Daniel Arango
@danyarango.bsky.social
Assistant Professor Dept. Pharmacology. Northwestern University, Chicago. RNA biologist. RNA-modifying enzymes. Protein synthesis.
Reposted by Daniel Arango
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
August 6, 2025 at 3:36 PM
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Congratulations!
Congratulations to the eight recipients of the 2025 Dr. Eddie Méndez Scholar Award! This award recognizes outstanding early-career scientists from underrepresented backgrounds who are studying cancer, infectious diseases and basic sciences. Learn more: bit.ly/4jWvT8O
June 19, 2025 at 3:36 AM
Congratulations!
Excited to share this preprint from my lab. We report a potent and site-specific inhibition of translation initiation by 2’O methylation.
It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology
It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology
Targeted Inhibition of Translation Initiation via 2'O-Methylation of Start Codons https://www.biorxiv.org/content/10.1101/2025.06.14.659565v1
June 18, 2025 at 11:17 AM
Excited to share this preprint from my lab. We report a potent and site-specific inhibition of translation initiation by 2’O methylation.
It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology
It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology
Reposted by Daniel Arango
New Wall Street Journal about Northwestern and the funding freeze.
[Gift link]
www.wsj.com/us-news/educ...
1/n
[Gift link]
www.wsj.com/us-news/educ...
1/n
How Trump Blew Up Northwestern’s Business Model
The federal government froze the university’s research funding. It hasn’t offered the school a way to get it back.
www.wsj.com
June 15, 2025 at 5:39 PM
New Wall Street Journal about Northwestern and the funding freeze.
[Gift link]
www.wsj.com/us-news/educ...
1/n
[Gift link]
www.wsj.com/us-news/educ...
1/n
👏
Seems a good time to invite Sen Britt to watch an NIH review panel (aka study section) analyze piles of grants over several days to identify the <10% that win funding. Applications that scientists spent months preparing, whose peers spent weeks poring through in advance of review mtg at NIH.
Republican Senator Katie Britt: We need to create a system "where the beat idea wins... This is our opportunity to make a dollar go further and to make it have a greater impact."
(NIH already generates $2.56 for every $1 spent it spends on research.)
(NIH already generates $2.56 for every $1 spent it spends on research.)
June 10, 2025 at 11:22 PM
👏
👏
My message to Trump’s NIH Director? No one in America wants us to do LESS cancer research.
No one is asking Trump to make it harder to cure Alzheimer's disease.
Yet Trump is cutting all of this NOW and demanding an $18 BILLION cut to NIH next year. Not on my watch.
No one is asking Trump to make it harder to cure Alzheimer's disease.
Yet Trump is cutting all of this NOW and demanding an $18 BILLION cut to NIH next year. Not on my watch.
June 10, 2025 at 11:21 PM
👏
Reposted by Daniel Arango
@thedailynu.bsky.social Northwestern is still supporting our research despite not receiving any $ from active and new fundable grants. Definitely unsustainable and anxieties are piling up..
Funding freeze at Northwestern from Emma Mairson at
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
June 7, 2025 at 11:08 PM
@thedailynu.bsky.social Northwestern is still supporting our research despite not receiving any $ from active and new fundable grants. Definitely unsustainable and anxieties are piling up..
Reposted by Daniel Arango
Funding freeze at Northwestern from Emma Mairson at
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
June 7, 2025 at 7:48 PM
Funding freeze at Northwestern from Emma Mairson at
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
Reposted by Daniel Arango
I helped explain to the Chicago Tribune the enourmous and irrational damage the NIH funding freeze is causing at Northwestern. “You’re at risk of losing an entire next generation of scientists" "it’s terrifying; it’s completely senseless." www.chicagotribune.com/2025/06/07/w...
Worried Northwestern lab directors describe ‘bleak’ atmosphere in wake of Trump research funding freeze
The Trump administration’s freezing of $790 million in federal research funding for Northwestern University has left concerned lab directors without key grants and forced the university to spend mi…
www.chicagotribune.com
June 7, 2025 at 7:45 PM
I helped explain to the Chicago Tribune the enourmous and irrational damage the NIH funding freeze is causing at Northwestern. “You’re at risk of losing an entire next generation of scientists" "it’s terrifying; it’s completely senseless." www.chicagotribune.com/2025/06/07/w...
Reposted by Daniel Arango
Keep in mind: these are AWARDED grants, with Notice of Awards. The federal government is not honoring existing contracts with this university, refusing to reimburse for costs charge on awarded grants.
Funding freeze at Northwestern from Emma Mairson at
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
June 7, 2025 at 8:30 PM
Keep in mind: these are AWARDED grants, with Notice of Awards. The federal government is not honoring existing contracts with this university, refusing to reimburse for costs charge on awarded grants.
Reposted by Daniel Arango
Professors and researchers at Chicago-area universities said federal funding cuts are leaving research projects unfinished.
Julius Lucks, a chemical engineering professor at Northwestern, speaks on if another sector could fund university research.
to.wttw.com/3Ygl3T8
Julius Lucks, a chemical engineering professor at Northwestern, speaks on if another sector could fund university research.
to.wttw.com/3Ygl3T8
April 25, 2025 at 7:30 PM
Professors and researchers at Chicago-area universities said federal funding cuts are leaving research projects unfinished.
Julius Lucks, a chemical engineering professor at Northwestern, speaks on if another sector could fund university research.
to.wttw.com/3Ygl3T8
Julius Lucks, a chemical engineering professor at Northwestern, speaks on if another sector could fund university research.
to.wttw.com/3Ygl3T8
Reposted by Daniel Arango
Ready for the next RNA session in @asbmb.bsky.social meeting. We start soon...
April 14, 2025 at 6:35 PM
Ready for the next RNA session in @asbmb.bsky.social meeting. We start soon...
Reposted by Daniel Arango
In the midst of everything it feels particularly appropriate to highlight all the amazing #RNA research taking place at #NIH!
Follow this thread to join us for our biannual #RNASymposium, this year featuring intramural research superstars!
Follow this thread to join us for our biannual #RNASymposium, this year featuring intramural research superstars!
April 3, 2025 at 1:18 PM
In the midst of everything it feels particularly appropriate to highlight all the amazing #RNA research taking place at #NIH!
Follow this thread to join us for our biannual #RNASymposium, this year featuring intramural research superstars!
Follow this thread to join us for our biannual #RNASymposium, this year featuring intramural research superstars!
Reposted by Daniel Arango
It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation
Cancer cells frequently enhance ribosome production to support rapid growth. Here,
Lee et al. demonstrate that an isoform of lncRNA CRNDE containing an ultraconserved
element (CRNDEUCE) promotes 60S r...
www.cell.com
April 3, 2025 at 4:47 PM
It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Daniel Arango
Finally got the notice. Very sad day for the MOSAIC program that supported some of the most amazing scientists I know, as well as some of the awesome people on my lab.
April 2, 2025 at 6:10 PM
Finally got the notice. Very sad day for the MOSAIC program that supported some of the most amazing scientists I know, as well as some of the awesome people on my lab.
Reposted by Daniel Arango
So proud of this incredible work from @g-agarwal.bsky.social from our group with help from many fantastic folks in our lab and inspiring collaborators, including @kharaslab.bsky.social, Alex Bick, @yashpershad.bsky.social, and many others! Please check out Gaurav's awesome 🧵👇👇
What protects individuals from developing blood cancers?
Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n)
www.biorxiv.org/content/10.1...
Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n)
www.biorxiv.org/content/10.1...
March 27, 2025 at 8:36 PM
So proud of this incredible work from @g-agarwal.bsky.social from our group with help from many fantastic folks in our lab and inspiring collaborators, including @kharaslab.bsky.social, Alex Bick, @yashpershad.bsky.social, and many others! Please check out Gaurav's awesome 🧵👇👇
Reposted by Daniel Arango
Small proteins can be more complex than they look!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
March 26, 2025 at 4:21 PM
Small proteins can be more complex than they look!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
Reposted by Daniel Arango
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
March 18, 2025 at 11:27 PM
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
Reposted by Daniel Arango
We were delighted to have @king5news.com.web.brid.gy visit us in the Termini Lab to discuss how NIH funding cuts could affect cancer research:
m.youtube.com/watch?v=Szo9...
We NEED indirect costs to provide funding needed complete research studies that will lead to life saving discoveries.
m.youtube.com/watch?v=Szo9...
We NEED indirect costs to provide funding needed complete research studies that will lead to life saving discoveries.
Potential NIH funding cuts could affect local cancer research
YouTube video by KING 5 Seattle
m.youtube.com
March 7, 2025 at 3:07 AM
We were delighted to have @king5news.com.web.brid.gy visit us in the Termini Lab to discuss how NIH funding cuts could affect cancer research:
m.youtube.com/watch?v=Szo9...
We NEED indirect costs to provide funding needed complete research studies that will lead to life saving discoveries.
m.youtube.com/watch?v=Szo9...
We NEED indirect costs to provide funding needed complete research studies that will lead to life saving discoveries.
Reposted by Daniel Arango
Reposted by Daniel Arango
The AACR is deeply concerned that the Administration’s recent actions are threatening NIH and its mission to accelerate progress for patients with cancer and other diseases that afflict millions of Americans. Read our statement: https://buff.ly/4gRXNB8
February 18, 2025 at 6:09 PM
The AACR is deeply concerned that the Administration’s recent actions are threatening NIH and its mission to accelerate progress for patients with cancer and other diseases that afflict millions of Americans. Read our statement: https://buff.ly/4gRXNB8
Reposted by Daniel Arango
Online Now: The integrated stress response regulates 18S nonfunctional rRNA decay in mammals
The integrated stress response regulates 18S nonfunctional rRNA decay in mammals
To maintain translational fidelity, cells degrade decoding-incompetent ribosomes through the 18S nonfunctional rRNA decay (NRD) pathway. Coria et al. demonstrate that the concerted actions of GCN2, RNF10, and RIOK3 lead to a block in translation…
dlvr.it
February 12, 2025 at 4:20 PM
Online Now: The integrated stress response regulates 18S nonfunctional rRNA decay in mammals
Reposted by Daniel Arango
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
January 28, 2025 at 9:45 PM
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
Reposted by Daniel Arango
Interested in RNA biology, cancer or vascular research? I have a position open for either a research assistant or a new postdoc to start expanding the fast-growing research area of cardio-oncology! Apply here: jobs.ncl.ac.uk/job/Newcastl...
Happy to have informal chats! Please share 🧬.
Happy to have informal chats! Please share 🧬.
Research Assistant/Associate - Regulation of gene expression
Research Assistant/Associate - Regulation of gene expression
jobs.ncl.ac.uk
December 3, 2024 at 4:21 PM
Interested in RNA biology, cancer or vascular research? I have a position open for either a research assistant or a new postdoc to start expanding the fast-growing research area of cardio-oncology! Apply here: jobs.ncl.ac.uk/job/Newcastl...
Happy to have informal chats! Please share 🧬.
Happy to have informal chats! Please share 🧬.