduced inoculum population) drive loss of diversity during transmission @plosbiology.org 🧪 plos.io/4ngicDK
Reposted by Jenna Guthmiller
Characterization of the glycoproteins of fish and amphibian influenza B–like viruses www.science.org/doi/10.1126/...
Characterization of the glycoproteins of fish and amphibian influenza B–like viruses
Fish and amphibian influenza B–like viruses show functional divergence and lack immunity in humans.
www.science.org
August 25, 2025 at 4:16 PM
Characterization of the glycoproteins of fish and amphibian influenza B–like viruses www.science.org/doi/10.1126/...
Reposted by Jenna Guthmiller
@vijayrathinam.bsky.social @vinnieviruses.bsky.social @raflynn5.bsky.social discovers why RNA undergoes glycosylation: N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 6, 2025 at 6:27 PM
@vijayrathinam.bsky.social @vinnieviruses.bsky.social @raflynn5.bsky.social discovers why RNA undergoes glycosylation: N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jenna Guthmiller
Recently, we found out that our R01 funded through PAR-22-241 was withdrawn by NIAID as the NIH no longer prioritizes research programs related to DEI. This has been devastating news for our young research group, and we are now trying to scram together for a path forward 🧵1/12
May 6, 2025 at 8:19 PM
Recently, we found out that our R01 funded through PAR-22-241 was withdrawn by NIAID as the NIH no longer prioritizes research programs related to DEI. This has been devastating news for our young research group, and we are now trying to scram together for a path forward 🧵1/12
Reposted by Jenna Guthmiller
I received a surprising and disturbing request from NIH on Friday. They wrote to cancel a subaward to Hong Kong on one of my grants. (This was disturbing but not surprising.) They also ordered us not to interact with our collaborators in Hong Kong on any work under the award:
April 27, 2025 at 7:26 PM
I received a surprising and disturbing request from NIH on Friday. They wrote to cancel a subaward to Hong Kong on one of my grants. (This was disturbing but not surprising.) They also ordered us not to interact with our collaborators in Hong Kong on any work under the award:
Reposted by Jenna Guthmiller
Not an auspicious date: 1 year ago today #USDA confirmed #H5N1 #birdflu in dairy cows in Texas, a first.
Since then nearly 1000 infected herds have been confirmed; lord knows how many others missed detection. 70 human cases were confirmed in the past year; again the true number is likely higher.
Since then nearly 1000 infected herds have been confirmed; lord knows how many others missed detection. 70 human cases were confirmed in the past year; again the true number is likely higher.
March 25, 2025 at 7:11 PM
Reposted by Jenna Guthmiller
Reposted by Jenna Guthmiller
Le Monde reporting that a French scientist traveling to Houston to attend a conference was denied entry to US after a search of his phone & computer revealed messages critical of Trump's science cuts, "which [says CPB] conveyed hatred of Trump & could be qualified as terrorism". Computer confiscated
March 19, 2025 at 6:11 PM
Le Monde reporting that a French scientist traveling to Houston to attend a conference was denied entry to US after a search of his phone & computer revealed messages critical of Trump's science cuts, "which [says CPB] conveyed hatred of Trump & could be qualified as terrorism". Computer confiscated
Reposted by Jenna Guthmiller
Excited to share @joelrc.bsky.social 's new paper examining the factors underlying cell-to-cell heterogeneity in interferon induction during flu infection:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Intrinsic OASL expression licenses interferon induction during influenza A virus infection
Effective control of viral infection requires rapid induction of the innate immune response, especially the type I and type III interferon (IFN) systems. Despite the critical role of IFN induction in ...
www.biorxiv.org
March 18, 2025 at 6:47 PM
Excited to share @joelrc.bsky.social 's new paper examining the factors underlying cell-to-cell heterogeneity in interferon induction during flu infection:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
I guess studying sex hormones equates to transgender mouse experiments… Tell that to the millions of people in the US alone that are medically receiving hormones for a multitude of reasons. Weird, anti-science times we are living in.
Today on :"this is not normal," here is an actual, official communication from the White House.
Beyond the insanity of the language used here, it manages to debunk its own point that the NIH spent millions of dollars to make transgender mice. If you actually read what the studies were for...
Beyond the insanity of the language used here, it manages to debunk its own point that the NIH spent millions of dollars to make transgender mice. If you actually read what the studies were for...
Yes, Biden Spent Millions on Transgender Animal Experiments
Last night, President Donald J. Trump highlighted many of the egregious examples of waste, fraud, and abuse funded by American taxpayers, including $8
www.whitehouse.gov
March 5, 2025 at 8:00 PM
I guess studying sex hormones equates to transgender mouse experiments… Tell that to the millions of people in the US alone that are medically receiving hormones for a multitude of reasons. Weird, anti-science times we are living in.
Reposted by Jenna Guthmiller
I love reading older papers, like Max Theiler's epic work from ~90 years ago when developing the 17D #vaccine for yellow fever.
I was intrigued to find the likely answer to: who was the first person vaccinated with 17D?
As it was the 1930's, it was Theiler: he tried it on himself. 1/4 🧪🦠🧫
I was intrigued to find the likely answer to: who was the first person vaccinated with 17D?
As it was the 1930's, it was Theiler: he tried it on himself. 1/4 🧪🦠🧫
March 3, 2025 at 8:30 PM
I love reading older papers, like Max Theiler's epic work from ~90 years ago when developing the 17D #vaccine for yellow fever.
I was intrigued to find the likely answer to: who was the first person vaccinated with 17D?
As it was the 1930's, it was Theiler: he tried it on himself. 1/4 🧪🦠🧫
I was intrigued to find the likely answer to: who was the first person vaccinated with 17D?
As it was the 1930's, it was Theiler: he tried it on himself. 1/4 🧪🦠🧫
Reposted by Jenna Guthmiller
A massive loss to the virology community. Ann was an amazing scientist and mentor, whose service to UW and the virology community in general will be sorely missed.
www.cressfuneralservice.com/obituaries/a...
www.cressfuneralservice.com/obituaries/a...
Ann Carol Palmenberg, Ph.D Obituary February 20, 2025 - Cress Funeral and Cremation Services
View Ann Carol Palmenberg, Ph.D's obituary, find service dates, and sign the guestbook.
www.cressfuneralservice.com
March 2, 2025 at 8:01 PM
A massive loss to the virology community. Ann was an amazing scientist and mentor, whose service to UW and the virology community in general will be sorely missed.
www.cressfuneralservice.com/obituaries/a...
www.cressfuneralservice.com/obituaries/a...
Reposted by Jenna Guthmiller
No indication as to why these types of meeting are being canceled. There are serious repercussions to public health by canceling these meetings. We are in the worst flu season in over a decade and we cannot afford to not be prepared for next year.
FDA cancels meeting to select flu strains for next season's shots www.nbcnews.com/health/healt...
FDA cancels meeting to select flu strains for next season's shots
The canceled meeting comes just days after a CDC vaccine advisory committee meeting was abruptly postponed.
www.nbcnews.com
February 27, 2025 at 5:43 AM
No indication as to why these types of meeting are being canceled. There are serious repercussions to public health by canceling these meetings. We are in the worst flu season in over a decade and we cannot afford to not be prepared for next year.
Reposted by Jenna Guthmiller
State AGs are looking for federal workers who have just been illegally fired to stand as litigants in a new lawsuit trying to freeze further action by DOGE.
DM me if that’s you and you’re interested and you’re live in one of the following states: NM, AZ, CA, CT, MD, MI, MN, NV, OR, WA, RI, or VT.
DM me if that’s you and you’re interested and you’re live in one of the following states: NM, AZ, CA, CT, MD, MI, MN, NV, OR, WA, RI, or VT.
February 17, 2025 at 3:54 AM
State AGs are looking for federal workers who have just been illegally fired to stand as litigants in a new lawsuit trying to freeze further action by DOGE.
DM me if that’s you and you’re interested and you’re live in one of the following states: NM, AZ, CA, CT, MD, MI, MN, NV, OR, WA, RI, or VT.
DM me if that’s you and you’re interested and you’re live in one of the following states: NM, AZ, CA, CT, MD, MI, MN, NV, OR, WA, RI, or VT.
Reposted by Jenna Guthmiller
Because there's not enough going on: Arizona has found #H5N1 #birdflu in milk and it looks like yet another spillover from wild birds.
www.statnews.com/2025/02/14/a...
www.statnews.com/2025/02/14/a...
Bird flu found in Arizona milk suggests another spillover from birds to cows
Another spillover of the H5N1 bird flu virus from wild birds to dairy cattle appears to have occurred, this time in Arizona.
www.statnews.com
February 14, 2025 at 10:53 PM
Because there's not enough going on: Arizona has found #H5N1 #birdflu in milk and it looks like yet another spillover from wild birds.
www.statnews.com/2025/02/14/a...
www.statnews.com/2025/02/14/a...
Reposted by Jenna Guthmiller
#USDA posted an analysis of the D1.1 #H5N1 #birdflu viruses that infected Nevada cows — the new spillover event. They spotted a mutation in the PB2 gene that is associated with mammalian adaptation. What's this mean? Dunno. But 2 spillovers means more could come. www.aphis.usda.gov/sites/defaul...
February 7, 2025 at 11:09 PM
#USDA posted an analysis of the D1.1 #H5N1 #birdflu viruses that infected Nevada cows — the new spillover event. They spotted a mutation in the PB2 gene that is associated with mammalian adaptation. What's this mean? Dunno. But 2 spillovers means more could come. www.aphis.usda.gov/sites/defaul...
Reposted by Jenna Guthmiller
Dairy cows in Nevada are infected with the D1.1 genotype of H5N1 indicating a second introduction of the virus into dairy cows. We still don't know how the initial outbreak started, but this indicates cows continue to be at risk of exposure to H5N1 www.aphis.usda.gov/news/program...
APHIS Confirms D1.1 Genotype in Dairy Cattle in Nevada | Animal and Plant Health Inspection Service
On January 31, 2025, the USDA Animal and Plant Health Inspection Service (APHIS) National Veterinary Services Laboratories (NVSL) confirmed by whole genome sequence the first detection of highly patho...
www.aphis.usda.gov
February 5, 2025 at 11:12 PM
Dairy cows in Nevada are infected with the D1.1 genotype of H5N1 indicating a second introduction of the virus into dairy cows. We still don't know how the initial outbreak started, but this indicates cows continue to be at risk of exposure to H5N1 www.aphis.usda.gov/news/program...
Reposted by Jenna Guthmiller
New development: this is the first detection of genotype D1.1 H5N1 virus in cattle. All cattle sequences to date were genotype B3.13 & were all descended from a single spillover.
New genotype means new introduction to cows from birds.
www.statnews.com/2025/02/05/u...
New genotype means new introduction to cows from birds.
www.statnews.com/2025/02/05/u...
USDA milk testing shows different strain of H5N1 bird flu in Nevada dairy herds
The USDA said four Nevada dairy herds were infected with an H5N1 bird flu strain that has circulated in wild birds, making prospects for containment in cows appear dim.
www.statnews.com
February 5, 2025 at 8:31 PM
New development: this is the first detection of genotype D1.1 H5N1 virus in cattle. All cattle sequences to date were genotype B3.13 & were all descended from a single spillover.
New genotype means new introduction to cows from birds.
www.statnews.com/2025/02/05/u...
New genotype means new introduction to cows from birds.
www.statnews.com/2025/02/05/u...
Want to read up on H5N1 ? A brief review out now from my group on where H5N1 came from, how it has or could evolve to better infect humans, and how the distribution of receptors for H5N1 can lead to varying symptoms, such as conjunctivitis.
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
The sweet side of H5N1 influenza virus infection
journals.plos.org
January 23, 2025 at 11:13 PM
Want to read up on H5N1 ? A brief review out now from my group on where H5N1 came from, how it has or could evolve to better infect humans, and how the distribution of receptors for H5N1 can lead to varying symptoms, such as conjunctivitis.
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Reposted by Jenna Guthmiller
🌟 #ESWI 🏆 are open for #EarlyCareerScientists! 🌟
✨ Young Scientist Vaccine Innovation Award
📅 Deadline: 28 February 2025
ℹ️ eswiconference.org/eswi-awards#...
📽️ Hear from @guthmillerjenna.bsky.social our inspiring 2023 winner. Will you be next? Showcase your innovation!
✨ Young Scientist Vaccine Innovation Award
📅 Deadline: 28 February 2025
ℹ️ eswiconference.org/eswi-awards#...
📽️ Hear from @guthmillerjenna.bsky.social our inspiring 2023 winner. Will you be next? Showcase your innovation!
ESWI Awards | ESWI2025
To support early career scientists in the field of respiratory virus infections, ESWI has launched an award recognizing the most promising body of work. Open to early career scientists worldwide, the ...
eswiconference.org
January 13, 2025 at 1:28 PM
🌟 #ESWI 🏆 are open for #EarlyCareerScientists! 🌟
✨ Young Scientist Vaccine Innovation Award
📅 Deadline: 28 February 2025
ℹ️ eswiconference.org/eswi-awards#...
📽️ Hear from @guthmillerjenna.bsky.social our inspiring 2023 winner. Will you be next? Showcase your innovation!
✨ Young Scientist Vaccine Innovation Award
📅 Deadline: 28 February 2025
ℹ️ eswiconference.org/eswi-awards#...
📽️ Hear from @guthmillerjenna.bsky.social our inspiring 2023 winner. Will you be next? Showcase your innovation!