It has been a real pleasure to dive deep into the wonderful world of the unique and peculiar shape of the neutrophil nucleus, together with Ananda and Irina in the @udalovalab.bsky.social, and I'm proud this literature review is now out in @natrevimmunol.nature.com.
rdcu.be/ePKFk

Researchers compared blood from Long Covid patients with healthy controls, focusing on two features: microclots and NETs (neutrophil extracellular traps). 2/
www.independent.co.uk/news/science...

Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...

Research source: 'Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients - Thierry et al - 2025 - Journal of Medical Virology - Wiley Online Library.' onlinelibrary.wiley.com/doi/10.1002/...
#LongCOVID

Inwardly rectifying potassium channels promote directional sensing during #neutrophil chemotaxis, say Tianqi Wang, Daniel Kim, Chang Ding, GuangJun Zhang, Qing Deng, and colleagues (Purdue University) rupress.org/jcb/article/...

#Migration #motility #Immunology

1) Dr. Vanessa Velasco gave preliminary results on OMF's new neutrophil study.

She found that neutrophils of ME/CFS patients died quicker and more often than those of healthy controls, under inflammatory conditions.

Qualitative and Quantitative Analysis of Circulating NET-derived chromatin and nucleosomes in... - goo.gl/scholar/MJk5Y4 #ScholarAlerts

A 52-year-old man with a history of splenectomy and hypogammaglobulinemia after CAR T-cell therapy for lymphoma 3 years earlier was admitted with septic shock. Encapsulated diplococci were seen in 20% of neutrophils. Read the full case details: nej.md/4oap9GL

#MedSky #IDSky

We've published our very first clinical study where we found that chronic low back pain rhythmicity contributes to biopsychosocial outcomes, including opioid use, via the neutrophil degranulation pathway t.co/0yFdJemScW

This issue’s cover art represents the potential for improving pain relief by restoring circadian rhythmicity

@ghasemloulab.bsky.social & team link daily pain rhythmicity with neutrophil activation, better biopsychosocial profiles, & reduced opioid use: buff.ly/GR3SOAK

New Blood issue out featuring:
The acute myeloid leukemia microenvironment impairs neutrophil maturation and function through NF-κB signaling buff.ly/0vhlcDl

#WeekendRead! #BeyondNETosis! @caroleparentlab.bsky.social @sbarya.bsky.social &co show @natcellbio.nature.com that neutrophils can secrete nuclear-derived exosomes containing LTB4 & DNA which direct migration but at also favor inflammation resolution via neutrophil retrotransmigration!

𝐏𝐡𝐚𝐠𝐨𝐜𝐲𝐭𝐨𝐬𝐢𝐬 is the process by which a phagocyte (a type of white cell such as macrophage, monocyte, or neutrophil) engulfs large particles, usually pathogens or debris from dead or dying cells, and removes them from the bloodstream.

#MedSky #ScienceSky

Excited to be involved with this work driven by @dremilygoldberg.bsky.social and her team! Read the preprint now!

"Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth"

To learn more about this NEJM Illustrated Glossary term, read the editorial “Defanging the Neutrophil to Treat Bronchiectasis” by Adam T. Hill, MD: nej.md/4cANv89 

Explore more terms: nej.md/glossary

This is a technical feat showing the progress in sample processing an instrument sensitivity, as we estimate we inject 30pg of protein content from a single neutrophil. Yet we can detect >3,000 proteins from 500 neutrophils and >1,100 from a single GBM associated neutrophil!

A new drug acting on neutrophils is FDA cleared - an event in that not many neutrophil-acting drugs are out there! This is an inhibitor of DPP1... read more insmed.com