Joana Vidigal
@vidigaljoana.bsky.social
Studying small RNAs and Argonaute proteins in mammals using mouse genetics. Part time runner, full time mom of Best Kiddo Ever (BKE)
https://ccr.cancer.gov/staff-directory/joana-a-vidigal
https://ccr.cancer.gov/staff-directory/joana-a-vidigal
Pinned
AGO2 slicing of a domesticated retrotransposon is necessary for normal vasculature development
Argonaute (AGO) mediated slicing of RNA, also known as RNAi, is a highly conserved phenomenon that is evolutionarily linked to the repression of transposons and other repeats. Although RNAi is no long...
www.biorxiv.org
What was that you said? You are looking for new #RNA research to read in the weekend?
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
Reposted by Joana Vidigal
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
September 8, 2025 at 3:15 PM
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
Reposted by Joana Vidigal
A giant thank you to @drjz.bsky.social and @vidigaljoana.bsky.social! It takes a village to celebrate #RNAday
NIH had fun celebrating another #RNAday. Thanks to @vidigaljoana.bsky.social for organizing this great event and @slwolin.bsky.social for building a strong RNA community.
August 1, 2025 at 9:09 PM
A giant thank you to @drjz.bsky.social and @vidigaljoana.bsky.social! It takes a village to celebrate #RNAday
Reposted by Joana Vidigal
NIH had fun celebrating another #RNAday. Thanks to @vidigaljoana.bsky.social for organizing this great event and @slwolin.bsky.social for building a strong RNA community.
August 1, 2025 at 8:28 PM
NIH had fun celebrating another #RNAday. Thanks to @vidigaljoana.bsky.social for organizing this great event and @slwolin.bsky.social for building a strong RNA community.
Reposted by Joana Vidigal
Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters
Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.
www.science.org
February 12, 2025 at 9:21 PM
Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
Reposted by Joana Vidigal
My research group seeks a highly motivated Post-Bacc (or Tech). This position offers a unique opportunity to contribute to research on cleavage-inducing tiny RNAs (cityRNAs) to treat neurological and neuromuscular disorders, Cancer, Alzheimer's diseases, etc.
u.osu.edu/cbcundergrad...
u.osu.edu/cbcundergrad...
Job Opportunity for Recent Graduates (Post-Bacc) | CBC Undergraduate Program
u.osu.edu
May 6, 2025 at 12:59 PM
My research group seeks a highly motivated Post-Bacc (or Tech). This position offers a unique opportunity to contribute to research on cleavage-inducing tiny RNAs (cityRNAs) to treat neurological and neuromuscular disorders, Cancer, Alzheimer's diseases, etc.
u.osu.edu/cbcundergrad...
u.osu.edu/cbcundergrad...
Reposted by Joana Vidigal
Why NIH/NIGMS funding of basic research matters with our latest work now out in @cp-cellreports.bsky.social sky.social. We solved a >30-year-old mystery of what transcription factor drives the Flamenco piRNA cluster required for female Drosophila fertility. /1
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Traffic Jam activates the Flamenco piRNA cluster locus and the Piwi pathway to ensure transposon silencing and Drosophila fertility
Rivera et al. discover Drosophila Flamenco piRNA cluster enhancers bound and activated
by the Traffic Jam transcription factor. Traffic Jam also binds many follicle cell
genes including activating mul...
www.cell.com
April 11, 2025 at 4:38 PM
Why NIH/NIGMS funding of basic research matters with our latest work now out in @cp-cellreports.bsky.social sky.social. We solved a >30-year-old mystery of what transcription factor drives the Flamenco piRNA cluster required for female Drosophila fertility. /1
www.cell.com/cell-reports...
www.cell.com/cell-reports...
What was that you said? You are looking for new #RNA research to read in the weekend?
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
AGO2 slicing of a domesticated retrotransposon is necessary for normal vasculature development
Argonaute (AGO) mediated slicing of RNA, also known as RNAi, is a highly conserved phenomenon that is evolutionarily linked to the repression of transposons and other repeats. Although RNAi is no long...
www.biorxiv.org
April 4, 2025 at 5:35 PM
What was that you said? You are looking for new #RNA research to read in the weekend?
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
In the midst of everything it feels particularly appropriate to highlight all the amazing #RNA research taking place at #NIH!
Follow this thread to join us for our biannual #RNASymposium, this year featuring intramural research superstars!
Follow this thread to join us for our biannual #RNASymposium, this year featuring intramural research superstars!
April 3, 2025 at 1:18 PM
In the midst of everything it feels particularly appropriate to highlight all the amazing #RNA research taking place at #NIH!
Follow this thread to join us for our biannual #RNASymposium, this year featuring intramural research superstars!
Follow this thread to join us for our biannual #RNASymposium, this year featuring intramural research superstars!
Reposted by Joana Vidigal
ARGONAUTES 2025
The grassroot meeting of Argonaute afficionados is looking for afficionados! Full coverage of Argonautes from prokaryotes to #RNAi, #piRNA and #microRNA Join us in Prague at @imgprague.bsky.social during 27-30/8, 2025. Registration, program and more info here:
argonautes.img.cas.cz
The grassroot meeting of Argonaute afficionados is looking for afficionados! Full coverage of Argonautes from prokaryotes to #RNAi, #piRNA and #microRNA Join us in Prague at @imgprague.bsky.social during 27-30/8, 2025. Registration, program and more info here:
argonautes.img.cas.cz
March 12, 2025 at 6:56 AM
ARGONAUTES 2025
The grassroot meeting of Argonaute afficionados is looking for afficionados! Full coverage of Argonautes from prokaryotes to #RNAi, #piRNA and #microRNA Join us in Prague at @imgprague.bsky.social during 27-30/8, 2025. Registration, program and more info here:
argonautes.img.cas.cz
The grassroot meeting of Argonaute afficionados is looking for afficionados! Full coverage of Argonautes from prokaryotes to #RNAi, #piRNA and #microRNA Join us in Prague at @imgprague.bsky.social during 27-30/8, 2025. Registration, program and more info here:
argonautes.img.cas.cz
Reposted by Joana Vidigal
Hi friends, If you haven't seen it already, I was part of a mess this week — about science in the United States, and about NIH research aimed at understanding things like Alzheimer's, schizophrenia, autism, and depression.
🧪 Thread with some details. 🧠📈 🧠🤖
1/10
🧪 Thread with some details. 🧠📈 🧠🤖
1/10
Compelling pushback from @jmgrohneuro.bsky.social and the Board of Scientific Counselors at the National Institute on Mental Health (NIMH) regarding termination of tenure-track investigators driven by DOGE.
1/2
1/2
March 10, 2025 at 3:59 AM
Hi friends, If you haven't seen it already, I was part of a mess this week — about science in the United States, and about NIH research aimed at understanding things like Alzheimer's, schizophrenia, autism, and depression.
🧪 Thread with some details. 🧠📈 🧠🤖
1/10
🧪 Thread with some details. 🧠📈 🧠🤖
1/10
Reposted by Joana Vidigal
Here is the peer-reviewed version of our study showing how some TAD borders are essential for gene regulation and development.
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Deletion of a single CTCF motif at the boundary of a chromatin domain with three FGF genes disrupts gene expression and embryonic development
Chromatin domains delimited by CTCF can restrict the range of enhancer action. However, disruption of some domain boundaries results in mild gene dysr…
www.sciencedirect.com
February 26, 2025 at 9:22 PM
Here is the peer-reviewed version of our study showing how some TAD borders are essential for gene regulation and development.
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Loss of a single CTCF motif is sufficient to cause embryonic lethality.
www.sciencedirect.com/science/arti...
Reposted by Joana Vidigal
#Argonautes2025 update ... it will happen this August (27-30) @imgprague.bsky.social. Our ITs are finishing and testing the website, the registration will open on March 1st. More info will be provided later (once all speakers reply to my e-mail, just saying, not pushing 😁). Poster announcement:
February 13, 2025 at 3:39 PM
#Argonautes2025 update ... it will happen this August (27-30) @imgprague.bsky.social. Our ITs are finishing and testing the website, the registration will open on March 1st. More info will be provided later (once all speakers reply to my e-mail, just saying, not pushing 😁). Poster announcement:
Reposted by Joana Vidigal
Out now in Dev Cell! scRNAseq trajectories describe the cascade of gene expression as cells differentiate, but turning them into a clear understanding of the underlying biology of a cell type's development remains challenging. authors.elsevier.com/c/1k9qj5Sx5g... (1/)
November 26, 2024 at 3:49 PM
Out now in Dev Cell! scRNAseq trajectories describe the cascade of gene expression as cells differentiate, but turning them into a clear understanding of the underlying biology of a cell type's development remains challenging. authors.elsevier.com/c/1k9qj5Sx5g... (1/)
It’s been a though couple of weeks, but joining this place has felt like a breath of fresh air.
Cherry on top of the cake: a visit from Narry Kim as part of NCI’s #RNAinitiative seminar series. An amazing talk by a giant in the #RNA field. What a treat!
Cherry on top of the cake: a visit from Narry Kim as part of NCI’s #RNAinitiative seminar series. An amazing talk by a giant in the #RNA field. What a treat!
November 19, 2024 at 2:24 PM
It’s been a though couple of weeks, but joining this place has felt like a breath of fresh air.
Cherry on top of the cake: a visit from Narry Kim as part of NCI’s #RNAinitiative seminar series. An amazing talk by a giant in the #RNA field. What a treat!
Cherry on top of the cake: a visit from Narry Kim as part of NCI’s #RNAinitiative seminar series. An amazing talk by a giant in the #RNA field. What a treat!
Reposted by Joana Vidigal
Polycomb-bound regions form some of the strongest and most interesting focal interactions in the nucleus! But what happens when these regions become active and lose H3K27me3? Check the preprint below by the Kassis/Sun labs.
🪰🪰🎉🎉
www.biorxiv.org/content/10.1...
🪰🪰🎉🎉
www.biorxiv.org/content/10.1...
November 6, 2023 at 6:01 PM
Polycomb-bound regions form some of the strongest and most interesting focal interactions in the nucleus! But what happens when these regions become active and lose H3K27me3? Check the preprint below by the Kassis/Sun labs.
🪰🪰🎉🎉
www.biorxiv.org/content/10.1...
🪰🪰🎉🎉
www.biorxiv.org/content/10.1...
Reposted by Joana Vidigal
Download our database of 313 different postdoctoral fellowships.
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
November 16, 2024 at 7:05 PM
Download our database of 313 different postdoctoral fellowships.
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
Reposted by Joana Vidigal
Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS.
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download freely here: research.jhu.edu/rdt/funding-...
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download freely here: research.jhu.edu/rdt/funding-...
November 17, 2024 at 4:38 PM
Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS.
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download freely here: research.jhu.edu/rdt/funding-...
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download freely here: research.jhu.edu/rdt/funding-...
Reposted by Joana Vidigal
Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705
https://www.rug.nl/about-ug/work-with-us/job-opportunities/?details=00347-02S000B06P
t.co
November 15, 2024 at 9:13 PM
Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705
Reposted by Joana Vidigal
I am really enjoying the surge of people to bluesky but still kind of missing the VERY early career group of people! (Aging in academia is a funny thing) - I went ahead and made this starter pack go.bsky.app/Jq8YaQM - if you would like to be removed/added please let me know
November 14, 2024 at 8:48 AM
I am really enjoying the surge of people to bluesky but still kind of missing the VERY early career group of people! (Aging in academia is a funny thing) - I went ahead and made this starter pack go.bsky.app/Jq8YaQM - if you would like to be removed/added please let me know
Reposted by Joana Vidigal
7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
November 11, 2024 at 7:33 PM
7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
Reposted by Joana Vidigal
Let's make a thread of RNA-related conferences in 2025 🧵 (add missing!)
November 13, 2024 at 6:03 AM
Let's make a thread of RNA-related conferences in 2025 🧵 (add missing!)