Denis Chrétien
@dchretien.bsky.social
Microtubule and cryo-ET addict!
Rosalind Franklin and the damage of gender harassment | Science | AAAS www.science.org/content/arti...
Rosalind Franklin and the damage of gender harassment
Spurred by a recent report on sexual harassment in academia, our columnist revisits a historical case and reflects on what has changed—and what hasn’t
www.science.org
November 8, 2025 at 4:45 PM
Rosalind Franklin and the damage of gender harassment | Science | AAAS www.science.org/content/arti...
Reposted by Denis Chrétien
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
Reposted by Denis Chrétien
I am beyond excited to share that my postdoc project @szndohrn.bsky.social and the @arnonelab.bsky.social is now available in #ScienceAdvances @science.org. www.science.org/doi/10.1126/...
November 5, 2025 at 7:02 PM
I am beyond excited to share that my postdoc project @szndohrn.bsky.social and the @arnonelab.bsky.social is now available in #ScienceAdvances @science.org. www.science.org/doi/10.1126/...
Reposted by Denis Chrétien
Diatoms – microscopic algae found almost everywhere there’s water – make up ~25% of Earth’s annual oxygen production.🌎
EMBL researchers have now found a way to easily reveal their inner structures by combining cryo-fixation with ultrastructural expansion microscopy 🔬
www.cell.com/current-biol...
EMBL researchers have now found a way to easily reveal their inner structures by combining cryo-fixation with ultrastructural expansion microscopy 🔬
www.cell.com/current-biol...
November 6, 2025 at 1:28 PM
Diatoms – microscopic algae found almost everywhere there’s water – make up ~25% of Earth’s annual oxygen production.🌎
EMBL researchers have now found a way to easily reveal their inner structures by combining cryo-fixation with ultrastructural expansion microscopy 🔬
www.cell.com/current-biol...
EMBL researchers have now found a way to easily reveal their inner structures by combining cryo-fixation with ultrastructural expansion microscopy 🔬
www.cell.com/current-biol...
Reposted by Denis Chrétien
In their Review, Olivier Mercey, @marinebrunet.bsky.social, Paul Guichard & Virginie Hamel @centriolelab.bsky.social highlight advances in microscopy that have significantly deepened our understanding of centriolar & ciliary structure & function.
journals.biologists.com/jcs/article/...
#OpenAccess
journals.biologists.com/jcs/article/...
#OpenAccess
Advances in high-resolution imaging of centrioles and cilia
Summary: A review of the progressive advances in light and electron microscopy that have revealed unprecedented structural and molecular insights into centrioles and cilia, and reshaped our view of th...
journals.biologists.com
November 5, 2025 at 3:37 PM
In their Review, Olivier Mercey, @marinebrunet.bsky.social, Paul Guichard & Virginie Hamel @centriolelab.bsky.social highlight advances in microscopy that have significantly deepened our understanding of centriolar & ciliary structure & function.
journals.biologists.com/jcs/article/...
#OpenAccess
journals.biologists.com/jcs/article/...
#OpenAccess
Reposted by Denis Chrétien
🎉New Paper Drop🎉 We just uploaded our latest findings on bioRxiv!
We report the identification of the limits of microtubule self-repair and how microtubule integrity is maintained under mechanical load.
Congratulations @bucklingmt.bsky.social
www.biorxiv.org/content/10.1...
We report the identification of the limits of microtubule self-repair and how microtubule integrity is maintained under mechanical load.
Congratulations @bucklingmt.bsky.social
www.biorxiv.org/content/10.1...
September 14, 2025 at 8:11 AM
🎉New Paper Drop🎉 We just uploaded our latest findings on bioRxiv!
We report the identification of the limits of microtubule self-repair and how microtubule integrity is maintained under mechanical load.
Congratulations @bucklingmt.bsky.social
www.biorxiv.org/content/10.1...
We report the identification of the limits of microtubule self-repair and how microtubule integrity is maintained under mechanical load.
Congratulations @bucklingmt.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Denis Chrétien
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
October 21, 2025 at 11:14 AM
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Denis Chrétien
I was one of > 100,000 in New York City
October 18, 2025 at 9:33 PM
I was one of > 100,000 in New York City
Reposted by Denis Chrétien
Cryo-Flow : when science freezes and flows ❄️
After turning her thesis on tuberculosis into a rap, Yaëlle Wormser aka Lady Pipette, doctoral student at the Institut Pasteur, is back with a new track — Cryo-Flow — a song that turns Cryo-Electron Microscopy (Cryo-EM) into rhythm & rhyme.
@pasteur.fr
After turning her thesis on tuberculosis into a rap, Yaëlle Wormser aka Lady Pipette, doctoral student at the Institut Pasteur, is back with a new track — Cryo-Flow — a song that turns Cryo-Electron Microscopy (Cryo-EM) into rhythm & rhyme.
@pasteur.fr
Cryo-Flow : when science freezes and flows ❄️
YouTube video by Institut Pasteur EDUCATION
youtube.com
October 15, 2025 at 10:02 AM
Cryo-Flow : when science freezes and flows ❄️
After turning her thesis on tuberculosis into a rap, Yaëlle Wormser aka Lady Pipette, doctoral student at the Institut Pasteur, is back with a new track — Cryo-Flow — a song that turns Cryo-Electron Microscopy (Cryo-EM) into rhythm & rhyme.
@pasteur.fr
After turning her thesis on tuberculosis into a rap, Yaëlle Wormser aka Lady Pipette, doctoral student at the Institut Pasteur, is back with a new track — Cryo-Flow — a song that turns Cryo-Electron Microscopy (Cryo-EM) into rhythm & rhyme.
@pasteur.fr
Reposted by Denis Chrétien
Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
October 15, 2025 at 4:02 PM
Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
Reposted by Denis Chrétien
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
October 14, 2025 at 1:50 PM
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
Trip to the center of the microtubule 😵💫
#microtubule
#microtubule
September 26, 2025 at 1:17 PM
Trip to the center of the microtubule 😵💫
#microtubule
#microtubule
Reposted by Denis Chrétien
🚨 Webinar Alert! - Revolutionizing Structural Biology
On Oct 1 Dr. Nick Ariotti (U. Queensland) will share how his team imaged microtubules in lysate at 7.1 Å with a cryoTEM and NO traditional purification steps.
Register here: ter.li/66bytl
#structuralbiology #proteinmicroscopy #cryoEM #cryoET
On Oct 1 Dr. Nick Ariotti (U. Queensland) will share how his team imaged microtubules in lysate at 7.1 Å with a cryoTEM and NO traditional purification steps.
Register here: ter.li/66bytl
#structuralbiology #proteinmicroscopy #cryoEM #cryoET
September 25, 2025 at 5:26 PM
🚨 Webinar Alert! - Revolutionizing Structural Biology
On Oct 1 Dr. Nick Ariotti (U. Queensland) will share how his team imaged microtubules in lysate at 7.1 Å with a cryoTEM and NO traditional purification steps.
Register here: ter.li/66bytl
#structuralbiology #proteinmicroscopy #cryoEM #cryoET
On Oct 1 Dr. Nick Ariotti (U. Queensland) will share how his team imaged microtubules in lysate at 7.1 Å with a cryoTEM and NO traditional purification steps.
Register here: ter.li/66bytl
#structuralbiology #proteinmicroscopy #cryoEM #cryoET
Microtubules: from atoms to complex systems www.embl.org/about/info/c...
Microtubules: from atoms to complex systems
www.embl.org
September 15, 2025 at 5:17 AM
Microtubules: from atoms to complex systems www.embl.org/about/info/c...
Reposted by Denis Chrétien
Happy to share that our paper on Tau- Microtubule interaction is now published in Nature Physics!🥳
We show that Tau isn’t just a microtubule stabiliser - it promotes removal of defects in the microtubule lattice.
Congratulations @subhambiswas.bsky.social!
www.nature.com/articles/s41...
We show that Tau isn’t just a microtubule stabiliser - it promotes removal of defects in the microtubule lattice.
Congratulations @subhambiswas.bsky.social!
www.nature.com/articles/s41...
September 11, 2025 at 6:03 PM
Happy to share that our paper on Tau- Microtubule interaction is now published in Nature Physics!🥳
We show that Tau isn’t just a microtubule stabiliser - it promotes removal of defects in the microtubule lattice.
Congratulations @subhambiswas.bsky.social!
www.nature.com/articles/s41...
We show that Tau isn’t just a microtubule stabiliser - it promotes removal of defects in the microtubule lattice.
Congratulations @subhambiswas.bsky.social!
www.nature.com/articles/s41...
Reposted by Denis Chrétien
Story on our Asgard microtubule paper by Nikki Greenwood: www.quantamagazine.org/tiny-tubes-r...
Thanks to all interviewees🎤
Thanks to all interviewees🎤
Tiny Tubes Reveal Clues to the Evolution of Complex Life | Quanta Magazine
Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons.
www.quantamagazine.org
September 10, 2025 at 7:07 AM
Story on our Asgard microtubule paper by Nikki Greenwood: www.quantamagazine.org/tiny-tubes-r...
Thanks to all interviewees🎤
Thanks to all interviewees🎤
Reposted by Denis Chrétien
📣 Paris Cytoskeleton day 2025 - Registrations are open!
📆 November 14th
📍 Institut Jacques Monod
🔗 pcd2025.sciencesconf.org
Abstract submission closes on 19 October
Registration closes on 7 November
@romet-jegou-lab.bsky.social @upcite.bsky.social @cnrs-idf-villejuif.bsky.social
📆 November 14th
📍 Institut Jacques Monod
🔗 pcd2025.sciencesconf.org
Abstract submission closes on 19 October
Registration closes on 7 November
@romet-jegou-lab.bsky.social @upcite.bsky.social @cnrs-idf-villejuif.bsky.social
September 10, 2025 at 9:14 AM
📣 Paris Cytoskeleton day 2025 - Registrations are open!
📆 November 14th
📍 Institut Jacques Monod
🔗 pcd2025.sciencesconf.org
Abstract submission closes on 19 October
Registration closes on 7 November
@romet-jegou-lab.bsky.social @upcite.bsky.social @cnrs-idf-villejuif.bsky.social
📆 November 14th
📍 Institut Jacques Monod
🔗 pcd2025.sciencesconf.org
Abstract submission closes on 19 October
Registration closes on 7 November
@romet-jegou-lab.bsky.social @upcite.bsky.social @cnrs-idf-villejuif.bsky.social
Reposted by Denis Chrétien
Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social
August 7, 2025 at 6:12 PM
Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social
Reposted by Denis Chrétien
The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by #cryoEM.
Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur...
#LMBNews 🧪🔬
Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur...
#LMBNews 🧪🔬
August 4, 2025 at 2:33 PM
The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by #cryoEM.
Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur...
#LMBNews 🧪🔬
Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur...
#LMBNews 🧪🔬
Reposted by Denis Chrétien
Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
July 29, 2025 at 9:04 AM
Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
Reposted by Denis Chrétien
Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...
To tilt or not to tilt? Strategies for in situ cryo-EM data collection
Recent breakthroughs in single-particle cryogenic electron microscopy (cryo-EM) and protein structure prediction have transformed our ability to resol…
www.sciencedirect.com
June 28, 2025 at 2:04 PM
Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...
Reposted by Denis Chrétien
After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
June 27, 2025 at 10:58 AM
After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
Reposted by Denis Chrétien
Our paper on Lymphostatin is now out (rdcu.be/etk2v). It shows #cryoEM structures of this huge virulence factor revealing amazing domain reorganisations.
Very enjoyable collaborating with the Stevens Lab in Edinburgh and the Boersch Lab in Jena to see how it gets into cells.
@uni-wuerzburg.de 🧪❄️
Very enjoyable collaborating with the Stevens Lab in Edinburgh and the Boersch Lab in Jena to see how it gets into cells.
@uni-wuerzburg.de 🧪❄️
June 25, 2025 at 3:59 PM
Our paper on Lymphostatin is now out (rdcu.be/etk2v). It shows #cryoEM structures of this huge virulence factor revealing amazing domain reorganisations.
Very enjoyable collaborating with the Stevens Lab in Edinburgh and the Boersch Lab in Jena to see how it gets into cells.
@uni-wuerzburg.de 🧪❄️
Very enjoyable collaborating with the Stevens Lab in Edinburgh and the Boersch Lab in Jena to see how it gets into cells.
@uni-wuerzburg.de 🧪❄️
Reposted by Denis Chrétien
🚨 New preprint!
Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM
www.biorxiv.org/content/10.1...
Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM
www.biorxiv.org/content/10.1...
June 19, 2025 at 8:58 AM
🚨 New preprint!
Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM
www.biorxiv.org/content/10.1...
Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM
www.biorxiv.org/content/10.1...